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Actively bleeding Dieulafoy's lesion of the small bowel identified by capsule endoscopy and treated by push enteroscopy

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World Journal of Gastroenterology 2006年第24期12卷 3936-3937页

作者： Giovanni D De Palma Francesco Patrone Maria Rega Immacolata Simeoli Stefania Masone Giovanni persico Centro per l'Innovazione Tecnologica in Chirurgia-Dipartimento di Chirurgia Generale Oncologica e Tecnologie Avanzate Universita degli Studi di Napoli Federico Ⅱ Facoltà di Medicina e ChirurgiaNapoliItaly

Dieulafoy＇s lesion is an unusual cause of recurrent GI bleeding. This report describes a case of actively bleeding Dieulafoy＇s lesion of the small bowel in which the diagnosis was made by capsule endoscopy, followed by treatment with the use of push enteroscopy. The case illustrates that capsule endoscopy and enteroscopy are highly complementary in patients with small bowel diseases.

关键词： Dieulafoy's lesion GI hemorrhage Smallbowel Capsule endoscopy Push enteroscopy

Radium-223 and metastatic castration-resistant prostate cancer: All that glitters is not gold

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World Journal of Radiology 2016年第10期8卷 816-818页

作者： Carlo Aprile Marco G persico Lorenzo Lodola Federica E Buroni Nuclear Medicine Unit Department of Oncohaematology Fondazione IRCCS Policlinico SanMatteo Scuola Universitaria Superiore IUSS Pavia

After being approved by the National Drug Agency in several countries, Radium-223 (Ra-223) is gaining wide acceptance in the treatment of bone metastatic castration resistant prostate cancer. The exact mechanism of action remain unclear: The established model of direct alpha-particle irradiation from the remodelling bone surface, where Ra-223 accumulates, surrounding the tumor foci can explain a lethal effect only on metastatic microdeposits, but not on higher tumor burden. According to the “pre-metastatic niche model”, it is likely that Ra-223 targets several non-tumoral cell types of the tumor microenvironment involved in the complex mechanism of cancer bone homing and colonization. A deeper insight into this hypothetical mechanism will lead to a more accurate dosimetric approach and to find optimal sequencing and/or combination with the other therapeutic options.

关键词： Radium-223 Bone metastases Castration resistant prostate cancer Tumor microenvironment Pre-metastatic niche model

In-vivo characterization of DALM in ulcerative colitis with high-resolution probe-based confocal laser endomicroscopy

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World Journal of Gastroenterology 2011年第5期17卷 677-680页

作者： Giovanni D De Palma Stefania Staibano Saverio Siciliano Francesco Maione Maria Siano Dario Esposito Giovanni persico Department of Surgery and Advanced Technologies Center of Excellence for Technical Innovation in SurgerySection of Diagnostic and Therapeutic EndoscopyUniversity of Naples Federico IISchool of Medicine80131NaplesItaly Department of Biomorphological and Functional Sciences Section of PathologyUniversity of Naples Federico IISchool of Medicine80131NaplesItaly

Recently,the use of confocal laser endomicroscopy(CLE) in the diagnosis of chronic ulcerative colitis(CUC) was *** this brief report we aimed to assess the application of probe-based CLE to characterize colonic mucosa and dysplasia in *** study involved a patient presenting long-standing *** imaging of both the inflamed mucosa,a circumscribed lesion(dysplasiaassociated lesional mass),and adjacent colonic mucosa are demonstrated and the correlation between the CLE and histological *** mucosa and dysplasia showed specific alteration of crypt architecture,cellular infiltration,and vessel architecture with an excellent correlation between CLE and standard histological examination.

关键词： Colonoscopy Confocal laser endomicros-copy Chronic ulcerative colitis Dysplasia-associatedlesional mass Histology

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共振荧光

华中师范大学学报(自然科学版) 1984年第2期 19-32页

作者： Franco. persico 意大利Palermo大学

本文提出了在强驱动场作用下的N个二能级原子系的共振荧光理论。应用了以驱动场修饰(Dress)原子的规范变换,以及修饰算符的Langevin方程,从而研究了系统的时间演化。此外还证明了在一些特定情况下,系统呈现出“准超辐射”和“超黑暗”(S... 详细信息

本文提出了在强驱动场作用下的N个二能级原子系的共振荧光理论。应用了以驱动场修饰(Dress)原子的规范变换,以及修饰算符的Langevin方程,从而研究了系统的时间演化。此外还证明了在一些特定情况下,系统呈现出“准超辐射”和“超黑暗”(Superdarkening)的行为。

关键词：共振荧光常数数学算符分子原子二能级激光场

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双光子过程的修饰Hamiltonians

华中师范大学学报(自然科学版) 1984年第2期 33-38页

作者： Franco. persico 意大利Palermo大学

采用规范变换技术给出描述双光子过程的修饰Hamiltonian.并得到了对于给定任一组参量ω,ω和ε时,系统Hamiltonian本征值谱。此外还讨论了真空基态的稳定性问题。

关键词：双光子过程多光子过程 Hamiltonians 二能级本征值谱

Metastatic tumors to the stomach: Clinical and endoscopicfeatures

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World Journal of Gastroenterology 2006年第45期12卷 7326-7328页

作者： Giovanni D De Palma Stefania Masone Maria Rega Immacolata Simeoli Mario Donisi Pietro Addeo Loredana Iannone Vincenzo Pilone Giovanni persico Centro per l'Innovazione Tecnologica in Chirurgia Dipartimento di Chirurgia Generale Oncologica e Tecnologie Avanzate. Università degli Studi di Napoli Federico II Facoltà di Medicina e Chirurgia Napoli Italy Centro per l’Innovazione Tecnologica in Chirurgia Dipartimento di Chirurgia Generale Oncologica e Tecnologie Avanzate. Università degli Studi di Napoli Federico II Facoltà di Medicina e Chirurgia Napoli Italy

AIM: To evaluate the clinical and endoscopic patterns in a large series of patients with metastatic tumors in the stomach. METHODS: A total of 64 patients with gastric meta- stases from solid malignant tumors were retros- pectively examined between 1990 and 2005. The clinicopathological findings were reviewed along with tumor characteristics such as endoscopic pattern, location, size and origin of the primary sites. RESULTS: Common indications for endoscopy were anemia, bleeding and epigastric pain. Metastases presented as solitary (62.5%) or multiple (37.5%) tumors were mainly located in the middle or upper third of stomach. The main primary metastatic tumors were from breast and lung cancer and malignant melanoma. CONCLUSION: As the prognosis of cancer patients has been improving gradually, gastrointestinal (GI) metastases will be encountered more often. Endoscopic examinations should be conducted carefully in patients with malignancies, and endoscopic biopsies and information on the patient’s clinical history are useful for correct diagnosis of gastric metastases.

关键词： Stomach Metastatic tumors Clinical findings Pathology Endoscopy

Contrast-free endoscopic stent insertion in malignant biliary obstruction

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World Journal of Gastroenterology 2007年第29期13卷 3973-3976页

作者： Giovanni D De Palma Giovanni Lombardi Maria Rega Immacolata Simeoli Stefania Masone Saverio Siciliano Francesco Maione Francesca Salvatori Antonio Balzano Giovanni persico Department of General Surgery Oncologic Surgery and Advanced Technologies-Center for Technical Innovation in Surgery University of Naples Federico Ⅱ School of Medicine Naples Italy Division of Gastroenterology General Hospital A. Cardarelli Naples Italy

AIM： To present a case series of MRCP-guided endoscopic biliary stent placement, performed entirely without contrast injection. METHODS： Contrast-free endoscopic biliary drainage was attempted in 20 patients with malignant obstruction, unsuitable for resection on the basis of tumor extent or medical illness. MRCP images were used to confirm the diagnosis of tumor, to exclude other biliary diseases and to demonstrate the stenoses as well as dilation of proximal liver segments. The procedure was carried out under conscious sedation. Patients were placed in the left lateral decubitus position. The endoscope was inserted, the papilla identified and cannulated by a papiUotome. A guide wire was inserted and guided deeply into the biliary tree, above the stenosis, by fluoroscopy. A papillotomy approximately 1 cm. long was performed and the papillotome was exchanged with a guiding-catheter. A 10 Fr＇ Amsterdam-type plastic stent, 7 to 15 cm long, was finally inserted over the guide wire/ guiding catheter by a pusher tube system. RESULTS： Successful stent insertion was achieved in all patients. There were no major complications. Successful drainage, with substantial reduction in bilirubin levels, was achieved in all patients. CONCLUSION： This new method of contrast-free endoscopic stenting in malignant biliary obstruction is a safe and effective method of palliation. However＇ a larger, randomized study comparing this new approach with the standard procedure is needed to confirm the findings of the present study.

关键词： Endoscopic retrograde cholangiopancreatography Biliary stenoses Biliary drainage Endoscopy Stents

Volvulus of the ascending colon in a non-rotated midgut:Plain film and MDCT findings

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World Journal of Radiology 2012年第10期4卷 439-442页

作者： Luigi Camera Milena Calabrese Pier Paolo Mainenti Stefania Masone Walter Del Vecchio Giovanni persico Marco Salvatore Department of Radiology University "Federico Ⅱ" Institute of Biostructures and Bioimages National Research Council(CNR) Department of General and Geriatric Surgery University "Federico Ⅱ"

Colonic volvulus is a relatively uncommon cause of large bowel obstruction usually involving mobile,intraperitoneal,colonic *** or acquired anatomic variation may be associated with an increased risk of colonic volvulus which can occasionally involve retro-peritoneal *** report a case of 54-year-old female who presented to our Institution to perform a plain abdominal film series for acute onset of cramping abdominal *** the upright and supine films showed signs of acute colonic obstruction which was thought to be due to an internal hernia of the transverse colon into the lesser *** patient was therefore submitted to a multi-detector contrast-enhanced computed tomography(CT).CT findings were initially thought to be consistent with the presumed diagnosis of internal hernia but further evaluation and coronal reformatting clearly depicted the presence of a colonic volvulus possibly resulting from a retro-gastric *** surgery,a volvulus of the ascending colon was found and a right hemi-colectomy had to be ***,a non rotated midgut with a right-sided duodeno-jejunal flexure and a left sided colon was also found at laparotomy and over-looked in the pre-operative *** evaluation of CT images was therefore performed and a number of CT signs of intestinal malrotation could be identified.

关键词： Colonic volvulus Intestinal malrotation Abdominal plain film Multi-detector computed tomography Large bowel obstruction

A spontaneous strangulated transomental hernia: Prospective and retrospective multi-detector computed tomography findings

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World Journal of Radiology 2014年第2期6卷 26-30页

作者： Luigi Camera Angela De Gennaro Margaret Longobardi Stefania Masone Emanuela Calabrese Walter Del Vecchio Giovanni persico Marco Salvatore Department of Radiology University "Federico II" Institute of Biostructures and Bioimaging (C.N.R.) University "Federico II" Department of General and Geriatric Surgery University "Federico II"

Transomental hernias are among the rarest type of all internal hernias which overall account for less than 6% of small bowel obstructions. Most transomental hernias occurring in adults are either iatrogenic or post-traumatic. More rarely, a spontaneous herniation of small bowel loops may result from senile atrophy of the omentum. We report a case of an 86-year-old male who presented with signs and symptoms of small bowel obstruction but had no past surgical or traumatic abdominal history. At contrast-enhanced multi-detector row computed tomography(CT), a cluster of fluid-filled dilated small bowel loops could be appreciated in the left flank, with associated signs of bowel wall ischemia. Swirling of the mesenteric vessels could also be appreciated and CT findings were prospectively considered consistent with a strangulated small bowel volvulus. At laparotomy, no derotation had to be performed but up to 100 cm of gangrenous small bowel loops had to be resected because of a transomental hernia through a small defect in the left part of the greater omentum. Retrospective reading of CT images was performed and findings suggestive of transomental herniation could then be appreciated.

关键词： Small bowel obstruction Internal hernias Transomental hernia Multi-detector row computed tomography Strangulation