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Data-Based Filters for Non-Gaussian Dynamic Systems With Unknown Output Noise Covariance

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IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 866-877页

作者： elham Javanfar Mehdi Rahmani the Department of Electrical Engineering Imam Khomeini International UniversityQazvin ***Iran

This paper proposes linear and nonlinear filters for a non-Gaussian dynamic system with an unknown nominal covariance of the output *** challenge of designing a suitable filter in the presence of an unknown covariance matrix is addressed by focusing on the output data set of the *** that data generated from a Gaussian distribution exhibit ellipsoidal scattering,we first propose the weighted sum of norms(SON)clustering method that prioritizes nearby points,reduces distant point influence,and lowers computational ***,by introducing the weighted maximum likelihood,we propose a semi-definite program(SDP)to detect outliers and reduce their impacts on each *** these weights paves the way to obtain an appropriate covariance of the output ***,two filtering approaches are presented:a cluster-based robust linear filter using the maximum a posterior(MAP)estimation and a clusterbased robust nonlinear filter assuming that output noise distribution stems from some Gaussian noise resources according to the ellipsoidal *** last,simulation results demonstrate the effectiveness of our proposed filtering approaches.

关键词： Data-based filter maximum likelihood estimation unknown covariance weighted maximum likelihood estimation weighted sum-of-norms clustering

Identification of time-varying system and energy-based optimization of adaptive control in seismically excited structure

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Earthquake Engineering and Engineering Vibration 2024年第1期23卷 227-240页

作者： elham Aghabarari Fereidoun Amini Pedram Ghaderi Department of Civil Engineering Iran University of Science and TechnologyTehran 16844Iran

The combination of structural health monitoring and vibration control is of great importance to provide components of smart *** synthetic algorithms have been proposed,adaptive control that is compatible with changing conditions still needs to be used,and time-varying systems are required to be simultaneously estimated with the application of adaptive *** this research,the identification of structural time-varying dynamic characteristics and optimized simple adaptive control are ***,reduced variations of physical parameters are estimated online using the multiple forgetting factor recursive least squares(MFRLS)***,the energy from the structural vibration is simultaneously specified to optimize the control force with the identified parameters to be *** is also performed based on the probability density function of the energy under the seismic excitation at any ***,the optimal control force is obtained by the simple adaptive control(SAC)algorithm and energy coefficient.A numerical example and benchmark structure are employed to investigate the efficiency of the proposed *** simulation results revealed the effectiveness of the integrated online identification and optimal adaptive control in systems.

关键词： integrated online identification time-varying systems structural energy multiple forgetting factor recursive least squares optimal simple adaptive control algorithm

A review of the literature on the use of CRISPR/Cas9 gene therapy to treat hepatocellular carcinoma

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Oncology Research 2024年第3期32卷 439-461页

作者： elham AMJAD RAFAELE PEZZANI BABAK SOKOUTI Biotechnology Research Center Tabriz University of Medical SciencesTabriz***Iran Phytotherapy Lab Endocrinology UnitDipartimento di Medicina(DIMED)University of PadovaVia Ospedale 105Padova35128Italy Associazione Italiana Per La Ricerca Oncologica Di Base Associazione Italiana Per La Ricerca Oncologica Di BasePadova35128Italy

Noncoding RNAs instruct the Cas9 nuclease to site speifillyl cleave DNA in the CRISPR/Cas9 *** the high incidence of hepatocellular carcinoma(HCC),the patient's outcome is *** a result of the emergence of therapeutic resistance in HCC patients,dlinicians have faced difficulties in treating such *** addition,CRISPR/Cas9 screens were used to identify genes that improve the dlinical response of HCC *** is the objective of this article to summarize the current understanding of the use of the CRISPR/Cas9 system for the treatment of cancer,with a particular emphasis on HCC as part of the current state of ***,in order to locate recent developments in oncology research,we examined both the Scopus database and the PubMed *** ability to selectively interfere with gene expression in combinatorial CRISPR/Cas9 screening can lead to the discovery of new effective HCC treatment regimens by combining clinically approved *** resistance can be overcome with the help of the CRISPR/Cas9 *** signature genes and resistance to treatment have been uncovered by genome-scale CRISPR activation screening although this method is not without *** has been extensively examined whether CRISPR can be used as a tool for disease research and gene *** and its applications to tumor research,particularly in HCC,are examined in this study through a review of the literature.

关键词： CRISPR/Cas9 system Gene therapy Tumor Hepatocellular carcinoma Liver cancer Gene editing

Black radish root extract alleviates sodium valproate-induced liver damage via inhibiting mitochondrial membrane potential collapse and oxidative stress in mice

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Asian Pacific Journal of Tropical Biomedicine 2024年第7期14卷 298-306页

作者： Mohammad Hadi Zarei Sami Akbulut Maryam Zafari elham Saghaei Zahra Lorigooini Hossein AminiKhoei Somaye Khosravi elham Bijad Medical Plants Research Center Basic Health Sciences InstituteShahrekord University of Medical SciencesShahrekordIran Department of Liver Transplant Institute and Biostatistics Inonu University Faculty of Medicine44280MalatyaTurkey Student Research Committee Shahrekord University of Medical SciencesShahrekordIran Physiology and Pharmacology Department School of MedicineShahrekord University of Medical SciencesShahrekordIran Department of Anatomical Sciences School of MedicineShahrekord University of Medical SciencesShahrekordIran

Objective:To explore the effect of black radish(Raphanus sativus *** niger)root extract on liver enzymes,oxidative stress,and histopathological alterations in mice with sodium valproate-induced ***:Thirty-two mice were divided into four groups:the control group received drinking water by gavage,the second group was administered with 100 mg/kg of sodium valproate,the third group received 300 mg/kg of black radish root extract,and the fourth group was given both sodium valproate(100 mg/kg)and black radish root extract(300 mg/kg).After 28 days,the mice were euthanized,and serum levels of aspartate aminotransferase(AST),alanine aminotransferase(ALT),and alkaline phosphatase(ALP),along with liver malondialdehyde(MDA),reactive oxygen species(ROS),mitochondrial parameters,tumor necrosis factor-alpha(TNF-α)gene expression,and histopathological changes were ***:Sodium valproate caused hepatic damage in mice,characterized by elevated serum levels of liver enzymes,increased MDA and ROS levels and TNF-αgene expression,as well as histopathological *** black radish root extract significantly alleviated sodium valproate-caused hepatic injury by decreasing the serum levels of ALT and AST,MDA,ROS,TNF-αgene expression,as well as mitochondrial impairment,but did not have a significant effect on sodium valproate-induced histopathological ***:The black radish root extract demonstrates protective effects against sodium valproate-induced liver injury,possibly through mitigating oxidative stress,mitochondrial impairment,and inflammatory mediator expression.

关键词： Black radish Raphanus sativus Sodium valproate Hepatotoxicity Oxidative stress Anti-inflammation

Subnormal Serum Liver Enzyme Levels:A Review of Pathophysiology and Clinical Significance

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Journal of Clinical and Translational Hepatology 2024年第4期12卷 428-435页

作者： elham M.Youssef George Y.Wu Biochemistry Department National Research CenterCairoEgypt Department of Medicine Division of Gastroenterology-HepatologyUniversity of Connecticut Health CenterFarmingtonCTUSA

Subnormal levels of liver enzymes,below the lower limit of normal on local laboratory reports,can be useful *** instance,subnormal levels of aminotransferases can be observed in vitamin B6 deficiency and chronic kidney *** alkaline phosphatase levels may indicate the presence of hypophosphatasia,Wilson's disease,deficiencies of divalent ions,or *** levels of gamma glutamyl transferase may be seen in cases of acute intrahepatic cholestasis,the use of certain medications,and in bone ***,subnormal levels of 5'-nucleotidase have been reported in lead poisoning and nonspherocytic hemolytic *** aim of this review is to bring attention to the fact that subnormal levels of these enzymes should not be ignored as they may indicate pathological conditions and provide a means of early diagnosis.

关键词： Transaminases Vitamin B6 Celiac disease Renal insufficiency Hepatolenticular Degeneration Crohn disease Malnutrition Clofibrate Bone diseases Lead poisoning Anemia Hemolytic

Differentiating rhythmic high-amplitude delta with superimposed(poly)spikes from extreme delta brushes:limitations of standardized nomenclature and implications for patient management

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World Journal of Pediatrics 2024年第8期20卷 764-773页

作者： Rene Andrade-Machado elham Abushanab Namrata D.Patel Avantika Singh Children’s Hospital of Wisconsin Wauwatosa:Milwaukee 8915 W Connell CtMilwaukeeWI53226USA

Background Following the standardized nomenclature proposed by the American Clinical Neurophysiology Society(ACNS),rhythmic high-amplitude delta activity with superimposed spikes(RHADS)can be reported as an extreme delta brush(EDB).The clinical implications of similar electrographic patterns being reported as RHADS versus EDB are important to *** aim to review the electrographic characteristics of RHADS,evaluate whether RHADS is seen in other neurological disorders,and identify the similar and unique characteristics between RHADS and EDB to ultimately determine the most accurate way to differentiate and report these *** believe that the differentiation of RHADS and EDB is important as there is a vast difference in the diagnostic approach and the medical management of associated underlying *** source We conducted an extensive search on MEDLINE and Pubmed utilizing various combinations of *** for“gamma polymerase and EEG”,or“RHADS”or“Alpers syndrome and EEG”or“EEG”AND“Alpers–Huttenlocher syndrome”.Results Three articles were found to be focused on the description of“RHADS”pattern in Alpers *** publication to date were found when searching for the terms“EDB”AND“children”,AND“infant”AND“adolescent”excluding“encephalitis”and“neonate”.Although RHADS and EDB appear as similar EEG patterns,meticulous analysis can differentiate *** is not exclusive to patients with Alpers–Huttenlocher syndrome and may manifest in regions beyond the posterior head *** to eye-opening and response to anesthesia can be two other elements that help in the differentiation of these *** RHADS is not exclusive to patients with AHS and may manifest in regions beyond the posterior head *** to eye-opening and response to anesthesia are features that help in the differentiation of these patterns.

关键词： Alpers-Huttenlocher syndrome Autoimmune encephalitis Extreme delta brush Neurological disorder Polyspike Rhythmic delta activity Rhythmic high-amplitude delta activity Seizure

MicroRNAs in thyroid cancer with focus on medullary thyroid carcinoma:potential therapeutic targets and diagnostic/prognostic markers and web based tools

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Oncology Research 2024年第6期32卷 1011-1019页

作者： elham SHAKIBA SETI BOROOMAND SIMA KHERADMAND KIA MEHDI HEDAYATI Department of Biochemistry Faculty of Biological SciencesNorth Tehran BranchIslamic Azad UniversityTehran***Iran Department of Pathology and Laboratory Medicine Vancouver General HospitalVancouverV5Z 1M9Canada Department of Blood Cell Research Laboratory for Red Blood Cell DiagnosticsSanquinAmsterdam1006 ANThe Netherlands Cellular and Molecular Endocrine Research Center Research Institute for Endocrine SciencesShahid Beheshti University of Medical SciencesTehran***Iran

This review aimed to describe the inculpation of microRNAs(miRNAs)in thyroid cancer(TC)and its subtypes,mainly medullary thyroid carcinoma(MTC),and to outline web-based tools and databases for bioinformatics analysis of miRNAs in ***,the capacity of miRNAs to serve as therapeutic targets and biomarkers in TC management will be *** review is based on a literature search of relevant articles on the role of miRNAs in TC and its subtypes,mainly ***,web-based tools and databases for bioinformatics analysis of miRNAs in TC were identified and *** can perform as oncomiRs or antioncoges,relying on the target mRNAs they *** replacement therapy using miRNA mimics or antimiRs that aim to suppress the function of certain miRNAs can be applied to correct miRNAs aberrantly expressed in diseases,particularly in *** are involved in the modulation of fundamental pathways related to cancer,resembling cell cycle checkpoints and DNA repair *** are also rather stable and can reliably be detected in different types of biological materials,rendering them favorable diagnosis and prognosis biomarkers as *** have emerged as promising tools for evaluating medical outcomes in TC and as possible therapeutic *** contribution of miRNAs in thyroid cancer,particularly MTC,is an active area of research,and the utility of web applications and databases for the biological data analysis of miRNAs in TC is becoming increasingly important.

关键词： Thyroid cancer MicroRNAs Biomarker Bioinformatics analysis Medullary thyroid carcinoma(MTC) OncomiRs Antioncoges

Optimizing Deep Learning for Computer-Aided Diagnosis of Lung Diseases: An Automated Method Combining Evolutionary Algorithm, Transfer Learning, and Model Compression

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Computer Modeling in Engineering & Sciences 2024年第3期138卷 2519-2547页

作者： Hassen Louati Ali Louati elham Kariri Slim Bechikh College of Information Technology Kingdom UniversityRiffa40434Bahrain SMART Lab University of TunisISGTunisTunisia Department of Information Systems College of Computer Engineering and SciencesPrince Sattam bin Abdulaziz UniversityAl-Kharj11942Saudi Arabia

Recent developments in Computer Vision have presented novel opportunities to tackle complex healthcare issues,particularly in the field of lung disease *** promising avenue involves the use of chest X-Rays,which are commonly utilized in *** fully exploit their potential,researchers have suggested utilizing deep learning methods to construct computer-aided diagnostic ***,constructing and compressing these systems presents a significant challenge,as it relies heavily on the expertise of data *** tackle this issue,we propose an automated approach that utilizes an evolutionary algorithm(EA)to optimize the design and compression of a convolutional neural network(CNN)for X-Ray image *** approach accurately classifies radiography images and detects potential chest abnormalities and infections,including ***,our approach incorporates transfer learning,where a pre-trainedCNNmodel on a vast dataset of chest X-Ray images is fine-tuned for the specific task of detecting *** method can help reduce the amount of labeled data required for the task and enhance the overall performance of the *** have validated our method via a series of experiments against state-of-the-art architectures.

关键词： Computer-aided diagnosis deep learning evolutionary algorithms deep compression transfer learning

Examining the Effect of Hydroalcoholic Extract of Dracaena cinnabari on Sex Hormones and Ovarian and Uterine Tissues of Rats

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World Journal of Traditional Chinese Medicine 2024年第2期10卷 213-219页

作者： elham Najafi Bahareh Babaei Hoolari Akbar Karimi Aliasghar Pilehvarian Department of Cellular Biology Genesis Evolution-Develoment Isfahan Payame Noor University IsfahanIran Department of Anatomy School of MedicineTehran University of Medical SciencesTehranIran Department of Biology Group Faculty Member of Isfahan Payame Noor UniversityIsfahanIran

Introduction: Dracaena cinnabari is considered a rich source of phytochemicals used widely in traditional medicine. In the present study, the effect of D. cinnabari hydraulic extract on the reproductive system of female rats was investigated. Methods: The samples were randomly divided into four groups(six samples in each group), including three treatment groups and one control group, and all samples were kept at the same conditions. Hydraulic extract of D. cinnabari and injected intraperitoneally daily for 10 days, while physiological serum was used for injection in to the control group. After 10 days of injection, estrogen and progesterone levels were measured by enzyme immunoassay technique. After dissection, the ovaries and uterine tissues were isolated for histological examination, and tissue changes were carefully examined. Results: The results revealed that the levels of estrogen and progesterone in experimental Groups 2 and 3 had a significant increase(P < 0.001). Regarding tissue changes, a significant increase was observed in epithelial thickness(P < 0.001), number of corpus luteum(P < 0.01), and Graafian follicle(P < 0.01) in doses of 100 and 150 mg/kg. Conclusions: Based on the results, it seems that D. cinnabari extract has an effect on the ovarian follicles.

关键词： Dracaena cinnabari herbal medicine ovarian tissues reproductive sex hormones