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Microsystems & Nanoengineering 2024年第2期10卷 173-180页

作者： Chhunheng lor.Ratanak Phon Sungjoon Lim Intelligent Semiconductor Engineering Chung-Ang UniversityHeukseok-DongDongjak-GuSeoul06974Republic of Korea School of Electrical and Electronic Engineering Chung-Ang UniversityHeukseok-DongDongjak-GuSeoul06974Republic of Korea

Polarization conversion and beam scanning metasurfaces are commonly used to reduce polarization mismatch and direct electromagnetic waves in a specific direction to improve the strength of a wireless ***,identifying suitable active and mechanically reconfigurable metasurfaces for polarization conversion and beam scanning is a considerable challenge,and the reported metasurfaces have narrow scanning ranges,are expensive,and cannot be independently *** this paper,we propose a reconfigurable transmissive metasurface combined with a scissor and rotation actuator for independently controlling beam scanning and polarization conversion *** metasurface is constructed with rotatable unit cells(UCs)that can switch the polarization state between right-handed(RHCP)and left-handed circular polarization(LHCP)by flipping the UCs to reverse their phase ***,independent beam scanning is achieved using the scissor actuator to linearly change the distance between the *** and experimental results confirm that the proposed metasurface can perform beam scanning in the range of 28°for both the positive and negative regions of a radiation pattern(RHCP and LHCP beams)at an operational frequency of 10.5 GHz.

关键词： beam rotation controlling

元话语在数字化学科研究交流中的再语境化作用:以心理学文摘为例

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Chinese Journal of Applied Linguistics 2024年第2期47卷 178-195,364页

作者：罗莎·洛雷斯萨拉戈萨大学西班牙

元话语(metadiscourse)最初被视作探究学术性、单一书面文本的专属工具。但随着数字话语研究的深入,元话语似乎演变为一个颇具挑战性的探索框架。首先,网络环境下的作者与读者互动变得隐晦难辨,这为元话语的研究带来了一定的困扰;其次,... 详细信息

元话语(metadiscourse)最初被视作探究学术性、单一书面文本的专属工具。但随着数字话语研究的深入,元话语似乎演变为一个颇具挑战性的探索框架。首先,网络环境下的作者与读者互动变得隐晦难辨,这为元话语的研究带来了一定的困扰;其次,数字文本的多模态特性进一步增加了元话语研究的复杂性。本研究旨在深入剖析交互式元语言资源在在线交流环境中所扮演的关键角色。因此,该研究聚焦于英国心理学会官方网站上发布的数字研究文摘语料库,该网站是英国心理学界最具权威性和代表性的机构之一。本研究专注于互动元话语的功能性探讨,视其为一种重构语境的重要工具,以助力非专业读者更好地理解复杂学科知识。经过深入研究,该研究确定了几类关键的互动资源,包括代码词汇、证据、过渡标记以及框架标记。这些资源通过战略性的运用,有效地促进了专业信息的传递和中介作用,同时充分利用了数字平台所赋予的各项能力。

关键词：互动元话语在线研究文摘专家学科知识再语境化

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Recent advances on the synthesis and application of tetrahydro-γ-carbolines

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Chinese Chemical Letters 2023年第12期34卷 119-136页

作者： Haibo Mei Klára Aradi lor.nd Kiss Jianlin Han Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources Nanjing Forestry University Institute of Organic Chemistry Research Centre for Natural Sciences Stereochemistry Research Group

Tetrahydro-γ-carbolines(THγ Cs) constitute one of the most important subtypes of indole alkaloids. In addition to being substructures of natural products, these structural motifs and moieties can often be found in pharmaceuticals due to their diverse bioactivities such as antiviral, antibacterial, antifungal,antiparasitic, antitumor, anti-inflammatory, and neuropharmacological activities. Beyond the pharmacological and biological aspects of these scaffolds, they have considerable synthetic applications for the construction of further bioactive compounds, too. The aim of this review is to summarize recent developments in the synthesis of this compound class.

关键词： Tetrahydro-γ -carbolines Synthetic methods Bioactive molecuels Asymmetric synthesis Indole Polycyclic compounds

Sex-dependent increase of movement activity in the freshwater isopod Asellus aquaticus following adaptation to a predator-free cave habitat

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Current Zoology 2023年第4期69卷 418-425页

作者： ELTE Eötvös lor.nd University Hajriz Berisha Gergely Horváth Žiga Fišer Gergely Balázs Cene Fišer Gábor Herczeg Author Notes Behavioural Ecology Group Department of Systematic Zoology and EcologyBiological InstituteELTE Eötvös Loránd UniversityPázmány Péter sétány 1/CBudapestHungary H-1117 ELKH-ELTE-MTM Integrative Ecology Research Group Pázmány Péter sétány 1/CBudapestHungary H-1117 Department of Biology Biotechnical FacultyUniversity of LjubljanaJamnikarjeva 1011000 LjubljanaSlovenia

Populations experiencing negligible predation pressure are expected to evolve higher behavioral ***,when sexes have different expected benefits from high activity,the adaptive shift is expected to be ***,we compared movement activity of one cave(lack of predation)and three adjacent surface(high and diverse predation)populations of Asellus aquaticus,a freshwater isopod known for its independent colonization of several caves across *** predicted 1)higher activity in cave than in surface populations,with 2)the difference being more pronounced in males as they are known for active mate searching behavior,while females are *** was assessed both in the presence and absence of *** results supported both predictions:movement activity was higher in the cave than in the surface populations,particularly in *** predation pressure in the cave-adapted population is most likely the main selective factor behind increased behavioral activity,but we also showed that the extent of increase is sex-specific.

关键词： adaptation cave colonization movement activity predator-free environment

Differential Effects of Strategies to Improve the Transduction Efficiency of Lentiviral Vector that Conveys an Anti-HIV Protein,Nullbasic,in Human T Cells

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Virologica Sinica 2018年第2期33卷 142-152页

作者： Lina Rustanti Hongping Jin Dongsheng Li Mary lor.Haran Sivakumaran David Harrich Faculty of Medicine The University of Queensland Department of Cell and Molecular Biology QIMR Berghofer Medical Research Institute National Institute of Health Research and Development the Ministry of Health of Republic of Indonesia Central Jakarta

Nullbasic is a mutant form of HIV-1 Tat that has strong ability to protect cells from HIV-1 replication by inhibiting three different steps of viral replication: reverse transcription, Rev export of viral m RNA from the nucleus to the cytoplasm and transcription of viral m RNA by RNA polymerase II. We previously showed that Nullbasic inhibits transduction of human cells including T cells by HIV-1-based lentiviral vectors. Here we investigated whether the Nullbasic antagonists huTat2(a Tat targeting intrabody), HIV-1 Tat or Rev proteins or cellular DDX1 protein could improve transduction by a HIV-1 lentiviral vector conveying Nullbasic-Zs Green1 to human T cells. We show that overexpression of huTat2, Tat-FLAG and DDX1-HA in virus-like particle(VLP) producer cells significantly improved transduction efficiency of VLPs that convey Nullbasic in Jurkat cells. Specifically, co-expression of Tat-FLAG and DDX1-HA in the VLP producer cell improved transduction efficiency better than if used individually. Transduction efficiencies could be further improved by including a spinoculation step. However, the same optimised protocol and using the same VLPs failed to transduce primary human CD4^+T cells. The results imply that the effects of Nullbasic on VLPs on early HIV-1 replication are robust in human CD4^+T cells. Given this significant block to lentiviral vector transduction by Nullbasic in primary CD4^+T cells, our data indicate that gammaretroviral, but not lentiviral, vectors are suitable for delivering Nullbasic to primary human T cells.

关键词：蛋白质房间向量传送 HIV-1 微分数据显示 RNA

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Buttress plate fixation of coronoid process fractures via a medial approach

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Chinese Journal of Traumatology 2019年第5期22卷 255-260页

作者： Kelvin Kah Ho lor.Dong Hao Toon Andy Teck Huat Wee Department of Orthopaedic Surgery Khoo Teck Puat HospitalSingapore Pinnacle Orthopaedic and Sports Centre Pinnacle Orthopaedic GroupSingapore

Purpose:To assess the clinical and radiographic outcomes of coronoid process fractures surgically managed with buttress plate fixation via a medial ***:A retrospective review of all coronoid fractures surgically fixed in our institution using a buttress plate technique via a medial approach between June 2012 and April 2015 by the senior author was *** fractures were all sizeable fractures contributing to persistent elbow instability in terrible triad or varus posteromedial rotatory instability injury patterns.A prospective telephone questionnaire was conducted to assess patient outcomes using the disabilities of the arm,shoulder and hand(DASH)score and Mayo hlbow performance score(MEPS).Results:Twelve patients were included in the study,comprising 10 males and 2 females with an average age of 39 years(range,19-72 years).Mean follow-up was 16 months(range.4-18 months).The average time to radiographic union was 4 months(range.3-7 months).Range of motion measurements at final follow-up were obtained in 11 out of 12 patients,with one patient defaulting *** 11 patients displayed a functional elbow range of motion of at least 30°-130°.with an average arc of motion of 130°(range.110°-140°).mean elbow flexion of 134°(range.110°-140°)and mean flexion contracture of 3°(range.0°-20°).The mean DASH score was 16(range.2.5-43.8)and the mean MEPS was 75(range.65-100).Complications observed included one patient with a superfic ial wound infection which resolved with a course of oral antibiotics and one patient with radiographic evidence of heterotopic ossification which was conservatively *** residual elbow instability was observed and no reoperations were ***:Buttress plate fixation via a medial approach of coronoid process fractures that contribute to persistent elbow instability represents a reliable method of treatment that produces satisfactory and predictable outcomes.

关键词： Coronoid process Anteromedial facet fracture Complex elbow instability Terrible triad injury

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Medical Equipment Technology Assessment Acquisitions,Resource and the Role of a Clinical Engineer

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Medical Equipment Technology Assessment Acquisitions,Resourc...

Retinoblastoma as an Epigenetic Disease: A Proposal

2008年中华临床医学工程及数字医学大会暨中华医学会医学工程学分会第九次学术年会

作者： Jin lor Regional Director ECRI Institute Asia Pacific Regional Office

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Journal of Cancer Therapy 2011年第3期2卷 362-371页

作者： Domenico Mastrangelo Cosimo lor. Giovanni Grasso 不详

The aim of the present review is to give new insights into the pathogenesis of retinoblastoma, by applying the principles of Epigenetics to the analysis of clinical, epidemiological, and biological data concerning the disease. As an emerging new scientific approach linking the genome to the environment, Epigenetics, as applied to the interpretation of clinical, epidemiological and biological data in retinoblastoma, can not only explain the inconsistencies of the mutational (“two hit”) model, but also open new outstanding scenarios in the fields of diagnosis, treatment and prevention of this eye tumour. This review is both a collection of literature data arguing against the role of the mutational (“two hit”) model in the genesis of retinoblastoma, and a documented evaluation of how the Epigenetic, rather than the genetic model fit the variegated phenotypic expression of the disease. The epigenetic model in the genesis of retinoblastoma, proposed herein, emphasizes the role of environment and the interaction of the environment with the genome, in generating reti-noblastoma in young children. Environmental toxicants, including radiations, wrong diets, and infectious diseases, among others, all play a major role in conditioning the degree of DNA methylation in embryos and foetuses during pregnancy, thus leading to stable, functional alterations of the genome, which, on the other hand, can be also transmit-ted from generation to generation, thus mimicking a hereditary disease. An accurate analysis of the currently available literature on both retinoblastoma and Epigenetics, coupled with the knowledge of the variegated phenotypic expression of the disease, can easily lead to the conclusion that retinoblastoma is an epigenetic, rather than a genetic disease.

关键词： Retinoblastoma Epigenetics Genome Imprinting DNA Methylation Histone Acetylation / Deacetylation

Long-period gratings in polymer ridge waveguides

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Long-period gratings in polymer ridge waveguides

3D Fluorescence Characterization of Synthetic Organic Dyes

Photonics Asia 2004;Optoelectronics,Microelectronics,and Nanotech

作者： Kin Seng Chiang Kar Pong lor Optoelectronics Research Centre and Department of Electronic Engineering City University of Hong Kong 83 Tat Chee Avenue Kowloon Hong Kong China Optoelectronics Research Centre and Department of Electronic Engineering City University of Hong Kong 83 Tat Chee Avenue Kowloon Hong Kong China

In this paper, we report the design and fabrication of a long-period waveguide grating (LPWG) in a polymer ridge waveguide, which has a benzocyclobutene (BCB) core and an epoxy cladding of the same wi

关键词： Long-period gratings, optical filters, optical waveguide filters, polymer waveguides, ridge waveguide, tunable filters.

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American Journal of Analytical Chemistry 2012年第9期3卷 622-631页

作者： Leonard J. Soltzberg Sandy lor.Nnennaya Okey-Igwe Richard Newman Department of Chemistry & Physics Simmons College Boston USA Scientific Research Lab Boston Museum of Fine Arts Boston USA

The identification of dyes is important in research on museum artefacts as well as in forensic applications. UV-visible absorption spectroscopy cannot unambiguously distinguish dyes with similar hues, while mass spectrometry may fail to distinguish isobaric dyes. The detailed patterns produced by 3D fluorescence spectroscopy appear to be virtually unique, even among dyes that are closely related positional isomers. We report these patterns for 65 dyes from the Schweppe Library of Synthetic Organic Dyes as well as measurements suggesting both the capabilities and limitations of this method.

关键词： Fluorescence Spectrophotometry Dye Analysis MALDI-TOF Mass Spectrometry