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Building Simulation 2024年第5期17卷 839-855页

作者： Pablo Aparicio-Ruiz elena Barbadilla-Martin Jose Guadix jesus Munuzuri Grupo de Ingenieria de organizacion Escuela Tecnica Superior de IngenieriaUniversidad de SevillaCamino de los Descubrimientos S/N41092SevilleSpain

Since indoor clothing insulation is a key element in thermal comfort models,the aim of the present study is proposing an approach for predicting it,which could assist the occupants of a building in terms of recommendations regarding their *** that,a systematic analysis of input variables is exposed,and 13 regression and 12 classification machine learning algorithms were developed and *** results are based on data from 3352 questionnaires and 21 input variables from a field study in mixed-mode office buildings in *** temperature at 6 a.m.,indoor air temperature,indoor relative humidity,comfort temperature and gender were the most relevant features for predicting clothing *** comparing machine learning algorithms,decision tree-based algorithms with Boosting techniques achieved the best *** proposed model provides an efficient method for forecasting the clothing insulation level and its application would entail optimising thermal comfort and energy efficiency.

关键词： clothing insulation simulation adaptive thermal comfort behavioural adaptive actions machine learning

A comprehensive review of genetic causes of obesity

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World Journal of Pediatrics 2024年第1期20卷 26-39页

作者： Marcio Jose Concepcion-Zavaleta Juan Eduardo Quiroz-Aldave Maria del Carmen Durand-Vasquez Elman Rolando Gamarra-osorio Juan del Carmen Valencia de la Cruz Claudia Mercedes Barrueto-Callirgos Susan Luciana Puelles-leon elena de jesus alvara.o-leon Frans Leiva-Cabrera Francisca elena Zavaleta-Gutierrez Luis Alberto Concepcion-Urteaga Jose Paz-Ibarra Universidad Cientifica del Sur Bolivar 2150 AvenuePueblo Libre15084LimaPeru Division of Medicine Hospital de Apoyo ChepénChepenPeru Division of Family Medicine Hospital de Apoyo ChepénChepenPeru Division of Endocrinology Hospital Victor Lazarte EchegarayTrujilloPeru Division of Pediatrics Hospital de Apoyo ChepenChepenPeru Division of Internal Medicine Hospital de Apoyo ChepenChepenPeru Division of Genetics Universidad Nacional de TrujilloTrujilloPeru Division of Neonatology Hospital Belen de TrujilloTrujilloPeru Division of Internal Medicine Universidad Nacional de TrujilloTrujilloPeru department of Medicine School of MedicineUniversidad Nacional Mayor de San MarcosLimaPeru

Background obesity is a multifactorial chronic disease with a high,increasing worldwide *** causes account for 7%of the cases in children with extreme *** sources This narrative review was conducted by searching for papers published in the PubMed/MEDLINE,Embase and SciELo databases and included 161 *** search used the following search terms:"obesity","obesity and genetics","leptin","Prader-Willi syndrome",and"melanocortins".The types of studies included were systematic reviews,clinical trials,prospective cohort studies,cross-sectional and prospective studies,narrative reviews,and case *** The leptin-melanocortin pathway is primarily responsible for the regulation of appetite and body ***,several important aspects of the pathophysiology of obesity remain *** causes of obesity can be grouped into syndromic,monogenic,and polygenic causes and should be assessed in children with extreme obesity before the age of 5 years,hyperphagia,or a family history of extreme obesity.A microarray study,an analysis of the melanocortin type 4 receptor gene mutations and leptin levels should be performed for this *** are three therapeutic levels:lifestyle modifications,pharmacological treatment,and bariatric *** Genetic study technologies are in constant development;however,we are still far from having a personalized approach to genetic causes of obesity.A significant proportion of the affected individuals are associated with genetic causes;however,there are still barriers to its approach,as it continues to be underdiagnosed.

关键词： Leptin Melanocortin obesity Prader-Willi syndrome Precision medicine

decommissioning of Uranium Pilot Plants at IPEN-CNEN/SP： Facilities Dismantling, decontamination and Reuse as New Laboratories for Strategic Programs

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Journal of Environmental Science and Engineering(B) 2016年第5期5卷 237-242页

作者： Paulo Emesto de oliveira Lainetti Antonio Alves de Freitas Francisco Mairio Feijo Vasques Robson de jesus Ferreira Marycel elena Barbosa Cotrim Maria Aparecida Faustino Pires Instituto de Pesquisas Energeticas e Nucleares-IPEN-CNEN/SP National Nuclear Energy Commission-CNEN C. Universitaria Butanta Sao Paulo-SP CEP 05508-000 Brazil Instituto de Pesquisas Energeticas e Nucleares-IPEN-CNEN/SP National Nuclear Energy Commission-CNEN C. Universitaria Butanta Sao Paulo CEP 05729-090 Brazil

From beginning of 90＇s, the Brazilian nuclear policy has been changed radically. This determined the interruption of most R＆D fuel cycle activities and the facilities shutdown at Nuclear and Energetic Research Institute （IPEN）. The existence of those facilities also implicated in the need of constant surveillance, representing additional obligations, costs and problems. The reasons to promote the dismantling of the IPEN＇s Nuclear Fuel Cycle Pilot Plants elapsed mainly from the need of physical space for new activities, since the R＆D in the nuclear fuel cycle area were interrupted. In the last decade, IPEN has changed its ＂nuclear profile＂ to a ＂comprehensive and multidisciplinary profile＂. With the end of most nuclear fuel cycle activities, the former facilities were distributed in four different centers. Each center has adopted a different strategy and priority to face the D＆D problem. The available resources depend on the specific program in each area＇s development （resources available from other sources, not only from Brazilian National Nuclear Energy Commission （CNEN）. one of those new activities is the IPEN＇s Environmental Program. This paper describes the procedures, problems faced and results related to the reintegration of the former pilot plant areas as new laboratories of the Chemical and Environmental Technology Center-CQMA of the IPEN.

关键词： decommissioning dismantling decontamination pilot plants reuse.

Identification of the child with influenza A (H1N1): Clinical criteria versus the rapid influenza A-B test

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open Journal of Preventive Medicine 2012年第2期2卷 225-228页

作者： jesus Reyna-Figueroa Karla Maldonado-Silva Ana elena Limon-Rojas department of Pediatrics High Specialty Central South Hospital PEMEX Mexico City Mexico

Introduction: During the influenza A (H1N1) pandemic infection, the Ministry of Health in Mexico recommended that it be considered as a suggestive clinical picture in patients with fever, cough and headache. In some places where the resource was available, the rapid seasonal influenza (A-B) test was used as an alternative identification strategy. Methods: From April 2009 to May 2010, patients under 18 years of age with acute respiratory tract symptoms were included in a retrospective study. They underwent the following procedures: 1) application of the clinical criteria recommended by the federal Ministry of Health during the A (H1N1) pandemic;2) rapid test for seasonal influenza (A-B), and 3) search for the influenza A (H1N1) virus by means of the real time polymerase chain reaction (RT-PCR). The study was approved by the research and ethics committee at the Central South Hospital of the government-owned Mexican Petroleum Company (PEMEX). Results: one hundred and thirty pediatric patients with a median age of eight years and a range between one and 17 years were included. Taking into account the Ministry of Health’s criteria, we found the following: 50% sensitivity, 69% specificity, 80% positive predictive value and 27% negative predictive value versus the rapid test that displayed 82% sensitivity, 70% specificity, 80% positive predictive value and 27% negative predictive value. Conclusions: Clinical criteria display low sensitivity in the infected children studied, whereas the rapid influenza A-B test constitutes a better option to identify these patients.

关键词： Diagnosis Influenza H1N1 Efficacy Criteria Rapid Test

Luminal oxidants selectively modulate electrogenic ion transport in rat colon

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World Journal of Gastroenterology 2006年第34期12卷 5523-5527页

作者： Julio M Mayol Yolanda Adame-Navarrete Pilar Alarma-Estrany elena Molina-Roldan Fernando Huete-Toral jesus A Fernandez-Represa Servicio de Cirugia I Hospital Clinico San Carlos Universidad Complutense De Madrid Madrid 28040 Spain

AIM： To investigate the effects of luminal exposure to H2o2 and two related thiol oxidizing agents on basal and stimulated chloride secretion in native colon using electrophysiological and pharmacological approaches. METHoDS： Unstripped rat distal colon segments were mounted in Ussing chambers. Potential difference, calculated resistance and short-circuit current across unstripped colon segments were monitored with a dual voltage/current clamp. Paracellular permeability was assessed by measuring the mucosa-to-serosa flux of a fluorescent probe （FITC）. RESULTS： Luminal exposure to hydrogen peroxide transitorily stimulated chloride secretion without altering barrier function. This stimulatory effect could be blocked by basolateral atropine but not indomethacin. The cysteine and methionine oxidizing compounds, phenylarsine oxide and chloramine T respectively, mimicked the effect of H2o2, except for a drop in transcolonic resistance after 30 min. In contrast to the observed stimulatory effect on basal secretion, cAMP-stimulated electrogenic ion transport was blunted by luminal H2o2. However, the Ca^2＋- activated response remained unchanged. CoNCLUSIoN： H2o2 may be an important selective modulator of intestinal ion and water secretion in certain pathologic conditions such as inflammation or ischemiareperfusion by multiple mechanisms.

关键词： Chloride secretion Ion transport Rat distal colon Hydrogen peroxide Acetylcholine Atropine

Association between an Incomplete Vaccination Schedule and Nosocomial Sepsis among Children with Cancer

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World Journal of Vaccines 2013年第1期3卷 10-15页

作者： jesus Reyna-Figueroa Diana PerezPena-Rosas Patricia Galindo-delgado Ana elena Limon-Rojas Vicente Madrid-Marina Program in Public Health Sciences National Institute of Public HealthMexico CityMexico Central South Hospital Petroleos MexicanosMexico CityMexico

Background: Patients with cancer constitute a special group where immunization programs are often interrupted to begin treatment with chemotherapy. Sepsis is one of the main complications in this group. Methods: A hospital-based case-control study matched by age was carried out among subjects ≤ 9 years of age with cancer diagnosis. Children with cancer without sepsis and children with surgical pathology were included as controls;children with sepsis were included as cases. A bivariate logistic regression was used to determine the factors associated to nosocomial sepsis, and odds ratios were calculated with 95% confidence intervals. The percentage of attributable risk was calculated for the variables included in the final model. Results: Nineteen children with cancer and sepsis and 83 controls were included. Twelve (44%) caseshad an incomplete vaccination schedule according to their age. The association force between incomplete schedule and sepsis was 10.1 (95% CI, 3 - 36;p onclusions: Approximately, 20% to 65% of the cases of serious nosocomial infection can be associated to an incomplete vaccination schedule. Strategies should be implemented to improve the general pediatric population’s vaccination status before a serious disease, such as cancer or another chronic condition preventing the application of vaccines, develops.

关键词： Vaccines Cancer Pediatrics Immunocompromise Association

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International Journal of Clinical Medicine 2013年第12期4卷 1-4页

作者： David Saez Martinez Felipe Lopez oliva Maria jesus Fernandez Acenero elena Fontoira Moyer Juan Luis Arranz Cozar ortrhopedic Surgery department Fundacion Jimenez DiazMadridSpain Pathology department Fundacion Jimenez DiazMad-ridSpain Radiology department Fundacion Jimenez DiazMadridSpain oncology department Fundacion Jimenez DiazMad-ridSpain

Background: IgG4-related disease is a systemic lymphoproliferative syndrome that shows IgG4-producing plasma cell expansion in affected organs with fibrotic or sclerotic changes. The lacrimal glands, salivary glands and pancreas are typically affected. We report a case of IgG4-related disease presenting a soft tissue tumor affecting skeletal muscle. Case Report: A 32-year-old man presented a soft tissue mass in his left arm. Magnetic resonance imaging revealed a spindle like, peripheral mass, in the lateral head of the triceps of his left arm. Tru-Cut Biopsy provided the diagnosis of IgG4-related disease affecting skeletal muscle. Glucocorticoid treatment was effective. Conclusion: To our knowledge, this is the first reported case of IgG4-related disease affecting skeletal muscle and presenting a soft tissue mass.

关键词： IgG4-Related Disease Soft Tissue Mass Skeletal Muscle

Successful Management of a Complicated Ulcer Caused by Autoimmune Vasculitis, with Sildenafil Citrate in a Patient with Primary Antiphospholipid Syndrome and Transient Steroid-Induced Diabetes Mellitus: A Case Report and Literature Review

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Journal of Diabetes Mellitus 2014年第3期4卷 189-193页

作者： Fernando Grover-Paez leonel Garcia-Benavides Ernesto German Cardona-Munoz Carlos Gerardo Ramos-Becerra jesus Ricardo Garcia-Corral Carlos Enrique Medina-Garcia Guillermo Adrian Alanis-Sanchez Sylvia elena Totsuka-Sutto Institute of Experimental and Clinical Therapeutics Department of PhysiologyUniversity Center of Health SciencesUniversity of GuadalajaraGuadalajaraMexico

Antiphospholipid syndrome (APS) is a prothrombotic condition that can affect both the venous circulation and the arterial system. The deep veins of the lower extremities and cerebral blood flow are the most common sites of venous and arterial thrombosis, respectively. Skin ulceration and gangrene may be associated with an active vasculitis in patients with APS. These kinds of ulcers are considered intractable because healing is difficult to achieve. Using steroids as immunesuppressant therapy is still a basic part of managing APS and vasculitis. Nevertheless, in the presence of steroid-induced diabetes mellitus, the priority is to achieve faster wound healing, because of the potential complications that can develop due to metabolic dysfunction and augmented vulnerability to infection. Until recently, there were few reports demonstrating the benefits of the use of adjuvant phosphodiesterase-5 inhibitors like sildenafil citrate in different clinical entities with courses like Raynaud’s phenomenon, scleroderma, and resistance to vasodilator therapy. We present the first report demonstrating the additional benefit of sildenafil citrate for the integration of grafts in a patient with steroid-induced diabetes and APS who had ulcers due to vasculitis resistant to the usual vasodilator therapy.

关键词： Autoimmune Vasculitis Sildenafil Citrate Steroid-Induced Diabetes Mellitus Primary Antiphospholipid Syndrome

Evaluation of Adverse Events Following Immunization against Rotavirus Regardless of Recommended Age Restriction

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Journal of Biosciences and Medicines 2017年第8期5卷 78-82页

作者： jesus Reyna-Figueroa Irina Jeanette Bercholc-Urinowsky Gabriela Cardoso-Yah Ricardo Platón Vazquez-alvara.o Dalila Ramos-López Freya Helena Campos-Romero Cory Handelsman Ana elena Limón-Rojas Central South Hospital Mexican Oil Company Petróleos Mexicanos México City Mexico Robert Wood Johnson University Hospital New Jersey USA

Introduction: Mild and moderate Adverse Events Following Immunization (AEFI) against Rotavirus has not received much attention when the vaccine is administered regardless of recommended age restriction. objectives: To describe the behavior of mild and moderate AEFI in immunized subjects against Rotavirus, in who age restriction period had not been considered. Methods: A case-control study in which we included immunized patients with monovalent oral vaccine against rotavirus and divided them into two groups: 1) Infants who received RV1 vaccine without considering the recommended period, and 2) Infants who were vaccinated with the recommended schedule. Results: From the total doses, 143/1894 (7.5%) were administered outside the restriction period. The most frequent AEFIs with the first dose were purpura, polypnea, and rhinorrhea;For the second dose: purpura, bloody stools, irritability and rhinorrhea. Conclusions: This study shows the benefits from vaccination regardless of age restriction are more beneficial compared to the possible risks of AEFI.

关键词： Rotavirus Vaccination Age Restriction Adverse Reaction

Regulatory circuits involving bud dormancy factor PpeDAM6

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Horticulture Research 2021年第1期8卷 3488-3505页

作者： Alba Lloret Carles Quesada-Traver Ana Conejero Vicent Arbona Concepcion Gomez-Mena Cesar Petri jesus A.Sanchez-Navarro elena Zuriaga Carmen Leida Maria Luisa Badenes Gabino Rios Instituto Valenciano de Investigaciones Agrarias 46113 MoncadaValenciaSpain departament de Ciencies Agraries i del Medi Natural Universitat Jaume ICastello de la PlanaSpain Instituto de Biologia Molecular y Celular de Plantas Universitat Politecnica de Valencia-Consejo Superior de Investigaciones Cientificas46022 ValenciaSpain departamento de Fruticultura Subtropical y Mediterranea IHSM-UMA-CSICAvenida Dr.Wienbergs/n 29750 Algarrobo-CostaMalagaSpain

DoRMANCY-ASSoCIATED MADS-BoX(DAM)genes have recently emerged as key potential regulators of the dormancy cycle and climate adaptation in perennial ***,PpeDAM6 has been proposed to act as a major repressor of bud dormancy release and bud break in peach(Prunus persica).PpeDAM6 expression is downregulated concomitantly with the perception of a given genotype-dependent accumulation of winter chilling time,and the coincident enrichment in H3K27me3 chromatin modification at a specific genomic *** have identified three peach BASIC PENTACYSTEINE PRoTEINs(PpeBPCs)interacting with two GA-repeat motifs present in this H3K27me3-enriched ***,PpeBPC1 represses PpeDAM6 promoter activity by transient expression *** the other hand,the heterologous overexpression of PpeDAM6 in European plum(Prunus domestica)alters plant vegetative growth,resulting in dwarf plants tending toward shoot meristem *** alterations in vegetative growth of transgenic lines associate with impaired hormone homeostasis due to the modulation of genes involved in jasmonic acid,cytokinin,abscisic acid,and gibberellin pathways,and the downregulation of shoot meristem factors,specifically in transgenic leaf and apical *** expression of many of these genes is also modified in flower buds of peach concomitantly with PpeDAM6 downregulation,which suggests a role of hormone homeostasis mechanisms in PpeDAM6-dependent maintenance of floral bud dormancy and growth repression.

关键词： homeostasis impaired winter