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Successful endovascular treatment of transplant intrarenal artery stenosis in renal transplant recipients: Two case reports

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World Journal of Transplantation 2015年第2期5卷 68-72页

作者： Maria Koukoulaki Elias Brountzos Ioannis Loukopoulos Maria Pomoni eleni Antypa Vasileios Vougas Spiros Drakopoulos Transplant Unit Evangelismos General Hospital of Athens Research Unit of Radiology and Medical Imaging Eugenideion Hospital University of Athens

Transplant renal artery stenosis(TRAS) is a relatively rare complication after renal transplantation. The site of the surgical anastomosis is most commonly involved, but sites both proximal and distal to the anastomosis may occur, as well. Angioplasty is the gold standard for the treatment of the stenosis, especially for intrarenal lesions. We report two cases of intrarenal TRAS and successful management with angioplasty without stent placement. Both patients were male, 44 and 55 years old respectively, and they presented with elevated blood pressure or serum creatinine within three months after transplantation. Subsequently, they have undergone angioplasty balloon dilatation with normalization of blood pressure and serum creatinine returning to baseline level. Percutaneous transluminal balloon renal angioplasty is a safe and effective method for the treatment of the intrarenal TRAS.

关键词： Transplant renal artery stenosis Intrarenal stenosis Hypertension Renal transplantation Allograft dysfunction Angioplasty Endovascular treatment

Pirfenidone inhibits epithelial–mesenchymal transition in keloid keratinocytes

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Burns & Trauma 2020年第1期8卷 441-451页

作者： Latha Satish Alexander Evdokiou eleni Geletu Jennifer M.Hahn Dorothy M.Supp Research Department Shriners Hospitals for Children—CincinnatiCincinnatiOH 45229 USA Department of Pathology&Laboratory Medicine University of CincinnatiCincinnatiOH 45229USA Department of Surgery University of CincinnatiCincinnatiOH 45229USA

Background:Keloids are benign fibroproliferative skin lesions that are difficult to treat and become a lifetime predicament for *** treatment modalities have been put forth,but as yet no satisfactory approach to the prevention or treatment of keloids has been *** process of epithelial-to-mesenchymal transition(EMT)has been implicated in keloid scarring,as keloid keratinocytes display an EMT-like *** study investigated the potential of pirfenidone,an antifibrotic agent,to counteract EMT-like alterations in keloid keratinocytes,including gene expression,cell migratory and proliferative ***:Normal and keloid keratinocytes were isolated from discarded normal skin tissues and from resected keloid tissues,*** were quiesced for 24 h without epidermal growth factor DS-Qi1MCDigital and were exposed to transforming growth factor-beta1(TGF-β1;10 ng/mL),with or without pirfenidone(400μg/mL),for an additional 24 *** effects of pirfenidone on cytotoxicity,cell migration,cell proliferation,and on expression of genes and proteins involved in EMT were *** significance was determined by two-way ANOVA using Sigma ***:We found that pirfenidone did not elicit any cytotoxic effect at concentrations up to 1000μg/mL.A statistically significant dose-dependent decrease in basal cell proliferation rate was noted in both normal and keloid keratinocytes when exposed to pirfenidone at concentrations ranging from 200 to 1000μg/*** significantly decreased basal cell migration in both normal and keloid keratinocytes,but a significant decrease in TGF-β1-induced cell migration was seen only in keloid *** inhibition of the expression of TGF-β1-induced core EMT genes,namely hyaluronan synthase 2,vimentin,cadherin-11,and wingless-type MMTV integration site family,member 5A along with fibronectin-1,was observed in both normal and keloid keratinocytes treated with *** addi

关键词： Keloids EMT genes Cell migration Proliferation Pirfenidone Fibronectin

Elderly adults with COVID-19 admitted to intensive care unit:A narrative review

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World Journal of Critical Care Medicine 2021年第5期10卷 278-289页

作者： Aikaterini Gkoufa eleni Maneta Georgios N Ntoumas Vasiliki E Georgakopoulou Athina Mantelou Stelios Kokkoris Christina Routsi First Department of Internal Medicine Laiko General HospitalNational and Kapodistrian University of AthensAthens 11527Greece First Department of Intensive Care School of MedicineNational and Kapodistrian University of AthensAthens 10676Greece

BACKGROUND In the context of the Coronavirus disease 2019(COVID-19)pandemic,it has been reported that elderly patients are particularly at risk of developing severe illness and exhibiting increased *** many studies on hospitalized elderly patients with COVID-19 have been published,limited information is available on the characteristics and clinical outcomes of those elderly patients admitted to intensive care unit(ICU).AIM To review the available evidence of the clinical data of elderly patients admitted to the ICU due to *** We searched for published articles available in English literature to identify those studies conducted in critically ill patients admitted to the ICU due to COVID-19,either exclusively designed for the elderly or for the whole ICU population with COVID-19,provided that analyses according to the patients’age had been *** Only one study exclusively focusing on critically ill elderly patients admitted to the ICU due to COVID-19 was *** additional studies involving 17011 ICU patients and providing information for elderly patients as a subset of the whole study population have also been included in the present review *** the whole patient population,included in these studies,8310 patients were older than 65 years of age and 2630 patients were older than 70 *** manifestations were similar for all patients;however,compared to younger ones,they suffered from more comorbidities and showed a varied,albeit high *** In summary,at present,although elderly patients constitute a considerable proportion of critically ill patients admitted to the ICU due to severe COVID-19,studies providing specific information are *** evidence so far suggests that advanced age and comorbidities are associated with worse clinical *** studies exclusively designed for this vulnerable group are needed.

关键词： SARS-CoV-2 COVID-19 Elderly Critically ill Intensive care unit mortality Respiratory failure

Comparison of Traps Collecting Propolis by Honey Bees

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Advances in Entomology 2017年第2期5卷 68-74页

作者： Antonios E. Tsagkarakis Tatiani Katsikogianni Konstantinos Gardikis Ioannis Katsenios eleni Spanidi Georgios N. Balotis Laboratory of Agricultural Zoology and Entomology Agricultural University of Athens Athens Greece APIVITA S.A. Markopoulo Mesogaias Greece Institute of Agronomical Sciences Hellenic Ministry of Rural Development and Food Κifissia Greece

The last few years numerous publications have been published about the properties and plant origin of propolis, the glue-like resinous product collected by honeybees. Although, only one scientific experiment has been previously conducted on propolis collection techniques by honey bees, making the relative literature extremely limited in this area. The present study scopes to evaluate the effect of the trap types on the quantity of propolis collected by honeybees. For this reason, at two different locations, five different types of propolis collection traps, applied on Langstroth bee hives, were tested: 3 hand-cut screens plus one commercial screen on the top bars, as well as a lateral side modification of a Langstroth hive. Results show that two hand-cut screens with smaller openings (1 × 1 mm and 2 × 2 mm) as well as the commercial screen collected significantly more propolis than the others (F4,41 = 43.21, P 0.0001). Furthermore, the two hand-cut screens filled faster with propolis.

关键词： Propolis Collection Honeybee Langstroth Hive

Youth gender differences in alcohol use: A prospective study of multiple youth assets and the neighborhood environment

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Open Journal of Preventive Medicine 2013年第2期3卷 219-228页

作者： Roy F. Oman eleni L. Tolma Sara K. Vesely Cheryl B. Aspy Department of Biostatistics and Epidemiology University of Oklahoma Health Sciences Center Oklahoma City USA Department of Family and Preventive Medicine University of Oklahoma Health Sciences Center Oklahoma City USA Department of Health Promotion Sciences University of Oklahoma Health Sciences Center Oklahoma City USA

Research has identified factors (assets) that protect youth from engaging in risk behaviors including alcohol use. Very little research has examined asset/nonuse of alcohol associations by youth gender or determined if asset/nonuse of alcohol associations are influenced by the neighborhood environment. The purpose of the study was to determine if multiple youth assets and neighborhood factors are differentially associated with youth nonuse of alcohol by gender. Method: Five waves of data were collected annually from households (N = 1111) randomly selected to participate in the Youth Asset Study. Seventeen assets and 6 neighborhood factors assessed at waves 1 - 4 were analyzed longitudinally using marginal logistic regression to predict nonuse of alcohol at waves 2 - 5. Results: Sample mean age was 14.3 years, 52% female;39% white, 28% Hispanic, 23% African-American, and 9% other. Numerous assets were prospec- tively associated with alcohol nonuse for females (12 assets) and males (16 assets). Three assets were significantly more protective from alcohol use for males compared to females. Final modeling indicated that three assets were protective from alcohol use for both genders and that one asset was protective only for males. There were no significant associations between the neighborhood variables and nonuse of alcohol, and the neighborhood variables did not influence the asset/nonuse of alcohol associations. Conclusions: Youth assets appear to protect both genders from future alcohol use but males may benefit even more from asset-building prevention programming. Youth alcohol use and alcohol nonuse/asset associations may not be influenced by the neighborhood environment.

关键词： Youth Tobacco Use Youth Assets Gender Analyses Neighborhood Environment

Studies on the Authenticity of Local Wines by Spectroscopic and Chemometric Analysis

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Journal of Chemistry and Chemical Engineering 2014年第2期8卷 101-107页

作者： Rebecca Kokkinofta Naso Economidou eleni Tzioni Katerina Damianou Konstantina Poulli Chara Savvidou Charalambos Louka Popi Kanari State General Laboratory Ministry of Health Nicosia 1451 Cyprus

The authenticity of 91 wines produced in Cyprus from both indigenous and other vine varieties were investigated by a holistic approach, using, advanced technology such as SNIF-NMR （site-specific natural isotopic fractionation-nuclear magnetic resonance） and 1R-MS （isotope ratio-mass spectrometry） for the determination of the stable isotopes and ICP （inductively coupled plasma spectroscopy） for some heavy metals. The spectroscopic characteristics were evaluated statistically using different chemometric methods. The dependency of the D/H （deuterium/hydrogen） ratio of the methylene site in the ethanol molecule （D/H）ll and also theδ ^18O values of the wine water, were the most useful discriminators. Isotopic results allow us to have a complete idea about the regional variability of the isotopes. Among the metals, Ni followed by Pb was the ones with the highest discrimination value. The determined concentrations of Pb, Ni, Cr and Cd that are related to the safety of wines were within the acceptable limits that have been established by the OIV （international organization of vine and wine） or comparable with the results of the wines of other European countries. The study of the correlation between the load of heavy metals and isotopes in wines showed a dependence on the grape variety but not the geographical location of the vineyard. This is probably due to the close proximity of wine regions in Cyprus.

关键词： SNIF-NMR IR-MS ICP Cypriot wines authenticity stable isotopes heavy metals chemometrics.

Successful management of adhesion related small bowel ischemia without intestinal resection: A case report and review of literature

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World Journal of Gastrointestinal Pathophysiology 2019年第2期10卷 29-35页

作者： Pantelis Vassiliu Vasiliki Ntella George Theodoroleas Zisis Mantanis Ioanna Pentara eleni Papoutsi Aikaterini Mastoraki Nikolaos Arkadopoulos 4th Department of Surgery National and Kapodistrian University of Athens Attikon University Hospital

BACKGROUND Intraabdominal adhesions develop spontaneously or after an inflammatory process or surgical procedure in the *** are the most common cause of small bowel obstruction(SBO).SBO occasionally leads to intestinal ischemia(In Is)which can be a life-threatening condition that requires management as soon as *** herein report a case of SBO with In Is presented in our institution and treated without intestinal *** SUMMARY A 34-year-old man presented at the emergency department after a 12-h-onset diffuse abdominal pain,bloating and *** had a history of traumatic right hepatectomy 11 years ago as well as adhesiolysis and resection of a long part of small bowel 2 years *** abdominal computed tomography(CT)showed dilated loops that led to the diagnosis of *** to deteriorating lactic acidosis,the patient was *** of the small bowel around an adhesion led to2.30 m of ischemic *** the application of N/S 40°C for 20 min,the intestine showed signs of improvement and it was decided to avoid resection and instead temporary close the abdomen with vacuum-pack *** the second-look laparotomy 48 h later,the intestine appeared *** patient was discharged on the 8 th post-op day in excellent *** In case of SBO caused by adhesions,extreme caution is needed if In Is is present,as the clinical signs are mild and you should rely for diagnosis in CT findings and lactate *** surgical approach could reverse the effects of In Is,if performed quickly,so that intestinal resection is avoided and should be used even when minimum signs of viability are present.

关键词： Intraabdominal adhesions Intestinal ischemia Small bowel obstruction Vacuum-pack technique Case report Conservative surgical approach

Dysbetalipoproteinemia: Two cases report and a diagnostic algorithm

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World Journal of Clinical Cases 2015年第4期3卷 371-376页

作者： Anastazia Kei Moses Elisaf George Miltiadous Marilena Hadjivassiliou Marios Cariolou eleni Bairaktari Department of Internal Medicine University of Ioannina Medical School Department of Cardiovascular Genetics and the Laboratory of Forensic Genetics Cyprus Institute of Neurology and Genetics Department of Biochemistry University of Ioannina Medical School

Dysbetalipoproteinemia is a rare familial dyslipidemia characterized by approximately equally elevated serum cholesterol and triglyceride levels due to accumulated remnant lipoproteins in apolipoprotein E2/E2 *** is associated with an increased risk for premature cardiovascular disease. Thus, making a diagnosis of dysbetalipoproteinemia aids in assessing cardiovascular risk correctly and allows for genetic counseling. However, the diagnostic work-up can be challenging. Diagnosis of dysbetalipoproteinemia should be considered in patients mixed dyslipidemia when the apolipoprotein B concentration is relatively low in relation to the total cholesterol concentration or when there is significant disparity between the calculated low density lipoprotein(LDL) and directly measured LDL cholesterol concentrations. Other indices are also informative in the diagnostic process. We present herein two phenotypically different cases(a 44-year-old man with severe hypertriglyceridemia and a 49-year-old woman with mixed dyslipidemia) of genotypically proven familial dysbetalipoproteinemia and a diagnostic algorithm of the disease.

关键词： Dysbetalipoproteinemia Chylomicronemia Hyperlipoproteinemia typeⅢ Hypertriglyceridemia

Has the time been reached for pseudopolyps to be re-enrolled in endoscopic inflammatory bowel disease scores?

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World Journal of Gastrointestinal Endoscopy 2019年第6期11卷 424-426页

作者： Dimitrios S Politis Konstantinos H Katsanos Konstantinos Papamichael Maria Saridi eleni Albani Dimitrios K Christodoulou Department of Gastroenterology University Hospital of IoanninaFaculty of MedicineSchool of Health SciencesUniversity of IoanninaIoannina 45110Greece Center for Inflammatory Bowel Diseases Division of GastroenterologyBeth-Israel Deaconess Medical CenterHarvard Medical SchoolBostonMA 02215United States General Hospital of Corinth Department of Social and Educational PolicyUniversity of PeloponneseCorinth 20100Greece Department of Nursing TEI of Western GreecePatra 26334Greece

Patients with inflammatory bowel diseases (IBD) represent heterogeneous groups with different characteristics and different clinical course. A great deal of effort is made to discover proxies for more severe disease needing more intense treatment and early intervention to gain the maximum therapeutic benefit. Endoscopy remains an invaluable method in assessment of patients with IBD. Pseudopolyps are often encountered during endoscopy and, although they are a well described entity, their presence is of unclear importance. In one of our recent studies and in conjunction with one study with a large cohort of patients with IBD and pseudopolyps, patients with pseudopolyps were found to face a higher inflammatory burden in terms of receiving more intense biological treatment. This letter comes as a comment and proposition regarding the concept of reevaluation of pseudopolyps as a promising marker in IBD scores.

关键词： Pseudopolyps Inflammatory bowel diseases Treatment escalation Endoscopic scores