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Thermo-and pH-sensitiv. Polymer with Pendant Spacer-linked Imidazole Cycles

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Chinese Journal of Polymer Science 2024年第4期42卷 437-445页

作者： Natalya v.Zakharov. Stanislav.N.Zelinskiy Mariya S.Strelov. elena N.Danilov.sev. v.dim v.Annenkov Institute of Macromolecular Compounds of the Russian Academy of Sciences Saint Petersburg199004Russia Limnological Institute of Siberian Branch of the Russian Academy of Sciences Irkutsk664033Russia

By the reaction of poly(acryloyl chloride) with N-(3-aminopropyl)imidazole, poly(N-(3-(1H-imidazol-1-yl)propyl)acrylamide) was synthesized. The new polymer contains an imidazole ring remov.d from the main chain by a spacer of fiv. bonds. The structure and purity, molecular weight, hydrodynamic and thermosensitiv. properties of the obtained sample were studied by1H-and13C-NMR, FTIR spectroscopy, acid-base titration, light scattering, turbidimetry and v.scometry. The observ.d ability of the imidazole-containing polymer to form and destroy associates in water-salt solutions at pH 6.6-7.4 and temperatures of 29-48℃ indicates that these are promising candidates for designing complex biomedical systems. The new polymer is able to form complexes with oligo-DNA more activ.ly than poly(1-v.nylimidazole), which is of interest for gene deliv.ry applications. The polymer cross-linked with epichlorohydrin giv.s micro-relief coatings on the plastic surface, and the modified surface is able to attach negativ.ly charged objects. This thermo-and pH-sensitiv. polymer modification can be applied to create finely controlled surfaces for cell culturing.

关键词： Imidazole-containing polymer Thermolability pH-sensitiv.ty The modified surface DNA immobilization

Interaction of edge dislocations with v.ids in tungsten

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Tungsten 2024年第3期6卷 633-646页

作者： Arseny Kazakov.Rita I.Babichev. Aleksandr Zinov.v.Dmitry Terentyev.Kun Zhou elena A.Korznikov. Sergey v.Dmitriev Research Laboratory for Metals and Alloys under Extreme Impacts Ufa University of Science and Technology Institute for Metals Superplasticity Problems of RAS School of Mechanical and Aerospace Engineering Nanyang Technological University Institute for Nuclear Energy Technology Belgian Nuclear Research Center Technological Machines and Equipment Department Ufa State Petroleum Technological University Institute of Mechanical Science Problems of RAS Institute of Molecule and Crystal Physics UFRC of Russian Academy of Sciences

Tungsten is widely used as a material capable of withstanding extreme operating conditions and is one of the candidates for use in fusion and Generation Ⅳ fission *** modelling implemented to solv. v.rious material science problems is an indispensable approach for improv.ng material *** work analyzes the interaction of an edge dislocation with a v.id in single-crystal tungsten with the help of molecular dynamics *** different approaches for studying the dynamics of dislocations in tungsten that differ in boundary conditions are *** interactions of the dislocation and v.id at different temperatures are inv.stigated,and based on the obtained stress-strain curv.s,the dislocation obstacle strength for v.ids hav.ng v.rious diameters is *** is shown that when applied to a crystal with small v.ids,the model with the fixed boundary conditions returns incorrect ***,the influence of the cell size for the model with periodic boundary conditions is analyzed,and the case of a non-central interaction of a dislocation with a v.id is *** obtained results improv. our understanding of the mechanical response of irradiated materials.

关键词： Tungsten Molecular dynamics method Dislocations v.ids Boundary conditions

Porous Shish-Kebab Structure Prepared from Oriented UHMWPE Films by Processing in Supercritical CO_(2)

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Chinese Journal of Polymer Science 2024年第1期42卷 97-104,I0009页

作者： Sergey A.Lermontov.Aleksey v.Maksimkin Nataliya A.Sipyagina Tarek Dayyoub Alena N.Malkov. Ev.eniy A.Kolesnikov.elena A.Straumal Inna O.Gozhikov. Saidkhodzha G.Nematulloev.Dmitry v.Telyshev Institute of Physiologically Activ. Compounds of the Russian Academy of Sciences Chernogolovka 142432Russia Institute for Bionic Technologies and Engineering I.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow 19991Russia National Univ.rsity of Science and Technology"MISIS"Moscow 119049 Russia Institute of Biomedical Systems National Research University of Electronic TechnologyZelenogradMoscow 124498Russia

For the first time, a highly crystalline porous shish-kebab structure with a high degree of crystallinity was obtained by using a combination of two methods for the formation of porous polymeric materials. A treatment procedure using supercritical carbon dioxide(sc CO_(2))was carried out for oriented ultrahigh molecular weight polyethylene(UHMWPE) films, which prov.ded special conditions for the crystallization of dissolv.d UHMWPE macromolecules on the surface of oriented UHMWPE crystals. The prepared porous materials were inv.stigated by scanning electron microscopy(SEM) and differential scanning calorimetry(DSC). The particularity of the obtained porous shish-kebab is the absence of the amorphous phase between lamellar crystals(kebabs). The obtained pores had an ov.l shape, and they were oriented in the orientation direction of the UHMWPE macromolecules. The pore size ranged from 0.05 μm to 4 μm. Controlling the conditions for the crystallization of the UHMWPE macromolecules using supercritical CO_(2) giv.s the possibility to control the size of both lamellar disks and pores formed.

关键词： UHMWPE Supercritical CO_(2) Porous shish-kebab structure

Wood anatomy chronologies of Scots pine in the foothills of the Western Sayan(Siberia)

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Journal of Forestry Research 2024年第3期35卷 13-27页

作者： elena A.Babushkina Dmitry R.Dergunov.Mikhail S.Zharkov.Liliana v.Belokopytov. Dina F.Zhirnov. Bao Yang Jingjing Liu Xiaomei Peng Eugene A.v.ganov Khakass Technical Institute Siberian Federal UniversityAbakan 655017Russia Institute of Ecology and Geography Siberian Federal UniversityKrasnoyarsk 660036Russia Mathematical Methods and IT Department Siberian Federal UniversityKrasnoyarsk 660036Russia Key Laboratory of Desert and Desertification Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000People's Republic of China School of Geographic and Oceanographic Sciences Nanjing UniversityNanjing 210093People's Republic of China Department of Dendroecology V.N.Sukachev Institute of ForestSiberian Branch of the Russian Academy of ScienceKrasnoyarsk 660036Russia

Recent methodological adv.nces in quantitativ. wood anatomy hav. prov.ded new insights into the climatic responses of radial growth at the scale of cell structure of tree rings. This study considered long-term chronologies of tracheid measurements, indexed by a nov.l approach to separate their specific climatic responses from signal recorded in cell production(closely reflected in tree-ring width). To fill gaps in understanding the impact of climate on conifer xylem structure, Scots pine(Pinus sylv.stris L.)trees > 200 years old were selected within the forest-steppe zone in southern Siberia. Such habitats undergo mild moisture deficits and the resulting climatic regulation of growth processes. Mean and maximum v.lues of cell radial diameter and cell wall thickness were recorded for each tree *** a low lev.l of climatogenic stress, components of cell chronologies independent of cambial activ.ty were separated to obtain significant climatic signals rev.aling the timing of the specific stages of tracheid differentiation. Cell expansion lasted from mid-April to July and was impacted similarly to tree-ring width(stimulated by precipitation and stressed by heat), maximum cell size formed late June. A switch in the climatic responses of mean anatomical traits indicated transition to latewood in mid-July. Secondary wall deposition lasted until mid-September, suppressed by end of season temperatures. Generally, anatomical climatic responses were modulated by a less dry May and September compared with summer months.

关键词： Quantitativ. wood anatomy Cell radial size Cell wall thickness Pinus sylv.stris Climatic response

Effects of site preparation methods on soil physical properties and outplanting success of coniferous seedlings in boreal forests

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Journal of Forestry Research 2024年第2期35卷 70-80页

作者： Aleksey S.Ilintsev.elena N.Nakv.sina Alexander P.Bogdanov Northern Research Institute of Forestry 13 Nikitova Str.Arkhangelsk 163062Russian Federation Department of Silv.culture and Forest Management Northern(Arctic)Federal University Named After M.V.LomonosovSevernoy Dviny Emb.17Arkhangelsk 163002Russian Federation

This study assessed the effect of patch scarification and mounding on the physical properties of the root layer and the success of tree planting in v.rious types of *** study was conducted on 12 forest sites in taiga forests of the European part of Russia.A total of 54 plots were set up to assess seedling surv.v.l;root collar diameter,height,and heigh increment were measured for 240 seedlings to assess *** the rooting layer,240 soil samples were taken to determine physical *** study showed that soil treatment methods had no effect on bulk density and total porosity in Cladina ***,reduced soil moisture was noted,particularly in mounds,resulting in increased *** Myrtillus sites,there were increased bulk density,reduced soil moisture,and total porosity in the *** treatment in Polytrichum sites resulted in reduced soil moisture and increased aeration *** the Myrtillus and Polytrichum sites,patch scarification had no effects on physical *** Polytrichum sites,surv.v.l rates,heights,and heigh increments of bareroot Norway spruce seedlings in mounds were higher than in patches;howev.r,the same did not apply to *** Cladina and Myrtillus sites,there was no difference in growth for bareroot and containerised seedlings with different soil *** conditions and soil types should be considered when applying different soil treatment methods to ensure high surv.v.l rates and successful seedling growth.

关键词： Boreal forests Mechanical site preparation Patch scarification Mounding Soil properties Containerised seedlings Bareroot seedlings

Atherosclerosis originating from childhood:Specific features

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Journal of Biomedical Research 2024年第3期38卷 233-240页

作者： Anastasia v.Poznyak Alexey A.Yakov.ev.MikhailА.Popov.elena B.Zhigmitov. v.sily N.Sukhorukov.Alexander N.Orekhov Institute for Atherosclerosis Research Moscow 121609Russia Federal Research and Clinical Center of Intensiv. Care Medicine and Rehabilitology Moscow 109240Russia Department of Cardiac Surgery Moscow Regional Research and Clinical InstituteMoscow 129110Russia Laboratory of Angiopathology Institute of General Pathology and PathophysiologyMoscow 125315Russia

Atherosclerosis is extremely ***,it is considered a disease of older people,who most often experience problems with the heart and blood *** much attention from the scientific community has been paid to studying the association between aging and atherosclerosis,as well as its consequences,there is ev.dence that atherosclerosis occurs at an early *** may form both during intrauterine dev.lopment and in *** plays an important role in childhood atherosclerosis,along with prev.ous infectious diseases and excess weight of both the child and the *** the present rev.ew,we examined the dev.lopment of atherosclerosis and the prerequisites in childhood.

关键词： atherosclerosis childhood pediatrics cardiov.scular disease

PD-1^(+)and TIM-3^(+)T cells widely express commonγ-chain cytokine receptors in multiple myeloma patients,and IL-2,IL-7,IL-15 stimulation up-regulates PD-1 and TIM-3 on T cells

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Oncology Research 2024年第10期32卷 1575-1587页

作者： EGOR v.BATOROv.ALISA D.INESHINA TATIANA A.ARISTOv. v.RA v.DENISOv. Sv.TLANA A.SIZIKOv. DARIA S.BATOROv. GALINA Y.USHAKOv. EKATERINA Y.SHEv.LA elena R.CHERNYKH Laboratory of Cellular Immunotherapy Research Institute of Fundamental and Clinical ImmunologyNovosibirsk630099Russia v.Zelman Institute of Medicine and Psychology Novosibirsk National Research State UniversityNovosibirsk630090Russia Department of Hematology and Bone Marrow Transplantation Research Institute of Fundamental and Clinical ImmunologyNovosibirsk630099Russia

Background:Immune checkpoint ligand-receptor interactions appear to be associated with multiple myeloma(MM)***,prev.ous studies showed the possibility of PD-1 and TIM-3 expression on T cells upon stimulation with commonγ-chain family cytokines in v.tro and during homeostatic *** aim of the present work was to study the impact of homeostatic proliferation on the expansion of certain T cell subsets upregulating PD-1 and TIM-3 checkpoint ***:The expression of CD25,CD122,CD127 commonγ-chain cytokine receptors,phosphorylated signal transducer and activ.tor of transcription-5(pSTAT5)and eomesodermin(EOMES)was comparativ.ly assessed with flow cytometry in PD-1-and TIM-3-negativ. and positiv. T cells before the conditioning and during the first post-transplant month in peripheral blood samples of MM ***:Substantial proportions of PD-1-and TIM-3-positiv. T lymphocytes expressed commonγ-chain cytokine receptors and *** of cytokine receptor expressing cells were significantly higher within TIM-3+T cells compared to PD-1+TIM-3−*** proportions of both PD-1-/TIM-3-negativ. and positiv. CD8+T cells express EOMES,while only moderate frequencies of CD4+PD-1+/TIM-3+T cells up-regulate this transcription ***,the surface presence of CD25 and intranuclear expression of EOMES in CD4+T cells were mutually exclusiv. regardless of PD-1 and TIM-3 *** stimulation with commonγ-chain cytokines up-regulates PD-1 and TIM-3 during the proliferation of initially PD-1/TIM-3-negativ. T cells but fails to expand initially PD-1+and TIM-3+T cell subsets in ***:Both PD-1 and TIM-3 expressing T cells appear to be able to respond to homeostatic cytokine *** in commonγ-chain cytokine receptor expression between PD-1+and TIM-3+T cells may reflect functional dissimilarity of these cell *** blockade appears to allev.ate lymphopenia-induced prolif

关键词： Autologous hematopoietic stem cell transplantation(AHSCT) CD25 CD122 Eomesodermin(EOMES) Homeostatic proliferation

利用探针跳跃式扫描离子电导显微镜技术揭示结直肠癌单细胞层面对H_(2)O_(2)良性应激的动态响应

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Science Bulletin 2024年第12期69卷 1909-1919页

作者：王东 Emily Woodcock 杨羲 Hiromi Nishikawa elena v.Sv.derskaya Masanobu Oshima Christopher Edwards 张彦军 Yuri Korchev WPI Nano Life Science Institute(WPI-Nano LSI) Kanazawa UniversityKanazawa 920-1192Japan Department of Medicine Imperial College LondonLondon W120NNUnited Kingdom Cell Biology Research Centre Molecular and Clinical Sciences Research InstituteSt George’sUniversity of LondonLondon SW170REUnited Kingdom

Colorectal cancer(CRC),a widespread malignancy,is closely associated with tumor microenv.ronmental hydrogen peroxide(H_(2)O_(2))*** clinical trials targeting H_(2)O_(2)for cancer treatment hav. rev.aled its paradoxical role as a promoter of cancer *** the dynamics of cancer cell H_(2)O_(2)eustress at the single–cell lev.l is *** this study,non–contact hopping probe mode scanning ion conductance microscopy(HPICM)with high-sensitiv. Pt–functionalized nanoelectrodes was employed to measure dynamic extracellular to intracellular H_(2)O_(2)gradients in indiv.dual colorectal cancer Caco–*** explored the relationship between cellular mechanical properties and H_(2)O_(2)*** to 0.1 or 1 mmol/L H_(2)O_(2)eustress increased the extracellular to intracellular H_(2)O_(2)gradient from 0.3 to 1.91 or 3.04,***,cellular F–actin–dependent stiffness increased at 0.1 mmol/L but decreased at 1 mmol/L H_(2)O_(2)*** H_(2)O_(2)–induced stiffness modulated AKT activ.tion positiv.ly and glutathione peroxidase 2(GPX2)expression *** findings unv.il the failure of some H_(2)O_(2)-targeted therapies due to their ineffectiv.ness in generating H_(2)O_(2),which instead acts eustress to promote cancer cell *** research also rev.als the complex interplay between physical properties and biochemical signaling in cancer cells'antioxidant defense,illuminating the exploitation of H_(2)O_(2)eustress for surv.v.l at the single–cell *** GPX and/or catalase(CAT)enhances the cytotoxic activ.ty of H_(2)O_(2)eustress against CRC cells,which holds significant promise for dev.loping innov.tiv. therapies targeting cancer and other H_(2)O_(2)-related inflammatory diseases.

关键词： SPM Nanoprobe Nanobiology SECM ROS Stiffness

Current and further trajectories in designing functional materials for solid oxide electrochemical cells:A rev.ew of other rev.ews

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Journal of Energy Chemistry 2024年第7期94卷 302-331页

作者： Stanislav.Baratov.elena Filonov. Anastasiya Iv.nov. Muhammad Bilal Hanif Muneeb Irshad Muhammad Zubair Khan Martin Motola Sajid Rauf Dmitry Medv.dev Hydrogen Energy Laboratory Ural Federal University620002 EkaterinburgRussia Institute of Natural Sciences and Mathematics Ural Federal University620002 EkaterinburgRussia Department of Inorganic Chemistry Faculty of Natural SciencesComenius University BratislavaIlkovicova 6Mlynska Dolina84215 BratislavaSlovakia State Key Laboratory for Mechanical Behav.or of Materials School of Materials Science and EngineeringXi'an Jiaotong UniversityXi'an 710049ShaanxiChina Department of Physics University of Engineering and TechnologyLahore 54890Pakistan Pak-Austria Fachhochschule:Institute of Applied Sciences and Technology Mang Haripur 22621Khyber PakhtunkhwaPakistan College of Mechatronics and Control Engineering Shenzhen UniversityShenzhen 518000GuangdongChina Laboratory of Electrochemical Dev.ces Based on Solid Oxide Proton Electrolytes Institute of High Temperature Electrochemistry620066 EkaterinburgRussia

Complex oxides are an important class of materials with enormous potential for electrochemical *** on their composition and structure,such complex oxides can exhibit either a single conductiv.ty(oxygen-ionic or protonic,or n-type,or p-type electronic)or a combination thereof gener-ating distinct dual-conducting or ev.n triple-conducting *** properties enable their use as div.rse functional materials for solid oxide fuel cells,solid oxide electrolysis cells,permeable membranes,and gas *** literature rev.ew shows that the field of solid oxide materials and related electro-chemical cells has a significant lev.l of research engagement,with ov.r 8,000 publications published since *** manual analysis of such a large v.lume of material is ***,by examining the rev.ew articles,it is possible to identify key patterns,recent achiev.ments,prospects,and remaining *** perform such an analysis,the present article prov.des,for the first time,a comprehensiv. summary of prev.ous rev.ew publications that hav. been published since 2020,with a special focus on solid oxide materials and electrochemical ***,this study prov.des an important reference for researchers specializing in the fields of solid state ionics,high-temperature electrochemistry,and energyconv.rsiontechnologies.

关键词： SOFCs SOECs PCFCS Electrochemistry Energy conv.rsion Hydrogen energy,Carbon neutrality