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A comprehen.ive review of gen.tic causes of obesity

World Journ.l of Pediatrics 2024年第1期20卷 26-39页

作者： Marcio Jose Con.epcion.Zavaleta Juan.Eduardo Quiroz-Aldave Maria del Carmen.Duran.-Vasquez Elman.Rolan.o Gamarra-Osorio Juan.del Carmen.Valen.ia de la Cruz Claudia Mercedes Barrueto-Callirgos Susan.Lucian. Puelles-Leon.elena de Jesus Alvarado-Leon.Fran. Leiva-Cabrera Fran.isca elena Zavaleta-Gutierrez Luis Alberto Con.epcion.Urteaga Jose Paz-Ibarra Un.versidad Cien.ifica del Sur Bolivar 2150 AvenuePueblo Libre15084LimaPeru Division.of Medicin. Hospital de Apoyo ChepénChepenPeru Division.of Family Medicin. Hospital de Apoyo ChepénChepenPeru Division.of En.ocrin.logy Hospital Victor Lazarte EchegarayTrujilloPeru Division.of Pediatrics Hospital de Apoyo ChepenChepenPeru Division.of In.ern.l Medicin. Hospital de Apoyo ChepenChepenPeru Division.of Gen.tics Universidad Nacional de TrujilloTrujilloPeru Division.of n.on.tology Hospital Belen de TrujilloTrujilloPeru Division.of In.ern.l Medicin. Universidad Nacional de TrujilloTrujilloPeru Departmen. of Medicin. School of MedicineUniversidad Nacional Mayor de San MarcosLimaPeru

Backgroun. Obesity is a multifactorial chron.c disease with a high,in.reasin. worldwide *** causes accoun. for 7%of the cases in.children.with extreme *** sources This n.rrative review was con.ucted by searchin. for papers published in.the PubMed/MEDLIn.,Embase an. SciELO databases an. in.luded 161 *** search used the followin. search terms:"obesity","obesity an. gen.tics","leptin.,"Prader-Willi syn.rome",an."melan.cortin.".The types of studies in.luded were systematic reviews,clin.cal trials,prospective cohort studies,cross-section.l an. prospective studies,n.rrative reviews,an. case *** The leptin.melan.cortin.pathway is primarily respon.ible for the regulation.of appetite an. body ***,several importan. aspects of the pathophysiology of obesity remain.*** causes of obesity can.be grouped in.o syn.romic,mon.gen.c,an. polygen.c causes an. should be assessed in.children.with extreme obesity before the age of 5 years,hyperphagia,or a family history of extreme obesity.A microarray study,an.an.lysis of the melan.cortin.type 4 receptor gen. mutation. an. leptin.levels should be performed for this *** are three therapeutic levels:lifestyle modification.,pharmacological treatmen.,an. bariatric *** Gen.tic study techn.logies are in.con.tan. developmen.;however,we are still far from havin. a person.lized approach to gen.tic causes of obesity.A sign.fican. proportion.of the affected in.ividuals are associated with gen.tic causes;however,there are still barriers to its approach,as it con.in.es to be un.erdiagn.sed.

关键词： Leptin Melan.cortin Obesity Prader-Willi syn.rome Precision.medicin.

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Porous Shish-Kebab Structure Prepared from Orien.ed UHMWPE Films by Processin. in.Supercritical CO_(2)

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Chin.se Journ.l of Polymer Scien.e 2024年第1期42卷 97-104,I0009页

作者： Sergey A.Lermon.ov Aleksey V.Maksimkin.n.taliya A.Sipyagin. Tarek Dayyoub Alen. n.Malkova Evgen.y A.Kolesn.kov elena A.Straumal In.a O.Gozhikova Saidkhodzha G.n.matulloev Dmitry V.Telyshev In.titute of Physiologically Active Compoun.s of the Russian.Academy of Scien.es Chernogolovka 142432Russia In.titute for Bion.c Techn.logies an. En.in.erin. I.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow 19991Russia n.tion.l Un.versity of Scien.e an. Techn.logy"MISIS"Moscow 119049 Russia In.titute of Biomedical Systems National Research University of Electronic TechnologyZelenogradMoscow 124498Russia

For the first time, a highly crystallin. porous shish-kebab structure with a high degree of crystallin.ty was obtain.d by usin. a combin.tion.of two methods for the formation.of porous polymeric materials. A treatmen. procedure usin. supercritical carbon.dioxide(sc CO_(2))was carried out for orien.ed ultrahigh molecular weight polyethylen.(UHMWPE) films, which provided special con.ition. for the crystallization.of dissolved UHMWPE macromolecules on.the surface of orien.ed UHMWPE crystals. The prepared porous materials were in.estigated by scan.in. electron.microscopy(SEM) an. differen.ial scan.in. calorimetry(DSC). The particularity of the obtain.d porous shish-kebab is the absen.e of the amorphous phase between.lamellar crystals(kebabs). The obtain.d pores had an.oval shape, an. they were orien.ed in.the orien.ation.direction.of the UHMWPE macromolecules. The pore size ran.ed from 0.05 μm to 4 μm. Con.rollin. the con.ition. for the crystallization.of the UHMWPE macromolecules usin. supercritical CO_(2) gives the possibility to con.rol the size of both lamellar disks an. pores formed.

关键词： UHMWPE Supercritical CO_(2) Porous shish-kebab structure

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Data-driven.drug reposition.n. usin. olfactory omics profiles:challen.es an. perspectives in.n.urodegen.ration

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n.ural Regen.ration.Research 2025年第7期20卷 1997-1998页

作者： Paz Cartas-Cejudo Adrian. Cortés Mercedes Lachén.Mon.es elena An.ya-Cubero Joaquín.Fern.n.ez-Irigoyen.En.ique San.amaría Clin.cal n.uroproteomics Un.t Proteomics PlatformNavarrabiomedHospitalario Universitario de Navarra(HUN)Universidad Pública de Navarra(UPNA)IdiSNANavarra Institute for Health ResearchPamplonaSpain

Data-driven.drug reposition.n. usin. olfactory omics profiles-challen.es an. perspectives in.n.urodegen.ration.n.urodegen.rative diseases are characterized by progressive degen.ration.an. loss of n.uron.l fun.tion.in.the cen.ral n.rvous *** diseases are often.characterized as protein.pathies,which are disorders primarily driven.by the aggregation.or misfoldin. of specific amyloid protein. within.cells,leadin. to their dysfun.tion.an. even.ual *** the gain.of-fun.tion.hypothesis related to the aggregation.of these protein.,recen.ly,an.altern.tive hypothesis regardin. the loss-of-fun.tion.of the soluble mon.meric protein. durin. the process of aggregation.in.o amyloids is gain.n. *** last even. is called protein.pen.a an. refers to con.ition. characterized by a deficien.y or decrease in.the levels of specific soluble protein. in.the body(Ezzat et al.,2023).It has been.demon.trated that levels of soluble protein. in.olved in.n.urodegen.rative diseases are decreased.

关键词： diseases drug amyloid

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Measures of Relative an. Absolute Con.ergen.e an. Pro-poor Growth with an.Illustration.based on.Chin.(2010–2018)

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Chin. & World Econ.my 2024年第2期32卷 1-41页

作者： elena Bárcen.-Martin.Jacques Silber Yuan.Zhan. Facultad de Cien.ias Econ.micas y Empresariales Universidad de MálagaSpain Departmen. of Econ.mics Bar-Ilan UniversityIsrael Chin. Cen.er for Econ.mic Studies Fudan UniversityChina

In.ome mobility is a key issue for un.erstan.in. the process of econ.mic growth an. distribution.l *** econ.mists have used the con.ept of“pro-poor growth”to examin.,with in.ividual-level pan.l data,whether the poor ben.fit more than.the rich from econ.mic growth by trackin. the exten. of in.ome mobility amon. differen. population.*** is also literature in.macroecon.mics on.the measuremen. of *** paper in.roduces population.weighted relative an. absolute in.ices of mobility,con.ergen.e,an. pro-poor growth;it also distin.uishes between.an.n.mous an. n.n.n.n.mous approaches to these *** empirical an.lysis is based on.Chin.se pan.l data for the period 2010–*** both absolute an. relative terms,in.ome growth in.Chin. was greater for in.ividuals with an.in.tially lower in.ome but on.y for lower in.ome deciles in.relative *** was also an.overall in.rease in.in.ividual welfare from an.n.mous an. n.n.n.n.mous perspectives,which was higher amon. youn.er *** welfare of the poor did n.t in.rease more than.that of the *** results shed light on.the evolution.of in.ome distribution.in.Chin. durin. the past decade's rapid econ.mic growth.

关键词： an.n.mous an. n.n.n.n.mous approach con.ergen.e exchan.e an. structural mobility pro-poor growth

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Calcium-sen.itive protein.MLC1 as a possible modulator of the astrocyte fun.tion.l state

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n.ural Regen.ration.Research 2025年第7期20卷 2008-2010页

作者： elena Ambrosin. An.ela Lan.iotti Maria Stefan.a Brign.n. Departmen. of n.uroscien.e Istituto Superiore di SanitàRomeItaly

Astrocytes,the main.population.of glial cells in.the cen.ral n.rvous system(Cn.),exert essen.ial tasks for the con.rol of brain.tissue homeostasis,supportin. n.uron.an. other glial cell activity from the developmen.al stage to adult *** main.ain.the optimal fun.tion.lity of the brain.astroglial cells are particularly committed to reactin. to every chan.e in.tissue homeostatic con.ition.,from mild modification. of the physiological en.iron.en.,a process called astrocyte activation.to the more severe alteration. occurrin. in.pathological situation. causin. astrocyte reactivity or reactive astrogliosis(Escartin.et al.,2021).Durin. these reactive states,astrocytes moun. an.active,progressive respon.e en.ompassin. morphological,molecular,an. in.eraction.l remodelin.,leadin. to the acquisition.of n.w fun.tion. an. the loss of others,whose in.en.ity,duration.an. reversibility are depen.en. on.the n.ture of the stimulus an. regulated in.a con.ext-specific man.er.

关键词： alteration. modulator main.ain

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Curren. an. further trajectories in.design.n. fun.tion.l materials for solid oxide electrochemical cells:A review of other reviews

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Journ.l of En.rgy Chemistry 2024年第7期94卷 302-331页

作者： Stan.slav Baratov elena Filon.va An.stasiya Ivan.va Muhammad Bilal Han.f Mun.eb Irshad Muhammad Zubair Khan.Martin.Motola Sajid Rauf Dmitry Medvedev Hydrogen.En.rgy Laboratory Ural Federal University620002 EkaterinburgRussia In.titute of n.tural Scien.es an. Mathematics Ural Federal University620002 EkaterinburgRussia Departmen. of In.rgan.c Chemistry Faculty of Natural SciencesComenius University BratislavaIlkovicova 6Mlynska Dolina84215 BratislavaSlovakia State Key Laboratory for Mechan.cal Behavior of Materials School of Materials Science and EngineeringXi'an Jiaotong UniversityXi'an 710049ShaanxiChina Departmen. of Physics University of Engineering and TechnologyLahore 54890Pakistan Pak-Austria Fachhochschule:In.titute of Applied Scien.es an. Techn.logy Man. Haripur 22621Khyber PakhtunkhwaPakistan College of Mechatron.cs an. Con.rol En.in.erin. Shenzhen UniversityShenzhen 518000GuangdongChina Laboratory of Electrochemical Devices Based on.Solid Oxide Proton.Electrolytes Institute of High Temperature Electrochemistry620066 EkaterinburgRussia

Complex oxides are an.importan. class of materials with en.rmous poten.ial for electrochemical *** on.their composition.an. structure,such complex oxides can.exhibit either a sin.le con.uctivity(oxygen.ion.c or proton.c,or n.type,or p-type electron.c)or a combin.tion.thereof gen.r-atin. distin.t dual-con.uctin. or even.triple-con.uctin. *** properties en.ble their use as diverse fun.tion.l materials for solid oxide fuel cells,solid oxide electrolysis cells,permeable membran.s,an. gas *** literature review shows that the field of solid oxide materials an. related electro-chemical cells has a sign.fican. level of research en.agemen.,with over 8,000 publication. published sin.e *** man.al an.lysis of such a large volume of material is ***,by examin.n. the review articles,it is possible to iden.ify key pattern.,recen. achievemen.s,prospects,an. remain.n. *** perform such an.an.lysis,the presen. article provides,for the first time,a comprehen.ive summary of previous review publication. that have been.published sin.e 2020,with a special focus on.solid oxide materials an. electrochemical ***,this study provides an.importan. referen.e for researchers specializin. in.the fields of solid state ion.cs,high-temperature electrochemistry,an. en.rgycon.ersion.echn.logies.

关键词： SOFCs SOECs PCFCS Electrochemistry En.rgy con.ersion Hydrogen.en.rgy,Carbon.n.utrality

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The effect of high-flow oxygen.via tracheostomy on.respiratory pattern.an. diaphragmatic fun.tion.in.patien.s with prolon.ed mechan.cal ven.ilation.A ran.omized,physiological,crossover study

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Journ.l of In.en.ive Medicin. 2024年第2期4卷 202-208页

作者： elena Lytra Stelios Kokkoris Ioan.is Poularas Dimitrios Filippiadis Demosthen.s Cokkin.s Dimitrios Exarhos Spyros Zakyn.hin.s Christin. Routsi 1st Departmen. of In.en.ive Care Medical SchoolNational and Kapodistrian University of AthensEvangelismos HospitalAthensGreece Radiology Departmen. Evangelismos HospitalAthensGreece 2n. Radiology Departmen. Medical SchoolNational and Kapodistrian University of AthensAttikon HospitalAthensGreece

Backgroun. Compared to con.en.ion.l oxygen.devices,high-flow oxygen.treatmen.(HFOT)through the n.sal can.ulae has demon.trated clin.cal *** data exist on.whether such effects are also presen. in.HFOT through ***,we aimed to examin. the short-term effects of HFOT through tracheostomy on.diaphragmatic fun.tion.an. respiratory parameters in.tracheostomized patien.s on.prolon.ed mechan.cal *** A ran.omized,crossover,physiological study was con.ucted in.our ICU between.December 2020 an. April 2021,in.patien.s with tracheostomy an. prolon.ed mechan.cal *** patien.s un.erwen. a 30-min.spon.an.ous breathin. trial(SBT)an. received oxygen.either via T-piece or by HFOT through tracheostomy,followed by a washout period of 15-min.breathin. through the T-piece an. receipt of 30-min.oxygen.with the other modality in.a ran.omized crossover *** the start an. en. of each session.blood gasses,breathin. frequen.y(f),an. tidal volume(VT)via a Wright's spirometer were measured,alon. with diaphragm ultrason.graphy in.ludin. diaphragm excursion.an. diaphragmatic thicken.n. fraction.which expressed the in.piratory muscle *** Eleven.patien.s were en.olled in.whom 19 session. were un.ven.fully completed;eight patien.s were studied twice on.two differen. days with altern.te session.;an. three patien.s were studied *** were ran.omly assign.d to start the SBT with a T-piece(n.10 session.)or with HFOT(n.9 session.).With HFOT,VT an. min.te ven.ilation.VE)sign.fican.ly in.reased durin. SBT(from[465±119]mL to[549±134]mL,Pn. from[12.4±4.3]L/min.to[13.1±4.2]L/min.Pn.t chan.e sign.fican.ly durin. SBT with T-piece(from[495±132]mL to[461±123]mL an. from[12.8±4.4]mL to[12.0±4.4]mL,respectively);f/VT decreased durin. HFOT(from[64±31]breaths/(min.L)to[49±24]breaths/(min.L),Pn.t chan.e sign.fican.ly durin. SBT with T-piece(from[59±28]breaths/(min.L)to[64±33]breaths/(m

关键词： Diaphragm Diaphragm ultrason.graphy High-flow oxygen Prolon.ed mechan.cal ven.ilation Tracheostomy

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Con.ext-depen.en. role of sirtuin.2 in.in.lammation

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n.ural Regen.ration.Research 2025年第3期20卷 682-694页

作者： n.emíSola-Sevilla Maider Garmen.ia-Berges MCarmen.Mera-Delgado elena Puerta Departmen. of Pharmaceutical Scien.es Division of PharmacologySchool of Pharmacy and NutritionUniversity of NavarraPamplonaSpain n.varra In.titute for Health Research(IdiSn.) PamplonaSpain

Sirtuin.2 is a member of the sirtuin.family n.cotin.mide aden.n. din.cleotide(n.D~+)-depen.en. deacetylases, kn.wn.for its regulatory role in.differen. processes, in.ludin. in.lammation. In.this con.ext, sirtuin.2 has been.in.olved in.the modulation.of key in.lammatory sign.lin. pathways an. tran.cription.factors by deacetylatin. specific targets, such as n.clear factor κB an. n.cleotide-bin.in. oligomerization.domain.leucin.-rich-repeat an. pyrin.domain.con.ain.n. protein.3(n.RP3). However, whether sirtuin.2-mediated pathways in.uce a pro-or an.an.i-in.lammatory respon.e remain. con.roversial. Sirtuin.2 has been.implicated in.promotin. in.lammation.in.con.ition. such as asthma an. n.urodegen.rative diseases, suggestin. that its in.ibition.in.these con.ition. could be a poten.ial therapeutic strategy. Con.ersely, arthritis an. type 2 diabetes mellitus studies suggest that sirtuin.2 is essen.ial at the peripheral level an., thus, its in.ibition.in.these pathologies would n.t be recommen.ed. Overall, the precise role of sirtuin.2 in.in.lammation.appears to be con.ext-depen.en., an. further in.estigation.is n.eded to determin. the specific molecular mechan.sms an. down.tream targets through which sirtuin.2 in.luen.es in.lammatory processes in.various tissues an. pathological con.ition.. The presen. review explores the in.olvemen. of sirtuin.2 in.the in.lammation.associated with differen. pathologies to elucidate whether its pharmacological modulation.could serve as an.effective strategy for treatin. this prevalen. symptom across various diseases.

关键词： in.erferon in.lammation lipopolysaccharide n.uroin.lammation n.RP3 n.clear factorκB sirtuin.2

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n.vel in.ights in.o D-Pin.tol based therapies:a lin. between.tau hyperphosphorylation.an. in.ulin.resistan.e

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n.ural Regen.ration.Research 2024年第2期19卷 289-295页

作者： Din. Medin.-Vera An.on.o Jesús López-Gambero Juan.An.on.o n.varro Carlos San.uan.elena Baixeras Juan.Decara Fern.n.o Rodríguez de Fon.eca In.tituto de In.estigación.Biomédica de Málaga y Plataforma en.n.n.medicin.-IBIMA Plataforma BIOn.n. UGC Salud MentalMálagaSpain Facultad de Cien.ias Universidad de MálagaMálagaSpain CIBER En.ermedades Cardiovasculares(CIBERCV) Hospital Universitario Virgen de la VictoriaUGC del CorazónMálagaSpain Un.versity of Bordeaux INSERMNeurocentre MagendieBordeauxFrance Euron.tra S.L.Calle Johan.es Kepler MálagaSpain Departamen.o de Bioquímica y Biología Molecular Facultad de MedicinaUniversidad de MálagaMálagaSpain

Alzheimer’s disease is a n.urodegen.rative disorder characterized by the amyloid accumulation.in.the brain. of patien.s with Alzheimer’s *** pathogen.sis of Alzheimer’s disease is main.y mediated by the phosphorylation.an. aggregation.of tau *** the multiple causes of tau hyperphosphorylation.brain.in.ulin.resistan.e has gen.rated much atten.ion.an. in.sitols as in.ulin.sen.itizers,are curren.ly con.idered can.idates for drug *** presen. n.rrative review revises the in.eraction. between.these three elemen.s:Alzheimer’s disease-tau-in.sitols,which can.even.ually iden.ify targets for n.w disease modifiers capable of brin.in. hope to the million. of people affected by this devastatin. disease.

关键词： Alzheimer’s disease cyclin.depen.en. kin.se 5 diabetes D-Pin.tol in.sitols in.ulin.resistan.e kin.ses phosphorylation PI3K/Akt tau

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Does the provision.of live black soldier fly an. yellow mealworm larvae improve Muscovy duck welfare?

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Journ.l of An.mal Scien.e an. Biotechn.logy 2024年第1期15卷 442-455页

作者： Marta Gariglio Sihem Dabbou Man.ela Ren.a Ilaria Biasato Sara Bellezza Oddon.Marco Men.guz Raul Dan.el Miazzo Stefan.a Bergagn. elena Colombin. Elisabetta Macchi Achille Schiavon. Departmen. of Veterin.ry Scien.es University of TurinLargo Paolo Braccini 2GrugliascoTorino(TO)10095Italy Cen.er Agriculture Food En.iron.en.(C3A) University of TrentoVia Edmund Mach 1San Michele All’AdigeTrento(TN)38098Italy Departmen. of Agricultural Forest and Food SciencesUniversity of TurinLargo Paolo Braccini 2GrugliascoTorino(TO)10095Italy BEF Biosystems s.r.l Via Tancredi Canonico 18/CTorino(TO)10156Italy Un.dad de In.estigacion.Aviar Produccion AvicolaFac.Agr.y Vet.Universidad Nacional de Rio CuartoCordobaArgentina Veterin.ry Medical Research In.titute for Piemon.e Liguria and Valle d’AostaVia Bologna 148Torino(TO)10154Italy

Backgroun. The provision.of en.iron.en.al en.ichmen.s to Muscovy ducks could reduce the expression.of the aggressive *** aim of the presen. study was to evaluate the effects of black soldier fly(BSF)an. yellow mealworm(YM)live larva provision.on.Muscovy duck performan.e,excreta corticosteron. metabolites(ECM),behavior,an. blood *** A total of 1263-day-old female Muscovy ducklin.s were allotted to 18 pen.(6 replicates/treatmen.,7 birds/pen.an. assign.d to 3 experimen.al treatmen.s:a con.rol group fed commercial feed,an. two experimen.al treatmen.s fed commercial feed plus the 5%(based on.the expected daily feed in.ake,as fed basis)of BSF an. YM live larvae(BSF an. YM groups,respectively).A two-phase feedin. program was applied:starter(from 3 to 31 days of age)an. grower-fin.sher(from 32 to 55 days of age).The live weight,average daily gain.average daily feed in.ake,an. feed con.ersion.ratio were *** con.umption.times were collected,an. video recordin.s were performed durin. 3 periods(P)each day:the hour before(P1),durin.(P2),an. after(P3)the larva *** were evaluated at 3,31,an. ***,the total red an. white blood cell coun.s,serum protein.,lipids,an. liver an. ren.l fun.tion.serum en.ymes were evaluated on.12 birds/*** The experimen.al treatmen. did n.t affect the growth performan.e of the birds(P>0.05).Larva con.umption.times were always similar between.the two in.ect species,except at 14–18 days of age,were BSF larvae were con.umed faster than.YM larvae(Pn. activity durin. P2,an. preen.n. behavior in.reased in.YM birds durin. *** C birds in.reased the attack behavior over the weeks(Pn. weeks 1–3 the YM group reduced the attack frequen.y(P1>P3;Pn.lly,the provision.of live BSF an. YM larvae sign.fican.ly reduced the ECM at 55 days of age an. the heterophil to lymphocyte ratio(Pn.lusion. Live BSF an. YM larva supplemen.atio

关键词： Behavior Cairin. moschata En.iron.en.al en.ichmen. Hermetia illucen. Poultry Ten.brio molitor Welfare

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