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Metal-Halide Perovskite Submicrometer-Thick Films for Ultra-Stable Self-Powered Direct X-Ray Detectors

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Nano-Micro Letters 2024年第9期16卷 410-431页

作者： Marco Girolami Fabio Matteocci Sara Pettinato Valerio Serpente eleonora Bolli Barbara Paci Amanda Generosi Stefano Salvatori Aldo Di Carlo Daniele M.Trucchi CNR‑ISM Consiglio Nazionale delle RicercheIstituto di Struttura della MateriaSede Secondaria di MontelibrettiDiaTHEMA LabStrada Provinciale 35D900010 MontelibrettiRomeItaly CHOSE–Centre for Hybrid and Organic Solar Energy Department of Electronic EngineeringUniversity of Rome“Tor Vergata”Via del Politecnico 100133 RomeItaly Faculty of Engineering Universita degli Studi Niccolo CusanoVia don Carlo Gnocchi 300166 RomeItaly SpecXLab CNR‑ISMConsiglio Nazionale Delle RicercheIstituto di Struttura Della MateriaArea della Ricerca di Tor VergataVia del Fosso del Cavaliere 10000133 RomeItaly

Metal-halide perovskites are revolutionizing the world of X-ray detectors,due to the development of sensitive,fast,and cost-effective ***-powered operation,ensuring portability and low power consumption,has also been recently demonstrated in both bulk materials and thin ***,the signal stability and repeatability under continuous X-ray exposure has only been tested up to a few hours,often reporting degradation of the detection *** it is shown that self-powered direct X-ray detectors,fabricated starting from a FAPbBr_(3)submicrometer-thick film deposition onto a mesoporous TiO_(2)scaffold,can withstand a 26-day uninterrupted X-ray exposure with negligible signal loss,demonstrating ultra-high operational stability and excellent *** structural modification is observed after irradiation with a total ionizing dose of almost 200 Gy,revealing an unexpectedly high radiation hardness for a metal-halide perovskite thin *** addition,trap-assisted photoconductive gain enabled the device to achieve a record bulk sensitivity of 7.28 C Gy^(−1)cm^(−3)at 0 V,an unprecedented value in the field of thin-film-based photoconductors and photodiodes for“hard”***,prototypal validation under the X-ray beam produced by a medical linear accelerator for cancer treatment is also introduced.

关键词： Metal-halide perovskite thin films Direct X-ray detectors Self-powered devices Operational stability Medical linear accelerator

Enhancing sensitivity of triple-negative breast cancer to DNA-damaging therapy through chemical inhibition of the m6A methyltransferase METTL3

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Cancer Communications 2024年第2期44卷 282-286页

作者： Bianca Cesaro Alessia Iaiza Fabio Piscopo Marco Tarullo eleonora Cesari Dante Rotili Antonello Mai Alberto Diana Michela Londero Luca del Giacco Riccardo Masetti Alba Di Leone Chiara Naro Silvia Masciarelli Giulia Fontemaggi Claudio Sette Francesco Fazi Alessandro Fatica Department of Anatomical HistologicalForensic&Orthopedic SciencesSection of Histology&Medical EmbryologySapienza University of RomeRomeItaly Department of Biology and Biotechnologies“Charles Darwin” Sapienza University of RomeRomeItaly GSTeP Organoids Research Core Facility Fondazione Policlinico A.Gemelli Istituto di Ricovero e Cura a Carattere Scientifico(IRCCS)RomeItaly Department of Drug Chemistry and Technologies Sapienza University of RomeRomeItaly Pasteur Institute Cenci-Bolognetti FoundationSapienza University of RomeRomeItaly Department of BioSciences University of MilanMilanItaly Multidisciplinary Breast Center Dipartimento Scienze della Salute della Donna e del Bambino e di SanitàPubblicaCatholic University of the Sacred HeartRomeItaly Department of Neuroscience Section of Human AnatomyCatholic University of the Sacred HeartRomeItaly Oncogenomic and Epigenetic Unit IRCCS Regina Elena National Cancer InstituteRomeItaly

Dear Editor,N 6-methyladenosine(m^(6)A)is a critical mRNA modi-fication catalyzed by the enzyme methyltransferase-like 3(METTL3),with implications in RNA ***3 upregulation is associated with cancer progres-sion,metast... 详细信息

关键词： cancer methyltransferase metastasis

COEXISTENCE FOR MULTIPLE LARGEST REPRODUCTION RATIOS OF A MULTI-STRAIN SIS EPIDEMIC MOdel

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Acta Mathematica Scientia 2016年第5期36卷 1524-1530页

作者： Yoshiaki MUROYA eleonora MESSINA Elvira RUSSO Antonia VECCHIO Department of Mathematics Waseda University Dipartimento di Matematica e Applicazioni Università degli Studi di Napoli "Federico Ⅱ"-Via Cintia Istituto per Applicazioni del Calcolo "M. Picone" Sede di Napoli-CNR-Via P.Castellino

In this paper, to complete the global dynamics of a multi-strains SIS epidemic model, we establish a precise result on coexistence for the cases of the partial and complete duplicated multiple largest reproduction rat... 详细信息

关键词： multi-strains SIS epidemic model global attractivity Lyapunov function coexistence

Nonalcoholic fatty liver disease and diabetes

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World Journal of Diabetes 2022年第9期13卷 668-682页

作者： Maria Irene Bellini Irene Urciuoli Giovanni del Gaudio Giorgia Polti Giovanni Iannetti Elena Gangitano eleonora Lori Carla Lubrano Vito Cantisani Salvatore Sorrenti Vito D’Andrea Department of Surgical Sciences Sapienza University of RomeRome 00161Italy Department of Radiological Sciences Oncology and PathologySapienza University of RomeRome 00161Italy Department of Experimental Medicine Section of Medical PhysiopathologyFood Science and EndocrinologySapienza University of RomeRome 00161Italy

Nonalcoholic fatty liver disease(NAFLD)is the most prevalent chronic liver disease in the world and represents a clinical-histopathologic entity where the steatosis component may vary in degree and may or may not have fibrotic *** key concept of NAFLD pathogenesis is excessive triglyceride hepatic accumulation because of an imbalance between free fatty acid influx and *** epidemiological,biochemical,and therapeutic evidence supports the premise that the primary pathophysiological derangement in most patients with NAFLD is insulin resistance;thus the association between diabetes and NAFLD is widely recognized in the *** NAFLD is the hepatic manifestation of a metabolic disease,it is also associated with a higher cardiovascular *** B-mode ultrasound is widely adopted as a first-line imaging modality for hepatic steatosis,although magnetic resonance imaging represents the gold standard noninvasive modality for quantifying the amount of fat in these *** of NAFLD patients depends on the disease severity,ranging from a more benign condition of nonalcoholic fatty liver to nonalcoholic *** from alcohol,a Mediterranean diet,and modification of risk factors are recommended for patients suffering from NAFLD to avoid major cardiovascular events,as per all diabetic *** addition,weight loss induced by bariatric surgery seems to also be effective in improving liver features,together with the benefits for diabetes control or resolution,dyslipidemia,and ***,liver transplantation represents the ultimate treatment for severe nonalcoholic fatty liver disease and is growing rapidly as a main indication in Western *** review offers a comprehensive multidisciplinary approach to NAFLD,highlighting its connection with diabetes.

关键词： Bariatric surgery Diabetes Hepatic steatosis Liver fibrosis Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis

Human Toxocariasis Presenting with Fever and Colestatic Hepatitis: An Underestimated but Current Zoonosis

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International Journal of Clinical Medicine 2012年第7期3卷 595-597页

作者： Vera Sicbaldi Andrea Bellodi Valerio del Bono eleonora Arboscello Riccardo Ghio Clinic of Infectious Disease IRCSS San Martino IST Genoa Italy Clinic of Internal Medicine 3 IRCSS San Martino IST Genoa Italy

Human toxocariasis is a widespread parasitic disease caused by ingestion of Toxocara canis or catis larvae or eggs. Parasitic diseases are uncommon in industrialized countries, yet this problem has not disappeared. Parasitic diseases can cause different syndrome (visceral larva migrans, ocular larva migrans) and the clinical features can be confusing. Severe organ involvement affecting the liver, lungs, nervous central system and eyes can lead to serious damage. We present a case of toxocariasis presenting with fever, desaturation and cholestatic hepatitis. Only the subsequent appearance of eosinophilia helped us to arrive at the correct diagnosis. Prompt diagnosis allowed specific therapy avoiding permanent complications.

关键词： Toxocariasis Visceral Larva Migrans Ocular Larva Migrans Parasitosis Cholestatic Hepatitis Eosinophilia

Gut microbiota in women:The secret of psychological and physical well-being

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World Journal of Gastroenterology 2023年第45期29卷 5945-5952页

作者： Giuseppe Marano Gianandrea Traversi eleonora Gaetani Antonio Gasbarrini Marianna Mazza Department of Neurosciences UniversitàCattolica del Sacro CuoreRome 00168Italy Unit of Psychiatry Fondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy Unit of Medical Genetics Department of Laboratory MedicineFatebenefratelli Isola Tiberina-Gemelli IsolaRome 00186Italy Department of Medical and Surgical Sciences UniversitàCattolica del Sacro CuoreRome 00168Italy Internal Medicine and Gastroenterology Unit Fondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy Medicina Interna e Gastroenterologia CEMAD Digestive Disease CenterUniversitàCattolica del Sacro CuoreFondazione Policlinico Universitario A Gemelli IRCCSRome 00168Italy

The gut microbiota works in unison with the host,promoting its *** particular,it has been shown to exert protective,metabolic and structural *** evidence has revealed the influence of the gut microbiota on other organs such as the central nervous system,cardiovascular and the endocrine-metabolic systems and the digestive *** study of the gut microbiota is outlining new and broader frontiers every day and holds enormous innovation potential for the medical and pharmaceutical *** and treatment of specific women’s diseases involves the need to deepen the function of the gut as a junction organ where certain positive bacteria can be very beneficial to *** gut microbiota is unique and dynamic at the same time,subject to external factors that can change it,and is capable of modulating itself at different stages of a woman’s life,playing an important role that arises from the intertwining of biological mechanisms between the microbiota and the female genital *** gut microbiota could play a key role in personalized medicine.

关键词： Gut microbiota Women Metabolites Health promotion Immune system Gut-brain axis

Ammonia Diffusion Phenomena through Nalophan<sup>TM</sup>Bags Used for Olfactometric Analyses

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Journal of Environmental Protection 2014年第11期5卷 949-961页

作者： Selena Sironi Lidia Eusebio Laura Capelli Emanuela Boiardi Renato del rosso Jean-Michel Guillot Department of Chemistry Materials and Chemical Engineering “Giulio Natta” Politecnico di Milano Milano Italy Laboratory of Industrial Environment Engineering Ecole des Mines d’Alès Alès cedex France

The ammonia loss through NalophanTM bags has been studied. Ammonia was chosen as target compound in order to be representative of odorous molecules of small dimensions. The losses observed for storage conditions and times as allowed by the reference standard for dynamic olfactometry (EN 13725:2003) indicate that odour concentration values due to the presence of small molecules may be significantly underestimated if samples are not analysed immediately after sampling. The diffusion coefficient of ammonia through the NalophanTM film was evaluated using the Fick’s law, and it turned out to be equal to 2.38E-12 (m2/s). The results and their theoretical interpretation indicate that concentration losses due to ammonia diffusion through the NalophanTM film can be decreased by using large bags and filling them up to their maximum capacity.

关键词： Sampling Bag Diffusion Odour Sampling Ammonia Nalophan

Plasmodium vivax cerebral malaria complicated with venous sinus thrombosis in Colombia

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Asian Pacific Journal of Tropical Medicine 2013年第5期6卷 413-415页

作者： Miguel A Pinzon Juan C Pineda Fernando rosso Masaru Shinchi Fabio Bonilla-Abadia Department of Infectious Diseases Hospital San Vicente de PaulMedellinColombia Department of Internal Medicine Fundacion Clinica Valle del LiliICESI UniversityCaliColombia Department of Infectious Diseases Fundacion Clinica Valle del LiliCaliColombia Department of Neurology Fundacion Clinica Valle del LiliCuliColombia Department of Rheumatology Fundacion Clinica Valle del LiliICESI UniversityCaliColombia

Complicated malaria is usually due to Plasmodium ***,Plasmodium vivax is infrequently related with life-threatening *** cases have been reported of severe Plasmodium vivax infection,and most of them from Southeast Asia and *** report the first case of cerebral malaria due to Plasmodium vivax in Latin America,complicated with sagittal sinus thrombosis and confirmed by a molecular method.

关键词： Cerebral malaria Vivax malaria Plasmodium vivax Intracranial sinus thrombosis

A measurement-based approach for power system instability early warning

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Protection and Control of Modern Power Systems 2016年第1期1卷 17-25页

作者： Feifei Bai Yong Liu Yilu Liu Kai Sun Navin Bhatt Alberto del rosso Evangelos Farantatos Xiaoru Wang Southwest Jiaotong University ChengduSichuan 610031China University of Tennessee KnoxvilleTN 37996USA Oak Ridge National Laboratory 1 Bethel Valley RdOak RidgeTN 37831USA Electrical Power Research Institute Palo AltoCA 94304USA.

Early warning of impending instability in a power system under disturbance conditions is important for preventing of system collapse.A measurement-based approach is proposed to assess the potential power system transient instability problem under cascading *** a measurement-based index is obtained as the estimation accuracy of a linear autoregressive exogenous(ARX)model to estimate the dynamic response of the power system and indicate the system stability to some extent after a *** proposed approach was verified using a set of marginally stable cases in a 179-bus WECC equivalent power *** the instability early warning threshold for this system is obtained as 0.44.

关键词： Autoregressive exogenous model Accuracy index Dynamic response estimation Instability early warning Measurement-based