检索结果-南通市图书馆

Hypoxic Preconditioning Eliminates Differences in the Innate Resistance of Rats to Severe Hypoxia

Journal of Biomedical Science and Engineering 2016年第12期9卷 563-575页

作者： elena I. zakharova Alexander M. Dudchenko Laboratory of General Pathology of Cardiorespiratory Systems Institute of General Pathology and Pathophysiology Moscow Russia

Hypoxic preconditioning is able to increase the body’s resistance to hypoxic/ischemic stress. Understanding how to apply the hypoxic response to initiate the protective mechanism of ischemic preconditioning is a high priority. However, the relationship between innate resistance to hypoxic stress and preconditioning efficiency of moderate hypoxia has been poorly studied. In our work, the efficiency of single moderate hypobaric hypoxia (HBH) for resistance to severe hypobaric hypoxia (SHBH) was studied on intact rats and those pre-tested under SHBH with low, intermediate and high resistance to hypoxia. HBH has a significant preconditioning action on the resistance to hypoxia over a wide range from 270 to 1464 s (4.5 to 24.5 min) and at the same time eliminates the differences in the endurance under SHBH between all rat groups. It is concluded that 1) HBH preconditioning efficiency does not depend on an innate resistance to SHBH and prior hypoxic experience of rats;and 2) the pretesting to severe hypoxia has no value for predicting the hypoxic preconditioning efficiency and study of adaptive mechanisms.

关键词： Resistance to Hypoxic Stress Severe Hypoxia Hypoxic Preconditioning

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Acoustic Sensorimotor Gating Predicts the Efficiency of Hypoxic Preconditioning. Participation of the Cholinergic System in This Phenomenon

引用

Journal of Biomedical Science and Engineering 2018年第1期11卷 10-25页

作者： elena I. zakharova Zinaida I. Storozheva Andrew T. Proshin Mikhail Yu. Monakov Alexander M. Dudchenko Laboratory of General Pathology of Cardiorespiratory System Institute of General Pathology and Pathophysiology Moscow Russia Laboratory of Clinical Neurophysiology National Medical Research Centre for Psychiatry and Narcology Moscow Russia Laboratory of Functional Neurochemistry P.K. Anokhin’ Institute of Normal Physiology Moscow Russia Laboratory of Functional Angioproteomic and Metabolomic Institute of General Pathology and Pathophysiology Moscow Russia

Moderate one-off hypobaric hypoxia (HBH) provokes preconditioning and prolongs the resistance (T, the time before apnoea) to severe hypobaric hypoxia (SHBH). Hypoxic preconditioning has therapeutic potential;however, the efficiency of hypoxic preconditioning varies greatly and the methods for its preliminary evaluation are absent in both animals and humans. This rodent study evaluates the dependence of SHBH resistance, initiated by HBH, on the rate of sensorimotor gating estimated in the model of the acoustic startle prepulse inhibition (PPI). A stable negative correlation was found between PPI and T. Low doses of the α7 nicotinic receptor agonist, PNU-282987 (PNU), and more pronouncedly dimethyl sulfoxide (DMSO) (a PNU solvent), inverted the correlation between PPI and T from negative to positive. The DMSO and PNU effects were reversed at PPIs of 0.36 - 0.40 (36% - 40%). DMSO increased T values by 52.2% ± 9.7% in the region of lower HBH efficiency (PPI ≥ 0.40) and reduced it by 35.2% ± 9.3% in the region of higher HBH efficiency (PPI < 0.40). PNU reduced both DMSO effects. The involvement of the central cholinergic mechanisms was substantiated in both DMSO and PNU influences on HBH. In conclusion, 1) PPI can be used to predict the efficiency of hypoxic preconditioning and to study its mechanisms, 2) two opposite cholinergic PPI-related mechanisms participate in the preconditioning effects of HBH, 3) the sensitivity of rats to DMSO and PNU diverges when the PPI is 0.36 - 0.40, and 4) DMSO can enhance resistance to severe hypoxia in the region of the lower preconditioning efficiency of HBH at PPI ≥ 0.4.

关键词： Hypoxic Preсonditioning PPI Cholinergic Mechanisms α7 Nicotinic Receptors

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

2018世界肾脏日：关注女性和肾脏疾病

引用

肾脏病与透析肾移植杂志 2018年第1期27卷 1-6页

作者： Giorgina B.Piccoli Mona Alrukhaimi Zhi-Hong Liu elena zakharova Adeera Levin Philip Kam Tao Li Guillermo Garcia-Garcia Mohammed Benghanem-Gharbi Kamyar Kalantar-Zadeh Charles Kernahan Latha Kumaraswami Giorgina Barbara Piccoli Gamal Saadi Louise Fox Sharon Andreoli 陈樱花 Department of Clinical and Biological Sciences University of Torino Nephrology Centre Hospitalier Le Mans Department of Medicine Dubai Medical College National Clinical Research Center of Kidney Diseases Jinling Hospital Nanjing University School of Medicine Nephrology Moscow City Hospital n.a. S.P. Botkin Nephrology Moscow State University of Medicine and Dentistry Nephrology Russian Medical Academy of Continuous Professional Education the World Kidney Day Steering Committee Department of Medicine Division of NephrologyUniversity of British Columbia 国家肾脏疾病临床医学研究中心南京总医院

女性是现代家庭和社会的重要贡献者。但目前在世界范围内,男性和女性在受教育程度、医疗保健等方面仍存在显著差异。2018年第13个世界肾脏日恰逢国际妇女节,其主题是"肾脏和女性健康",给我们提供了一个关注女性健康,尤其是女性肾脏健康... 详细信息

女性是现代家庭和社会的重要贡献者。但目前在世界范围内,男性和女性在受教育程度、医疗保健等方面仍存在显著差异。2018年第13个世界肾脏日恰逢国际妇女节,其主题是"肾脏和女性健康",给我们提供了一个关注女性健康,尤其是女性肾脏健康的重要契机。为此,世界肾脏日指导委员会(World Kidney Day Steering Committee)特别组织了全球具有代表性的5位女性肾脏病学家,撰写了述评文章,借机呼吁肾脏病学术领域和全社会更加重视女性健康,让更多女性从肾脏病学术研究中获益。关注女性肾脏健康,利在当代功在千秋!

关键词：女性健康肾脏疾病世界范围肾脏病学学术研究国际妇女节现代家庭医疗保健

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Intestinal microbiome analysis demonstrates azithromycin post-treatment effects improve when combined with lactulose

引用

World Journal of Pediatrics 2020年第2期16卷 168-176页

作者： Elpiniki Nikolaou elena Kamilari Dragana Savkov Artemy Sergeev Irina zakharova Paris Vogazianos Marios Tomazou Athos Antoniades Christos Shammas Genetics Department AVVA Pharmaceuticals Ltd23A Spyrou Kyprianou4001 LimassolCyprus Research and Development MC Development LLCMoscowRussia Russian Medical Academy of Continuing Professional Education MoscowRussia Stremble Ventures Ltd LimassolCyprus

Background Next-generation sequencing has revolutionized our perspective on the gut microbiome composition,revealing the true extent of the adverse effects of *** impact of antibiotic treatment on gut microbiota must be considered and researched to provide grounds for establishing new treatment strategies that are less devastating on commensal *** study investigates the impact on gut microbiome when a commonly used antibiotic,azithromycin is administered,as well as uncovers the benefits induced when it is used in combination with lactulose,a prebiotic known to enhance the proliferation of commensal *** 16S rRNA gene sequencing analysis of stool samples obtained from 87 children treated with azithromycin in combination with or without lactulose have been ***'s gut microbial profile was established at the pre-and post-treatment *** Azithromycin caused an increase in the relative abundance of opportunistic pathogens such as Streptococcus that was evident 60 days after *** few days after treatment,children who also received lactulose started to show a higher relative abundance of saccharolytic bacteria such as Lactobacillus,Enterococcus,Anaerostipes,Blautia and Roseburia,providing a protective role against opportunistic *** addition,azithromycin-prebiotic combination was able to provide a phylogenetic profile more similar to the pre-treatment *** It is suggested that during azithromycin treatment,lactulose is able to reinstate the microbiome equilibrium much faster as it promotes saccharolytic microbes and provides a homeostatic effect that minimizes the opportunistic pathogen colonization.

关键词： Antibiotics Azithromycin Lactulose Microbiome Prebiotics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Thermo-and pH-sensitive Polymer with Pendant Spacer-linked Imidazole Cycles

引用

Chinese Journal of Polymer Science 2024年第4期42卷 437-445页

作者： Natalya V.zakharova Stanislav N.Zelinskiy Mariya S.Strelova elena N.Danilovtseva Vadim V.Annenkov Institute of Macromolecular Compounds of the Russian Academy of Sciences Saint Petersburg199004Russia Limnological Institute of Siberian Branch of the Russian Academy of Sciences Irkutsk664033Russia

By the reaction of poly(acryloyl chloride) with N-(3-aminopropyl)imidazole, poly(N-(3-(1H-imidazol-1-yl)propyl)acrylamide) was synthesized. The new polymer contains an imidazole ring removed from the main chain by a spacer of five bonds. The structure and purity, molecular weight, hydrodynamic and thermosensitive properties of the obtained sample were studied by1H-and13C-NMR, FTIR spectroscopy, acid-base titration, light scattering, turbidimetry and viscometry. The observed ability of the imidazole-containing polymer to form and destroy associates in water-salt solutions at pH 6.6-7.4 and temperatures of 29-48℃ indicates that these are promising candidates for designing complex biomedical systems. The new polymer is able to form complexes with oligo-DNA more actively than poly(1-vinylimidazole), which is of interest for gene delivery applications. The polymer cross-linked with epichlorohydrin gives micro-relief coatings on the plastic surface, and the modified surface is able to attach negatively charged objects. This thermo-and pH-sensitive polymer modification can be applied to create finely controlled surfaces for cell culturing.

关键词： Imidazole-containing polymer Thermolability pH-sensitivity The modified surface DNA immobilization

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：