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The Phenols of the Genus <i>Agave</i>(Agavaceae)

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Journal of Biomaterials and Nanobiotechnology 2013年第3期4卷 9-16页

作者： Norma Almaraz-Abarca eli amanda delgado-alvarado José Antonio ávila-Reyes José Natividad Uribe-Soto Laura Silvia González-Valdez Centro Interdisciplinario de Investigación para el Desarrollo Integral Regional Unidad Durango Instituto Politécnico Nacional Durango Dgo México

A review is presented about the studies that have been carried out on the phenolic composition of the species of the genus Agave in order to show which species of the genus has been analyzed, what is the potential of the species of Agave as source of phenolics with important biological activities, and what is the significance of the phenolic profiles as chemotaxonomic markers in the genus. The results of the analysis of a dozen of Agave species reveal an important richness of phenolic compounds, including flavonoids, homoisoflavonoids, and phenolic acids, and a broad diversity of biological activities associated to those compounds, as antioxidant, antibacterial, antifungal, antinematod, and immunomodulatory capabilities. The phenols of Agave also have a major potential as specific chemotaxonomic markers.

关键词： Genus Agave Phenol Profiles Homoisoflavanoids Biological Activity Chemotaxonomic Markers

Seed Vigor Variation of <i>Agave durangensis</i>Gentry (Agavaceae)

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American Journal of Plant Sciences 2013年第11期4卷 2227-2239页

作者： Gerardo Barriada-Bernal Norma Almaraz-Abarca Tzahyri Gallardo-Velázquez Isabel Torres-Morán Yolanda Herrera-Arrieta Socorro González-elizondo eli amanda delgado-alvarado 1Interdisciplinary Research Center for the Integral Regional Development Durango National Polytechnical Institute (CIIDIR IPN Durango) Durango México Interdisciplinary Research Center for the Integral Regional Development Durango National Polytechnical Institute (CIIDIR IPN Durango) Durango México National School of Biological Sciences National Polytechnical Institute (ENCB IPN) México DF México University Center of Biological and Agropecuary Sciences University of Guadalajara (CUCBA) Zapopan México

Agave durangensis propagates basically by seeds. This species is economically important because it supports a mescal industry in Durango, Mexico. At present, its exploitation is overall by collecting plants from the wild populations. In order to reduce the negative impact of the collection in the natural populations of A. durangensis and to improve the mescal industry, it is necessary to establish plantations with selected seeds for a high vigor. In this paper, the variation in morphological features, physiological behavior of germination, and biochemical indicators of seed vigor among three natural populations of A. durangensis was assessed. Variation was found in the seed weight (0.68 to 1.15 mg/seed), seed dimensions (3.51 × 5.29 to 4.62 × 5.92 mm), germinability reduction at 15°°C related to 25°C (4% to 51%), germination rate at 25°C (44.0 to 48.5 seeds/day) and at 15°C (5.17 to 6.77 seeds/day), development reduction at 15°C related to 25°C (86.66% to 91.99%), levels of seed accumulated phenols (71 to 85 μg/seed), antioxidant potential (42% to 50% reduction of DPPH*), seed alcohol dehydrogenase activity (ADH) (180 to 1100 μmol NAD+/mg protein/min), highest ADH activity after imbibitions at 25°C (310.24 to 520.2 μmol NAD+/mg protein/min), and highest ADH activity after imbibitions at 15°C (170.74 to 440.71 μmol NAD+/mg protein/min). The variation in the seed vigor was revealed by a principal component analysis (PCA) based on all the parameters evaluated. PCA clearly discriminated among the three populations.

关键词： Agave Durangensis Seed Vigor Germinability Natural Variation

A new database of building-space-specific internal loads and load schedules for performance based code compliance modeling of commercial buildings

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Building Simulation 2024年第6期17卷 877-892页

作者： Yunyang Ye Cary A.Faulkner Wooyoung Jung Jian Zhang eli Brock Pacific Northwest National Laboratory RichlandWA99354USA University of Pittsburgh PittsburghPA15260USA

Building-level loads and load schedules prescribed by current modeling rules save modelers time and provide standards during whole building performance ***,recent studies show that they sometimes insufficiently capture the entire building performance due to the varied loads and load schedules for different space *** a solution to this issue,this paper presents a database of default building-space-specific loads and load schedules for use in energy modeling,and in particular code compliance modeling for commercial *** existing sets of default loads and load schedules are reviewed and the challenges behind using them for specific research topics are ***,the proposed method to develop the building-space-specific loads and load schedules is *** that,the database for these building-space-specific loads and load schedules is *** addition,one case is studied to demonstrate the applications of these loads and load *** this case study,three methods are used to develop building energy models:space-specific(using knowledge of the distribution and location of space types and applying the space-specific data in the developed database),building-level(assuming a lack of knowledge of the space types and using the building-level data in the developed database),and calculated-ratio(assuming knowledge of the distribution of space types but not their locations and calculating weighted average values based on the space-specific data in the developed database).The energy results simulated by using these three methods are compared,which shows building-level methods can produce significantly different absolute energy and energy savings results than the results using space-specific ***,this paper discusses the application scope and maintenance of this new database.

关键词： load load schedule space specific building energy modeling code compliance

Rational molecular design of efficient yellow-red dendrimer TADF for solution-processed OLEDs: a combined effect of substitution position and strength of the donors

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Science China Chemistry 2024年第5期67卷 1613-1623页

作者： Changfeng Si Dianming Sun Tomas Matulaitis David B.Cordes Alexandra M.Z.Slawin eli Zysman-Colman Organic Semiconductor Centre EaStCHEM School of ChemistryUniversity of St AndrewsSt AndrewsKY169STUK

The development of high-performance solution-processed red organic light-emitting diodes(OLEDs) remains a challenge,particularly in terms of maintaining efficiency at high luminance. Here, we designed and synthesized four novel orange-red thermally activated delayed fluorescence(TADF) dendrimers that are solution-processable: 2GCz BP, 2DPACz BP, 2FBP2GCz and 2FBP2DPACz. We systematically investigated the effect of substitution position and strength of donors on the optoelectronic properties. The reverse intersystem crossing rate constant(kRISC) of the emitters having donors substituted at positions 11and 12 of the dibenzo[a,c]phenazine(BP) is more than 10-times faster than that of compounds substituted having donors substituted at positions 3 and 6. Compound 2DPACz BP, containing stronger donors than 2GCz BP, exhibits a red-shifted emission and smaller singlet-triplet energy splitting, ΔE_(ST), of 0.01 e V. The solution-processed OLED with 10 wt% 2DPACz BP doped in m CP emitted at 640 nm and showed a maximum external quantum efficiency(EQE_(max)) of 7.8%, which was effectively maintained out to a luminance of 1,000 cd m-2. Such a device's performance at relevant display luminance is among the highest for solution-processed red TADF OLEDs. The efficiency of the devices was improved significantly by using 4Cz IPN as an assistant dopant in a hyperfluorescence(HF) configuration, where the 2DPACz BP HF device shows an EQEmaxof 20.0% at λEL of 605 nm and remains high at 11.8% at a luminance of 1,000 cd m-2, which makes this device one of the highest efficiency orange-to-red HF SP-OLEDs to date.

关键词： thermally activated delayed fluorescence solution-processing red OLEDs dibenzo[a,c]phenazine dendrimers

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Islet organoid as a promising model for diabetes

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Protein & Cell 2022年第4期13卷 239-257页

作者： Xiaofei Zhang Zhuo Ma eli Song Tao Xu National Laboratory of Biomacromolecules CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China Key Laboratory of Molecular Biophysics of the Ministry of Education College of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China College of Life Sciences University of Chinese Academy of SciencesBeijing 100049China Guangzhou Regenerative Medicine and Health Guangdong Laboratory(Bioland Laboratory) Guangzhou 510005China

Studies on diabetes have long been hampered by a lack of authentic disease models that,ideally,should be unlimited and able to recapitulate the abnormalities involved in the development,structure,and function of human pancreatic islets under pathological *** cell-based islet organoids faithfully recapitulate islet development in vitro and provide large amounts of three-dimensional functional islet biomimetic materials with a morphological structure and cellular composition similar to those of native ***,islet organoids hold great promise for modeling islet development and function,deciphering the mechanisms underlying the onset of diabetes,providing an in vitro human organ model for infection of viruses such as SARS-CoV-2,and contributing to drug screening and autologous islet ***,the currently established islet organoids are generally immature compared with native islets,and further efforts should be made to improve the heterogeneity and functionality of islet organoids,making it an authentic and informative disease model for ***,we review the advances and challenges in the generation of islet organoids,focusing on human pluripotent stem cell-derived islet organoids,and the potential applications of islet organoids as disease models and regenerative therapies for diabetes.

关键词： islet organoid diabetes pluripotent/adult stem cell pancreaticβcell disease model

Modeling of a Sn-Based HTM-Free Perovskite Solar Cell Using a One-Dimensional Solar Cell Capacitance Simulator Tool

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Transactions of Tianjin University 2023年第1期29卷 62-72页

作者： eli Danladi Muhammad Kashif Andrew Ichoja Bikimi Bitrus Ayiya Department of Physics Federal University of Health SciencesPMB 145OtukpoBenue StateNigeria School of Electrical Automation and Information Engineering Tianjin UniversityTianjin 300072China Faculty of Engineering and Applied Technology Universal College of LearningPrivate Bag 11022Palmerston NorthNew Zealand

Tin(Sn)-based perovskite solar cells(PSCs)have received increasing attention in the domain of photovoltaics due to their environmentally friendly *** this paper,numerical modeling and simulation of hole transport material(HTM)-free PSC based on methyl ammonium tin triiodide(CH_(3) NH_(3) SnI_(3))was performed using a one-dimensional solar cell capacitance simulator(SCAPS-1D)*** eff ect of perovskite thickness,interface defect density,temperature,and electron transport material(ETM)on the photovoltaic performance of the device was *** to optimization,the device demonstrated a power conversion effi ciency(PCE)of 8.35%,fi ll factor(FF)of 51.93%,short-circuit current density(J_(sc))of 26.36 mA/cm 2,and open circuit voltage(V_(oc))of 0.610 *** the above parameters individually while keeping others constant,the obtained optimal absorber thickness was 1.0μm,the interface defect density was 1010 cm-2,the temperature was 290 K,and the TiO 2 thickness was 0.01μ*** simulating with the optimized data,the fi nal device gave a PCE of 11.03%,FF of 50.78%,J_(sc) of 29.93 mA/cm 2,and V_(oc) of 0.726 *** the optimized and unoptimized metric parameters,an improvement of~32.10%in PCE,~13.41%in J_(sc),and~19.02%in V_(oc) were ***,the results of this study are encouraging and can pave the path for developing highly effi cient PSCs that are cost-eff ective,eco-friendly,and comparable to state-of-the-art.

关键词： Perovskite solar cells Sn-based perovskite absorber TiO_(2) Defect density Temperature HTM-free

Mechanisms of neratinib resistance in HER2-mutant metastatic breast cancer

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Cancer Drug Resistance 2022年第4期5卷 873-881页

作者： Lisa D.eli Shyam M.Kavuri Translational Medicine and Diagnostics Puma BiotechnologyInc.Los AngelesCA 90024USA Lester and Sue Smith Breast Center Baylor College of MedicineHoustonTX 77030USA Department of Medicine Baylor College of MedicineHoustonTX 77030USA

Human epidermal growth factor receptor 2 (HER2) is a major drug target and clinical biomarker in breast cancertreatment. Targeting HER2 gene amplification is one of the greatest successes in oncology, resulting in the use of awide array of HER2-directed agents in the clinic. The discovery of HER2-activating mutations as novel therapeutictargets in breast and other cancers marked a significant advance in the field, which led to the metastatic breast andother solid tumor trials MutHER (NCT01670877), SUMMIT (NCT01953926), and one arm of plasmaMATCH(NCT03182634). These trials reported initial clinical benefit followed by eventual relapse ascribed to eitherprimary or acquired resistance. These resistance mechanisms are mediated by additional secondary genomicalterations within HER2 itself and via hyperactivation of oncogenic signaling within the downstream signaling axis.

关键词： Neratinib HER2 ERBB2 estrogen receptor mutation

A plant-based diet supplemented with Hermetia illucens alone or in combination with poultry by-product meal:one step closer to sustainable aquafeeds for European seabass

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Journal of Animal Science and Biotechnology 2022年第6期13卷 1818-1839页

作者： vana Lepen Pleić Ivana Bušelić Maria Messina Jerko Hrabar LukaŽuvić Igor Talijančić IvaŽužul Tina Pavelin Ivana Anđelić Jelka Pleadin Jasna Puizina Leon Grubišić Emilio Tibaldiand TanjaŠegvić-Bubić Laboratory of Aquaculture Institute of Oceanography and FisheriesŠetalište I.Meštrovića 6321000 SplitCroatia Department of Agriculture FoodEnvironmental and Animal SciencesUniversity of UdineUdineItaly Department of Chemistry Faculty of ScienceUniversity of SplitRuđera Boškovića 3321000 SplitCroatia Croatian Veterinary Institute Laboratory for Analytical ChemistrySavska Cesta 14310000ZagrebCroatia Department of Biology Faculty of ScienceUniversity of SplitRuđera Boškovića 3321000 SplitCroatia

Background:Increasing demand for high-value fish species and pressure on forage fish is challenging aquaculture to ensure sustainable growth by replacing protein sources in aquafeeds with plant and terrestrial animal proteins,without compromising the economic value and quality of the final fish *** the present study,the effects of a plant protein-based diet(CV),two plant-based diets in which graded amounts of plan protein mixtures were replaced with Hermetia illucens meal alone(VH10)or in combination with poultry by-product meal(PBM)(VH10P30),a fishmeal(FM)diet(CF)and an FM diet supplemented with ***(FH10)on growth performance,gut health and homeostasis of farmed subadult European seabass were tested and ***:Fish fed the VH10 and VH10P30 diets showed the highest specific growth rates and lowest feed conversion ratios among the tested ***,the best preservation of PI morphology was observed in fish fed the CF or FH10 diets,while fish fed the CV diet exhibited significant degenerative changes in the proximal and distal ***,PBM supplementation mitigated these effects and significantly improved all gut morphometric parameters in the VH10P30 *** substitution of the plant mixture with insect meal alone or PBM also induced most BBM genes and activated BBM enzymes,suggesting a beneficial effect on intestinal digestive/absorption *** intestinal microbiota,fish fed diets containing *** meal(FH10,VH10,VH10P30)had the highest richness of bacterial communities and abundance of beneficial genera such as Lactobacillus and *** the other hand,fish fed CV had the highest microbial diversity but lost a significant component of fish intestinal microbiota,the phylum ***,skin pigmentation most similar to that of farmed or even wild seabass was also observed in the fish groups fed CF,FH10 or ***:Plant-based diets supplemented with PBM and *** pupae meal h

关键词： Avian by-product meal Circular economy Dicentrarchus labrax Fitness Growth Insect

Energy use efficiency and greenhouse gas emissions(GHG)analysis of garlic cultivation in Turkey

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International Journal of Agricultural and Biological Engineering 2023年第4期16卷 63-67页

作者： Mehmet Fırat Baran Cihan Demir Ahmet Konuralp eliçin Osman Gökdoğan Department of Biosystem Engineering Faculty of AgricultureUniversity of SiirtSiirtTurkey Department of Mechanical and Metal Technologies Vocational School of Technical SciencesUniversity of KırklareliKırklareliTurkey Department of Agricultural Machinery and Technologies Engineering Faculty of AgricultureUniversity of DicleDiyarbakırTurkey Department of Agricultural Machinery and Technologies Engineering Faculty of AgricultureIsparta University of Applied SciencesIspartaTurkey

This study has been conducted with the purpose of determining energy use efficiency and greenhouse gas emissions of garlic cultivation during the 2020-2021 cultivation season in Adıyaman province of ***,observations and field works were performed in 134 garlic farms in the region through simple random *** garlic cultivation,energy input was calculated as 32103.20 MJ/hm^(2)and energy output was calculated as 30096 MJ/hm^(2).With regards to the three highest inputs in garlic production,46.66%of the energy inputs consisted of chemical fertilizers energy(14979.26 MJ/hm^(2)),11.29%consisted of farmyard manure energy(3625.71 MJ/hm^(2))and 10.48%consisted of human labour energy(3363.36 MJ/hm^(2)).Energy use efficiency,specific energy,energy productivity and net energy in garlic cultivation were calculated as 0.94,1.71 MJ/kg,0.59 kg/MJ,and−2007.20 MJ/hm^(2),*** total energy input consumed in garlic cultivation was classified as 27.19%direct energy,72.81%indirect energy,35.17%renewable energy and 64.87%nonrenewable *** GHG emissions and GHG ratio were calculated as 8636.60 kg CO_(2)-eq/hm^(2)and 0.46 kg CO_(2)-eq/kg,respectively.

关键词： Energy use efficiency garlic greenhouse gas emissions specific energy Turkey