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Acute bacterial infection negatively impacts cancer specific survival of colorectal cancer patients

World Journal of Gastroenterology 2014年第38期20卷 13930-13935页

作者： Regina Attiê Ludmilla Thomé Domingos Chinen eliane muta yoshioka Michele Cristina F Silva Vladmir Cláudio Cordeiro de Lima Pharmacy Department A.C.Camargo Cancer Center Medical Oncology Department International Research Center Research Department A.C.Camargo Cancer Center

AIM:To assess the impact of bacterial infections on cancer-specific survival in patients with colorectal cancer. METHODS:This was a retrospective cohort study of colorectal cancer patients treated at the A.C. Camargo Cancer Center between January 2006 and April 2010. The presence of bacterial infection during cancer treatment,or up to one year after,was confirmed by laboratory tests or by the physician. Infections of the urinary,respiratory or digestive tracts,bloodstream,skin or surgical site were defined by testing within a single laboratory. Criteria for exclusion from the study were:chronically immunosuppressed patients;transplant patients(due to chronic immunosuppression);human immunodeficiency virus carriers;chronic use of corticosteroids or other immunosuppressive drugs;patients with autoimmune disease or primary immunodeficiency;known viral or parasitic infections. Patients with infections that did not require hospitalization were not included in the study because of the difficulty of collecting and tracking data related to infectious processes. In addition,patients hospitalized for pulmonary thromboembolism,stroke,acute myocardial infarction,uncontrolled diabetes,malignant hypercalcemia or other serious non-infectious complications not directly related to infection were also excluded. Survival curves were plotted using the Kaplan-Meier method,and logrank tests(univariate analysis) and a Cox test assuming a proportional hazards model(multivariate analysis) were performed to examine associations between clinical history and characteristics of infection with cancer-specific survival. RESULTS:One-hundred and six patients with colorectal cancer were divided into two groups based on the presence or absence of bacterial infection. Patient ages ranged from 23 to 91 years,with a median of 55 years. The majority of patients were male(57/106,53.77%) with stage Ⅲ colorectal cancer(45/106,44.11%). A total of 86 bacteriologic events were recorded. Results indicate that t

关键词： Colorectal cancer Bacterial infections Survival

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