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Day case paediatric microlaryngobronchosocopy:A prospective study

World Journal of Otorhinolaryngology 2017年第1期7卷 1-4页

作者： Arwa El-Sheemy Jagdeep Singh Virk Jay Ahmed eleni nikolopoulou Sahar Kazmi Yogesh Bajaj ENT Department Barts Childrens and Royal London Hospital

AIM To assess the feasibility and parental acceptance of diagnostic microlaryngobronchoscopy(MLB) as day case *** A prospective study was performed over a 26 moperiod at a tertiary paediatric ENT centre. Patients were selected in clinic using set criteria. All MLBs were performed using a standardised anaesthetic protocol and patients monitored post-operatively. Six weeks following surgery, parents underwent questionnaire *** Ninety-four out of 101 MLBs was successfully performed as day case surgery over the set period. Seven patients required an overnight stay for further observation. Fiftyseven parents took part in the questionnaire of which 68.4% were highly satisfied with same day discharge. CONCLUSION MLB is feasible, safe and acceptable as day case surgery in carefully selected patients.

关键词： Child Laryngoscopy Anaesthetics General Microlaryngoscopy Ambulatory surgical procedure Microlaryngobronchoscopy Bronchoscopy

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Adipokines levels are associated with the severity of liver disease in patients with alcoholic cirrhosis

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World Journal of Gastroenterology 2015年第10期21卷 3020-3029页

作者： Maria Kalafateli Christos Triantos Emmanuel Tsochatzis Marina Michalaki Efstratios Koutroumpakis Konstantinos Thomopoulos Venetsanea Kyriazopoulou eleni Jelastopulu Andrew Burroughs Chryssoula Lambropoulou-Karatza Vasiliki nikolopoulou Department of Gastroenterology University Hospital of Patras The Royal Free Sheila Sherlock Liver Centre Royal Free Hospital Department of Endocrinology University Hospital of Patras Department of Public Health Medical SchoolUniversity of Patras Department of Internal Medicine University Hospital of Patras

AIM:To investigate the adipokine levels of leptin,adiponectin,resistin,visfatin,retinol-binding protein 4(RBP4),apelin in alcoholic liver cirrhosis(ALC).METHODS:Forty non-diabetic ALC patients[median age:59 years,males:35(87.5%),Child-Pugh(CP)score:median 7(5-12),CP A/B/C:18/10/12,Model for End-stage Liver Disease(MELD):median 10(6-25),follow-up:median 32.5 mo(10-43)]were prospectively *** serum adipokine levels were estimated in duplicate by *** characteristics were assessed with tetrapolar bioelectrical impedance ***’s rank correlation coefficient was used to assess possible associations with adipokine *** and multivariate Cox regression analysis was used to determine independent predictors for ***:Body mass index:median 25.9(range:20.1-39.3),fat:23.4%(7.6-42.1),fat mass:17.8(5.49-45.4),free fat mass:56.1(39.6-74.4),total body water(TBW):40.6(29.8-58.8).Leptin and visfatin levels were positively associated with fat mass(P<0.001/P=0.027,respectively)and RBP4 with TBW(P=0.025).Median adiponectin levels were significantly higher in CPC compared to CPA(CPA:7.99±14.07,CPB:7.66±3.48,CPC:25.73±26.8,P=0.04),whereas median RBP4 and apelin levels decreased across the spectrum of disease severity(P=0.006/P=0.034,respectively).Following adjustment for fat mass,visfatin and adiponectin levels were significantly increased from CPA to CPC(both P<0.001),whereas an inverse correlation was observed for both RBP4 and apelin(both P<0.001).In the multivariate Cox regression analysis,only MELD had an independent association with overall survival(HR=1.53,95%CI:1.05-2.32;P=0.029).CONCLUSION:Adipokines are associated with deteriorating liver function in a complex manner in patients with alcoholic liver cirrhosis.

关键词： Adipokines Adiponectin Cirrhosis Leptin Resistin

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