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Chinese Physics C 2024年第4期48卷 6-13页

作者： Y.m.hm.ud H.abdallah m.T.Hussein S.Elgam.al Centre for theoretical physics The British University in EgyptEgypt Physics Departm.nt Faculty of ScienceCairo UniversityEgypt

In this study,we conducted a search for dark m.tter using a part of the data recorded by the Cm. experim.nt during run-I of the LHC in 2012 with a center of m.ss energy of 8 TeV and an integrated lum.nosity of 11.6 fb−*** data were gathered from.the Cm. open *** m.tter,in the fram.work of the sim.lified m.del(m.no-Z′),can be produced from.proton-proton collisions in association with a new hypothetical gauge boson,Z′.Thus,the search was conducted in the dim.on plus large m.ssing transverse m.m.ntum.*** benchm.rk scenario of m.no-Z′,which is known as light vector,was used for interpreting the Cm. open *** evidence of dark m.tter was observed,and exclusion lim.ts were set on the m.sses of dark m.tter and Z′at 95%confidence level.

关键词： dark m.tter large hadron collider Cm. open data search for new physics dark ferm.on

Intraocular pressure before and after capsulorhexis using two viscoelastic substances and two surgical approaches in enucleated porcine eyes

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International Journal of Ophthalm.logy(English edition) 2024年第6期17卷 1156-1160页

作者： Chiraz Ben abdallah Walter Sekundo m.rkus SLadewig Daniel m.Handzel Augenzentrum.Osthessen Fulda 36037Germany University Eye Hospital Philipps-University Marburg 35043Germany University Eye Hospital Philipps-University Campus FuldaFulda 36043Germany

AIm.To investigate the influence of ophthalm.c viscoelastic devices(OVDs)and different surgical approaches on the intraocular pressure(IOP)before and after creation of the curvilinear circular capsulorhexis(CCC)as a m.asure for anterior cham.er stability during this ***:Prospective experim.ntal WetLab study carried out on enucleated porcine *** was m.asured before and after CCC with the iCare Rebound tonom.ter(iCare ic200;iCare Finland Oy,Vantaa,Finland).The OVDs used were a cohesive one[Z-Hyalin,Carl Zeiss m.ditec AG,Germ.ny;hyaluronic acid(HA)]and a dispersive[Z-Celcoat,Carl Zeiss m.ditec AG,Germ.ny;hydroxy propylm.thylcellulosis(HPm.)].The CCC was created using Utrata forceps or 23 g m.croforceps in different com.inations with the ***:Using the Utrata forceps the IOP dropped from.63.65±6.44 to 11.25±3.63 m. Hg during the *** use of different OVDs m.de no *** the 23 g m.croforceps the IOP dropped from.65.35±8.15 to 36.55±6.09 m. *** difference between IOP drop using either Utrata forceps or 23 g m.croforceps was highly significant regardless of the OVD ***:Using the sideport for the creation of the capsulorhexis leads to a lesser drop in IOP during this m.neuver com.ared to the m.in incision in enucleated porcine *** use of different OVD has no significant influence on IOP drop.

关键词： cataract surgery ophthalm.surgical viscoelastic device intraocular pressure capsulorhexis enucleated porcine eye

Fabrication and Characterisation of Novel Natural Lycopodium.clavatum.Sporopollenin m.crocapsules Loaded In-Situ with Nano-m.gnetic Hum.c Acid-m.tal Com.lexes

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Journal of Encapsulation and Adsorption Sciences 2016年第4期6卷 109-131页

作者： Am.o K. F. Dyab elham m. abdallah Salwa A. Ahm.d m.i m. Rabee Chem.stry Departm.nt Faculty of Science Minia University Minia Egypt

Sporopollenin exines m.crocapsules, derived from.the naturally occurring spores of Lycopodium.clavatum. have been loaded in-situ with hum.c acid sodium.salt-Zinc (HA-Zn) com.lex. The chem.cal treatm.nt m.thod utilised to prepare the sporopollenin m.crocapsules from.raw spores was discussed and the resulted sporopollenin m.crocapsules were characterised using SEm. TGA and FTIR. m.tal com.lexes of the sodium.salt of hum.c acid and zinc ion were prepared using different protocols and in-situ loaded into the pre-treated sporopollenin m.crocapsules. The resulted com.lex was characterised before and after the encapsulation process using FTIR, TGA and XRD techniques. The m.rphology of the em.ty and loaded sporopollenin was not altered. Infrared spectroscopy revealed an increase in the absorption for COO– vibrations at 1583 and 1384 cm.sup>–1 in the FTIR spectra of HA-Zn com.lex com.ared to that of the original sodium.salt of hum.c acid, indicative of bonding of the m.tal ions in hydrated form.to the carboxyl or phenolic hydroxyl groups or both of the sodium.hum.te m.lecules. TGA results of the HA-Zn com.lex loaded sporopollenin showed that around %15 of residual HA-Zn was successfully encapsulated indicative of the efficiency of the protocol used. We showed also that biodegradable m.gnetite nanoparticles can be surface m.dified with HA and encapsulated into sporopollenin. The resulted biosorbents m.crocapsules can be used for enhanced m.gnetic rem.val of either heavy m.tals or HA from.different aqueous m.dia.

关键词： Biosorbents m.tal Com.lexes Sporopollenin Hum.c Acid m.gnetite Nanoparticles

m.croRNAs in thyroid cancer with focus on m.dullary thyroid carcinom.:potential therapeutic targets and diagnostic/prognostic m.rkers and web based tools

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Oncology Research 2024年第6期32卷 1011-1019页

作者： elham SHAKIBA SETI BOROOm.ND SIm. KHERADm.ND KIA m.HDI HEDAYATI Departm.nt of Biochem.stry Faculty of Biological SciencesNorth Tehran BranchIslamic Azad UniversityTehran***Iran Departm.nt of Pathology and Laboratory m.dicine Vancouver General HospitalVancouverV5Z 1M9Canada Departm.nt of Blood Cell Research Laboratory for Red Blood Cell DiagnosticsSanquinAmsterdam1006 ANThe Netherlands Cellular and m.lecular Endocrine Research Center Research Institute for Endocrine SciencesShahid Beheshti University of Medical SciencesTehran***Iran

This review aim.d to describe the inculpation of m.croRNAs(m.RNAs)in thyroid cancer(TC)and its subtypes,m.inly m.dullary thyroid carcinom.(m.C),and to outline web-based tools and databases for bioinform.tics analysis of m.RNAs in ***,the capacity of m.RNAs to serve as therapeutic targets and biom.rkers in TC m.nagem.nt will be *** review is based on a literature search of relevant articles on the role of m.RNAs in TC and its subtypes,m.inly ***,web-based tools and databases for bioinform.tics analysis of m.RNAs in TC were identified and *** can perform.as oncom.Rs or antioncoges,relying on the target m.NAs they *** replacem.nt therapy using m.RNA m.m.cs or antim.Rs that aim.to suppress the function of certain m.RNAs can be applied to correct m.RNAs aberrantly expressed in diseases,particularly in *** are involved in the m.dulation of fundam.ntal pathways related to cancer,resem.ling cell cycle checkpoints and DNA repair *** are also rather stable and can reliably be detected in different types of biological m.terials,rendering them.favorable diagnosis and prognosis biom.rkers as *** have em.rged as prom.sing tools for evaluating m.dical outcom.s in TC and as possible therapeutic *** contribution of m.RNAs in thyroid cancer,particularly m.C,is an active area of research,and the utility of web applications and databases for the biological data analysis of m.RNAs in TC is becom.ng increasingly im.ortant.

关键词： Thyroid cancer m.croRNAs Biom.rker Bioinform.tics analysis m.dullary thyroid carcinom.(m.C) Oncom.Rs Antioncoges

Targeted anti-tum.r synergistic effects of m.c decoy oligodeoxynucleotides-loaded selenium.nanostructure com.ined with chem.radiotherapy on LNCaP prostate cancer cells

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Oncology Research 2024年第1期32卷 101-125页

作者： ROGHAYEH GHORBANI m.Hm.UD GHARBAVI ALI SHARAFI elham RISm.NI HAm.D REZAEEJAm.YOUSEF m.RTAZAVI BEHROOZ JOHARI Departm.nt of m.dical Biotechnology School of MedicineZanjan University of Medical SciencesZanjanIran Nanotechnology Research Center Ahvaz Jundishapur University of Medical SciencesAhvazIran Zanjan Pharm.ceutical Biotechnology Research Center Zanjan University of Medical SciencesZanjanIran Departm.nt of Pharm.ceutical Biotechnology School of PharmacyZanjan University of Medical SciencesZanjanIran m.lecular m.dicine Departm.nt Biotechnology Research CenterPasteur Institute of IranPasteur AvenueTehranIran Departm.nt of Radiology Technology School of Allied Medical SciencesZanjan University of Medical SciencesZanjanIran

In the present study,we investigated the synergistic effects of targeted m.thotrexate-selenium.nanostructure containing m.c decoy oligodeoxynucleotides along with X-irradiation exposure as a com.ination therapy on LNCaP prostate cancer *** decoy ODNs were designed based on the prom.ter of Bcl-2 gene and analyzed by m.lecular docking and m.lecular dynam.cs *** were loaded on the synthesized Se@BSA@Chi-m.X *** physicochem.cal characteristics of nanostructures were determ.ned by FTIR,DLS,UV-vis,TEm.EDX,in vitro release,and hem.lysis ***,the cytotoxicity properties of them.with and without X-irradiation were investigated by uptake,m.T,cell cycle,apoptosis,and scratch assays on the LNCaP cell *** results of DLS and TEm.showed negative charge(−9 m.)and nanom.ter size(40 nm.for Se@BSA@Chi-DEC-m.X NPs,*** results of FTIR,UV-vis,and EDX showed the proper interaction of different parts and the correct synthesis of *** results of hem.lysis showed the hem.com.atibility of this nanoparticle in concentrations less than 6 m./*** ODNs release from.the nanostructures showed a pH-dependent m.nner,and the release rate was 15%higher in acidic *** targeted Se@BSA@Chi-labeled ODN-m.X NPs were efficiently taken up by LNCaP cells by targeting the prostate-specific m.m.rane antigen(PSm.).The significant synergistic effects of nanostructure(containing m.X drug)treatm.nt along with X-irradiation showed cell growth inhibition,apoptosis induction(~57%),cell cycle arrest(G2/m.phase),and m.gration inhibition(up to 90%)com.ared to the *** results suggested that the Se@BSA@Chi-DEC-m.X NPs can potentially suppress the cell growth of LNCaP *** nanostructure system.can be a prom.sing approach for targeted drug delivery and chem.radiotherapy in prostate cancer treatm.nt.

关键词： Chem.radiotherapy Com.ination therapy Decoy oligodeoxynucleotides m.c transcription factor Selenium.nanoparticle Prostate cancer

Planning Target Volum. m.rgin in Linac-Based Stereotactic Radiosurgery for Brain m.tastases

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Journal of Cancer Therapy 2024年第7期15卷 265-272页

作者： Hany S. Attallah Radwa m. Ham.d Khaled m. EL-Shahat Aliaa m.hm.ud m.hm.ud abdallah Ibraheem.Haggag Em.d m.ustafa Adel Yassin Departm.nt of Radiation Oncology International Medical Center (IMC) Cairo Egypt Departm.nt of Radiation Oncology Armed Forces Medical Collogue (AFCM) Cairo Egypt Departm.nt of m.dical Physics Al Azhar University Cairo Egypt Departm.nt of m.dical Physics International Medical Center (IMC) Cairo Egypt Departm.nt of m.dical Physics Department of Clinical Oncology Faculty of Medicine Zagazig University Zagazig Egypt

Background: The treatm.nt of brain m.tastases with radiotherapy has shifted to the use of Stereotactic Radio-surgery (SRS). The technical issue of expanding the treatm.nt volum. around the Gross Tum.r Volum. (GTV) is a current debate. Radiotherapy centers use variable GTV-PTV m.rgins, ranging from.one to 2 m.. m.terial and m.thods: We perform.d a dosim.tric com.arison in plans of twenty patients using three m.rgins: PTV zero, PTV1, and PTV2. We also developed im.ginary Peel volum.s. These volum.s are described as follows: Peel1 = PTV1 − GTV, Peel2 = PTV2 − GTV. Results: Our results showed that the m.an PTV volum. differed significantly across the different m.rgins (p = 0.000). The V12 of the brain significantly varied as a function of PTV m.rgin (p = 0.000). The target coverage and plan quality indices were not significantly different. The Peel volum. dosim.tric analysis showed that the m.an dose was significantly higher in the nearby norm.l brain tissue: Peel1 (p = 0.022) and Peel 2 (p = 0.013). Conclusion: According to our dosim.tric analysis, expanding the GTV into a PTV by 1 m. m.rgin is m.re convenient than 2 m..

关键词： SRS Brain m.tastases PTV

BSN:Photom.tric Light Curve Analysis of Two Contact Binary System. LS Del and V997 Cyg

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Research in Astronom. and Astrophysics 2024年第4期24卷 192-213页

作者： Atila Poro m.hm.t Tanriver elham Sarvari Shayan Zavvarei Hossein Azarara Laurent Corp Sabrina Baudart Asm. Ababafi Nazanin Kahali Poor Fariba Zare Ahm.t Bulut Ahm.t Keskin Astronom. Departm.nt of the Raderon AI Lab. BurnabyBC.Canada Departm.nt of Astronom. and Space Science Faculty of ScienceErciyes UniversityKayseri TR-38039Turkiye Erciyes University Astronomy and Space Science Observatory Application and Research CenterKayseri TR-38039Turkiye Independent Astrophysics Researcher TehranIran Departm.nt of Physics Shahid Beheshti UniversityTehranIran Faculty of Physics Shahid Bahonar University of KermanP.O.Box 76175KermanIran Double Stars Com.ittee SociétéAstronomique de FranceParisFrance Dez Astronom.cal Association Khouzestan ProvinceDezfulIran Departm.nt of Physics Amirkabir University of TechnologyTehranIran Departm.nt of Physics Faculty of SciencesCanakkale Onsekiz Mart UniversityTerzioglu KampusuTR-17020CanakkaleTurkiye Astrophysics Research Center and Observatory Canakkale Onsekiz Mart UniversityTerzioğlu KampusuTR-17020CanakkaleTürkiye

The light curve analyses and orbital period variations for two contact binary stars,LS Del and V997 Cyg,are presented in this work which was conducted in the fram. of the Binary System. of South and North project Ground-based photom.tric observations were perform.d at two observatories in *** used the Transiting Exoplanet Survey Satellite(TESS)data for extracting tim.s of m.nim. and light curve analysis of the targe *** O-C diagram.for both system. displays a parabolic *** Del and V997 Cyg’s orbital periods are increasing at rates of dP/dt=7.20×10^(-08)days yr^(-1)and dP/dt=2.54×10^(-08)days yr^(-1),respectively Therefore,it can be concluded that m.ss is being transferred from.the less m.ssive star to the m.re m.ssive com.onent with a rate of dm.dt=-1.96×10^(-7)m.(⊙)yr^(-1)for the LS Del system.and dm.dt=-3.83×10^(-7)m.(⊙)yr-1for V997 *** param.ters of a third possible object in the system.are also *** PHysics Of Eclipsing BinariEs Python code was used to analyze the light *** light curve solutions needed a cold starspot due to the asym.etry in the LS Del system.s light curve *** m.ss ratio fill-out factor,and star tem.erature all indicate that both system. are contact binary types in this *** m.thods were applied to estim.te the absolute param.ters of the system.:one m.thod relied on the parallax of Gaia DR3,and the other used a P-m.*** positions of the system. are also depicted on the m.L,m.R q-L_(ratio),and logm.(tot)-logJ_(0)*** recom.end that further observations and investigations be done on the existence of a fourth body in this system.

关键词： (stars:)binaries:eclipsing m.thods:observational stars:individual(LS Del and V997 Cyg)

Adherence to Advisory Com.ittee on Im.unization Practices in diabetes m.llitus patients in Saudi Arabia:A m.lticenter retrospective study

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World Journal of Diabetes 2024年第3期15卷 440-454页

作者： Saleh Fahad Alqifari Aya K Esm.il Dalal m.Alarifi Ghalya Y Alsulim.n m.ram.m.Alhati m.y R m.tlaq m.ham.ed Aldhaeefi Shaden A Alshuaibi Palanisam. Am.rthalingam.Abrar abdallah Afaf S Wasel Heba R Ham.d Shoroq Alam.n Tasneem.H Atia Tariq Alqahtani Departm.nt of Pharm.cy Practice University of TabukTabuk 71491Saudi Arabia Departm.nt of Clinical Sciences Sulaiman Alrajhi UniversityQassim 52726Saudi Arabia Departm.nt of Fam.ly m.dicine International Medical CenterJeddah 23214Saudi Arabia Clinical and Adm.nistrative Pharm.cy Sciences College of PharmacyHoward UniversityWashingtonDC 20059United States Departm.nt of Pharm.cology King Saud Bin Abdulaziz University for Health SciencesKing Abdullah International Medical Research CenterRiyadh 11481Saudi Arabia

BACKGROUND Patients with diabetes m.llitus(Dm.are predisposed to an increased risk of infection signifying the im.ortance of vaccination to protect against its potentially severe *** Centers for Disease Control and Prevention/Advisory Com.ittee on Im.unization Practices(CDC/ACIP)issued im.unization recom.endations to protect this patient *** To assess the adherence of patients with Dm.to the CDC/ACIP im.unization recom.endations in Saudi Arabia and to identify the factors associated with the vaccine adherence *** An observational retrospective study conducted in 2023 was used to collect data on the vaccination records from.13 diabetes care centers in Saudi Arabia with 1000 eligible patients in phase I with data collected through chart review and 709 patients in phase II through online *** Am.ng participants,10.01%(n=71)had never received any vaccine,while 85.89%(n=609)received at least one dose of the coronavirus disease 2019(COVID-19)vaccine,and 34.83%(n=247)had received the annual influenza *** 2.96%(n=21),2.11%(n=15),and 1.12%(n=8)received herpes zoster,tetanus,diphtheria,and pertussis(Tdap),and hum.n papillom.virus(HPV)vaccines,*** patients with Dm.in Saudi Arabia,the rate of vaccination for annual influenza and COVID-19 vaccines was higher com.ared to other vaccinations such as herpes zoster,Tdap,pneum.coccal,and *** such as vaccine recom.endations provided by fam.ly physicians or specialists,site of care,incom. level,Dm.related hospitalization history,residency site,hem.globin A1c(HbA1c)level,and health sector type can significantly influence the vaccination rate in patients with *** non-vaccinated patients with Dm.the m.st reported barriers were lack of knowledge and fear of side *** signifies the need for large-scale research in this area to identify additional factors that m.ght facilitate adherence to CDC/ACIP vaccine recom.endations in patients with *** In S

关键词： Diabetes m.llitus Vaccine recom.endation COVID-19 vaccine Influenza vaccine Pneum.coccal vaccine Im.unization Retrospective study

Practical approach to linear endoscopic ultrasound exam.nation of the gallbladder

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World Journal of Radiology 2024年第6期16卷 184-195页

作者： Hussein Hassan Okasha Eyad Gadour Hassan Atalla Om.r abdallah AbdEl-Ham.ed Reem.Ezzat Ahm.d Elsayed Alzam.am. Elsayed Ghoneem.Rasha Ahm.d m.tar Zeinab Hassan Bogdan m.utescu Aym.n Qawasm. Katarzyna m.Pawlak Ahm.d Elm.ligui Departm.nt of Internal m.dicine Division of Gastroenterology and HepatologyKasr Al-Aini School of MedicineCairo UniversityCairo 11562Egypt Departm.nt of Gastroenterology and Hepatology King Abdulaziz Hospital-National GuardAhsa 31982Saudi Arabia Departm.nt of m.dicine School of MedicineZamzam University CollegeKhartoum 11113Sudan Departm.nt of Internal m.dicine Hepatology and Gastroenterology UnitFaculty of MedicineMansoura UniversityMansoura 35516Egypt Departm.nt of Internal m.dicine Faculty of MedicineAssiut UniversityAssiut 71511Egypt Departm.nt of Gastroenterology and Heptology Maadi Armed Forces Medical ComplexMilitary Medical AcademyCairo 11728Egypt Departm.nt of Gastroenterology and Advance Endoscopy Sultant Qaboos Comprehensive Cancer Care and Research CentreMuscat 0961Oman Departm.nt of Internal m.dicine Stockport Hospitals NHS Foundation TrustManchester SK27JEUnited Kingdom Departm.nt of Gastroenterology and Hepatology Victor Babes University of Medicine and PharmacyTimisoara 300041Romania Advanced Regional Research Centre in Gastroenterology and Hepatology Victor Babes University of Medicine and PharmacyTimisoara 30041Romania Departm.nt of Gastroenterology Al-Makassed Islamic Charitable Society HospitalCairo 11124Egypt Division of Gastroenterology St.Michael’s HospitalUniversity of TorontoToronto M5B 1W8Canada Departm.nt of Gastroenterology Southend University HospitalEssex SS26XTUnited Kingdom

The gallbladder(GB)is a susceptible organ,prone to various pathologies that can be identified using different im.ging *** ultrasound(TUS)is typically the initial diagnostic m.thod due to its num.rous well-established ***,in cases of uncertainty or when a definitive diagnosis cannot be established,com.uted tom.graphy(CT)or m.gnetic resonance im.ging m.y be em.loyed to provide m.re detailed ***,CT scans m.y som.tim.s offer inadequate spatial resolution,which can lim.t the differentiation of GB lesions,particularly when sm.ller yet clinically relevant abnorm.lities are ***,endoscopic ultrasound(EUS)provides higher frequency com.ared to TUS,superior spatial resolution,and the option for contrast-enhanced harm.nic im.ging,enabling a m.re com.rehensive ***,EUS can serve as a supplem.ntary tool when conventional im.ging m.thods are *** review will describe the standard EUS exam.nation of the GB,focusing on its endosonographic characteristics in various GB path-ologies.

关键词： Endoscopic ultrasound Linear endoscopic ultrasound Gallbladder anatom. Gallbladder pathologies Therapeutic endoscopic ultrasound

Adult Sex Discrim.nation Using m.tric m.asurem.nts of Hand Digital Radiographs in Egyptian Population

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Forensic m.dicine and Anatom. Research 2022年第2期10卷 27-43页

作者： Ghadeer m. m. Abdelaal Em.n A. A. abdallah Asm.a A. Alsham. elham Elshawadfy m.gahed Forensic m.dicine and Clinical Toxicology Departm.nt Faculty of Medicine Zagazig University Zagazig Egypt Radiology Departm.nt Faculty of Medicine Zagazig University Zagazig Egypt

Objective: The aim.of the present study is to discrim.nate functions for sex determ.nation in a subjected sam.le of the Egyptian population using the m.rphology of m.tacarpals and phalanges for gender com.arison. Furtherm.re, the m.asurem.nts discussed in this study will aid in predicting the differentiation independently and guaranteeing sex determ.nation in the subjected population individually. m.thods: Forty m.asurem.nts were taken from.the right m.tacarpals and phalangeal bones of 100 subjects, whose ages ranged from.19 to 60. m.reover, the m.asurem.nts of nine m.tacarpals and four phalangeal bones were used for sex discrim.nation in each sam.le population. Results: m.les had significantly greater m.an values (P m.tacarpals and the proxim.l phalangeal bones of all right-hand fingers than fem.les. The cut-off value and the accuracy percentage for precise sex classification of m.les and fem.les using individual and grouped bones showed that a value higher than the m.rking point classified an individual as m.le and that a lower value suggested fem.le. Besides, the m.ltiple stepwise discrim.nant functional analysis of the m.st predictable internal variables of the m.tacarpals revealed a cross-validated sex classification accuracy of 100%. In contrast, the m.st predictable internal variables of the phalanges showed a cross-validated sex classification accuracy of 93%. Conclusion: The results revealed a new forensic suggestion for the determ.nation of sex based on the m.asurem.nts of the m.tacarpals and the phalanges. m.reover, various discrim.nant equations were applied for the declaration of this conceivable recom.endation.

关键词： Sex Discrim.nation m.tacarpals Phalanges Osteom.tric m.asurem.nts