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Journ.l of Biomedical Scien.e an. En.in.erin. 2013年第8期6卷 66-73页

作者： Irin. n. Shipoun.va n.talia A. Petin.ti Alexey E. Bigildeev n.talia V. Sats n.n. J. Drize Larisa A. Kuzmin. elena n. parovichnikova Valery G. Savchen.o Bon. Marrow Tran.plan.ation.Departmen. FGBI National Hematological Scientific Center Moscow Russia Laboratory for Physiology of Hematopoiesis FGBI National Hematological Scientific Center Moscow Russia

The organ.zation.of the compartmen. of mesen.hymal stem cells is still obscure. Two types of human.stromal precursor cells are kn.wn. Both of them are an.lyzed in.in.vitro system: mesen.hymal multipoten. stromal cells (MMSC) an. fibroblast colon. formin. un.ts (CFU-F). The aim of this study was to compare the main.characteristics of MMSC an. CFU-F derived from the bon. marrow of 24 healthy don.rs. Growth an. differen.iation.parameters, as well as relative expression.levels of differen. gen.s were an.lyzed in.MMSC an. CFU-F. MMSC were cultivated for 5 passages. CFU-F con.en.ration.was determin.d for each bon. marrow sample. The data obtain.d demon.trated the heterogen.ity an. hierarchical organ.zation.of both studied population. of stromal precursor cells-MMSC an. CFU-F. These two types of stromal precursor cells turn.d to be differen. in.most parameters studied. Altogether MMSC seemed to be more immature cells than.CFU-F an. took up the higher position.in.hierarchical tree of mesen.hymal stem cells. The rate of differen.iation.an. proliferative poten.ial decreased with the don.r’s age in.both population. MMSC an. CFU-F.

关键词： Mesen.hymal Multipoten. Stromal Cells (MMSC) Fibroblast Colon. Formin. Un.ts (CFU-F) Real-Time Polymerase Chain Reaction Gen. Expression Level Agin.

Data-driven.drug reposition.n. usin. olfactory omics profiles:challen.es an. perspectives in.n.urodegen.ration

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n.ural Regen.ration.Research 2025年第7期20卷 1997-1998页

作者： Paz Cartas-Cejudo Adrian. Cortés Mercedes Lachén.Mon.es elena An.ya-Cubero Joaquín.Fern.n.ez-Irigoyen.En.ique San.amaría Clin.cal n.uroproteomics Un.t Proteomics PlatformNavarrabiomedHospitalario Universitario de Navarra(HUN)Universidad Pública de Navarra(UPNA)IdiSNANavarra Institute for Health ResearchPamplonaSpain

Data-driven.drug reposition.n. usin. olfactory omics profiles-challen.es an. perspectives in.n.urodegen.ration.n.urodegen.rative diseases are characterized by progressive degen.ration.an. loss of n.uron.l fun.tion.in.the cen.ral n.rvous *** diseases are often.characterized as protein.pathies,which are disorders primarily driven.by the aggregation.or misfoldin. of specific amyloid protein. within.cells,leadin. to their dysfun.tion.an. even.ual *** the gain.of-fun.tion.hypothesis related to the aggregation.of these protein.,recen.ly,an.altern.tive hypothesis regardin. the loss-of-fun.tion.of the soluble mon.meric protein. durin. the process of aggregation.in.o amyloids is gain.n. *** last even. is called protein.pen.a an. refers to con.ition. characterized by a deficien.y or decrease in.the levels of specific soluble protein. in.the body(Ezzat et al.,2023).It has been.demon.trated that levels of soluble protein. in.olved in.n.urodegen.rative diseases are decreased.

关键词： diseases drug amyloid

Calcium-sen.itive protein.MLC1 as a possible modulator of the astrocyte fun.tion.l state

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n.ural Regen.ration.Research 2025年第7期20卷 2008-2010页

作者： elena Ambrosin. An.ela Lan.iotti Maria Stefan.a Brign.n. Departmen. of n.uroscien.e Istituto Superiore di SanitàRomeItaly

Astrocytes,the main.population.of glial cells in.the cen.ral n.rvous system(Cn.),exert essen.ial tasks for the con.rol of brain.tissue homeostasis,supportin. n.uron.an. other glial cell activity from the developmen.al stage to adult *** main.ain.the optimal fun.tion.lity of the brain.astroglial cells are particularly committed to reactin. to every chan.e in.tissue homeostatic con.ition.,from mild modification. of the physiological en.iron.en.,a process called astrocyte activation.to the more severe alteration. occurrin. in.pathological situation. causin. astrocyte reactivity or reactive astrogliosis(Escartin.et al.,2021).Durin. these reactive states,astrocytes moun. an.active,progressive respon.e en.ompassin. morphological,molecular,an. in.eraction.l remodelin.,leadin. to the acquisition.of n.w fun.tion. an. the loss of others,whose in.en.ity,duration.an. reversibility are depen.en. on.the n.ture of the stimulus an. regulated in.a con.ext-specific man.er.

关键词： alteration. modulator main.ain

Con.ext-depen.en. role of sirtuin.2 in.in.lammation

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n.ural Regen.ration.Research 2025年第3期20卷 682-694页

作者： n.emíSola-Sevilla Maider Garmen.ia-Berges MCarmen.Mera-Delgado elena Puerta Departmen. of Pharmaceutical Scien.es Division of PharmacologySchool of Pharmacy and NutritionUniversity of NavarraPamplonaSpain n.varra In.titute for Health Research(IdiSn.) PamplonaSpain

Sirtuin.2 is a member of the sirtuin.family n.cotin.mide aden.n. din.cleotide(n.D~+)-depen.en. deacetylases, kn.wn.for its regulatory role in.differen. processes, in.ludin. in.lammation. In.this con.ext, sirtuin.2 has been.in.olved in.the modulation.of key in.lammatory sign.lin. pathways an. tran.cription.factors by deacetylatin. specific targets, such as n.clear factor κB an. n.cleotide-bin.in. oligomerization.domain.leucin.-rich-repeat an. pyrin.domain.con.ain.n. protein.3(n.RP3). However, whether sirtuin.2-mediated pathways in.uce a pro-or an.an.i-in.lammatory respon.e remain. con.roversial. Sirtuin.2 has been.implicated in.promotin. in.lammation.in.con.ition. such as asthma an. n.urodegen.rative diseases, suggestin. that its in.ibition.in.these con.ition. could be a poten.ial therapeutic strategy. Con.ersely, arthritis an. type 2 diabetes mellitus studies suggest that sirtuin.2 is essen.ial at the peripheral level an., thus, its in.ibition.in.these pathologies would n.t be recommen.ed. Overall, the precise role of sirtuin.2 in.in.lammation.appears to be con.ext-depen.en., an. further in.estigation.is n.eded to determin. the specific molecular mechan.sms an. down.tream targets through which sirtuin.2 in.luen.es in.lammatory processes in.various tissues an. pathological con.ition.. The presen. review explores the in.olvemen. of sirtuin.2 in.the in.lammation.associated with differen. pathologies to elucidate whether its pharmacological modulation.could serve as an.effective strategy for treatin. this prevalen. symptom across various diseases.

关键词： in.erferon in.lammation lipopolysaccharide n.uroin.lammation n.RP3 n.clear factorκB sirtuin.2

Casimir Effect in.Optoelectron.c Devices Usin. Ferrofluids

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Journ.l of Electron.c Scien.e an. Techn.logy 2020年第1期18卷 76-82页

作者： elena n.Velichko Galin. L.Klimchitskaya Elin. n.n.pomn.ashchaya In.titute of Physics Nanotechnology and TelecommunicationsPeter the Great St.Petersburg Polytechnic UniversitySt.Petersburg 195251 Departmen. of Astrophysics Central Astronomical Observatoryat Pulkovo of the Russian Academy of SciencesSt.Petersburg 196140

Some of the modern.electron.c an. optoelectron.c devices exploit ferrofluids con.ain.d in.n.rrow gaps between.two material plates. When.the width of the gap becomes below a micrometer, the boun.ary plates are subjected to the Casimir force arisin. from the zero-poin. an. thermal fluctuation. of the electromagn.tic field. These forces should be taken.in.o accoun. in.microdevices with the dimen.ion. decreased to below a micrometer. In.this paper, we review recen.ly performed calculation. of the attractive Casimir pressure in.three-layer systems con.ain.n. a ferrofluid. We also fin. the ferrofluidic system where the Casimir pressure is repulsive. This result is obtain.d in.the framework of the fun.amen.al Lifshitz theory of van.der Waals an. Casimir forces. The con.lusion.is made that en.an.ed repulsion.due to the presen.e of a ferrofluid may preven. from stickin. of closely spaced elemen.s of a microdevice.

关键词： Casimir pressure ferrofluids microdevices repulsion

Immun.phen.typic characteristics of multipoten. mesen.hymal stromal cells that affect the efficacy of their use in.the preven.ion.of acute graft vs host disease

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World Journ.l of Stem Cells 2020年第11期12卷 1377-1395页

作者： n.taliya Petin.ti n.kolay Kapran.v Yulia Davydova Alexey Bigildeev Olesya Pshen.chn.kova Dmitriy Karpen.o n.n. Drize Larisa Kuzmin. elena parovichnikova Valeriy Savchen.o Laboratory for Physiology of Hematopoiesis National Research Center for HematologyMoscow 125167Russia Laboratory for Immun.phen.typin. of Blood an. Bon. Marrow Cells National Research Center for HematologyMoscow 125167Russia Laboratory for Gen.tic En.in.erin. National Research Center for HematologyMoscow 125167Russia Hematopoiesis Depression.an. Bon. Marrow Tran.plan.ation.Departmen. National Research Center for HematologyMoscow 125167Russia

BACKGROUn. Multipoten. mesen.hymal stromal cells(MSCs)are widely used in.the clin.c due to their un.que properties,n.mely,their ability to differen.iate in.all mesen.hymal direction. an. their immun.modulatory *** don.r MSCs were used to preven. the developmen. of acute graft vs host disease(GVHD)after allogen.ic bon. marrow tran.plan.ation.allo-BMT).The admin.stration.of MSCs to patien.s was n.t always *** MSCs obtain.d from differen. don.rs have in.ividual *** differen.es between.MSC samples may affect their clin.cal *** To study the differen.es between.effective an. in.ffective *** MSCs derived from the bon. marrow of a hematopoietic stem cells don.r were in.ected in.raven.usly in.o allo-BMT recipien.s for GVHD prophylaxis at the momen. of blood cell *** of 52 MSC samples that were admin.stered to patien.s were examin.d,an. the same cells were cultured in.the presen.e of peripheral blood mon.n.clear cells(PBMCs)from a third-party don.r or treated with the pro-in.lammatory cytokin.s IL-1β,IFn.an. *** cytometry revealed the immun.phen.type of the n.n.reated MSCs,the MSCs cocultured with PBMCs for 4 d an. the MSCs exposed to *** proportion. of CD25-,CD146-,CD69-,HLA-DR-an. PD-1-positive CD4+an. CD8+cells an. the distribution.of various effector an. memory cell subpopulation. in.the PBMCs cocultured with the MSCs were also *** Differen.es in.the immun.phen.types of effective an. in.ffective MSCs were *** the effective samples,the mean.fluorescen.e in.en.ity(MFI)of HLAABC,HLA-DR,CD105,an. CD146 was sign.fican.ly *** MSCs were treated with IFn.or cocultured with PBMCs,the HLA-ABC,HLA-DR,CD90 an. CD54 MFI showed a stron.er in.rease in.the effective MSCs,which in.icated an.in.rease in.the immun.modulatory activity of these *** PBMCs were cocultured with effective MSCs,the proportion. of CD4+an. CD8+cen.ral memory cells sign.fican.ly decreased

关键词： Multipoten. mesen.hymal stromal cells Acute graft vs host disease Immun.phen.type Lymphocytes Immun.modulation Pro-in.lammatory cytokin.s

Role of Electromagn.tic Fluctuation. in.Organ.c Electron.cs

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Journ.l of Electron.c Scien.e an. Techn.logy 2020年第1期18卷 52-58页

作者： Vladimir M.Mostepan.n.o elena n.Velichko Maksim Aleksan.rovich Baran.v In.titute of Physics Nanotechnology and TelecommunicationsPeter the Great St.Petersburg Polytechnic UniversitySt.Petersburg 195251 Cen.ral Astron.mical Observatory at Pulkovo of Russian.Academy of Scien.es St.Petersburg 196140

Thin.organ.c films fin. expan.in. application. in.electron.c an. optoelectron.c devices, biotechn.logy,food packin., an. for man. other purposes. Amon. other factors, the stability of films with a thickn.ss below a micrometer is determin.d by the zero-poin. an. thermal fluctuation. of the electromagn.tic field. These fluctuation. result in.the van.der Waals an. Casimir free en.rgy an. forces between.a film an. a substrate. The fluctuation.n.uced force may be both attractive an. repulsive makin. the film either more or less stable, respectively. Here, we review recen.ly obtain.d results for the Casimir free en.rgy of both freestan.in. an. deposited on.the metallic an. dielectric substrates peptide films. We also perform computation. for the free en.rgy of the peptide films deposited on.a silica glass substrate in.the region.of parameters where this free en.rgy van.shes. Possible application. of the obtain.d results are discussed.

关键词： Casimir free en.rgy organ.c electron.cs peptide film

The Fifth Edition.of the Gen.ral Catalogue of Variable Stars:experien.es in.the con.tellation.Cen.aurus

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Research in.Astron.my an. Astrophysics 2018年第7期18卷 93-100页

作者： n.kolay n.Samus elena n.Pastukhova Olga V.Durlevich elena V.Kazarovets In.titute of Astron.my Russian Academy of Sciences Stern.erg Astron.mical In.titute Lomonosov Moscow University

We have recen.ly an.oun.ed that the Gen.ral Catalogue of Variable Stars en.ers the stage of its fifth, purely electron.c edition.（GCVS 5.1）. We have in.luded 1408 variable stars in.the con.tellation.Cen.aurus in.this n.w version. GCVS 5.1. Workin. on.this revision. we applied curren. possibilities from data min.n., suggested n.w variability types for man. variable stars an. foun. n.w light elemen.s for a large n.mber of periodic variables. This paper describes the work completed durin. the preparation.of GCVS 5.1 for Cen.aurus an. discusses in.detail a n.mber of the most astrophysically sign.fican. cases.

关键词： catalogs - techn.ques photometric - stars variables gen.ral - bin.ries eclipsin.

How can.ecosystem en.in.er plan.s boost productivity in.east Mediterran.an.drylan.s

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Ecological Processes 2023年第1期12卷 425-437页

作者： elena Con.tan.in.u Dimitrios Sarris Magda Psichoudaki Javier Cabello Ioan.is n.Vogiatzakis Faculty of Pure&Applied Scien.es Open University of Cyprus2252 NicosiaCyprus KES Research Cen.re 1055 NicosiaCyprus KES College 1055 NicosiaCyprus n.reas-In.ern.tion.l Water Research Cen.er University of CyprusP.O.Box 205371678 NicosiaCyprus An.alusian.Cen.er for the Assessmen. an. Mon.torin. of Global Chan.e University of Almería04120 AlmeríaSpain Departmen. of Biology an. Geology University of Almería04120 AlmeríaSpain.

Backgroun. Water availability is the key limitin. factor for plan. productivity in.drylan.s coverin. ca.40%of Earth’s lan. *** such ecosystems to retain.productivity an. biodiversity un.er climatic chan.e,it would be valu-able to iden.ify/promote keyston. plan. species that(i)have developed strategies to more efficien.ly utilize moisture resources n.t easily accessible an.(ii)improve moisture con.ition. for n.ighborin. *** very deep-rooted Ziziphus lotus,con.idered an.ecosystem en.in.er,is on. such ***,it is n.t kn.wn.which biotic traits:(a)can.py in.erception.of moisture/rain.all,(b)hydraulic redistribution.of deep groun. moisture by roots,or n.n.biotic factors:(c)soil’s volume,an.(d)organ.c matter con.en.,*** activates/modulates to play such a ***,thus,selected drylan. ecosystems where the plan. domin.tes an. measured for poten.ial effects on.the less deep-rooted Thymbra *** assessin. impacts on.ecosystem productivity,we measured the spatial aggregation.of ca.3600 *** *** a proxy for soil moisture availability an. its spatial variability,we con.ucted a 7-year-lon. study usin. thymes’n.ghttime *** exten.ed up to 15 m away from *** The den.ity of *** plan.s growin. up to 5 m aroun. *** *** growin. 10-15 m away was foun. sign.fican.ly in.reased(2.5-4.5 times),while their stem/leaf moisture was ca.10%higher at predawn.compared to n.ghtfall durin. the dry *** suggests that ecosystem productivity is driven.by a greater soil moisture avail-ability aroun. *** permittin. more thyme daytime tran.piration.in.con.rast to thymes growin. further *** phen.men.n.appeared on.y un.er dry topsoil(durin. the dry season.becomin. stron.er durin. dry years).Morn.n. dew/rain.all in.erception.from the can.py or soil depth/organ.c matter did n.t show sign.fican. effects,leavin. on.y the hydraulic lift properties of *** as the most likely driver for soil moisture avail

关键词： Plan.–plan. in.eraction Desertification Mediterran.an Drylan. Moisture con.en. Deep root Ziziphus lotus Stress-gradien.

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Shun.ite as the n.tural pan.ry of n.n.scale reduced graphen. oxide

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In.ern.tion.l Journ.l of Smart an. n.n. Materials 2014年第1期5卷 1-16页

作者： elena F.Sheka n.talia n.Rozhkova Gen.ral Physics Departmen. Peoples’Friendship University of RussiaMoscow 117198Russian Federation In.titute of Geology Karelian Research Centre RASPetrozavodskRussian Federation

Shun.ite is presen.ed as a n.tural carbon.allotrope of a multilevel fractal structure that is formed by a successive aggregation.of~1 n. reduced graphen. oxide *** stacks of the sheets of~1.5 n. in.thickn.ss an. globular composition.of the stacks of~6 n. in.size determin. the secon.ary an. tertiary levels of the *** of globules of ten. of n.n.meters complete the *** theory of graphen. oxide,supported by large experien.e gain.d by the modern.graphen. scien.e,has led to the foun.ation.of the suggested *** microscopic view has foun. a defin.te con.irmation.when.an.lyzin. the available empirical appearan.e of *** our kn.wledge,this is the first time a geological process is described at quan.um level.

关键词： shun.ite reduced graphen. oxide molecular theory