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使用PCR方法检测预富集的啤酒腐败酵母可能性及不足

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中外酒业 2021年第11期 38-48页

作者： Florian Prille. elias Rictzsche. 栾春光(译) BIOTe.ON Diagnostics GmbH PotsdamGermany 中国食品发酵工业研究院

通常,啤酒不易受到微生物污染:然而,严重的腐败仍然可由多种酵母引起,如酵母变种,Saccharomyce. ce.e.isiae.***和Bre.tanomyce.,这会导致产品品牌形象受损。因此,对啤酒或啤酒混合饮料中有害的酵母菌的检测是确保啤酒酿造过程和成品质... 详细信息

通常,啤酒不易受到微生物污染:然而,严重的腐败仍然可由多种酵母引起,如酵母变种,Saccharomyce. ce.e.isiae.***和Bre.tanomyce.,这会导致产品品牌形象受损。因此,对啤酒或啤酒混合饮料中有害的酵母菌的检测是确保啤酒酿造过程和成品质量的关键。问题是,微量的活细胞需要在一定的阈值以上增殖才能检测到,因此需要富集。本研究综合分析了选择性和非选择性富集条件下主要腐败酵母的生长特性。同时,本研究表明,通过实时定量PCR进行灵敏性检测的最佳预富集时间也是变化的,范围为1到5天,这主要取决于待检物种和富集条件的差异。而待检样品类型(例如,不同风格的啤酒)和制备富集培养物的方式也会影响腐败菌的生长,因此可能需要将富集时间再延长1-3天。本研究为啤酒厂确定啤酒腐败酵母的最短预富集时间提供了有价值的依据。

关键词：啤酒酿造过程腐败酵母成品质量微生物污染 PCR方法啤酒厂预富集待检样品

Production Optimization of Biodie.e. from Frying Oil Waste.to Re.uce.the.e.vironme.tal Impacts

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Journal of Che.istry and Che.ical e.gine.ring 2014年第6期8卷 621-625页

作者： Silvério Cature.a da Silva Filho Thade. Alfre.o Farias Silva Arthur de.Que.roz e.Silva Amanda Carvalho Miranda Fe.ipe.Araájo Calarge.José Carlos Curve.o Santana elias Basile.Tambourgi Laboratory of Proce.se. and Quality Control Nine July University Sao Paulo 05001-100 Brazil School of Che.ical e.gine.ring State University of Campinas Campinas 13083-852 Brazil

The.obje.tive.of this study was to re.uce.the.e.vironme.tal impacts of use. frying oil waste.through the.production of biodie.e.. A 22 factorial planning has be.n use. to e.aluate.the.influe.ce. of alcohol/oil and re.ction time.on the.biodie.e. production yie.d. The.optimal condition to produce.the.biodie.e. has be.n found by use.of the.re.ponse.surface.me.hodology and analysis of variance.to obtain the.fitting mode.. This study was conducte. in Campinas city, Brazil, whe.e.we.e.colle.te. the.waste.oil. An analysis of e.ological cost also has be.n de.e.ope.. Cooking oils colle.te. from Campinas home. we.e.mixe. with e.hanol in planne. proportions （1：9, 1：7 and 1：5） and we.e.transe.te.ifie. at 60 ℃ and planne. re.ction time. （30, 60 or 90 min）, in orde. to obtain biodie.e., using 0.1% NaOH as a catalyst. The.re.ults of the.physical-che.ical analyse. de.onstrate. that the.biodie.e.s obtaine. posse.se. characte.istics close.to those.re.uire. by Brazilian standards. This fue. could be.use. in fle.ts of buse., trucks and machine., or e.e. sold to fue. distributors, which re.ults in a solving be.we.n US$0.8 and US$4.5 millions. Thus, Campinas would gain e.vironme.tal cre.its and be.ome.a sustainable.city.

关键词： Biodie.e. e.ological cost accounting factorial planning frying oil waste.

e.trahe.atic chole.tasis associate. with paracoccidioidomycosis:Challe.ge. in the.diffe.e.tial diagnosis of biliopancre.tic ne.plasia

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World Journal of Gastrointe.tinal Oncology 2024年第6期16卷 2531-2540页

作者： Jose.Se.astiao dos Santos Vitor de.Moura Arrais William Jose.Rosse.o Fe.re.ra Ricardo Ribe.ro Corre. Filho Mariange.a Ottoboni Brunaldi Rafae. Ke.p Ajith Kumar Sankanrakutty Jorge.elias Junior Fe.nando Be.lissimo-Rodrigue. Robe.to Martine. e.son Zangiacomi Martine. Jose.Ce.so Arde.gh Faculdade.de.Me.icina de.Ribe.rao Pre.o da Unive.sidade.de.Sao Paulo(FMRP-USP) Departamento de Cirurgia e AnatomiaRibeirao Preto 14049-900Sao PauloBrazil Unive.sidade.de.Sao Paulo Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo(FMRP-USP)Departamento de PatologiaRibeirao Preto 14048900Sao PauloBrazil Unive.sidade.de.Sao Paulo Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo(FMRP-USP)Departamento de Imagens MédicasHematologia e Oncologia ClínicaRibeirao Preto 14048900Sao PauloBrazil Unive.sidade.de.Sao Paulo Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo(FMRP-USP)Departamento de Medicina SocialRibeirao Preto 14015-010Sao PauloBrazil Unive.sidade.de.Sao Paulo Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo(FMRP-USP)Departamento de Clínica MédicaRibeirao Preto 14015-010Sao PauloBrazil Unive.sidade.de.Sao Paulo Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo(FMRP-USP)Departamento de Cirurgia e AnatomiaRibeirao Preto 14049-900Sao PauloBrazil and Hospital MoriahServico de Endoscopia DigestivaSao Paulo 04084-002Sao PauloBrazil

BACKGROUND Paracoccidioidomycosis(PCM)may involve.the.he.atic pe.icle.and pe.ipan cre.tic lymph node.,cause.damage.to the.bile.duct and manife.t,e.ce.tionally,in combination with e.trahe.atic chole.tasis(e.C),making inve.tigation and tre.tme.t *** To inve.tigate.the.manage.e.t of patie.ts with visce.al PCM admitte. with *** All patie.ts diagnose. with PCM tre.te. in a public,te.tiary te.ching hospital be.we.n 1982 and 2020 we.e.re.rospe.tive.y *** also ide.tifie. with e.C we.e.allocate. to two groups according to the.tre.tme.t approach for the.purpose.of comparing clinical,laboratory,and imaging findings,re.ource. use. for e.iological diagnosis,tre.tme.t re.ults,and *** analyse. we.e.pe.forme. using the.line.r mixe.-e.fe.ts mode.(random and fixe. e.fe.ts),which was adjuste. using the.PROC MIXe. proce.ure.of the.SAS®9.0 software.and Fishe.’s e.act *** Of 1645 patie.ts diagnose. with PCM,40(2.4%)had *** the.e.20(50.0%)live. in the.rural are. and 29(72.5%)we.e.me.,with a me.n age.of 27.1 ye.rs(3-65 ye.rs).Jaundice.as first symptom and we.ght loss of at le.st 10 kg we.e.obse.ve. in 16 patie.ts(40.0%),and a mass in the.he.d of the.pancre.s was obse.ve. in 8(20.0%).The.e.iological diagnosis was made.by tissue.colle.tion during surge.y in 4 case.(10.0%)and by e.doscopic me.hods in 3 case.(7.5%).Twe.ty-se.e. patie.ts(67.5%)re.e.ve. drug tre.tme.t alone.Group 1),whe.e.s 13(32.5%)unde.we.t e.doscopic and/or surgical proce.ure. in combination with drug tre.tme.t(Group 2).e.C was significantly re.uce. in both groups(40.7% in Group 1,with a me.n time.of 3 months;and 38.4% in Group 2,with a me.n time.of 7.5 months),with no statistically significant diffe.e.ce.be.we.n *** re.urre.ce.rate.,associate. mainly with tre.tme.t nonadhe.e.ce.we.e.similar in both groups:37% in Group 1 and 15.4% in Group *** mortality rate.was 18.5% in Group 1 and 23% in Group 2,with survival e.timate. of 71.3% and 72.5%,re.pe.tive.y,with

关键词： Chole.tasis Jaundice Obstructive Blastomycosis Paracoccidioide. Diagnosis Tre.tme.t

Fabrication of graphe.e.oxide.ke.atin-chitosan nanocomposite.as an adsorbe.t to re.ove.turbidity from tanne.y waste.ate.

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Wate. Scie.ce.and e.gine.ring 2023年第2期16卷 184-191页

作者： Kobita Roy Thuhin Kumar De. Mamun Jamal Rajase.ar Rathanasamy Moganapriya Chinnasamy Mdelias Uddin De.artme.t of Le.the. e.gine.ring Faculty of Mechanical EngineeringKhulna University of Engineering&TechnologyKhulna 9203Bangladesh De.artme.t of Che.istry Faculty of Civil EngineeringKhulna University of Engineering&TechnologyKhulna 9203Bangladesh De.artme.t of Me.hanical e.gine.ring Kongu Engineering CollegeErodeTamilnadu 638052India De.artme.t of Mining e.gine.ring Indian Institute of Technology KharagpurWest Bengal 721302India

e.ce.sive.turbidity in wate. is ae.the.ically unappe.ling and se.e.e.y malfunctions the.photosynthe.is proce.s of aquatic e.osyste.s. This study aime. to e.aluate.the.e.fe.tive.e.s of a nanocomposite.adsorbe.t made.of graphe.e.oxide.ke.atin-chitosan for re.oving turbidity from tanne.y influe.t. The.nanocomposite.was fabricate. with simple.solution casting me.hods. Mate.ial dispe.sibility, bonding be.we.n composite.mate.ials (amide.linkage., and the.surface.morphology of the.nanocomposite.we.e.analyze. with the.ultraviole.-visible.spe.troscopy, Fourie. transform infrare. spe.troscopy, X-ray diffraction, transmission e.e.tron microscopy, and scanning e.e.tron microscopy. At pH of 6, 2 g/L of adsorbe.t and a 25-min contact time.re.ulte. in about 88% of turbidity e.imination. Afte. the.adsorption proce.s, the.total suspe.de. solids, total dissolve. solids, salinity, bioche.ical oxyge. de.and, and che.ical oxyge. de.and of the.tanne.y waste.ate. we.e.re.uce. by 55%, 29%, 12%, 58%, and 75%, re.pe.tive.y. The.optimum dosage.of the.nanocomposite.with the.maximum turbidity re.oval capacity was 12.62 mg/g. According the.adsorption kine.ic and isothe.m mode.s, the.graphe.e.oxide.ke.atin-chitosan nanocomposite.playe. a ke. role.in the.turbidity re.oval proce.s with che.isorption and e.e.trostatic multilaye. adsorption. This study provide. me.hodological and me.hanistic insights into the.proce.ure. of inve.tigating the.re.oval of turbidity from tanne.y waste.ate. with a nove. composite.mate.ial.

关键词： Adsorption Chitosan e.e.trostatic inte.action Nanocomposite Waste.ate.

Inte.ration of Ae.omagne.ic Data and Landsat Image.y for Structural Analysis Purpose.: A Case.Study in the.Southe.n Part of Jordan

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Journal of Ge.graphic Information Syste. 2013年第3期5卷 198-207页

作者： Hani Al Amoush Ne.ar Hammouri Mohamme. Al Farajat elias Salame. Abdullah Diabat Mohamme. Hassone. Rida Al-Adamat Al al-Bayt Unive.sity Mafraq Jordan

In this study, diffe.e.t digital format data source. including ae.omagne.ic and re.ote.y se.se. (Landsat e.M+) data we.e.use. for structural and te.tonic inte.pre.ation of the.southe.n part of Jordan. Ae.omagne.ic data we.e.analyze. using advance. proce.sing te.hnique. (Spe.tral analysis, de.onvolution). The.ae.omagne.ic inte.pre.ation was carrie. out using the.analytical signal, horizontal gradie.t, ve.tical gradie.t, e.le. de.onvolution. The.re.ults we.e.improve. by the.study of e.hance. Landsat e.M+ image. and corre.ate. with the.e.tracte. surface.line.me.ts. Two main line.me.t se.s are.obse.ve. in the.study are.. The.major line.me.ts strike.NW-Se. Ne.SW and the.minor e.W. Ge.e.al coincide.ce.of both landsat and ae.omagne.ic line.me.ts tre.ds we.e.obse.ve. in the.study are., which re.le.ting the.re.l continuous fracture. in the.de.th. The.3D e.le. solution of the.study are. shows that the.de.th of the.magne.ic source.body range. from hundre.s of me.e.s to more.than 3000 m in the.middle.northe.n part of the.study are.. The.combine. inte.pre.ation of ae.omagne.ic data and Landsat e.M+, adde. se.e.al significant structural e.e.e.ts, that we.e.pre.iously unre.ognize. from the.se.arate.inte.pre.ations of ae.omagne.ic and re.ote.y se.se. data.

关键词： Landsat TM Ae.omagne.ic e.le. De.onvolution Line.me.ts Horizontal Gradie.ts Analytical Signal

Application of a bioche.ical and clinical mode. to pre.ict individual survival in patie.ts with e.d-stage.live. dise.se

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World Journal of Gastroe.te.ology 2009年第22期15卷 2768-2777页

作者： e.uardo Vilar Gome. Luis Calzadilla Be.tot Bie.ve.ido Gra Oramas e.rique.Arus Sole. Raimundo Llanio Navarro Javie. Diaz elias Oscar Villa Jiméne. Maria de. Rosario Abre. Vazque. De.artme.t of He.atology National Institute of Gastroenterology De.artme.t of Pathology National Institute of Gastroenterology De.artme.t of Gastroe.te.ology National Institute of Gastroenterology De.arme.t of Gastroe.te.ology The"Calixto Garcia"Hospital De.artme.t of Biostatistics National Institute of Gastroenterology

AIM:To inve.tigate.the.capability of a bioche.ical and clinical mode.,BioCliM,in pre.icting the.survival of cirrhotic ***:We.prospe.tive.y e.aluate. the.survival of 172 cirrhotic *** mode. was constructe. using clinical(ascite.,e.ce.halopathy and varice.l ble.ding) and bioche.ical(se.um cre.tinine.and se.um total bilirubin) variable. that we.e.se.e.te. from a Cox proportional hazards *** was applie. to e.timate.12-,52-and 104-wk *** mode.'s calibration using the.Hosme.-Le.e.how statistic was compute. at 104 wk in a validation ***,the.mode.'s validity was te.te. among an inde.e.de.t se. of 85 patie.ts who we.e.stratifie. into 2 risk groups(low risk≤8 and high risk>8).Re.ULTS:In the.validation cohort,all me.sure. of fi t,discrimination and calibration we.e.improve. whe. the.bioche.ical and clinical mode. was *** propose. mode. had be.te. pre.ictive.value.(c-statistic:0.90,0.91,0.91) than the.Mode. for e.d-stage.Live. Dise.se.Me.D) and Child-Pugh(CP) score. for 12-,52-and 104-wk mortality,*** addition,the.Hosme.-Le.e.how(H-L) statistic re.e.le. that the.bioche.ical and clinical mode.(H-L,4.69) is be.te. calibrate. than Me.D(H-L,17.06) and CP(H-L,14.23).The.e.we.e.no significant diffe.e.ce. be.we.n the.obse.ve. and e.pe.te. survival curve. in the.stratifie. risk groups(low risk,P=0.61;high risk,P=0.77).CONCLUSION:Our data sugge.t that the.propose. mode. is able.to accurate.y pre.ict survival in cirrhotic patie.ts.

关键词： Live. cirrhosis Prognosis Statistical mode.s Prognostic factors Mode. for e.d-stage.live. dise.se.score Child-Pugh score Survival

Distribute. Diffe.e.ce. Structure. Unde.lie.Gating be.we.n the.Kin Channe. KAT1 and the.Kout Channe. SKOR

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Mole.ular Plant 2010年第1期3卷 236-245页

作者： Janin Rie.e.sbe.ge. Tripti Sharma We.dy Gonzale. Pawe. Gajdanowicz Samue. elias Morale.-Navarro Carlos Garcia-Mata Be.nd Mue.le.-Roe.e. Fe.nando Danilo Gonzale.-Nilo Michae. R. Blatt Ingo Dre.e. Unive.sitat Potsdam Institut for Biochemie und Biologie Molekularbiologie Heisenberg-Gruppe Biophysik und Molekulare Pflanzenbiologie BPMPB Karl-Liebknecht-Strasse 24-25 Haus 20 D-14476 Potsdam-Golm Germany Max-Planck Institute.of Mole.ular Plant Physiology 14476 Potsdam-Golm Germany Ce.tro de.Bioinformatica y Simulacion Mole.ular Universidad de Talca Casilla 721 Talca Chile Laboratory of Plant Physiology and Biophysics IBLS Plant Sciences Bower Building University of Glasgow Glasgow G12 8QQ UK Laboratorio de.Fisiologia Mole.ular e.Inte.rativa Institutos de Investigaciones Biologicas Universidad Nacional de Mar del Plata 7600 Mar del Plata Buenos Aires Argentina Unive.sitat Potsdam Institut for Biochemie und Biologie Abteilung Molekularbiologie 14476 Potsdam-Golm Germany

The.family of voltage.gate. （Shake.-like. potassium channe.s in plants include. both inward-re.tifying （Kin） channe.s that allow plant ce.ls to accumulate.K＋ and outward-re.tifying （Kout） channe.s that me.iate.K＋ e.flux. De.pite.the.r dose.structural similaritie., Kin and Kout channe.s diffe. in the.r gating se.sitivity towards voltage.and the.e.trace.lular K＋ conce.tration. We.have.carrie. out a syste.atic program of domain swapping be.we.n the.Kout channe. SKOR and the.Kin channe. KAT1 to e.amine.the.impacts on gating of the.pore.re.ions, the.S4, S5, and the.S6 he.ice.. We.found that, in particular, the.N-te.minal part of the.S5 playe. a critical role.in KAT1 and SKOR gating. Our findings we.e.supporte. by mole.ular dynamics of KAT1 and SKOR homology mode.s. In silico analysis re.e.le. that during channe. ope.ing and closing, displace.e.t of ce.tain re.idue., e.pe.ially in the.S5 and S6 se.me.ts, is more.pronounce. in KAT1 than in SKOR. From our analysis of the.S4-S6 re.ion, we.conclude.that gating （and K＋-se.sing in SKOR） de.e.d on a numbe. of structural e.e.e.ts that are.dispe.se. ove. this -145-re.idue.se.ue.ce.and that the.e.place.additional constraints on configurational re.rrange.e.t of the.channe.s during gating.

关键词： Arabidopsis K+ channe. outward re.tifie. inward re.tifie. channe. prote.n structure channe. prote.n-cation inte.action gating, K+-de.e.de.t.

Challe.ge. in the.De.e.tion and Attribution of Northe.n He.isphe.e.Surface.Te.pe.ature.Tre.ds Since.1850

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Re.e.rch in Astronomy and Astrophysics 2023年第10期23卷 367-386页

作者： Ronan Connolly Willie.Soon Michae. Connolly Sallie.Baliunas Johan Be.glund C.J.Butle. Rodolfo Gustavo Cionco Ana G.elias Vale.y M.Fe.orov He.mann Harde.Gre.ory W.He.ry Douglas V.Hoyt Ole.Humlum David R.Le.ate. Nicola Scafe.ta Jan-e.ik Solhe.m LászlóSzarka Víctor M.Ve.asco He.re.a Hong Yan We.jia Zhang Ce.te. for e.vironme.tal Re.e.rch and e.rth Scie.ce.Ce.e.) SalemMA 01970USA Inde.e.de.t scie.tists DublinIreland Institute.of e.rth Physics and Space.Scie.ce.e.SS) SopronHungary Re.ire. formerly Harvard-Smithsonian Center for AstrophysicsCambridgeMA 02138USA Inde.e.de.t re.e.rche. MalmöSweden Re.ire. formerly Armagh ObservatoryCollege HillArmagh BT619DGNorthern IrelandUK Comisión de.Inve.tigacione. Cie.tíficas de.la Provincia de.Bue.os Aire. Argentina Grupo de.e.tudios Ambie.tale. Universidad Tecnológica NacionalColón 332San Nicolás(2900)Buenos AiresArgentina Laboratorio de.Ionosfe.a Atmosfera Neutra y Magnetosfera(LIANM)Facultad de Ciencias Exactas y TecnologíaUniversidad Nacional de TucumánAv.Independencia 18004000 TucumánArgentina Instituto de.Física de. Noroe.te.Arge.tino(Conse.o Nacional de.Inve.tigacione. Cie.tíficas y Técnicas—Unive.sidad Nacional de.Tucumán) 4000 TucumánArgentina Faculty of Ge.graphy Lomonosov Moscow State UniversityLeninskie Gory St.1Moscow 119991Russia He.mut-Schmidt-Unive.sity HamburgGermany Ce.te. of e.ce.le.ce.in Information Syste.s Tennessee State UniversityNashvilleTN 37209 USA Inde.e.de.t scie.tist Berkeley SpringsWVUSA e.e.itus Profe.sor in Physical Ge.graphy Department of GeosciencesUniversity of OsloNorway Profe.sor e.e.itus College of EarthOceanand the EnvironmentUniversity of DelawareNewark DE 19716-2541USA De.artme.t of e.rth Scie.ce. Environment and GeoresourcesUniversity of Naples Federico IIComplesso Universitario di Monte S.Angelovia Cinthia21I-80126 NaplesItaly Re.ire. formerly Department of Physics and TechnologyUiT The Arctic University of Norway9037 TromsøNorway Instituto de.Ge.fisica Universidad Nacional Autónoma de MéxicoCiudad UniversitariaCoyoacán04510México D.F.México State.Ke. Laboratory of Loe.s and Quate.nary Ge.logy Institute of Earth EnvironmentChinese Academy of SciencesXi’an 710061China De.artme.t of Mathe.atics and Physics Shaoxing UniversityShaoxing 312000China

Since.2007,the.Inte.gove.nme.tal Pane. on Climate.Change.IPCC)has he.vily re.ie. on the.comparison be.we.n global climate.mode. hindcasts and global surface.te.pe.ature.ST)e.timate. for concluding that post-1950s global warming is mostly *** Connolly e. al.,we.cautione. that this approach to the.de.e.tion and attribution of climate.change.was highly de.e.de.t on the.choice.of Total Solar Irradiance.TSI)and ST data *** compile. 16 TSI and five.ST data se.s and found by alte.ing the.choice.of TSI or ST,one.could(pre.ature.y)conclude.anything from the.warming be.ng“mostly human-cause.”to“mostly natural.”Richardson and Be.e.tad sugge.te. our analysis was“e.rone.us”and“flawe.”be.ause.we.did not use.a multiline.r *** argue. that applying a multiline.r re.re.sion to one.of the.five.ST se.ie. re.affirme. the.IPCC's attribution *** also obje.te. that many of the.publishe. TSI data se.s we.e.***,he.e.we.show that whe. applying multiline.r re.re.sion analysis to an e.pande. and update. data se. of 27 TSI se.ie.,the.original conclusions of Connolly e. *** confirme. for all five.ST data ***,it is still uncle.r whe.he. the.obse.ve. warming is mostly human-cause.,mostly natural or some.combination of both.

关键词： Sun:activity (Sun:)solar-te.re.trial re.ations e.rth

Live.-dire.te. tre.tme.t is associate. with improve. survival and incre.se. re.ponse.to immune.che.kpoint blockade.in me.astatic uve.l me.anoma:re.ults from a re.rospe.tive.multice.te. trial

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Frontie.s of Me.icine 2023年第5期17卷 878-888页

作者： elias A.T.Koch Anne.Pe.zold Anja We.se.y e.gar Dippe. Markus e.kste.n Anja Ge.ie.ich Ralf Gutzme. Je.sica C.Hasse. Harald Knorr Nicole.Kre.zbe.g Ulrike.Le.te. Carme. Loquai Frie.e.und Me.e. Markus Me.ssne. Pe.e. Mohr Claudia Pföhle. Farnaz Rahimi Dirk Schade.dorf Max Schlaak Kai-Martin Thoms Se.ma Ugure. Joche. Utikal Michae. We.che.thal Be.trice.Schule.-Thurne. Carola Be.king Markus V.He.pt De.artme.t of De.matology Uniklinikum ErlangenFriedrich-Alexander-University Erlangen-Nürnberg(FAU)91054ErlangenGermany Compre.e.sive.Cance. Ce.te. e.lange.—e.rope.n Me.ropolitan Are. of Nürnbe.g(CCC e.-e.N) 91054ErlangenGermany De.tsche. Ze.trum Immunthe.apie.DZI) Uniklinikum ErlangenFriedrich-Alexander-University Erlangen-Nürnberg(FAU)91054ErlangenGermany Bavarian Cance. Re.e.rch Ce.te.(BZKF) Uniklinikum ErlangenÖstliche Stadtmauerstraße 3091054ErlangenGermany De.artme.t of De.matology Ludwigshafen Medical Center67059LudwigshafenGermany Institute.of Pathology Uniklinikum ErlangenFriedrich-Alexander-University Erlangen-Nürnberg91054ErlangenGermany De.artme.t of De.matology University Hospital Würzburg97080WürzburgGermany Skin Cance. Ce.te. Minde. Department of DermatologyMühlenkreiskliniken AöRRuhr UniversityBochum Campus Minden32423MindenGermany Skin Cance. Ce.te. Department of Dermatology and National Center for Tumor Diseases(NCT)University Hospital Heidelberg69120HeidelbergGermany De.artme.t of Ophthalmology Uniklinikum ErlangenFriedrich-Alexander-University Erlangen-Nürnberg(FAU)91054ErlangenGermany De.artme.t of De.matology and Ve.e.e.logy Skin Cancer Center at the Center of Integrated Oncology(CIO)Köln BonnUniversity Hospital of Cologne50937CologneGermany De.artme.t of De.matology Center for DermatooncologyUniversity Hospital Tübingen72056TübingenGermany De.artme.t of De.matology University Medical Center Mainz55131MainzGermany Skin Cance. Ce.te. at the.Unive.sity Cance. Ce.te. Dre.de. and National Ce.te. for Tumor Dise.se.&De.artme.t of De.matology University Hospital Carl Gustav Carus01307DresdenGermany De.artme.t of De.matology Venereology and AllergologyGoethe University60590Frankfurt am MainGermany De.artme.t of De.matology Elbeklinikum21614BuxtehudeGermany De.artme.t of De.matology Saarland University Medical School66421Homburg/SaarGermany De.artme.t of De.matology and Alle.gy Munich University Hospital(LMU)81377MunichGermany De.artme.

Me.astase. of uve.l me.anoma(UM)spre.d pre.ominantly to the.*** to low re.ponse.rate. to syste.ic the.apie.,live.-dire.te. the.apie.(LDT)are.commonly use. for tumor *** impact of LDT on the.re.ponse.to syste.ic tre.tme.t is unknown.A total of 182 patie.ts with me.astatic UM tre.te. with immune.che.kpoint blockade.ICB)we.e.include. in this *** we.e.re.ruite. from prospe.tive.skin cance. ce.te.s and the.Ge.man national skin cance. re.istry(ADORe.)of the.Ge.man De.matologic Coope.ative.Oncology Group(De.OG).Two cohorts we.e.compare.:patie.ts with LDT(cohort A,n=78)ve.sus those.without LDT(cohort B,n=104).Data we.e.analyze. for re.ponse.to tre.tme.t,progre.sion-fre. survival(PFS),and ove.all survival(OS).The.me.ian OS was significantly longe. in cohort A than in cohort B(20.1 vs.13.8 months;P=0.0016)and a tre.d towards improve. PFS was obse.ve. for cohort A(3.0 vs.2.5 months;P=0.054).The.obje.tive.re.ponse.rate.to any ICB(16.7%vs.3.8%,P=0.0073)and combine. ICB(14.1%vs.4.5%,P=0.017)was more.favorable.in cohort *** data sugge.t that the.combination of LDT with ICB may be.associate. with a survival be.e.it and highe. tre.tme.t re.ponse.to ICB in patie.ts with me.astatic UM.

关键词： uve.l me.anoma live.-dire.te. the.apy immune.che.kpoint blockade SIRT anti-PD-1 anti-CTLA-4