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The Role of Asymmetric Dimethylarginine and Lipoprotein Associated Phospholipase A2 in Children and Adolescents with Dyslipidemia

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Health 2014年第12期6卷 1440-1446页

作者： eleni klinaki Alexandra Soldatou Antonios Marmarinos Athanasia Pagoni Charalampos Tsentidis Dimitrios Gourgiotis Anastasia Garoufi Laboratory of Clinical Biochemistry and Molecular Diagnostics Second Department of Pediatrics Athens Uni-versity “P. & A. Kyriakou” Children’s Hospital Athens Greece Lipid Outpatient Clinic Second Department of Pediatrics Athens University “P. & A. Kyriakou” Children’s Hospital Athens Greece Second Department of Pediatrics Athens University “P. & A. Kyriakou” Children’s Hospital Athens Greece

Background: The pathophysiologic mechanisms which lead to cardiovascular (CV) events begin early in childhood. Atherosclerosis is recognized as a process of chronic and dynamic vascular inflammation induced primarily by endothelial dysfunction. Asymmetric dimethylarginine (ADMA) and lipoprotein associated phospholipase A2 (Lp-PLA2) are considered markers of early atherosclerosis and predictors of late complications in adults. Objectives: To establish the relationship between ADMA, Lp-PLA2 and traditional biochemically determined markers in children and adolescents with dyslipidemia. Material and Methods: The study population consisted of 102 children, 57 males/45 females, with a median age of 9.9 years. Seventy-one out of 102 had dyslipidemia (LDL-C levels ≥ 130 mg/dl). Lipid levels were estimated after an overnight fasting. LDL-C concentration was directly measured. ADMA and Lp-PLA2 levels were assessed by enzyme-linked immunosorbent assay (ELISA). Statistical analysis was performed using STATA for Windows v8.5. Results: ADMA was significantly positively correlated with all TC, LDL-C and non-HDL-C. Even small changes of the ADMA concentration were found to be followed by corresponding alterations in lipid levels. A positive correlation of borderline significance between Lp-PLA2 and LDL-C or non- HDL-C was observed. In addition, ADMA and Lp-PLA2 were significantly correlated. A strong correlation between Lp-PLA2 and dyslipidemia or lipid levels could not be established, probably due to the size and heterogeneity of our sample. Conclusions: A relationship of ADMA and Lp-PLA2 levels with biochemical markers associated with long-term risk of atherosclerosis in children and adolescents is supported. The assessment of these two biomarkers combined may improve CV risk prediction and future management strategies in the pediatric population.

关键词： Atherosclerosis LDL-C ADMA Lp-PLA2 Childhood

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Proteomic-based evidence for adult neurogenesis in birds and mammals as indicated from cerebrospinal fluid

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Neural Regeneration Research 2022年第12期17卷 2576-2581页

作者： eleni Voukali Michal Vinkler Department of Zoology Faculty of ScienceCharles UniversityPragueCzech Republic

Adult neurogenesis is the life-long process of neural stem cell proliferation,differentiation into neurons,migration,and incorporation into the existing neuronal *** decades of research,it is now widely accepted that mammals and birds retain the capacity to regenerate neurons even after their subadult *** fluid participates in the regulation of the neurogenic niches of the vertebrate brain through signaling pathways not fully *** studies of cerebrospinal fluid have the potential to allow the in-depth characterization of its molecular *** studies help to delineate those pathways that are universally critical for the regulation of neurogenesis in *** this review,we performed literature-based data mining in studies using liquid chromatography-tandem mass spectroscopy that analyzed cerebrospinal fluid samples from healthy adult humans(Homo sapiens);mice(Mus musculus);sheep(Ovis aries);chickens(Gallus gallus);and two parrot species,the budgerigar(Melopsittacus undulatus)and cockatiel(Nymphicus hollandicus).We identified up to 911 proteins represented in cerebrospinal fluid,involved in various pathways regulating adult ***,only 196 proteins were common across humans,mice,and *** components involved in nervous system development,cell migration,and axonal guidance were commonly evident in all species investigated so *** bioinformatic analysis revealed that the universally over-represented pathways involved L1 cell adhesion molecule protein interactions,cell-adhesion molecules,signals regulating extracellular matrix remodeling,regulation of insulin growth factor signaling,axonal guidance,programmed cell death,immune signaling,and post-translational *** of the reported proteins are part of extracellular vesicles enriched in cerebrospinal ***,the information presently available is still highly fragmentary,and far more questions persist than

关键词： adult neurogenesis birds cerebrospinal fluid chicken comparative proteomics human mammals mass spectrometry parrots

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Immunohistochemical localization of glutathione S-transferase-pi in human colorectal polyps

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World Journal of Gastroenterology 2008年第26期14卷 4179-4184页

作者： eleni Gaitanarou eleni Seretis Dimitrios Xinopoulos Emmanuel Paraskevas Niki Arnoyiannaki Irene Voloudakis-Baltatzis Department of Electron Microscopy-Cell Biology "G. Papanicolaou" Research Center of Oncology and Experimental Surgery"Agios Savvas" Anticancer Hospital of Athens Athens 11522Greece Department of Electron Microscopy-Cell Biology "G. Papanicolaou" Research Center of Oncology and Experimental Surgery"Agios Savvas" Anticancer Hospital of Athens Athens 11522Greece Department of Gastroenterology "Agios Savvas" Anticancer Hospital of AthensAthens 11522Greece Department of Gastroenterology "Agios Savvas" Anticancer Hospital of AthensAthens 11522Greece Department of Pathology of the Regional Anticancer-Oncologic Hospital of Athens "Agios Savvas" Athens 11522Greece Department of Electron Microscopy-Cell Biology "G. Papanicolaou" Research Center of Oncology and Experimental Surgery"Agios Savvas" Anticancer Hospital of Athens Athens 11522Greece

AIM:To investigate the distribution of the placental form of glutathione-S-transferase (GST) in colon polyps in order to evaluate the role of GST-pi in these tissues. METHODS: Sixteen polyp tissues removed at colonoscopy were examined. Tissues were investigated histologically and ultrastructurally. GST-pi expression was also analysed immunohistochemically, using peroxidase anti-peroxidase (PAP) method and immunogold labelling method, for light and electron microscope respectively. RESULTS: All polyp tissues examined were adenoma of low, mild and high-grade dysplasia as shown in the histopathological reports. Nevertheless, the examination of the above specimens with electron microscope revealed that 3 of 9 adenoma of mild dysplasia had ultrastuctural features similar to high-grade dysplasia adenoma. GST-pi was variably expressed in adenoma, with the lowest relative levels occurring in low-gradeadenoma and the highest levels found in high-grade adenoma. GST-pi was located mainly in undifferentiated epithelial cells. GST-pi positive particles were found in the cytoplasm and especially in the nucleus adjacent to the nuclear membrane of these cells. CONCLUSION:The overexpression of GST-pi in mildgrade adenomas with significant subcellular changes and in the majority of high-grade dysplasia adenoma suggests that this might be related to the carcinogenetic proceeding. Immunohistochemical localization of GST-pi in combination with ultrastructural changes indicate that GST-pi might be a sensitive agent for the detection of preneoplastic transformations in adenoma.

关键词： Glutathione S-transferase-pi Colorectal polyps Adenoma Electron microscopy Peroxidase anti-peroxidase method Immunogold method

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Global transplantation:Lessons from organ transplantation organizations worldwide

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World Journal of Transplantation 2025年第1期15卷 44-56页

作者： Solonas Symeou eleni Avramidou Vassilios Papalois Georgios Tsoulfas Medical School University of IoanninaIoannina 45110Greece Department of Transplantation Surgery Center for Research and Innovation in Solid Organ TransplantationSchool of MedicineAristotle University of ThessalonikiThessaloniki 54642Greece Imperial College Renal and Transplant Centre Imperial College Healthcare NHS TrustHammersmith HospitalLondon W120HSUnited Kingdom Department of Surgery and Cancer Imperial College LondonLondon SW72AZUnited Kingdom

Although national transplant organizations share common visions and goals,the creation of a unified global organization remains *** in ethnicity,culture,religion,and education shape local practices and infrastructure,making the establishment of a single global entity *** with these social disparities aside,logistical factors such as time and distance between organ procurement and transplantation sites pose significant *** technological advancements have extended organ preservation times,they have yet to support the demands of transcontinental transplantations *** review presents a comparative analysis of the structures,operational frameworks,policies,and legislation governing various transplant organizations around the *** differences pertain to the administration of these organizations,trends in organ donation,and organ allocation policies,which reflect the financial,cultural,and religious diversity across different *** a global transplant organization may be out of reach,agreeing on best practices for the benefit of patients is essential.

关键词： Organ transplantation National transplant organizations Organ donation Global transplantation Transplant systems

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Influence of an External DC Electric Current on Plasma Cleaning Rate: an Application on the Enlarged Plasma-Surface Theor

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Plasma Science and Technology 2013年第5期15卷 448-454页

作者： Constantine L. XAPLANTERIS eleni D. FILIPPAKI Plasma Physics Lab IMS NCSR "Demokritos" Hellenic Military Academy

During the last decades many researchers have been occupied with other plasma applications apart from the big challenge which the thermonuclear fusion poses. Many experiments have been carried out on the plasma behavior in contact with a solid surface; when the surface material consists of chemical compounds （e.g. oxides of metals）, then the plasma chemistry takes place. The present paper contains the final experimental and theoretical work of Plasma Laboratory at ＂Demokritos＂, which consists of an elaboration of plasma sheath parameters adapted to experimental conditions, a suitable choice of plasma gases （either H 2 or N 2 ）, and an electric po-tential current enforcement on objects. Additionally, a brief theory is given to explain the results, with a short reference to both boundary phenomena in thermonuclear reactors and low pressure plasma of glow discharges, so as to reveal the similarities and differences of these two cases. An extensive examination of the treated objects by X-ray diffraction method （XRD） gives results in agreement with the theoretical predictions. Using this improvement on plasma restoration system, （a combination of electric current on metallic object into suitable plasma）, it is shown that better results can be achieved on the cleaning and conservation of archaeological objects.

关键词： impurities plasma sheath parameters reduction of surfaces external poten-tial treatment rate

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eleni Kounalakis attends the Second Belt and Road Forum for International Cooperation

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Voice of Friendship 2019年第2期 28-30页

作者： eleni Kounalakis 不详

eleni Kounalakis,Lieutenant Governor of California,visited Beijing to attend the Second Belt and Road Forum for International Cooperation from April 23 to 26.

关键词： China Road Cooperation

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Probing top-quark couplings indirectly at Higgs factories

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Chinese Physics C 2018年第12期42卷 53-65页

作者： Gauthier Durieux Jiayin Gu eleni Vryonidou Cen Zhang DESY Notkestratle 85 D-22607HamburgGermany PRISMA Cluster of Excellence Institut ffir PhysikJohannes Gutenberg-Universitgt55099 MainzGermany Theoretical Physics Department CERN1211 Geneva 23Switzerland Institute of High Energy Physics and School of Physical SciencesUniversity of Chinese Academy of SciencesBeijing 100049China

We perform a global effective-field-theory analysis to assess the combined precision of Higgs couplings, triple gauge-boson couplings, and top-quark couplings, at future circular e＋e- colliders, with a focus on runs below the tt-production threshold. Deviations in the top-quark sector entering as one-loop corrections are consistently taken into account in the Higgs and diboson processes. We find that future lepton colliders running at center-of-mass energies below the tt production threshold can still provide useful information on top-quark couplings, by measuring virtual top-quark effects. With rate and differential measurements, the indirect individual sensitivity achievable is better than at the high-luminosity LHC. However, strong correlations between the extracted top-quark and Higgs couplings are also present and lead to much weaker global constraints on top-quark couplings. This implies that a direct probe of top-quark couplings above the t~ production threshold is also helpful for the determination of Higgs and triple-gauge-boson couplings. In addition, we find that below the e＋e- -＋tth production threshold, the top-quark Yukawa coupling can be determined by its loop corrections to all Higgs production and decay channels. Degeneracy with the ggh coupling can be resolved, and even a global limit is competitive with the prospects of a linear collider above the threshold. This provides an additional means of determining the top-quark Yukawa coupling indirectly at lepton colliders.

关键词： effective field theory top quark lepton collider

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Adrestus:Secure,scalable blockchain technology in a decentralized ledger via zones

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Blockchain(Research and Applications) 2022年第4期3卷 56-80页

作者： Panagiotis Drakatos eleni Koutrouli Aphrodite Tsalgatidou Department of Informatics and Telecommunications National and Kapodistrian University of AthensPanepistimiopolis15784IlisiaAthensGreece

Nowadays,an increasing number of blockchain architectures provide well-promising protocols for pseudonymous online payments via proposed *** of them suffer from a number of extensibility and scalability issues,as their capacity regarding the number of transactions they are capable of processing per second is *** is also a challenge for this kind of *** paper presents the design and implementation of the Adrestus system,a blockchain-based transaction system with a novel consensus mechanism that is able to tolerate Byzantine faults and is designed to scale without compromising system *** of the main components of the Adrestus design is a consistent hashing mechanism for the efficient assignment of transactions on parallel regions,called zones,and for solving load balancing *** claim that the Adrestus blockchain system scales linearly without compromising system security and achieves its goals without introducing the unnecessary overhead and by eliminating energy and computational *** theoretical simulations and results reflect that Adrestus exceeds the average throughput of the most well-known cryptocurrencies like Bitcoin,and thus,it achieves a higher *** this paper,we present this proposed approach along with simulation results and examine the conditions for the proposed fault-tolerant system to meet safety and liveness.

关键词： Blockchain Consensus protocol Byzantine fault tolerance Scalability Distributed systems Aggregated signatures

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Fighting Financial Crime:Who Designs Global Governance and Who Does The Work?

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Fudan Journal of the Humanities and Social Sciences 2020年第2期13卷 169-179页

作者： eleni Tsingou Department of Organisation Copenhagen Business SchoolKilevej 14A2000FrederiksbergDenmark

Fighting financial crime is a highly institutionalised global governance *** a time of crisis for many of the institutions of global governance,tackling money laundering and combatting terrorist financing through global cooperation continues to be a priority for public *** global regime,if anything,is *** essay provides an overview of the regime’s development and addresses questions of design and *** is structured around three sets of questions:(1)What does the regime look like and what is it for?(2)Who does the work?(3)And,in conclusion,what can we say about winners and losers?

关键词： Compliance Financial Action Task Force Financial crime Money laundering Terrorist financing

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Forecast electricity demand in commercial building with machine learning models to enable demand response programs

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Energy and AI 2022年第1期7卷 18-30页

作者： Fabiano Pallonetto Changhong Jin eleni Mangina School of Computer Science University College DublinIreland School of Business Maynooth UniversityIreland

Electricity load forecasting is an important part of power system *** forecasting electricity load have great impact on a number of departments in power *** to electricity load simulation(white-box model),electricity load forecasting(black-box model)does not require expertise in building *** development cycle of the electricity load forecasting model is much shorter than the design cycle of the electricity load *** developments in machine learning have lead to the creation of models with strong fitting and accuracy to deal with nonlinear *** on the real load dataset,this paper evaluates and compares the two mainstream short-term load forecasting *** the experiment,this paper first enumerates the common methods of short-term load forecasting and explains the principles of Long Short-term Memory Networks(LSTMs)and Support Vector Machines(SVM)used in this ***,based on the characteristics of the electricity load dataset,data pre-processing and feature selection takes *** paper describes the results of a controlled experiment to study the importance of feature *** LSTMs model and SVM model are applied to one-hour ahead load forecasting and one-day ahead peak and valley load *** predictive accuracy of these models are calculated based on the error between the actual and predicted loads,and the runtime of the model is *** results show that the LSTMs model have a higher prediction accuracy when the load data is ***,the overall performance of the SVM model is better when the load data used to train the model is insufficient and the time cost is prioritized.

关键词： Deep neural network Model assessment Short-term load forecasting Feature selection Support Vector Machines Artificial Neural Networks Long Short-term Memory Networks Demand response

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