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microRNAs in thyroid cancer with focus on medullary thyroid carcinoma:potential therapeutic targets and diagnostic/prognostic markers and web based tools

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Oncology Research 2024年第6期32卷 1011-1019页

作者： elham SHAKIBA SETI BOROOmAND SImA KHERADmAND KIA mEHDI HEDAYATI Department of Biochemistry Faculty of Biological SciencesNorth Tehran BranchIslamic Azad UniversityTehran***Iran Department of Pathology and Laboratory medicine Vancouver General HospitalVancouverV5Z 1M9Canada Department of Blood Cell Research Laboratory for Red Blood Cell DiagnosticsSanquinAmsterdam1006 ANThe Netherlands Cellular and molecular Endocrine Research Center Research Institute for Endocrine SciencesShahid Beheshti University of Medical SciencesTehran***Iran

This review aimed to describe the inculpation of microRNAs(miRNAs)in thyroid cancer(TC)and its subtypes,mainly medullary thyroid carcinoma(mTC),and to outline web-based tools and databases for bioinformatics analysis of miRNAs in ***,the capacity of miRNAs to serve as therapeutic targets and biomarkers in TC management will be *** review is based on a literature search of relevant articles on the role of miRNAs in TC and its subtypes,mainly ***,web-based tools and databases for bioinformatics analysis of miRNAs in TC were identified and *** can perform as oncomiRs or antioncoges,relying on the target mRNAs they *** replacement therapy using miRNA mimics or antimiRs that aim to suppress the function of certain miRNAs can be applied to correct miRNAs aberrantly expressed in diseases,particularly in *** are involved in the modulation of fundamental pathways related to cancer,resembling cell cycle checkpoints and DNA repair *** are also rather stable and can reliably be detected in different types of biological materials,rendering them favorable diagnosis and prognosis biomarkers as *** have emerged as promising tools for evaluating medical outcomes in TC and as possible therapeutic *** contribution of miRNAs in thyroid cancer,particularly mTC,is an active area of research,and the utility of web applications and databases for the biological data analysis of miRNAs in TC is becoming increasingly important.

关键词： Thyroid cancer microRNAs Biomarker Bioinformatics analysis medullary thyroid carcinoma(mTC) OncomiRs Antioncoges

BSN:The First Light Curve Analysis of the Total Eclipse Binary System EL Tuc

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Research in Astronomy and Astrophysics 2024年第10期24卷 66-75页

作者： elham Sarvari Eduardo Fernández Lajús Atila Poro Independent researcher TehranIran Instituto de Astrofísica de La Plata(CCT La Plata-CONICET-UNLP) La PlataArgentina BSN Project &Astronomy Department of the Raderon AI Lab.BurnabyBCCanada

We conducted the first light curve study of the binary star EL Tuc within the Binary Systems of South and North project's *** photometric observations were made using standard multiband BVR_cI_c filters at an observatory in *** presented a new ephemeris for EL Tuc and a linear fit to the O–C diagram,utilizing our extracted times of minima and additional *** employed the PHysics Of Eclipsing BinariEs Python code and the markov chain monte Carlo approach for the system's light curve *** target system's light curve solution required a cold starspot on the hotter *** conclude that EL Tuc is a total contact binary system with a low mass ratio of q=0.172±0.002,an orbital inclination of i=83°.74±0°.40,and a fillout factor of f=53.7%±1.6%.We used the P-a relationship and the Gaia Data Release 3 parallax method to determine the absolute parameters of EL Tuc to compare the precision of our *** system was classified as W-type based on the mass and effective temperature of the companion *** positions of the systems were depicted on the m-L,m-R,T-m,and *** relationship between the spectroscopic and photometric mass ratios of binaries was discussed.

关键词： (stars:)binaries:eclipsing stars:individual(EL Tuc) line:identification

Targeted anti-tumor synergistic effects of myc decoy oligodeoxynucleotides-loaded selenium nanostructure combined with chemoradiotherapy on LNCaP prostate cancer cells

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Oncology Research 2024年第1期32卷 101-125页

作者： ROGHAYEH GHORBANI mAHmOUD GHARBAVI ALI SHARAFI elham RISmANI HAmED REZAEEJAm YOUSEF mORTAZAVI BEHROOZ JOHARI Department of medical Biotechnology School of MedicineZanjan University of Medical SciencesZanjanIran Nanotechnology Research Center Ahvaz Jundishapur University of Medical SciencesAhvazIran Zanjan Pharmaceutical Biotechnology Research Center Zanjan University of Medical SciencesZanjanIran Department of Pharmaceutical Biotechnology School of PharmacyZanjan University of Medical SciencesZanjanIran molecular medicine Department Biotechnology Research CenterPasteur Institute of IranPasteur AvenueTehranIran Department of Radiology Technology School of Allied Medical SciencesZanjan University of Medical SciencesZanjanIran

In the present study,we investigated the synergistic effects of targeted methotrexate-selenium nanostructure containing myc decoy oligodeoxynucleotides along with X-irradiation exposure as a combination therapy on LNCaP prostate cancer *** decoy ODNs were designed based on the promoter of Bcl-2 gene and analyzed by molecular docking and molecular dynamics *** were loaded on the synthesized Se@BSA@Chi-mTX *** physicochemical characteristics of nanostructures were determined by FTIR,DLS,UV-vis,TEm,EDX,in vitro release,and hemolysis ***,the cytotoxicity properties of them with and without X-irradiation were investigated by uptake,mTT,cell cycle,apoptosis,and scratch assays on the LNCaP cell *** results of DLS and TEm showed negative charge(−9 mV)and nanometer size(40 nm)for Se@BSA@Chi-DEC-mTX NPs,*** results of FTIR,UV-vis,and EDX showed the proper interaction of different parts and the correct synthesis of *** results of hemolysis showed the hemocompatibility of this nanoparticle in concentrations less than 6 mg/*** ODNs release from the nanostructures showed a pH-dependent manner,and the release rate was 15%higher in acidic *** targeted Se@BSA@Chi-labeled ODN-mTX NPs were efficiently taken up by LNCaP cells by targeting the prostate-specific membrane antigen(PSmA).The significant synergistic effects of nanostructure(containing mTX drug)treatment along with X-irradiation showed cell growth inhibition,apoptosis induction(~57%),cell cycle arrest(G2/m phase),and migration inhibition(up to 90%)compared to the *** results suggested that the Se@BSA@Chi-DEC-mTX NPs can potentially suppress the cell growth of LNCaP *** nanostructure system can be a promising approach for targeted drug delivery and chemoradiotherapy in prostate cancer treatment.

关键词： Chemoradiotherapy Combination therapy Decoy oligodeoxynucleotides myc transcription factor Selenium nanoparticle Prostate cancer

BSN:Photometric Light Curve Analysis of Two Contact Binary Systems LS Del and V997 Cyg

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Research in Astronomy and Astrophysics 2024年第4期24卷 192-213页

作者： Atila Poro mehmet Tanriver elham Sarvari Shayan Zavvarei Hossein Azarara Laurent Corp Sabrina Baudart Asma Ababafi Nazanin Kahali Poor Fariba Zare Ahmet Bulut Ahmet Keskin Astronomy Department of the Raderon AI Lab. BurnabyBC.Canada Department of Astronomy and Space Science Faculty of ScienceErciyes UniversityKayseri TR-38039Turkiye Erciyes University Astronomy and Space Science Observatory Application and Research CenterKayseri TR-38039Turkiye Independent Astrophysics Researcher TehranIran Department of Physics Shahid Beheshti UniversityTehranIran Faculty of Physics Shahid Bahonar University of KermanP.O.Box 76175KermanIran Double Stars Committee SociétéAstronomique de FranceParisFrance Dez Astronomical Association Khouzestan ProvinceDezfulIran Department of Physics Amirkabir University of TechnologyTehranIran Department of Physics Faculty of SciencesCanakkale Onsekiz Mart UniversityTerzioglu KampusuTR-17020CanakkaleTurkiye Astrophysics Research Center and Observatory Canakkale Onsekiz Mart UniversityTerzioğlu KampusuTR-17020CanakkaleTürkiye

The light curve analyses and orbital period variations for two contact binary stars,LS Del and V997 Cyg,are presented in this work which was conducted in the frame of the Binary Systems of South and North project Ground-based photometric observations were performed at two observatories in *** used the Transiting Exoplanet Survey Satellite(TESS)data for extracting times of minima and light curve analysis of the targe *** O-C diagram for both systems displays a parabolic *** Del and V997 Cyg’s orbital periods are increasing at rates of dP/dt=7.20×10^(-08)days yr^(-1)and dP/dt=2.54×10^(-08)days yr^(-1),respectively Therefore,it can be concluded that mass is being transferred from the less massive star to the more massive component with a rate of dm/dt=-1.96×10^(-7)m_(⊙)yr^(-1)for the LS Del system,and dm/dt=-3.83×10^(-7)m_(⊙)yr-1for V997 *** parameters of a third possible object in the system are also *** PHysics Of Eclipsing BinariEs Python code was used to analyze the light *** light curve solutions needed a cold starspot due to the asymmetry in the LS Del system’s light curve *** mass ratio fill-out factor,and star temperature all indicate that both systems are contact binary types in this *** methods were applied to estimate the absolute parameters of the systems:one method relied on the parallax of Gaia DR3,and the other used a P-m *** positions of the systems are also depicted on the m-L,m-R q-L_(ratio),and logm_(tot)-logJ_(0)*** recommend that further observations and investigations be done on the existence of a fourth body in this system.

关键词： (stars:)binaries:eclipsing methods:observational stars:individual(LS Del and V997 Cyg)

Effect of Al substitution on phase evolution in synthesized mg_(2)Cu nanoparticles

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International Journal of minerals,metallurgy and materials 2023年第1期30卷 63-71页

作者： elham mohseni-Sohi Farshid Kashani Bozorg School of metallurgy and materials Engineering College of EngineeringUniversity of TehranTehranPO Box 11155/4563Iran

The effect of mg replacement with Al on the discharge capacity of mg_(2)Cu powder mixture was *** mixture of nano-crystalline powder was prepared via mechanical alloying(mA)technique with a high energy planetary ball *** addition,different moles of Al(0.05,0.1,0.15,0.2,and 0.3 m)were substituted to mg_(2)Cu powder.X-ray diffraction(XRD),scanning electron microscopy(SEm),and transmission electron microscopy(TEm)were used to analyze changes in structure,morphology,and grain *** obtained powder was utilized as an anode in a nickel-metal hydride battery(Ni-mH).In the specimens with 0.05 m Al content,the orthorhombic structure of mg_(2)Cu is emerged after 5 h *** results reveal that more than 0.1 m Al substitution leads to an appearance of mgCu_(2) *** substi-tution does not affect microstructure uniformity;however,it causes a decrease in crystalline size and lattice *** selected area diffraction(SAD)pattern elucidates that the electrode with the mg_(1.9)Al_(0.1)Cu chemical composition and 20 h milling has the maximum discharge capacity.

关键词： mg_(2)Cu mechanical alloying nanocrystalline discharge capacity

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基于前馈模型预测控制的类车机器人路径跟踪

工程科学学报 2024年第6期46卷 1130-1139页

作者：白国星伊力夏提·伊力哈木江付薛洁孟宇刘立顾青北京科技大学机械工程学院北京100083 北京科技大学顺德研究生院顺德528399 烟台南山学院智能科学与工程学院烟台265713

在类车机器人路径跟踪控制方法中,模型预测控制(model predictive control,mPC)在处理系统约束方面具有较大优势,但是现有的非线性模型预测控制(Nonlinear mPC,NmPC)实时性较差,线性模型预测控制(Linear mPC,LmPC)精确性较差,因此亟需... 详细信息

在类车机器人路径跟踪控制方法中,模型预测控制(model predictive control,mPC)在处理系统约束方面具有较大优势,但是现有的非线性模型预测控制(Nonlinear mPC,NmPC)实时性较差,线性模型预测控制(Linear mPC,LmPC)精确性较差,因此亟需提出一种同时具有较高精确性与实时性的类车机器人路径跟踪控制方法.为此,以无预瞄点的LmPC为基础,引入基于逆运动学模型的前馈转向角信息,提出了一种前馈模型预测控制(Feedforward mPC,FmPC)方法,并通过mATLAB和Carsim进行了联合仿真测试.FmPC具有较高的精确性,在所有仿真结果中,位移误差绝对值不超过0.1110 m,航向误差绝对值不超过0.1177 rad.在相同工况下,FmPC与NmPC精确性相当,LmPC、前馈控制和Stanley控制误差发散.FmPC也具有较高的实时性,在每个控制周期内的解算时间不超过4.31 ms.在相同工况下,FmPC与LmPC实时性相当,相比NmPC能将每个控制周期内解算时间的最大值减小80.68%,平均值减小65.14%.此外,FmPC能够保证控制变量在系统约束范围内,且受定位误差的影响较小.

关键词：机器人类车机器人路径跟踪预测控制实时性

Estimation of the evaporative losses from Lake Nasser, Egypt using optical satellite imagery

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International Journal of Digital Earth 2012年第2期5卷 133-146页

作者： Islam H.Abou El-magd elham m.Ali National Authority for Remote Sensing and Space Sciences CairoEgypt Department of Environmental Sciences Suez Canal UniversitySuez BranchEgypt

Water shortage in the arid region is an existing and future severe problem that threatens this part of the *** has a limited budget of 55 Bm3 per year from the river Nile basin that has always been stored in the Lake Nasser reservoir,southern *** has been estimated that the water losses from the lake ranges from 10 to 20 Bm3 a year*** paper discusses the possibility of estimating the surface evaporation from Lake Nasser using optical remotely sensed *** surface energy balance algorithm for land(SEBAL)algorithm was used to estimate the monthly evaporation rate using National Oceanic and Atmospheric Administration-Advanced Very High Resolution Radiometer(NOAA-AVHRR)satellite images based on the energy balance *** main variable within these components is the surface temperature,which was calculated by a calibrated split window equation from the remotely sensed ***-four satellite images during the year 2008 were used to estimate the maximum and minimum evaporative losses from the lake at 16.3 and 12.5 Bm3 year1,*** compared with the Penman-monteith mathematical formula,a high correlation was obtained with r2*** study demonstrated that remotely sensed data can provide a robust estimate of evaporative losses from Lake Nasser that can aid decision makers in better management and Digital Earth studies.

关键词： Lake Nasser remote sensing Digital Earth evaporation energy balance surface temperature

Homological Dimensions with Respect to a Semidualizing module and Tensor Products of Algebras

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Algebra Colloquium 2015年第2期22卷 215-222页

作者： maryam Salimi elham Tavasoli Siamak Yassemi Department of mathematics East Tehran Branch Islamic Azad University Tehran Iran Department of mathematics University of Tehran Tehran IranSchool of Mathematics Institute for Research in Fundamental Sciences (IPM) Tehran Iran

Let C be a semidualizing module for a commutative ring R. It is shown that the ：IC-injective dimension has the ability to detect the regularity of R as well as the Pc-projective dimension. It is proved that if D is dualizing for a Noetherian ring R such that idR（D） = n 〈 ∞, then ：ID-idR（F） ≤ n for every flat R-module F. This extends the result due to Enochs and Jenda. Finally, over a Noetherian ring R, it is shown that if m is a pure submodule of an R-module N, then/TC-idR（m） ≤ IC-idR（N）. This generalizes the result of Enochs and Holm.

关键词： semidualizing C-projectives C-injectives pure submodules

Sediment transport mechanisms and selective removal of soil particles under unsteady-state conditions in a sheet erosion system

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International Journal of Sediment Research 2022年第2期37卷 151-161页

作者： elham Sirjani majid mahmoodabadi Artemi Cerdà Department of Soil Science Faculty of Agriculture Shahid Bahonar University of Kerman Departament de Geografia Universitat de València

Selective removal of particles and nutrients by water erosion is a key factor in soil erosion *** agricultural soils are located on gentle slopes where fertility is high;however,until now,the main attention on sediment transport mechanisms was paid to high-slope gradients,where soil erosion is intense,but soils are less *** the importance of sediment size distribution(SSD) and transport mechanisms under unsteady-state conditions,few studies have been done on this *** sediment concentrations in the early stages of the runoff indicate the need to deal with unsteady-state *** address this issue,sheet erosion experiments were done using a 0.2 m by 1 m tilting flume under controlled laboratory *** inflow rates(75,100,125,150,175,and 200 mL/s) were applied on two contrasting soils,including an adjacent agricultural soil and a not cultivated soil(namely Cropland soil and Control soil,respectively) at two low slope gradients(1.5% and 2%).No rill formation was observed during the *** sediment-laden runoff was sampled during unsteady-state flow to determine the SSDs and sediment transport mechanisms of eroded particles for unsteadystate *** results indicated different trends in the selective removal of sediment particles depending on hydraulic conditions and soil aggregate *** contribution of suspension-saltation(SS)to the total sediment load for the Cropland and Control soils varied from 22% to 68% and from 35% to 59%,respectively,while up to 78% and 65% of soil particles were transported by bed load(BL),***,SS and BL indicated a reverse trend with stream *** Cropland soil showed a single peak in the SSD at low stream powers because of the selective removal of fine particles(0.042 mm),whereas the SSD was shifted to a bimodal distribution at higher stream powers with the selective depletion of both fine(≤0.084 mm) and coarse(1.5 mm) *** Control soil experienced a

关键词： Aggregate breakdown Bed load Stream power Suspension-saltation Tilting flume