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Role of Mediterranean diet in preventing platinum based gastrointestinal toxicity in gynecolocological malignancies: A single Institution experience

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World Journal of Clinical Oncology 2019年第12期10卷 391-401页

作者： eleonora ghisoni Valentina Casalone Gaia Giannone Gloria Mittica Valentina Tuninetti Giorgio Valabrega Candiolo Cancer Institute FPO-IRCCSTorino 10060 Italy University of Torino Torino 10060Italy

BACKGROUND Gynecological malignancies represent a major cause of death in women and are often treated with platinum-based *** undergoing chemotherapy suffer from alterations in nutritional status which may worsen gastrointestinal(GI)toxicities,quality of life and affect the overall ***,assuring a good nutritional status and limiting toxicities during treatment are still major goals for *** To assess the role of Mediterranean Diet(MD)in reducing GI toxicities in patients with gynecological cancers treated with platinum-based *** We conducted an observational study on 22 patients with gynecological tumors treated with a platinum-based chemotherapy at Candiolo Cancer Institute FPO/IRCCS between January 2018 and June *** food and frequency(FFQ)and the Patient-Reported Outcomes Common Terminology Criteria For Adverse Events(PRO-CTCAE)questionnaires were administered at baseline and at every Day 1 of each *** evaluate the differences in GI toxicities the study population was divided in two groups according to the currently validated Mediterranean Diet Serving Score(MDSS)at *** Patients with high MDSS reported a trend toward lower GI toxicities according to PRO-CTCAE at each timepoint(first evaluation:P=0.7;second:P=0.52;third:P=0.01).In particular,difference in nausea frequency and gravity(P<0.001),stomach pain frequency and gravity(P=0.01 and P=0.02),abdomen bloating frequency and gravity(P=0.02 and P=0.03),and interference with daily activities(P=0.02)were highly statistically significant at the end of *** than 60%of patients changed their food habits during chemotherapy mainly because of GI toxicities.A higher reduction of food intake,both in terms of caloric(P=0.29)and of single nutrients emerged in the group experiencing higher *** Our results show that adherence to MD possibly reduces GI toxicity and prevents nutritional status impairment during chemotherapy treatmen

关键词： Mediterranean diet Gynecological malignancies Gastrointestinal toxicities Platinum-based chemotherapy Nutritional status

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