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Unveiling the morphogenetic code:A new path at the intersection of physical energies and chemical signaling

World Journal of Stem Cells 2021年第10期13卷 1382-1393页

作者： Riccardo Tassinari Claudia Cavallini elena olivi Valentina Taglioli Chiara Zannini Carlo Ventura National Laboratory of Molecular Biology and Stem Cell Engineering National Institute of Biostructures and Biosystems–ELDOR LABBologna 40129Italy

In this editorial,we discuss the remarkable role of physical energies in the control of cell signaling networks and in the specification of the architectural plan of both somatic and stem *** particular,we focus on the biological relevance of bioelectricity in the pattern control that orchestrates both developmental and regenerative *** this end,the narrative starts from the dawn of the first studies on animal electricity,reconsidering the pioneer work of Harold Saxton Burr in the light of the current *** finally discuss the most recent evidence showing that bioelectric signaling is an essential component of the informational processes that control pattern specification during embryogenesis,regeneration,or even malignant *** conclude that there is now mounting evidence for the existence of a Morphogenetic Code,and that deciphering this code may lead to unprecedented opportunities for the development of novel paradigms of cure in regenerative and precision medicine.

关键词： Physical energies Stem cells Bioelectricity Electromagnetic radiation Mechanical forces Morphogenetic code

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Deer antler stem cell niche: An interesting perspective

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World Journal of Stem Cells 2024年第5期16卷 479-485页

作者： Claudia Cavallini elena olivi Riccardo Tassinari Chiara Zannini Gregorio Ragazzini Martina Marcuzzi Valentina Taglioli Carlo Ventura National Laboratory of Molecular Biology and Stem Cell Engineering National Institute of Biostructures and Biosystems-Eldor LabBologna 40128Italy Eldor Lab Bologna 40128Italy Department of Medical and Surgical Sciences(DIMEC) University of BolognaBologna 40138Italy

In recent years,there has been considerable exploration into methods aimed at enhancing the regenerative capacity of transplanted and/or tissue-resident ***,in particular,have garnered significant interest for their potential to serve as natural scaffolds for *** this editorial,we provide commentary on the study by Wang et al,in a recently published issue of World J Stem Cells,which investigates the use of a decellularized xenogeneic extracellular matrix(ECM)derived from antler stem cells for repairing osteochondral defects in rat knee *** focus lies specifically on the crucial role of biological scaffolds as a strategy for augmenting stem cell potential and regenerative capabilities,thanks to the establishment of a favorable microenvironment(niche).Stem cell differen-tiation heavily depends on exposure to intrinsic properties of the ECM,including its chemical and protein composition,as well as the mechanical forces it can ***,these physicochemical cues contribute to a bio-instructive signaling environment that offers tissue-specific guidance for achieving effective repair and *** interest in mechanobiology,often conceptualized as a form of“structural memory”,is steadily gaining more validation and momen-tum,especially in light of findings such as these.

关键词： Extracellular matrix Antler stem cells Stem cell niche Regenerative medicine Decellularized scaffolds Cell memory

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Physical energies to the rescue of damaged tissues

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World Journal of Stem Cells 2019年第6期11卷 297-321页

作者： Federica Facchin Silvia Canaider Riccardo Tassinari Chiara Zannini Eva Bianconi Valentina Taglioli elena olivi Claudia Cavallini Marco Tausel Carlo Ventura Department of Experimental Diagnostic and Specialty Medicine (DIMES)School of MedicineUniversity of BolognaBologna 40100Italy National Laboratory of Molecular Biology and Stem Cell Engineering National Institute of Biostructures and BiosystemsCNRBologna 40100Italy iB3 SA Lugano 6900Switzerland

Rhythmic oscillatory patterns sustain cellular dynamics, driving the concerted action of regulatory molecules, microtubules, and molecular motors. We describe cellular microtubules as oscillators capable of synchronization and swarming, generating mechanical and electric patterns that impact biomolecular recognition. We consider the biological relevance of seeing the inside of cells populated by a network of molecules that behave as bioelectronic circuits and chromophores. We discuss the novel perspectives disclosed by mechanobiology, bioelectromagnetism, and photobiomodulation, both in term of fundamental basic science and in light of the biomedical implication of using physical energies to govern (stem) cell fate. We focus on the feasibility of exploiting atomic force microscopy and hyperspectral imaging to detect signatures of nanomotions and electromagnetic radiation (light), respectively, generated by the stem cells across the specification of their multilineage repertoire. The chance is reported of using these signatures and the diffusive features of physical waves to direct specifically the differentiation program of stem cells in situ, where they already are resident in all the tissues of the human body. We discuss how this strategy may pave the way to a regenerative and precision medicine without the needs for (stem) cell or tissue transplantation. We describe a novel paradigm based upon boosting our inherent ability for self-healing.

关键词： Stem cells Physical energies Mechanical forces Electric fields Electromagnetic fields Electromagnetic radiation Photobiomodulation Damaged tissues

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