检索结果-南通市图书馆

Plant cell wall-mediated disease resistance:Current understanding and future perspectives

Molecular Plant 2024年第5期17卷 699-724页

作者： Antonio Molina Lucıa Jorda Miguel Angel Torres Marina Martın-Dacal Diego Jose Berlanga Patricia Fernandez-Calvo elena gomez-rubio Sonsoles Martın-Santamarıa Centro de Biotecnología y Genómica de Plantas Universidad Politécnica de Madrid(UPM)-Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria(INIA/CSIC)Campus de Montegancedo UPMPozuelo de Alarcon(Madrid)Spain Departamento de Biotecnologıa-Biología Vegetal Escuela Técnica Superior de Ingenierıa AgronomicaAlimentarıa y de BiosistemasUPMMadridSpain Centro de Investigaciones Biologicas Margarita Salas Consejo Superior de Investigaciones Científicas(CSIC)Ramiro de Maeztu 928040 MadridSpain Misión Biológica de Galicia Consejo Superior de Investigaciones Científicas(CSIC)Campus de Montegancedo UPMPozuelo de Alarcón(Madrid)Spain

Beyond their function as structural barriers,plant cell walls are essential elements for the adaptation of plants to environmental *** walls are dynamic structures whose composition and integrity can be altered in response to environmental challenges and developmental *** wall changes are perceived by plant sensors/receptors to trigger adaptative responses during development and upon stress *** cell wall damage caused by pathogen infection,wounding,or other stresses leads to the release of wall molecules,such as carbohydrates(glycans),that function as damage-associated molecular patterns(DAMPs).DAMPs are perceived by the extracellular ectodomains(ECDs)of pattern recognition receptors(PRRs)to activate pattern-triggered immunity(PTI)and disease ***,glycans released from the walls and extracellular layers of microorganisms interacting with plants are recognized as microbe-associated molecular patterns(MAMPs)by specific ECD-PRRs triggering PTI *** number of oligosaccharides DAMPs/MAMPs identified that are perceived by plants has increased in recent ***,the structural mechanisms underlying glycan recognition by plant PRRs remain ***,this knowledge is mainly focused on receptors of the LysM-PRR family,which are involved in the perception of various molecules,such as chitooligosaccharides from fungi and lipo-chitooligosaccharides(i.e.,Nod/MYC factors from bacteria and mycorrhiza,respectively)that trigger differential physiological ***,additional families of plant PRRs have recently been implicated in oligosaccharide/polysaccharide *** include receptor kinases(RKs)with leucine-rich repeat and Malectin domains in their ECDs(LRR-MAL RKs),Catharanthus roseus RECEPTOR-LIKE KINASE 1-LIKE group(CrRLK1L)with Malectin-like domains in their ECDs,as well as wall-associated kinases,lectin-RKs,and *** characterization of structural basis of glycans recogniti

关键词： Arabidopsis thaliana cell wall damage-associated molecular patterns DAMPs disease resistance glycans oligosaccharides pattern-triggered immunity PTl pattern recognition receptor PRRs

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Calcium-sensitive protein MLC1 as a possible modulator of the astrocyte functional state

引用

Neural Regeneration Research 2025年第7期20卷 2008-2010页

作者： elena Ambrosini Angela Lanciotti Maria Stefania Brignone Department of Neuroscience Istituto Superiore di SanitàRomeItaly

Astrocytes,the main population of glial cells in the central nervous system(CNS),exert essential tasks for the control of brain tissue homeostasis,supporting neuron and other glial cell activity from the developmental stage to adult *** maintain the optimal functionality of the brain,astroglial cells are particularly committed to reacting to every change in tissue homeostatic conditions,from mild modifications of the physiological environment,a process called astrocyte activation,to the more severe alterations occurring in pathological situations causing astrocyte reactivity or reactive astrogliosis(Escartin et al.,2021).During these reactive states,astrocytes mount an active,progressive response encompassing morphological,molecular,and interactional remodeling,leading to the acquisition of new functions and the loss of others,whose intensity,duration,and reversibility are dependent on the nature of the stimulus and regulated in a context-specific manner.

关键词： alterations modulator maintain

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Beyond wrecking a wall:revisiting the concept of blood–brain barrier breakdown in ischemic stroke

引用

Neural Regeneration Research 2025年第7期20卷 1944-1956页

作者： Julia Castillo-González elena González-Rey Institute of Parasitology and Biomedicine Lopez-Neyra(IPBLN) CSICPT SaludGranadaSpain

The blood–brain barrier constitutes a dynamic and interactive boundary separating the central nervous system and the peripheral *** tightly modulates the ion transport and nutrient influx,while restricting the entry of harmful factors,and selectively limiting the migration of immune cells,thereby maintaining brain *** the well-established association between blood–brain barrier disruption and most neurodegenerative/neuroinflammatory diseases,much remains unknown about the factors influencing its physiology and the mechanisms underlying its ***,the role of blood–brain barrier breakdown in the translational failure underlying therapies for brain disorders is just starting to be *** review aims to revisit this concept of“blood–brain barrier breakdown,”delving into the most controversial aspects,prevalent challenges,and knowledge gaps concerning the lack of blood–brain barrier *** moving beyond the oversimplistic dichotomy of an“open”/“bad”or a“closed”/“good”barrier,our objective is to provide a more comprehensive insight into blood–brain barrier dynamics,to identify novel targets and/or therapeutic approaches aimed at mitigating blood–brain barrier ***,in this review,we advocate for considering the diverse time-and location-dependent alterations in the blood–brain barrier,which go beyond tight-junction disruption or brain endothelial cell breakdown,illustrated through the dynamics of ischemic stroke as a case *** this exploration,we seek to underscore the complexity of blood–brain barrier dysfunction and its implications for the pathogenesis and therapy of brain diseases.

关键词： blood–brain barrier disruption drug delivery ischemic stroke neuroinflammation tight-junctions

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Ozone risk assessment of common cypress(Cupressus sempervirens L.)clones and effects of Seiridium cardinale infection

引用

Journal of Environmental Sciences 2025年第5期151卷 441-453页

作者： Jacopo Manzini Yasutomo Hoshika Roberto Danti Barbara Baesso Moura elena Paoletti Gianni Della Rocca Institute of Research on Terrestrial Ecosystems(IRET) National Research Council of Italy(CNR)Via Madonna del Piano 10Sesto Fiorentino 50019Italy Department of agricultural foodenvironmental and forestry science and technology(DAGRI)University of FlorencePiazzale delle Cascine18Firenze 50144Italy Institute for Sustainable Plant Protection(IPSP) National Research Council of Italy(CNR)Via Madonna del Piano 10Sesto Fiorentino 50019Italy

Cupressus sempervirens is a relevant species in the Mediterranean for its cultural,economic and landscape *** species is threatened by Seiridium cardinale,the causal agent of the cypress canker disease(CCD).The effects of biotic stressors on O_(3)risk assessment are unknown and a comprehensive O_(3)risk assessment in *** is *** fill these gaps,two clones of ***,one resistant(Clone R)and one susceptible to CCD(Clone S),were subjected to three levels of O_(3)(Ambient Air-AA;1.5×AA;2.0×AA)for two consecutive years in an O_(3)-free-air controlled exposure facility and artificially inoculated with *** the exposure-(AOT40)and flux-based(PODy)indices were *** found that PODy performed better than AOT40 to assess O_(3)effects on biomass and the critical level for a 4%biomass loss was 2.51 mmol/m^(2)***,significant O_(3)dose-response relationships were not found for the inoculated cypresses because the combination of middle level O_(3)(1.5×AA)and inoculation stimulated a biomass growth in Clone S as hormetic ***,we found a different inter-clonal response to both stressors with a statistically significant reduction of total and belowground biomass following O_(3),and lower root biomass in Clone S than in Clone R following pathogen *** summary,Clone R was more resistant to O_(3),and inoculation altered O_(3)risk via an hormetic effect on *** results warrant further studies on how biotic stressors affect O_(3)responses and risk assessment.

关键词： Abiotic stress Air pollution Ozone risk assessment Plant pathology PODy Stomatal conductance model

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Context-dependent role of sirtuin 2 in inflammation

引用

Neural Regeneration Research 2025年第3期20卷 682-694页

作者： NoemíSola-Sevilla Maider Garmendia-Berges MCarmen Mera-Delgado elena Puerta Department of Pharmaceutical Sciences Division of PharmacologySchool of Pharmacy and NutritionUniversity of NavarraPamplonaSpain Navarra Institute for Health Research(IdiSNA) PamplonaSpain

Sirtuin 2 is a member of the sirtuin family nicotinamide adenine dinucleotide(NAD~+)-dependent deacetylases, known for its regulatory role in different processes, including inflammation. In this context, sirtuin 2 has been involved in the modulation of key inflammatory signaling pathways and transcription factors by deacetylating specific targets, such as nuclear factor κB and nucleotide-binding oligomerization domain-leucine-rich-repeat and pyrin domain-containing protein 3(NLRP3). However, whether sirtuin 2-mediated pathways induce a pro-or an anti-inflammatory response remains controversial. Sirtuin 2 has been implicated in promoting inflammation in conditions such as asthma and neurodegenerative diseases, suggesting that its inhibition in these conditions could be a potential therapeutic strategy. Conversely, arthritis and type 2 diabetes mellitus studies suggest that sirtuin 2 is essential at the peripheral level and, thus, its inhibition in these pathologies would not be recommended. Overall, the precise role of sirtuin 2 in inflammation appears to be context-dependent, and further investigation is needed to determine the specific molecular mechanisms and downstream targets through which sirtuin 2 influences inflammatory processes in various tissues and pathological conditions. The present review explores the involvement of sirtuin 2 in the inflammation associated with different pathologies to elucidate whether its pharmacological modulation could serve as an effective strategy for treating this prevalent symptom across various diseases.

关键词： interferon inflammation lipopolysaccharide neuroinflammation NLRP3 nuclear factorκB sirtuin 2

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Productive and metabolomic consequences of arginine supplementation in sows during different gestation periods in two different seasons

引用

Journal of Animal Science and Biotechnology 2025年第1期16卷 218-237页

作者： Sara Virdis Diana Luise Federico Correa Luca Laghi Norma Arrigoni Roxana elena Amarie Andrea Serra Giacomo Biagi Clara Negrini Francesco Palumbo Paolo Trevisi Department of Agricultural and Food Sciences University of BolognaViale G.Fanin 4440127 BolognaItaly Istituto Zooprofilattico Sperimentale Della Lombardia E Dell’Emilia Romagna(IZSLER)“Bruno Ubertini” Via Bianchi925124 BresciaItaly Department of Agriculture Food and EnvironmentUniversity of PisaVia del Borghetto 8056124 PisaItaly Department of Veterinary Medicine University of BolognaVia Tolara Di Sopra 5040064 Ozzano Dell’Emilia(BO)Italy.

Background The prolificacy of sows(litter size at birth)has markedly increased,leading to higher post-natal *** stress can exacerbate this *** plays an important role in several physiological pathways;its effect on gestating sows can depend on the period of *** study evaluated the effects of arginine supplementation on the productive performance and physiological status of sows during different gestation periods and seasons,using a multi-omics *** A total of 320 sows were divided into 4 groups over 2 seasons(warm/cold);a control group(CO)received a standard diet(including 16.5 g/d of arginine)and 3 other groups received the standard diet supplemented with 21.8 g/d of arginine(38.3 g/d of arginine)either during the first 35 d(Early35),the last 45 d(Late45)or through-out the entire gestation period(COM).The colostrum was analyzed for nutritional composition,immunoglobulins and metabolomic *** and feces were analyzed on d 35 and 106 for the metabolomic and microbial *** body weight and mortality were recorded at birth,d 6,d 26,and on d 14 *** Interactions between arginine and season were never *** Early35 group had a lower percent-age of stillborn(P<0.001),mummified(P=0.002)and low birthweight(LBW)piglets(P=0.02)than the CO *** Late45 group had a lower percentage of stillborn piglets(P=0.029)and a higher percentage of high birthweight piglets(HBW;P<0.001)than the CO *** COM group had a higher percentage of LBW(P=0.004)and crushed piglets(P<0.001)than the CO *** supplementation modifies the metabolome characterization of colos-trum,urine,and *** and nitric oxide pathways,as well as metabolites related to microbial activity,were influenced in all matrices.A slight trend in the beta diversity index was observed in the microbiome profile on d 35(P=0.064).Conclusions Arginine supplementation during early gestation reduced the percentage o

关键词： Colostrum Feces Microbiota Piglets’birth weight Stillborn Urine

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Data-driven drug repositioning using olfactory omics profiles:challenges and perspectives in neurodegeneration

引用

Neural Regeneration Research 2025年第7期20卷 1997-1998页

作者： Paz Cartas-Cejudo Adriana Cortés Mercedes Lachén-Montes elena Anaya-Cubero Joaquín Fernández-Irigoyen Enrique Santamaría Clinical Neuroproteomics Unit Proteomics PlatformNavarrabiomedHospitalario Universitario de Navarra(HUN)Universidad Pública de Navarra(UPNA)IdiSNANavarra Institute for Health ResearchPamplonaSpain

Data-driven drug repositioning using olfactory omics profiles-challenges and perspectives in neurodegeneration:Neurodegenerative diseases are characterized by progressive degeneration and loss of neuronal function in the central nervous *** diseases are often characterized as proteinopathies,which are disorders primarily driven by the aggregation or misfolding of specific amyloid proteins within cells,leading to their dysfunction and eventual *** the gain-of-function hypothesis related to the aggregation of these proteins,recently,an alternative hypothesis regarding the loss-of-function of the soluble monomeric proteins during the process of aggregation into amyloids is gaining *** last event is called proteinopenia and refers to conditions characterized by a deficiency or decrease in the levels of specific soluble proteins in the body(Ezzat et al.,2023).It has been demonstrated that levels of soluble proteins involved in neurodegenerative diseases are decreased.

关键词： diseases drug amyloid

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于自由空间传播的光子极限学习机设计与分析

引用

光学学报 2025年第03期 180-187页

作者：徐志宏 Schoenhardt Steffen 陈希顾敏 Goi elena 上海理工大学智能科技学院上海理工大学光子芯片研究院

极限学习机（ELM）是一种机器学习范式，在模型中，大多数连接通过随机初始化的非线性隐藏层建立，只有一小部分权重在下采样过程后的训练期间被调整。该模型的主要优点是显著减少了训练时间，用简单的岭回归取代了耗时的误差反向传播... 详细信息

极限学习机（ELM）是一种机器学习范式，在模型中，大多数连接通过随机初始化的非线性隐藏层建立，只有一小部分权重在下采样过程后的训练期间被调整。该模型的主要优点是显著减少了训练时间，用简单的岭回归取代了耗时的误差反向传播。但在电子ELM中，模型性能严重依赖于隐藏层中的节点数量，从而使用大量内存。因此，用光学平台代替电子计算是一种理想的解决方案。通过部署随机散射体，可以被动地实现大规模隐藏节点，同时具有非线性的可能性。虽然光学方案具有这种潜力，但关于光学ELM的研究尚未充分探索其在速度、非线性和并行性方面的能力。为了解决这个问题，搭建了ELM的光学框架（光学ELM），并研究了投影和成像光束路径中的变焦对光学ELM的作用。在实验过程中存在光学像差、误差及缺陷，在光学ELM的背景下将其充当为随机分量，对应了数字极限学习机中的随机传输矩阵。目标是设计一个易于部署的光学极限学习机，不需要对输入和输出数据进行复杂的处理，而是通过光域中的被动传播实现随机投影。该方法旨在简化系统架构，同时利用光学技术的优势实现高效并行计算。

关键词：光计算极限学习机光神经网络模拟计算神经形态光子学

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Small heat shock protein B8:from cell functions to its involvement in diseases and potential therapeutic applications

引用

Neural Regeneration Research 2025年第10期20卷 2872-2886页

作者： Marta Chierichetti Riccardo Cristofani Valeria Crippa Veronica Ferrari Marta Cozzi elena Casarotto Paola Pramaggiore Laura Cornaggia Guglielmo Patelli Ali Mohamed Margherita Piccolella Mariarita Galbiati Paola Rusmini Barbara Tedesco Angelo Poletti Laboratory of Experimental Biology Dipartimento di Scienze Farmacologiche e Biomolecolari“Rodolfo Paoletti”(DiSFeB)Universitàdegli Studi di MilanoMilanItaly

Heat shock protein family B(small)member 8(HSPB8)is a 22 kDa ubiquitously expressed protein belonging to the family of small heat shock ***8 is involved in various cellular mechanisms mainly related to proteotoxic stress response and in other processes such as inflammation,cell division,and ***8 binds misfolded clients to prevent their aggregation by assisting protein refolding or degradation through chaperone-assisted selective *** line with this function,the pro-degradative activity of HSPB8 has been found protective in several neurodegenerative and neuromuscular diseases characterized by protein misfolding and *** cancer,HSPB8 has a dual role being capable of exerting either a pro-or an anti-tumoral activity depending on the pathways and factors expressed by the model of cancer under ***,HSPB8 exerts a protective function in different diseases by modulating the inflammatory response,which characterizes not only neurodegenerative diseases,but also other chronic or acute conditions affecting the nervous system,such as multiple sclerosis and intracerebellar *** note,HSPB8 modulation may represent a therapeutic approach in other neurological conditions that develop as a secondary consequence of other *** is the case of cognitive impairment related to diabetes mellitus,in which HSPB8 exerts a protective activity by assuring mitochondrial *** review aims to summarize the diverse and multiple functions of HSPB8 in different pathological conditions,focusing on the beneficial effects of its ***-based and alternative therapeutic approaches targeting HSPB8 and its regulated pathways will be discussed,emphasizing how new strategies for cell and tissue-specific delivery represent an avenue to advance in disease treatments.

关键词： aggregation autophagy cancer chaperone chaperone-assisted selective autophagy cognitive impairment HSPB8 neuroinflammation neuromuscular diseases therapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

生长的力量莫斯科Choux服饰精品店

引用

室内设计与装修 2025年第3期 16-21页

作者： elena Lokastova

Choux服饰精品店位于莫斯科Bol'shoy Patriarshiy Pereulok街。它占据了所在建筑的2层空间，每层均采用不同的色彩与材质，却又能巧妙地统一在同一个主题之下。店铺一层中央是一个巨大的金色豆荚装置，它既是整个空间的视觉焦点，又兼...

Choux服饰精品店位于莫斯科Bol'shoy Patriarshiy Pereulok街。它占据了所在建筑的2层空间，每层均采用不同的色彩与材质，却又能巧妙地统一在同一个主题之下。店铺一层中央是一个巨大的金色豆荚装置，它既是整个空间的视觉焦点，又兼具实用功能。金色豆荚被嵌于地面与天花板之间，来往于街道的人们可以透过店铺玻璃清晰地看到它。这一独特的造型源于设计师对仿生美学的探索与研究。Choux在法语中有“卷心菜”之意，

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：