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Effect of Aspergillus niger prolyl endopeptidase in patients with celiac disease on a long-term gluten-free diet

World Journal of Gastroenterology 2024年第11期30卷 1545-1555页

作者： Juan Pablo Stefanolo Verónica Segura Martina Grizzuti Abel Heredia Isabel Comino Ana Florencia Costa Roberto Puebla María Paz Temprano Sonia Isabel Niveloni Gabriel de Diego María E Oregui Edgardo Gustavo Smecuol Mauricio C de Marzi elena F Verdú Carolina Sousa Julio César Bai Small Bowel Section Department of MedicineGastroenterology Hospital of Buenos Aires“Dr.C.Bonorino Udaondo”Buenos Aires 1264Argentina Department of Microbiology and Parasitology Faculty of PharmacyUniversity of SevilleSeville 41080Spain Department of Medicine Dr.C.Bonorino Udaondo Gastroenterology HospitalBuenos Aires 1264Argentina Basic and Applied Research Group in Immunology and Bioactives(GIBAIB) Institute of Ecology and Sustainable Development(INEDES)National University of LujanLuján 6700Buenos AiresArgentina Department of Medicine Farncombe Family Digestive Health Research InstituteMcMaster UniversityHamilton L8S 4L8OntarioCanada Facultad de Medicina Universidad del SalvadorBuenos Aires C1051ABBArgentina

BACKGROUND The gluten-free diet(GFD)has limitations,and there is intense research in the development of adjuvant *** To examine the effects of orally administered Aspergillus niger prolyl endopeptidase protease(AN-PEP)on inadvertent gluten exposure and symptom prevention in adult celiac disease(CeD)patients following their usual *** This was an exploratory,double-blind,randomized,placebo-controlled trial that enrolled CeD patients on a long-term *** a 4-wk run-in period,patients were randomized to 4 wk of two AN-PEP capsules(GliadinX;AVI Research,LLC,United States)at each of three meals per day or *** endpoints were:(1)Average weekly stool gluten immunogenic peptides(GIP)between the run-in and end of treatments and between AN-PEP and placebo;(2)celiac symptom index(CSI);(3)CeD-specific serology;and(4)quality of *** samples were collected for GIP testing by ELISA every Tuesday and Friday during run-ins and *** Forty patients were randomized for the intention-to-treat analysis,and three were excluded from the per-protocol ***,628/640(98.1%)stool samples were *** was undetectable(0.32μg/g)to potentially cause mucosal *** GIP concentration in the AN-PEP arm was 44.7%lower than in the run-in ***-third of patients exhibiting GIP>0.08μg/g during run-in had lower or undetectable GIP after AN-PEP *** with the run-in period,the proportion of symptomatic patients(CSI>38)in the AN-PEP arm was significantly lower(P<0.03).AN-PEP did not result in changes in specific *** This exploratory study conducted in a real-life setting revealed high adherence to the *** AN-PEP treatment did not significantly reduce the overall GIP stool ***,given the observation of a significantly lower prevale

关键词： Celiac disease Aspergillus niger prolyl endoprotease Gluten immunogenic peptides Trial Symptoms Real-life trial

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英伟达一股独霸的秘决

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商业周刊（中文版） 2024年第4期 24-25页

作者： elena Popina Jess Menton 竹西(译) 不详

●历史上很少有规模如此之大的公司增长如此之快。这就像19世纪的淘金热时期早在2001年,当科技行业在互联网泡沫破灭的余震中挣扎时,标普500指数成员股有一个空缺要填补。丑闻缠身的安然公司(Enron Corp.)即将被踢出这个大盘股基准指数... 详细信息

●历史上很少有规模如此之大的公司增长如此之快。这就像19世纪的淘金热时期早在2001年,当科技行业在互联网泡沫破灭的余震中挣扎时,标普500指数成员股有一个空缺要填补。丑闻缠身的安然公司(Enron Corp.)即将被踢出这个大盘股基准指数,问题是,应该由谁来取代它?标准普尔公司选定了一家名不见经传的芯片制造商,它就是英伟达(NvidiaCorp.)。

关键词：安然公司芯片制造商标准普尔公司泡沫破灭淘金热大盘股互联网基准指数

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Better understanding of c-reactive protein and leukocytes in psychiatric inpatients with affective disorders:A biopsychosocial approach

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World Journal of Clinical Cases 2024年第19期12卷 3824-3836页

作者： Felix Kölblinger elena MD Schönthaler Andreas Baranyi Tatjana Stross Frederike T Fellendorf Dirk von Lewinski Robert Queissner Eva Z Reininghaus Nina Dalkner Clinical Department of Psychiatry and Psychotherapeutic Medicine Medical University of GrazGraz 8036Austria Clinical Department of Cardiology Medical University of GrazGraz 8036Austria

BACKGROUND Affective disorders(AD)have been linked to inflammatory processes,although the underlying mechanisms of this relationship are still not fully *** is hypothesized that demographic,somatic,lifestyle,and personality variables predict inflammatory parameters in *** To identify biopsychosocial factors contributing to inflammation in AD measured with two parameters,C-reactive protein(CRP)and *** This observational study investigated 186 hospital inpatients diagnosed with AD using demographic parameters,serum inflammatory markers,somatic variables,psychological questionnaires,and lifestyle *** regression analyses were used to predict inflammatory markers from demographic,somatic,lifestyle,and personality *** Analyses showed that 33.8%of the variance of CRP was explained by body mass index and other somatic medication(***-diabetics),age and education,and age of affective disorder *** leukocytes,20.1%of the variance was explained by smoking,diet,metabolic syndrome(MetS),and anti-inflammatory medication(***-steroidal anti-inflammatory drugs).Other psychiatric or behavioural variables did not reach *** Metabolic components seem important,with mounting evidence for a metabolic affective disorder *** modifications and psychoeducation should be employed to prevent or treat MetS in AD.

关键词： Affective disorders C-reactive protein Leukocytes Metabolic syndrome Health behaviour Personality

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大陆俯冲界面之上大规模硅富集流体的地球物理学证据

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中国科学：地球科学 2024年第9期54卷 2848-2863页

作者：毛元彤赵亮 Marco G.MALUSÀ Stefano SOLARINO Silvia PONDRELLI 孙宝璐 Coralie AUBERT Simone SALIMBENI elena EVA Stéphane GUILLOT 中国科学院地质与地球物理研究所岩石圈演化与环境演变全国重点实验室北京100029 中国科学院大学地球与行星科学学院北京100049 Department of Earth and Environmental Sciences University of Milano-BicoccaMilan 20126Italy Istituto Nazionale di Geofisica e Vulcanologia Osservatorio Nazionale TerremotiGenova 16145Italy Istituto Nazionale di Geofisica e Vulcanologia Sezione di BolognaBologna 40127Italy UniversitéGrenoble Alpes UniversitéSavoie Mont BlancCNRSIRDUGEISTerreGrenoble 38000France

俯冲带中的流体可能对俯冲过程产生重要影响.然而,关于大陆俯冲期间流体规模及其作用的地球物理约束仍然有限.西阿尔卑斯造山带是全球保存最完好的大陆俯冲带之一,为认识大陆俯冲过程中流体作用的影响提供了重要的参考.本文综合多种地... 详细信息

俯冲带中的流体可能对俯冲过程产生重要影响.然而,关于大陆俯冲期间流体规模及其作用的地球物理约束仍然有限.西阿尔卑斯造山带是全球保存最完好的大陆俯冲带之一,为认识大陆俯冲过程中流体作用的影响提供了重要的参考.本文综合多种地球物理方法分析了西阿尔卑斯造山带地区的V_(P)/V_(S)比值,发现在俯冲区的上盘侧存在高V_(P)/V_(S)(>1.9)带,与部分蛇纹岩化的上覆地幔楔位置一致;而在下盘侧存在异常低的V_(P)/V_(S)(<1.7)带,异常深度浅于30km.本文认为,观测到的低V_(P)/V_(S)比值异常是由地壳内广泛分布的富硅岩脉导致,指示了在俯冲时期大陆俯冲界面之上可能存在的富硅流体流动.本文的结果暗示俯冲时期的流体流动可能降低了俯冲界面的有效应力,从而促进了大陆俯冲.

关键词：西阿尔卑斯造山带地壳精细结构接收函数 V_(P)/V_(S)波速比硅富集

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Hormetic effects of abiotic environmental stressors in woody plants in the context of climate change

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Journal of Forestry Research 2023年第1期34卷 7-19页

作者： elena A.Erofeeva Department of Ecology Lobachevsky State University of Nizhni Novgorod23 Gagarina PrNizhni NovgorodRussian Federation 603950

Woody plants contribute to the stability and productivity of terrestrial ecosystems and are significantly affected by climate *** to the concept of environmental hormesis,any environmental stressors can cause hormesis,that is,stimulation in low doses and inhibition in high *** studies have demonstrated plant hormesis under low doses of various abiotic ***,the hormetic responses of woody plants to abiotic stressors from climate change are insufficiently *** review analyses data on the stimulating effects of low doses of climate stressors in experiments and in real *** laboratory and field experiments show that single and combined exposure to various climate stressors(temperature,humidity,and elevated carbon dioxide concentrations) can cause hormesis in various species and functional types of woody plants,which can be accompanied by hormetic trade-offs and *** addition,there is evidence of climate hormesis in woody plants in ecosystem *** experiments in various ecosystems show that elevated temperatures and/or precipitation or elevated carbon dioxide concentrations causing hormesis in dominant tree species can stimulate ecosystem ***,climate hormesis of the growth and reproduction of dominant forest tree species contributes to the spread of forests,that is,climate-driven ecological *** main commonalities of climate hormesis in woody species include:(1) Low-dose climate stressors cause hormesis in woody plants when strong(limiting) stressors do not affect plants or these limiting stressors are mitigated by climate change.(2) Hormesis can occur with the direct impact of climatic stressors on trees and with the indirect impact of these stressors on plants through other parts of the ecosystem.(3)Climate stressor interactions(e.g.,synergism,antagonism)can affect hormesis.(4) Hormesis may disappear due to tree acclimatization with consequent changes in the

关键词： Abiotic stress Ecological succession Ecosystem Forest Hormesis

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New Exceptional Sets and Convergence of the Square Partial Sums of Walsh–Fourier Series

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Acta Mathematica Sinica,English Series 2020年第7期36卷 733-748页

作者： elena PRESTINI Dipartimento di Matematica Universitàdi Roma"Tor Vergata"Via della Ricerca Scientifica 100133 RomaItalia

For double Walsh–Fourier series and with f∈L2([0,1)×[0,1))we prove two almost orthogonality results relative to the linearized maximal square partial sums operator SN(x,y)f(x,y).Assumptions are N(x,y)non-decreasing as a function of x and of y and,roughly speaking,partial derivatives with approximately constant ratio■≌2n0 for all x and y,where n0 is any fixed non-negative ***,independent of N(x,y)and n0,are then extended to Lr,110.

关键词： Walsh integer Convergence

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Magnetic cycles of Sun-like stars with different levels of coronal and chromospheric activity——comparison with the Sun

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Research in Astronomy and Astrophysics 2016年第9期16卷 123-136页

作者： elena Shimanovskaya Vasiliy Bruevich elena Bruevich Sternberg Astronomical Institute Moscow State University

The atmospheric activity of the Sun and Sun-like stars is analyzed involving observations from the HK-project at the Mount Wilson Observatory, the California and Carnegie Planet Search Program at the Keck and Lick Observatories and the Magellan Planet Search Program at the Las Campanas Observatory. We show that for stars of E G and K spectral classes, the cyclic activity, similar to the 11-yr solar cycle, is different： it becomes more prominent in K-stars. Comparative study of Sun-like stars with different levels of chromospheric and coronal activity confirms that the Sun belongs to stars with a low level of chromospheric activity and stands apart among these stars by its minimum level of coronal radiation and minimum level of variations in photospheric flux.

关键词： Sun activity -- Sun-like stars activity

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Singular Integrals with Bilinear Phases

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Acta Mathematica Sinica,English Series 2006年第1期22卷 251-260页

作者： elena PRESTINI Dipartimento di Matematica Universita di Roma 'Tor Vergata' Roma 00133 Italy

We prove the boundedness from Lp（T2） to itself, 1 〈 p 〈∞, of highly oscillatory singular integrals Sf（x, y） presenting singularities of the kind of the double Hilbert transform on a non-rectangular domain of integration, roughly speaking, defined by ｜y′｜〉｜x′｜, and presenting phases λ（Ax ＋ By） with 0≤ A, B ≤ 1 and λ≥ 0. The norms of these oscillatory singular integrals are proved to be independent of all parameters A1 B and A involved. Our method extends to a more general family of phases. These results are relevant to problems of almost everywhere convergence of double Fourier and Walsh series.

关键词： Hardy-Littlewood maximal function Maximal Hilbert transform Maximal Carleson operator Oscillatory singular integrals a.e. convergence of double Fourier series

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Deciphering the presence of axial-planar veins in tectonites

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Geoscience Frontiers 2019年第6期10卷 2101-2115页

作者： elena Druguet Departament de Geologia Universitat Autonoma de Barcelona

Veins and dikes are often oriented subparallel to the axial surfaces of folds in the adjacent layered or foliated *** implies an awkward situation,since veins would lay in planes close-to-parallel to the maximum stretching axis.A series of geometric models have been conceived in order to gain insight into the possible mechanisms for their *** models are based on the analysis of a varied selection of field structures and on the review of similar structures in the existing literature.A first categorization consists on distinguishing between axial-planar veins achieved by either progressive or polyphase *** models of axial-planar veins resulting from progressive deformation are described and discussed:(1) fold-related veins associated with the standard folding mechanisms,(2) fracture arrays localized along the short limbs of folds(asymmetric fold-related veins),(3) folds associated with rotation of extension veins(vein-related folds),(4) high strain and transposition of early veins,and(5) high strain and late veins parallel to axial planar foliations(axial planar foliation-related veins).The axial planar geometry is achieved through variable amounts of progressive rotational strain,except in model 5,in which the co-planarity is acquired at the time of vein *** possibility for axial-planar veins to have developed in two distinct phases in the context of polyphase or polyorogenic tectonics has also been explored and *** study contributes to a better understanding of the intriguing interplays between deformation,metamorphic and magmatic processes in orogenic belts.

关键词： Dike Fold Fracture Metamorphic rock Migmatite Shear

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Plant hormesis and Shelford’s tolerance law curve

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Journal of Forestry Research 2021年第5期32卷 1789-1802页

作者： elena A.Erofeeva Department of Ecology Lobachevsky State University of Nizhny Novgorod23 Gagarina PrNizhni NovgorodRussian Federation 603950

Shelford’s law of tolerance is illustrated by a bell-shaped curve depicting the relationship between environmental factor/factors’intensity and its favorability for species or *** is a fundamental basis of ecology when considering the regularities of environment impacts on living systems,and applies in plant biology,agriculture and forestry to manage resistance to environmental limiting factors and to enhance *** recent years,the concept of hormesis has been increasingly used to study the dose-response relationships in living organisms of different complexities,including *** requires the need for an analysis of the relationships between the hormetic dose-response model and the classical understanding of plant reactions to environments in terms of Shelford’s law of *** paper analyses various dimensions of the relationships between the hormetic model and Shelford’s tolerance law curve under the influence of natural environmental factors on plants,which are limiting for plants both in deficiency and *** analysis has shown that Shelford’s curve and hormetic model do not contradict but instead complement each *** hormetic response of plants is localized in the stress zone of the Shelford’s curve when adaptive mechanisms are disabled within the ecological *** the same time,in a species range,the ecological optimum is the most favorable combination of all or at least the most important environmental factors,each of which usually deviates slightly from its optimal *** mechanisms cannot be completely disabled in the optimum,and hormesis covers optimum and stress *** can modify the plant tolerance range to environmental factors by preconditioning and makes limits of plant tolerance to environmental factors flexible to a certain *** turn,as a result of tolerance range evolution,quantitative characteristics of hormesis(width and magnitude of hormetic zone)as well as the range of stimulatin

关键词： Hormetic dose-response Environmental limiting factor Plant stress Phenotypic plasticity Adaptive response

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