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Efficacy of neoadjuvant therapy and surgical rescue for locally advanced hepatoblastomas:10 year single-center experience and literature review

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World Journal of Gastroenterology 2014年第29期20卷 10137-10143页

作者： Dolores Ayllon Teran Oscar Gómez Beltran Rubén Ciria Bru elena mateos gonzález María José Pea Rosa Antonio Luque Molina Pedro López Cillero Javier Briceo Delgado Department of Surgery Reina Sofia Hospital Department of Pediatric Surgery Reina Sofia Hospital Department of Pediatric Oncology Reina Sofia Hospital

AIM: To report our experience with long-term outcomes after multimodal management therapy.

关键词： Liver tumors Chemotherapy Liver surgery Multimodal management

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Albumin-bound paclitaxel as new treatment for metastatic cholangiocarcinoma: A case report

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World Journal of Clinical Oncology 2020年第10期11卷 844-853页

作者： Roberto Martin Huertas Raquel Fuentes-mateos Juan Jose Serrano Domingo elena Corral de la Fuente Mercedes Rodríguez-Garrote Medical Oncology Department Hospital Universitario Ramon y CajalMadrid 28034Spain

BACKGROUND Cholangiocarcinomas are rare and very aggressive *** patients have advanced-stage or unresectable disease at presentation,and the systemic therapies have limited ***-bound paclitaxel(nab-paclitaxel)is a solvent-free taxane that has been approved for the treatment of some cancers such as breast,non-small cell lung and pancreatic cancer,however it has not been applied to treat *** have both preclinical and clinical evidence of the efficacy of nab-paclitaxel in cholangiocarcinoma,yet no phase 3 trials have been *** SUMMARY A 63-year-old man was diagnosed in December 2016 with stage III B intrahepatic *** was performed,followed by adjuvant chemotherapy treatment with capecitabine and gemcitabine;although,the gemcitabine was suspended due to allergic reaction after two *** April 2019,metastatic cholangiocarcinoma relapse was diagnosed,and a first-line treatment with FOLFOX scheme was *** cycles were administered,producing an initial clinical improvement and decrease in blood tumor marker *** and serological progression was noted in September *** a second-line treatment,FOLFIRI was not recommended due to risk of worsening the patient’s tumor-related diarrhea.A combination therapy with gemcitabine was not feasible,as the patient had previously suffered from an allergic reaction to this *** decided to use nab-paclitaxel as a second-line treatment,and four cycles were *** clinical and serological responses were observed,and a radiological mixed response was also *** Advanced cholangiocarcinoma could be treated with nab-paclitaxel monotherapy,which should be studied in combination with other types of treatment(chemotherapy,fibroblast growth factor receptor inhibitors).

关键词： Cholangiocarcinoma Chemotherapy Albumin-bound paclitaxel Case report Metastatic Clinical trial

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Production of Volatile Moth Sex Pheromones in Transgenic Nicotiana benthamiana Plants

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BioDesign Research 2021年第1期2021卷 79-95页

作者： Rubén mateos-Fernández elena Moreno-Giménez Silvia Gianoglio Alfredo Quijano-Rubio Jose Gavaldá-García Lucía Estellés Alba Rubert JoséLuis Rambla Marta Vazquez-Vilar Estefanía Huet Asunción Fernández-del-Carmen Ana Espinosa-Ruiz Mojca Juteršek Sandra Vacas Ismael Navarro Vicente Navarro-Llopis Jaime Primo Diego Orzáez Institute for Plant Molecular and Cell Biology(IBMCP) Consejo Superior de Investigaciones Científicas(CSIC)-Universidad Politécnica de Valencia(UPV)ValenciaSpain Jaume I University Castellon de la PlanaSpain Department of Biotechnology and Systems Biology National Institute of BiologyLjubljanaSlovenia Jožef Stefan International Postgraduate School LjubljanaSlovenia Centro de Ecología Química Agrícola Instituto Agroforestal del MediterráneoUniversitat Politècnica de ValènciaValenciaSpain Ecología Y Protección Agrícola SL ValenciaSpain

Plant-based bioproduction of insect sex pheromones has been proposed as an innovative strategy to increase the sustainability of pest control in ***,we describe the engineering of transgenic plants producing(Z)-11-hexadecenol(Z11-16OH)and(Z)-11-hexadecenyl acetate(Z11-16OAc),two main volatile components in many Lepidoptera sex pheromone *** assembled multigene DNA constructs encoding the pheromone biosynthetic pathway and stably transformed them into Nicotiana benthamiana *** constructs contained the Amyelois transitella AtrΔ11 desaturase gene,the Helicoverpa armigera fatty acyl reductase HarFAR gene,and the Euonymus alatus diacylglycerol acetyltransferase EaDAct gene in different *** the pheromone-producing plants showed dwarf phenotypes,the severity of which correlated with pheromone *** but one of the recovered lines produced high levels of Z11-16OH,but very low levels of Z11-16OAc,probably as a result of recurrent truncations at the level of the EaDAct *** one plant line(SxPv1.2)was recovered that harboured an intact pheromone pathway and which produced moderate levels of Z11-16OAc(11.8μg g^(-1) FW)and high levels of Z11-16OH(111.4μg g^(-1)).Z11-16OAc production was accompanied in SxPv1.2 by a partial recovery of the dwarf ***1.2 was used to estimate the rates of volatile pheromone release,which resulted in 8.48 ng g-1 FW per day for Z11-16OH and 9.44 ng g^(-1 )FW per day for *** results suggest that pheromone release acts as a limiting factor in pheromone biodispenser strategies and establish a roadmap for biotechnological improvements.

关键词： release dwarf transformed

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