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Journal of Pharmaceutical Analysis 2017年第4期7卷 208-213页

作者： María del Mar Contreras aránzazu Morales-Soto Antonio Segura-Carretero Javier Valverde Department of Analytical Chemistry Faculty of SciencesUniversity of GranadaAvenida Fuentenueva s/n18071 GranadaSpain Research and Development Functional Food Centre (CIDAF) Bioregión BuildingHealth Science Technological ParkAvda. Del Conocimiento s/n18016 GranadaSpain

Sofosbuvir is one of the new direct-acting antiviral drugs against hepatitis C virus(HCV) infection. This drug has recently been launched into the market, and generic versions of the medication are expected to be produced by local drug producers in some countries. Therefore, new methods are required to control sofosbuvir in pharmaceuticals. In the present study, a new method based on reversed phase(RP)-ultra-high performance liquid chromatography(UHPLC) coupled to diode array detection(DAD) and mass spectrometry(MS) was developed to facilitate the qualitative and quantitative analysis of sofosbuvir in film coated tablets. A wavelength of 260 nm was selected to perform a cost-effective quantification and the method showed adequate linearity,with an R^2 value of 0.9998, and acceptable values of accuracy(75%–102%) and precision(residual standard deviation armaceutical dosage forms, but also for potential degradants.

关键词： Film coated tablets Mass spectrometry RP-UHPLC Sofosbuvir

Cleaning method of InSb [111] B of n-InSb [111] A/B for the growth of epitaxial layers by liquid phase epitaxy

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Journal of Semiconductors 2011年第5期32卷 146-148页

作者： Gh.Sareminia F.Zahedi Sh.Eminov ar.Karamian Electronic Component Industry(ECI)-Optoelectronic Industry P.O.Box 19575-199TehranIran Institute of Physics Azerbaijan UniversityBakuAzerbaijan Department of Mathematics Razi UniversityKermanshaIran

The crystal structure of InSb [111] A/B surfaces shows that this structure is polarized. This means that the surfaces of InSb [111] A and InSb [1^-1^- 1^-] B contain two different crystallized directions and they have different physical and chemical properties. Experiments were carried out on the InSb [ 111 ] A/B surfaces, showing that tartaric acid etchant could create a very smooth surface on the InSb [1^-1^- 1^-] B without any traces of oxides and etch pit but simultaneously create etch pit on InSb [ 111 ] A surfaces. After lapping and polishing, some particles remained on the InSb [1^-1^- 1^-] B surface, they could not be removed easily by standard cleaning process and if these particles remain on the surface of the substrate, the growth layer was not uniform and some island-like regions were observed. The purpose of this work is to remove these particles on the lnSb [1^-1^- 1^-] B surface. Some morphology images of both surfaces, InSb [11 1] A/B, will be presented.

关键词： cleaning lnSb lapping polishing InSb [1^-1^- 1^-] B

Resistant patterns of Pseudomonas aeruginosa in a Malaysian teaching hospital

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Asian Pacific Journal of Tropical Medicine 2009年第6期2卷 59-62页

作者： Zaidah ar Siti SMN Zahiruddin WM Zeehaida M Department of Medical Microbiology and Parasitology School of Medical SciencesUniversiti Sains MalaysiaKelantanMalaysia Department of Community Medicine School of Medical SciencesUniversiti Sains MalaysiaKelantanMalaysia

Objective:Pseudomonas aeruginosa is an opportunistic pathogen and the leading cause of nosocomial infections. Currently a notable increase in the prevalence of multidrug-resistant *** worldwide has been reported in hospitalized patients and was associated with high morbidity and ***:A retrospective laboratory based analysis regarding the spectrum and distribution of *** from a wide range of clinical samples in Hospital Universiti Sains Malaysia since January 2003 to December 2007 was ***: Altogether,there were 2 308 clinical isolates *** main sources of *** were from swab,respiratory,urine and blood specimens which accounted for 28.2%,21.8%,13.2%and 12.8% *** showed significant reduction in percentage of resistant towards three antibiotic namely ciprofloxacin,ceftazidime and *** the percentage of pan-resistant *** increased steadily over these ***:This data is helpful to the clinician in guiding the choice of appropriate antibiotic to treat *** *** the same time,it warrants a more aggressive infection control activity to be implemented to control the spread of pan resistant strain in this centre.

关键词： Pseudomonas aeruginosa Resistant pattern Infection

Supercritical carbon dioxide extraction of Triognella foenum graecum Linn seeds:Determination of bioactive compounds and pharmacological analysis

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Asian Pacific Journal of Tropical Biomedicine 2017年第12期7卷 1085-1091页

作者： Ola Basa’ar Samreen Fatema Ali Alrabie Mohammed Mohsin Mazahar Farooqui Department of Chemistry Hodeidah University Post Graduate & Research Center Maulana Azad College Dr.Rafiq Zakaria College for women

Objective: To investigate the effect of temperature and pressure on supercritical CO_2 extraction of Triognella foenum graecum Linn seeds, to determine the optimal condition which leads to highest percentage of the accumulative yield and revealing the chemical composition of supercritical CO_2 ***: Temperatures in the range of 40–60C and pressures in the range of 10–25 MPa were used. FTIR and GC–MS analysis were used to detect the bioactive compounds present in the extract. The broth dilution method and slope method were used to evaluate the anti-microbial and anti-tuberculosis activities and the in vitro anti-malarial assay was carried out according to the micro assay protocol of Rieckmann and his ***: The temperature was more affected than the pressure on the extraction performance and the highest yield of the extract(3.111%) was attained at 60C and 10 *** and GC–MS showed that the chemical composition of the extract included conjugated linoleic acid methyl ester as the major active principle(with concentration of72.28%), followed by saturated fatty acid methyl esters(16.03%), steroids(8.09%) and organic siloxane compound(3.61%). The extract showed moderate anti-bacterial activity with MIC values 100, 250, 125 mg/m L towards Escherichia coli, Staphylococcus aureus and Streptococcus pyogenus respectively. It exhibited high inhibition effect towards the fungi Candida albican with MFC value(250 mg/m L). The extract had low antituberculosis activity with MIC value(100 mg/m L) and comparable MIC value(0.29 mg/m L) towards Plasmodium ***: Supercritical CO_2 extraction as alternate and green technology is performed successfully to extract the bioactive compounds from the seeds of T. foenum graecum Linn and it is concluded that this extract can be used as an alternate source of synthetic anti-biotic drugs.

关键词： Anti-bacterial Anti-fungal Anti-malarial Anti-tuberculosis Sc–CO2 extraction Triognella foenum graecum Linn

Aquatic fungal diversity in two freshwater ecosystems of Madhya Pradesh,India

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Studies in Fungi 2021年第1期6卷 116-137页

作者： Mehboob A Ganie AH Dar ar Soni KK Rani Durgawati Vishwavidyalaya Jabalpur M.P-India Departments of Botany University of KashmirKargil CampusIndia Govt Degree College Bemina J&K-India Forest Pathology Division Tropical Forest Research Institute Jabalpur M.P-India

Aquatic fungi play an important role in litter decomposition in aquatic *** in view the importance of aquatic fungi,diversity of these organisms was studied in two freshwater ecosystems of Gaur River and Khurji Nala Jabalpur Madhya Pradesh *** the present study,34 fungal species and 6 chromista species have been recorded on decomposing *** number of fungal genera were recorded in submerged litter samples of Tectona grandis followed by Dendroclamus *** maximum percentage frequencies of various fungal species which colonize litter of different tree species were also *** cluster analysis revealed that different fungal communities on various plant hosts vary significantly.

关键词： Colonization decomposing substrate fruits litter mixed twigs

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中美互换摘要

中华高血压杂志（中英文） 2024年第2期32卷 200-200页

作者： Heckel ar arcidiacono DM Coonan KA Glasgow AC DeBlois JP Gump BB Kim JY Heffernan KS 刘青练桂丽

曾患与未患新型冠状病毒成年人的24h中心血流动力学负荷。高血压虽是新型冠状病毒(corona virus disease2019,COVID-19)重症的危险因素,但COVID-19对血压的影响尚不明确。相比于与单一时间点测量肱动脉血压,24 h动态血压监测(24 hour am... 详细信息

曾患与未患新型冠状病毒成年人的24h中心血流动力学负荷。高血压虽是新型冠状病毒(corona virus disease2019,COVID-19)重症的危险因素,但COVID-19对血压的影响尚不明确。相比于与单一时间点测量肱动脉血压,24 h动态血压监测(24 hour ambulatory blood pressure monitoring,ABPM)测量的中心血压对评估心血管疾病(cardiovascular disease,CVD)风险更有预测价值。本研究采用ABPM测量24 h中心血流动力学负荷,评估曾患与未患COVID-19成年人的CVD风险。

关键词：肱动脉血压新型冠状病毒心血管疾病 ABPM 点测量危险因素

A Crystallization Study of Nanocrystalline PZT 53/47 Granular arrays Using a Sol-Gel Based Precursor

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Journal of Materials Science & Technology 2011年第6期27卷 489-496页

作者： A.Surez-Gómez J.M.Saniger-Blesa F.Calderón-Pinar CCADET-Universidad Nacional Autónoma de México Cd.UniversitariaCirc.Exterior s/nA.P.70-186Coyoacn 04510México D.F.México Laboratorio de Ingeniería Electroquímica Facultad de QuímicaUniversidad Nacional Autónoma de MéxicoCd.UniversitariaCoyoacn 04510México D.F.México Facultad de Física/IMRE San Lzaro y LUniversidad de la Habana

In this work,we intend to perform a detailed study on the crystallization process of PZT 53/47 nanostructured powders by starting out with an amorphous precursor synthesized by a sol-gel based *** interests also lie in the feasibility for controlling the average grain size of the final structure in the submicron range on an ab initio ***,Fourier transform infrared spectroscopy（FT-IR）,Raman（Stokes and Anti-Stokes）,X-ray diffraction（XRD） and scanning electron microscopy（SEM） are used to examine the microstructural characteristics based on previously reported differential thermal analysis/thermal gravimetric analysis（DTA/TGA） *** results show a crystallization temperature of 800℃ to attain pure perovskite phase with excellent morphological quality,average grain size 〈DG〉〈 300 nm and with average crystallite size 〈DC〉〈15 nm.

关键词： Powders-chemical preparation PZT synthesis Sol-gel precursors Microstructure- final Vibrational spectroscopies X-ray diffraction

Cholesterol or Fat Rich Diets Accelerate Natural Age-Decline on Adult Hippocampal Neurogenesis and Have an Impact in Memory and Like-Anxiety Behavior

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Advances in Bioscience and Biotechnology 2019年第10期10卷 331-345页

作者： Perla Leal-Galicia María Carmen Sánchez-Torres Marco Antonio meraz-Ríos Departamento de Biomedicina Molecular Centro de Investigación y de Estudios Avanzados del InstitutoPolitécnico Nacional Instituto Politécnico Nacional México City México

Diet is an important health factor and it has been recently associated with neurodegenerative diseases and cognitive decline. Here it was investigated the effect of fatty acid or cholesterol rich diets with the possible acceleration of the biological decline in adult hippocampal neurogenesis associated with aging in middle-age rats, and its impact on anxiety and memory function. It was found that a diet of 10 weeks with saturated fatty acids and cholesterol has a detrimental effect on memory function, exerts like-anxiety behavior and diminishes the presence of new generated neurons in the hippocampus in six months old rats.

关键词： High-Fat Diet High-Cholesterol Diet Adult Hippocampal Neurogenesis Memory Like-Anxiety Behavior

Computational Prediction of Micro RNAs from Toxoplasma gondii Potentially Regulating the Hosts' Gene Expression

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Genomics, Proteomics & Bioinformatics 2014年第5期12卷 228-238页

作者： Müs?erref Duygu Saar Caner Bagc? Jens Allmer Molecular Biology and Genetics Izmir Institute of Technology Urla Izmir 35430 Turkey Biotechnology Izmir Institute of Technology Urla Izmir 35430 Turkey Bionia Incorporated IZTEKGEB A8 Urla Izmir 35430 Turkey

MicroRNAs （miRNAs） were discovered two decades ago, yet there is still a great need for further studies elucidating their genesis and targeting in different phyla. Since experimental discovery and validation of miRNAs is difficult, computational predictions are indispensable and today most computational approaches employ machine learning. Toxoplasma gondii, a parasite residing within the cells of its hosts like human, uses miRNAs for its post-transcriptional gene reg- ulation. It may also regulate its hosts＇ gene expression, which has been shown in brain cancer. Since previous studies have shown that overexpressed miRNAs within the host are causal for disease onset, we hypothesized that T. gondii could export miRNAs into its host cell. We computationally predicted all hairpins from the genome of T. gondii and used mouse and human models to filter possible candidates. These were then further compared to known miRNAs in human and rodents and their expression was examined for T. gondii grown in mouse and human hosts, respectively. We found that among the millions of potential hairpins in T. gondii, only a few thousand pass filtering using a human or mouse model and that even fewer of those are expressed. Since they are expressed and differentially expressed in rodents and human, we suggest that there is a chance that T. gondii may export miRNAs into its hosts for direct regulation.

关键词： Toxoplasma gondii MicroRNA Regulation Host interaction Parasite

Size Structure and Biomass of the Panama Grunt (Pomadasys panamensis) from Bycatch inthe Southeastern Gulf of California

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Open Journal of Marine Science 2012年第1期2卷 1-7页

作者： José Alberto Rodríguez-Preciado Juan Madrid-Vera Ricardo meraz-Sánchez 不详

A population analysis was made using data of the grunt Pomadasys panamensis. The information is from the catch from 260 hauls in estuarine waters, open-ocean waters, and off the coast of Sinaloa and northern Nayarit, Mexico, in the southeastern Gulf of California. The area of influence is about 120,000 km2 and includes about a third of the drag area of the largest shrimp fleet of the American Pacific. The average length in the population was 210 mm. The maximum length was 430 mm and the minimum was 50 mm. The analysis for the frequency distributions of the lengths and the multinomial solution produced representative modal groups for 160 mm, 190 mm, and 230 mm. The simulation of the biomass density gave an estimate close to 90 t, with 650,000 organisms before starting the fishing season in the region. The density was 0.19 kg ha–1. The colonization was 0.42% or 42 %. The model was validated using the Aikaikae criterion (AIC). The results provide an overview of the initial biomass densities and population structure of the species caught as bycatch, demonstrating the importance of this species abundance in the shrimp fishery, and generating a source of monetary income to the crew of the fishing fleet. The persistence of the species to fishing provides an example to study the mechanisms of survival.

关键词： Colonization Multinomial Solution Model Pomadasys panamensis Aikaikae