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SIMULATION, ANALYSIS AND OPTIMIZATION OF CONTAINER TERMINALS PROCESSES

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International Journal of Modeling, Simulation, and Scientific Computing 2012年第3期3卷 1-20页

作者： AGOSTINO BRUZZONE FRANCESCO LONGO LETIZIA NICOLETTI eleonora BOTTANI ROBERTO MONTANARI Simulation Team University of Genoa Via Magliotto 217100 SavonaItaly MSC-LES Mechanical Department University of CalabriaVia P.Bucci 44C 87036 Rende(CS)Italy Department of Industrial Engineering University of Parma Viale G.P.Usberti 181/A43124 ParmaItaly

The freight logistics includes all the processes needed to supply industry,retailers and wholesalers and final customers with *** processes generate a flow of goods that,in the global supply chain,mainly relies on the activities carried out within worldwide container *** this paper,the authors present a simulation model of a real container *** some preliminary analyses,the simulation model is first used with Design of Experiments and Analysis of Variance to investigate the effects of different resources allocations(i.e.,number of forklifts and tractors)and some parameters(i.e.,inter-arrival times,container unloading time)on the container terminal performances in terms of total number of handled containers per ***,based on the results achieved through the Design of Experiments and Analysis of Variance,the simulation model is used with genetic algorithms to carry out a range allocation optimization on berth assignment to incoming ships and number of tractors serving each quay *** aim of the optimization is the minimization of the average time spent by each ship in the port area(decreasing,as consequence,costs and increasing service level provided to final customers).

关键词： Container terminals supply chain node simulation optimization genetic algorithms analysis of variance.

Gut microbiota in women:The secret of psychological and physical well-being

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World Journal of Gastroenterology 2023年第45期29卷 5945-5952页

作者： Giuseppe Marano Gianandrea Traversi eleonora Gaetani Antonio Gasbarrini Marianna Mazza Department of Neurosciences UniversitàCattolica del Sacro CuoreRome 00168Italy Unit of Psychiatry Fondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy Unit of Medical Genetics Department of Laboratory MedicineFatebenefratelli Isola Tiberina-Gemelli IsolaRome 00186Italy Department of Medical and Surgical Sciences UniversitàCattolica del Sacro CuoreRome 00168Italy Internal Medicine and Gastroenterology Unit Fondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy Medicina Interna e Gastroenterologia CEMAD Digestive Disease CenterUniversitàCattolica del Sacro CuoreFondazione Policlinico Universitario A Gemelli IRCCSRome 00168Italy

The gut microbiota works in unison with the host,promoting its *** particular,it has been shown to exert protective,metabolic and structural *** evidence has revealed the influence of the gut microbiota on other organs such as the central nervous system,cardiovascular and the endocrine-metabolic systems and the digestive *** study of the gut microbiota is outlining new and broader frontiers every day and holds enormous innovation potential for the medical and pharmaceutical *** and treatment of specific women’s diseases involves the need to deepen the function of the gut as a junction organ where certain positive bacteria can be very beneficial to *** gut microbiota is unique and dynamic at the same time,subject to external factors that can change it,and is capable of modulating itself at different stages of a woman’s life,playing an important role that arises from the intertwining of biological mechanisms between the microbiota and the female genital *** gut microbiota could play a key role in personalized medicine.

关键词： Gut microbiota Women Metabolites Health promotion Immune system Gut-brain axis

Mycobacterium avium subspecies paratuberculosis in the etiology of Crohn's disease, cause or epiphenomenon?

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World Journal of Gastroenterology 2014年第36期20卷 13060-13070页

作者： Elisa Liverani eleonora Scaioli Carla Cardamone Paola Dal Monte Andrea Belluzzi Gastroenterology Division Department of Medical and Surgical Sciences Sant’Orsola-Malpighi University Hospital 40138 Bologna Italy Diagnostic and Speciality Medicine Department of Experimental Microbiology Unit Sant’Orsola-Malpighi University Hospital 40138 Bologna Italy

The origin of inflammatory bowel disease is unknown. Attempts have been made to isolate a microorganism that could explain the onset of inflammation, but no pathological agent has ever been identified. Johne’s disease is a granulomatous chronic enteritis of cattle and sheep caused by Mycobacterium avium subspecies paratuberculosis (MAP) and shows some analogies with Crohn’s disease (CD). Several studies have tried to clarify if MAP has a role in the etiology of CD. The present article provides an overview of the evidence in favor and against the “MAP-hypothesis”, analyzing the methods commonly adopted to detect MAP and the role of antimycobacterial therapy in patients with inflammatory bowel disease. Studies were identified through the electronic database, MEDLINE, and were selected based on their relevance to the objective of the review. The presence of MAP was investigated using multiple diagnostic methods for MAP detection and in different tissue samples from patients affected by CD or ulcerative colitis and in healthy controls. On the basis of their studies, several authors support a close relationship between MAP and CD. Although increasing evidence of MAP detection in CD patients is unquestionable, a clear etiological link still needs to be proven.

关键词： Mycobacterium avium paratuberculosis Crohn’ s disease Inflammatory bowel disease Johne’ s disease Mycobacterial protein tyrosine phosphatase

Non-alcoholic fatty liver disease connections with fat-free tissues: A focus on bone and skeletal muscle

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World Journal of Gastroenterology 2017年第10期23卷 1747-1757页

作者： eleonora Poggiogalle Lorenzo Maria Donini Andrea Lenzi Claudio Chiesa Lucia Pacifico Department of Experimental Medicine-Medical Pathophysiology Food Science and Endocrinology SectionSapienza University of Rome Institute of Translational Pharmacology National Research Council Policlinico Umberto I Hospital Sapienza University of Rome

The estimates of global incidence and prevalence of non-alcoholic fatty liver disease(NAFLD) are worrisome, due to the parallel burden of obesity and its metabolic complications. Indeed, excess adiposity and insulin resistance represent two of the major risk factors for NAFLD; interestingly, in the last years a growing body of evidence tended to support a novel mechanistic perspective, in which the liver is at the center of a complex interplay involving organs and systems, other than adipose tissue and glucose homeostasis. Bone and the skeletal muscle are fat- free tissues which appeared to be independently associated with NAFLD in several cross-sectional studies. The deterioration of bone mineral density and lean body mass, leading to osteoporosis and sarcopenia, respectively, are age-related processes. The prevalence of NAFLD also increases with age. Beyond physiological aging, the three conditions share some common underlying mechanisms, and their elucidations could be of paramount importance to design more effective treatment strategies for the management of NAFLD. In this review, we provide an overview on epidemiological data as well as on potential contributors to the connections of NAFLD with bone and skeletal muscle.

关键词： Non-alcoholic fatty liver disease Bone Skeletal muscle Osteoporosis Sarcopenia

The reaction electronic flux in chemical reactions

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Science China Chemistry 2011年第12期54卷 1982-1988页

作者： CERON María Luisa ECHEGARAY eleonora GUTIRREZ-OLIVA Soledad HERRERA Barbara TORO-LABB Alejandro Laboratorio de Química Teorica Computacional(QTC) Facultad de Química Pontificia Universidad Catolica de Chile

The mechanism of a chemical reaction can be characterized in terms of chemical events that take place during the *** events are bond weakening/breaking and/or bond strengthening/*** reaction electronic flux(REF),a concept that identifies and rationalizes the electronic activity taking place along the reaction coordinate,has emerged recently as a powerful tool for characterizing the mechanism of chemical reactions.A quantitative theory introducing new descriptors for characterizing reaction mechanisms is presented in detail and three illustrative examples are *** nucleophilic substitution reactions the REF indicates that bond breaking or forming events may be leading the electronic activity whereas in the methanol decomposition reaction by copper oxide,the REF allows to discover that consecutive electronic reductions of copper together with bond breaking processes control the course of the reaction.

关键词： reaction mechanisms chemical potential conceptual DFT reaction electronic flux (REF)

Increased risk of postsurgical macular edema in high stage idiopathic epiretinal membranes

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Eye and Vision 2021年第1期8卷 286-294页

作者： Lorenzo Iuliano Gloria Cisa di Gresy Giovanni Fogliato eleonora Corbelli Francesco Bandello Marco Codenotti Department of Ophthalmology Vita-Salute UniversitySan Raffaele Scientific InstituteVia Olgettina 6020132 MilanItaly

Purpose:To assess the rate of occurrence and the risk factors of postsurgical macular edema(PSME)in eyes with idiopathic epiretinal membrane(iERM)or full-thickness macular hole(FTMH).Methods:Retrospective longitudinal analysis of all subjects scheduled for vitrectomy with or without combined cataract surgery over a 6-month *** medical charts and imaging data were analyzed preoperatively and at 1,3 and 6 months after ***:From 101 patients diagnosed with iERM or FTMH,71 patients were eligible for the ***-nine eyes with iERM(69.0%)and 22 eyes with FTMH(31.0%)underwent vitrectomy either isolated(31.0%)or combined with cataract extraction(69.0%).The overall rate of PSME was 26.7%,without differences between the two groups(P=0.9479).Combined cataract extraction did not affect the overall occurrence of PSME rate in both groups(P=0.9255 in FTMH and P=0.8658 in iERM).If grouped by stage,eyes with stage 4 iERM though disclosed an increased rate of PSME(57.1%)compared to lower(1 to 3)stages(14.3%,P=0.0021),particularly when combined with cataract surgery(71.4%vs.15.4%in stages≤3,P=0.0021).The PSME odds ratio for a stage 4 iERM is 8(95%CI:1.933-33.1;P=0.0041)compared to stages 3 and ***:PSME remains a clinically relevant and frequent event after surgery for iERM and *** with stage 4 iERM have an 8-fold higher likelihood of developing PSME in a 6-month postsurgical period compared to iERM in 1-3 stages,especially when combined with cataract extraction.

关键词： Epiretinal membrane Macular edema Macular hole Vitrectomy Postsurgical macular edema

Predictors of persistence of functional mitral regurgitation after cardiac resynchronization therapy:Review of literature

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World Journal of Cardiology 2022年第3期14卷 170-176页

作者： eleonora Russo Giulio Russo Maurizio Braccio Mauro Cassese Department of Cardiovascular Surgery Casa Sollievo della Sofferenza HospitalIRCCSSan Giovanni Rotondo 71013Italy Institute of Cardiology Catholic University of the Sacred HeartRome 00168Italy

Functional mitral regurgitation is a common finding among heart failure patients with ischemic and non-ischemic dilated *** presence of moderate or severe mitral regurgitation is associated with higher morbidity and *** failure patients meeting electrocardiogram and left ventricle function criteria are good candidates for cardiac resynchronization therapy,which may reduce the degree of functional mitral regurgitation in the short and long term,specifically targeting myocardial dyssynchrony and inducing left ventricle reverse *** this article,we analyze data from the literature about predictors of mitral regurgitation improvement after cardiac resynchronization therapy implantation.

关键词： Functional mitral regurgitation Cardiac resynchronization therapy Predictors Mitral regurgitation improvement Dyssynchrony

Impact of jejunostomy during esophagectomy for cancer on health related quality of life

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Chinese Journal of Cancer Research 2014年第6期26卷 678-684页

作者： Marco Scarpa Francesco Cavallin Giulia Noaro eleonora Pinto Rita Alfieri Matteo Cagol Carlo Castoro Surgical Oncology Unit Veneto Institute of Oncology (IOV-IRCCS) Padua 35128 Italy

Background： The aim of this study was to evaluate the impact of jejunostomy during esophagectomy for cancer on postoperative health-related quality of life（HRQL）.Methods： We evaluate all consecutive patients who underwent esophagectomy for cancer at the surgical oncology unit of the Veneto Institute of Oncology（IOV-IRCCS） between January 2008 and March 2014. The primary outcome was HRQL, which was assessed using nine scales of EORTC C30 and OES18 questionnaires. General linear models were estimated to evaluate mean score difference（MD） of each selected scale in patients with and without jejunostomy, adjusting for clinically relevant confounders. The secondary outcomes were morbidity, hospital stay, postoperative weight loss and postoperative albumin impairment. Results： Jejunostomy was performed in 40 on 109 patients（41.3%） who participated in quality of life investigation. A clinically and statistically significantly worse eating at admission（P=0.009） became not clinically significant at 3 months after surgery（MD =9.1）. Jejunostomy was associated to clinically and statistically significantly poorer emotional function（EF） at 3 months after surgery（MD =-15.6; P=0.04）. Hospital stay was longer in jejunostomy group（median, 20 vs. 17 days, P=0.02）.Conclusions： In our series patients who had a jejunostomy during esophagectomy had been selected for their risk for postoperative complication. However, their postoperative outcome was actually similar compared to those without jejunostomy. Nevertheless, jejunostomy was associated to clinically and statistically significantly poorer EF at 3 months after surgery. Therefore, patient candidate to esophagectomy and feeding jejunostomy should receive additional psychological support.

关键词： Health-related quality of life(HRQL) jejunostomy esophagectomy esophageal cancer

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中亚成矿域斑岩铜矿床基本特征

岩石学报 2015年第2期31卷 315-332页

作者：申萍潘鸿迪 SEITMURATOVA eleonora 中国科学院地质与地球物理研究所、中国科学院矿产资源研究重点实验室北京100029 长安大学地球科学与资源学院西安710052 沙特巴耶夫地质研究所、地层实验室阿拉木图050010

中亚成矿域发育许多大型和超大型斑岩铜矿床,是世界上重要的斑岩铜矿成矿域。我们对9个大型和超大型斑岩铜矿床进行了研究,包括地质特征、含矿岩体地球化学、SIMS锆石U-Pb定年和成矿流体成分等,结合前人成果,我们认为中亚成矿域斑岩铜... 详细信息

中亚成矿域发育许多大型和超大型斑岩铜矿床,是世界上重要的斑岩铜矿成矿域。我们对9个大型和超大型斑岩铜矿床进行了研究,包括地质特征、含矿岩体地球化学、SIMS锆石U-Pb定年和成矿流体成分等,结合前人成果,我们认为中亚成矿域斑岩铜矿床具有如下特点:(1)成矿时代为古生代和中生代,成矿高峰期为泥盆纪和石炭纪;(2)含矿岩浆为钙碱性中酸性岩浆和少量的碱性岩浆,含矿岩体为花岗闪长岩、闪长岩、英云闪长岩和少量的二长岩;(3)含矿岩浆大多数源于新生的洋壳,少量有古老的基底物质和围岩物质参与;(4)成矿构造背景主要为岛弧,少量为陆缘弧和岛弧向陆缘弧过渡的环境;(5)矿床可分为三类,包括斑岩型Cu-Au、Cu(Au,Mo)和Cu-Mo矿床;(6)成矿流体可分为两类,包括氧化性H2O-Na Cl-CO2-SO2体系和少量的还原性H2O-Na Cl-CH4-CO2体系;(7)成矿系统可分为三类,包括简单的斑岩系统和少量的斑岩-矽卡岩成矿系统和斑岩-浅成低温热液成矿系统。

关键词：斑岩铜矿床锆石SIMS U-Pb年龄氧化和还原流体含矿岩浆成矿构造背景中亚成矿域