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Cardiovascular efficacy and safety of dipeptidyl peptidase-4 inhibitors:A meta-analysis of cardiovascular outcome trials

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World Journal of Cardiology 2021年第10期13卷 585-592页

作者： Dimitrios Ioannis Patoulias Aristi Boulmpou eleftherios Teperikidis Alexandra Katsimardou Fotios Siskos Michael Doumas Christodoulos E Papadopoulos Vassilios Vassilikos Second Propedeutic Department of Internal Medicine Aristotle University of ThessalonikiHippokration General HospitalThessaloniki 54642Greece Third Department of Cardiology Aristotle University of ThessalonikiHippokration General HospitalThessaloniki 54642Greece

BACKGROUND Dipeptidyl peptidase-4(DPP-4)inhibitors are a generally safe and well tolerated antidiabetic drug class with proven efficacy in type 2 diabetes mellitus(T2DM).Recently,a series of large,randomized controlled trials(RCTs)addressing cardiovascular outcomes with DPP-4 inhibitors have been *** To pool data from the aforementioned trials concerning the impact of DPP-4 inhibitors on surrogate cardiovascular efficacy outcomes and on major cardiac *** We searched PubMed and grey literature sources for all published RCTs assessing cardiovascular outcomes with DPP-4 inhibitors compared to placebo until October *** extracted data concerning the following“hard”efficacy outcomes:fatal and non-fatal myocardial infarction,fatal and non-fatal stroke,hospitalization for heart failure,hospitalization for unstable angina,hospitalization for coronary revascularization and cardiovascular *** also extracted data regarding the risk for major cardiac arrhythmias,such as atrial fibrillation,atrial flutter,ventricular fibrillation and ventricular *** We pooled data from 6 trials in a total of 52520 patients with T2DM assigned either to DPP-4 inhibitor or ***-4 inhibitors compared to placebo led to a non-significant increase in the risk for fatal and non-fatal myocardial infarction[risk ratio(RR)=1.02,95%CI:0.94-1.11,I2=0%],hospitalization for heart failure(RR=1.09,95%CI:0.92-1.29,I2=65%)and cardiovascular death(RR=1.02,95%CI:0.93-1.11,I2=0%).DPP-4 inhibitors resulted in a non-significant decrease in the risk for fatal and non-fatal stroke(RR=0.96,95%CI:0.85-1.08,I2=0%)and coronary revascularization(RR=0.99,95%CI:0.90-1.09,I2=0%),Finally,DPP-4 inhibitors demonstrated a neutral effect on the risk for hospitalization due to unstable angina(RR=1.00,95%CI:0.85-1.18,I2=0%).As far as cardiac arrhythmias are concerned,DPP-4 inhibitors did not significantly affect the risk for atrial fibrillation(RR=0.95,95%CI:0.78-1.17,I2=0%),whil

关键词： Dipeptidyl peptidase-4 inhibitors Cardiovascular outcomes Atrial fibrillation Atrial flutter Type 2 diabetes mellitus

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Use of Sunflower Cake in the Diet of ISA Brown Pullets

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Journal of Agricultural Science and Technology(A) 2017年第2期7卷 129-134页

作者： Anastasios Kargopoulos eleftherios Bonos Zoitsa Basdagianni Ioannis Nikolakakis Department of Agricultural Technology Division of Animal Production Technological Educational Institution of WesternMacedonia Florina 53100 Greece Research Institute of Animal Science~Hellenic Agricultural Organization-Dimiter Paralimni Giannitsa Pella 58100 Greece Faculty of Agriculture Forestry and Natural Environment School of Agriculture Aristotle University of ThessalonikiThessaloniki 54124 Greece

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Feasibility of Performing Sentinel Lymph Node Biopsy (SLNB) after Mastectomy: A Case Report

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Journal of Cancer Therapy 2010年第2期1卷 91-93页

作者： Hanadi Bu-Ali eleftherios P. Mamouna Aultman Cancer Center Canton OH and Akron General Medical Center Akron USA Aultman Cancer Center Canton OH and Northeastern Ohio Universities College of Medicine Rootstown USA

Introduction: Previous mastectomy remains a contraindication to SLNB as normal drainage patterns of the breast can be disturbed. Patients diagnosed with DCIS on core biopsy and later found to have microinvasive or invasive carci-noma at the time of mastectomy are deprived of the opportunity for SLNB and need to undergo axillary dissection. We explored the option and feasibility of performing SLNB in a 39-year-old female who underwent a simple mastectomy without axillary sampling for extensive DCIS and later found to have microinvasive ductal carcinoma on permanent pathology. Results: Lymphatic mapping using subdermal injection of 99mTc-labeled sulfur colloid and blue dye led to the identification of five SLNs. Histopathologic examination showed no metastasis. Conclusion: SNLB is feasible in this setting. However, before its use is routinely adopted, its feasibility and accuracy has to be demonstrated in larger num-bers of patients in whom a negative SLNB is followed by a completion axillary dissection.

关键词： Sentinel Lymph Node Biopsy Lymphatic Mapping Mastectomy Lymphoscintigraphy Axillary Lymph Node Dissection

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Dementia and osteoporosis in a geriatric population: Is there a common link?

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World Journal of Orthopedics 2017年第5期8卷 412-423页

作者： Candice L Downey Adam Young Emily F Burton Simon M Graham Robert J Macfarlane Eva-Maria Tsapakis eleftherios Tsiridis University of Leeds School of Medicine Department of Anaesthetics Pinderfields Hospital Department of Trauma and Orthopaedics the Royal Liverpool University Hospital Academic Department of Orthopaedics and Trauma Aristotle University Medical School

AIM To determine the existence of a common pathological link between dementia and osteoporosis through reviewing the current evidence base. METHODS This paper reviews the current literature on osteoporosis and dementia in order to ascertain evidence of a common predisposing aetiology. A literature search of Ovid MEDLINE(1950 to June 2016) was conducted. The keywords "osteoporosis", "osteoporotic fracture", "dementia" and "Alzheimer's disease"(AD) were used to determine the theoretical links with the most significant evidence base behind them. The key links were found to be vitamins D and K, calcium, thyroid disease, statins, alcohol and sex steroids. These subjects were then searched in combination with the previous terms and the resulting papers manually examined. Theoretical, in vitro and in vivo research were all used to inform this review which focuses on the most well developed theoretical common causes for dementia(predominantly Alzheimer's type) and *** Dementia and osteoporosis are multifaceted disease processes with similar epidemiology and a marked increase in prevalence in elderly populations. The existence of a common link between the two has been suggested despite a lack of clear pathological overlap in our current understanding. Research to date has tended to be fragmented and relatively weak in nature with multiple confounding factors reflecting the difficulties of in vivo experimentation in the population of interest. Despite exploration of various possible mechanisms in search for a link between the two pathologies, this paper found that it is possible that these associations are coincidental due to the nature of the evidence available. One finding in this review is that prior investigation into common aetiologies has found raised amyloid beta peptide levels in osteoporotic bone tissue, with a hypothesis that amyloid beta disorders are systemic disorders resulting in differing tissue manifestations. However, our findings were that t

关键词： Osteoporosis Fracture Dementia Thyroid disease Alzheimer’s disease Elderly Vitamin D Vitamin K Calcium Statins Alcohol Sex steroids

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Endothelial progenitor cells mobilization after maximal exercise according to heart failure severity

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World Journal of Cardiology 2020年第11期12卷 526-539页

作者： Christos Kourek eleftherios Karatzanos Katherina Psarra Georgios Georgiopoulos Dimitrios Delis Vasiliki Linardatou Gerasimos Gavrielatos Costas Papadopoulos Serafim Nanas Stavros Dimopoulos Department of Clinical Ergospirometry Exercise&Rehabilitation LaboratoryEvaggelismos HospitalAthens 10676Greece Immunology and Histocompatibility Department Evaggelismos HospitalAthens 10676Greece Department of Clinical Therapeutics Alexandra HospitalAthens 11528Greece Department of Cardiology Tzaneio General Hospital of PiraeusPiraeus 18536Greece 2nd Cardiology Department Korgialenio-Benakio Red Cross HospitalAthens 11526Greece Cardiac Surgery Intensive Care Unit Onassis Cardiac Surgery CenterAthens 17674Greece

BACKGROUND Vascular endothelial dysfunction is an underlying pathophysiological feature of chronic heart failure(CHF).Patients with CHF are characterized by impaired vasodilation and inflammation of the vascular *** also have low levels of endothelial progenitor cells(EPCs).EPCs are bone marrow derived cells involved in endothelium regeneration,homeostasis,and *** has been shown to improve vasodilation and stimulate the mobilization of EPCs in healthy people and patients with cardiovascular ***,the effects of exercise on EPCs in different stages of CHF remain under *** To evaluate the effect of a symptom-limited maximal cardiopulmonary exercise testing(CPET)on EPCs in CHF patients of different *** Forty-nine consecutive patients(41 males)with stable CHF[mean age(years):56±10,ejection fraction(EF,%):32±8,peak oxygen uptake(VO2,mL/kg/min):18.1±4.4]underwent a CPET on a cycle *** blood was sampled before and after *** circulating endothelial populations were quantified by flow cytometry:Three subgroups of EPCs[CD34+/CD45-/CD133+,CD34+/CD45-/CD133+/VEGFR2 and CD34+/CD133+/vascular endothelial growth factor receptor 2(VEGFR2)]and two subgroups of circulating endothelial cells(CD34+/CD45-/CD133-and CD34+/CD45-/CD133-/VEGFR2).Patients were divided in two groups of severity according to the median value of peak VO2(18.0 mL/kg/min),predicted peak VO2(65.5%),ventilation/carbon dioxide output slope(32.5)and EF(reduced and mid-ranged EF).EPCs values are expressed as median(25th-75th percentiles)in cells/106 enucleated *** Patients with lower peak VO2 increased the mobilization of CD34+/CD45-/CD133+[pre CPET:60(25-76)vs post CPET:90(70-103)cells/106 enucleated cells,P<0.001],CD34+/CD45-/CD133+/VEGFR2[pre CPET:1(1-4)vs post CPET:5(3-8)cells/106 enucleated cells,P<0.001],CD34+/CD45-/CD133-[pre CPET:186(141-361)vs post CPET:488(247-658)cells/106 enucleated cells,P<0.001]an

关键词： Chronic heart failure Endothelial progenitor cells Circulating endothelial cells Maximal exercise Cardiopulmonary exercise testing Severity

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护卫舰横摇稳定舵的H∞/H2控制器的设计和比较（英文）

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Journal of Marine Science and Application 2019年第4期18卷 492-509页

作者： Lijun Wang Nikolaos I.Xiros eleftherios K.Loghis School of Navigation Guangdong Ocean UniversityZhanjiang 524088China School of Naval Architecture and Marine Engineering University of New OrleansNew OrleansLA 70148USA School of Electrical and Computer Engineering National Technical University of Athens15780 ZografouGreece

Roll motion of ships can be distinguished in two parts:an unavoidable part due to their natural movement while turning and an unwanted and avoidable part that is due to encounter with waves and rough seas in *** the attenuation of the unwanted part of roll motion,ways have been developed such as addition of controllable fins and changes in *** paper investigates the effectiveness of augmenting the rudder used for rejecting part of the unwanted roll,while maintaining steering and course changing *** this purpose,a controller is designed,which acts through intentional superposition of fast,compared with course change,movements of rudder,in order to attenuate the high-frequency roll effects from encountering rough *** results obtained by simulation to exogenous disturbance support the conclusion that the roll stabilization for displacement can be effective at least when displacement hull vessels are ***,robust stability and performance is verified for the proposed control scheme over the entire operating range of interest.

关键词： Rudder roll stabilization H∞/H2 Controllers Frigate

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Role of probiotics,prebiotics and synbiotics in chemoprevention for colorectal cancer

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World Journal of Gastroenterology 2008年第42期14卷 6453-6457页

作者： Constantine Iosif Fotiadis Christos Nikolaou Stoidis Basileios Georgiou Spyropoulos eleftherios Dimitriou Zografos 3rd Surgical Clinic of the university hospital 'ATTIKON' Athens Greece

Colorectal cancer is the third most common form of *** treatments are all associated with a high risk of complications and a low success ***,synbiotics have been proposed as a new preventive and therapeutic *** is no direct experimental evidence for cancer suppression in humans as a result of the consumption of pro-,pre-or ***,there is a wealth of evidence emerging from laboratory *** mechanisms by which pro-,pre-and synbiotics may inhibit colon cancer are now beginning to be understood and will be addressed in the present review.

关键词：生命起源前生命期结肠直肠癌治疗方法

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From diagnosis to treatment of hepatocellular carcinoma: An epidemic problem for both developed and developing world

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World Journal of Gastroenterology 2017年第29期23卷 5282-5294页

作者： Dimitrios Dimitroulis Christos Damaskos Serena Valsami Spyridon Davakis Nikolaos Garmpis eleftherios Spartalis Antonios Athanasiou Demetrios Moris Stratigoula Sakellariou Stylianos Kykalos Gerasimos Tsourouflis Anna Garmpi Ioanna Delladetsima Konstantinos Kontzoglou Gregory Kouraklis Second Department of Propedeutic Surgery Laiko General Hospital Medical School National and Kapodistrian University of Athens Blood Transfusion Department Aretaieion Hospital Medical School National and Kapodistrian Athens University First Department of Surgery Laiko General Hospital Medical School National and Kapodistrian University of Athens N.S. Christeas Laboratory of Experimental Surgery and Surgical Research Medical School National and Kapodistrian University of Athens Department of Surgery Mercy University Hospital Lerner Research Institute Cleveland Clinic Foundation First Department of Pathology Medical School National and Kapodistrian University of Athens Internal Medicine Department Laiko General Hospital University of Athens Medical School

Hepatocellular carcinoma(HCC) is the most frequent primary liver malignancy and the third cause of cancer-related death in the Western Countries. The well-established causes of HCC are chronic liver infections such as hepatitis B virus or chronic hepatitis C virus, nonalcoholic fatty liver disease, consumption of aflatoxins and tobacco smocking. Clinical presentation varies widely; patients can be asymptomatic while symptomatology extends from right upper abdominal quadrant paint and weight loss to obstructive jaundice and lethargy. Imaging is the first key and one of the most important aspects at all stages of diagnosis, therapy and follow-up of patients with HCC. The Barcelona Clinic Liver Cancer Staging System remains the most widely classification system used for HCC management guidelines. Up until now, HCC remains a challenge to early diagnose, and treat effectively; treating management is focused on hepatic resection, orthotopic liver transplantation, ablative therapies, chemoembolization and systemic therapies with cytotocix drugs, and targeted agents. This review article describes the current evidence on epidemiology, symptomatology, diagnosis and treatment of hepatocellular carcinoma.

关键词： Hepatocellular 癌症传染病学治疗诊断阶段移植

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Overview of coronary artery variants, aberrations and anomalies

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World Journal of Cardiology 2018年第10期10卷 127-140页

作者： Stylianos Kastellanos Konstantinos Aznaouridis Charalambos Vlachopoulos eleftherios Tsiamis Evangelos Oikonomou Dimitris Tousoulis Cardiology Department Castle Hill HospitalHull and East Yorkshire NHS Trust Peripheral Vessels Unit and EKKAN (Unit for the athletes and for hereditary cardiovascular diseases) 1st Department of CardiologyHippokration HospitalMedical School of National and Kapodistrian University of Athens

Coronary artery anomalies and variants are relatively uncommon congenital disorders of the coronary artery anatomy and constitute the second most common cause of sudden cardiac death in young competitive athletes. The rapid advancement of imaging techniques, including computed tomography, magnetic resonance imaging, intravascular ultrasound and optical coherence tomography, have provided us with a wealth of new information on the subject. Anomalous origin of a coronary artery from the contralateral sinus is the anomaly most frequently associated with sudden cardiac death, in particular if the anomalous coronary artery has a course between the aorta and the pulmonary artery. However, other coronary anomalies, like anomalous origin of the left coronary artery from the pulmonary artery, atresia of the left main stem and coronary fistulae, have also been implicated in cases of sudden cardiac death. Patients are usually asymptomatic, and in most of the cases, coronary anomalies are discovered incidentally during coronary angiography or on autopsy following sudden cardiac death. However, in some cases, symptoms like angina, syncope, heart failure and myocardial infarction may occur. The aims of this article are to present a brief overview of the diverse coronary variants and anomalies, focusing especially on anatomical features, clinical manifestations, risk of sudden cardiac death and pathophysiologic mechanism of symptoms, as well as to provide valuable information regarding diagnostic workup, follow-up, therapeutic choices and timing of surgical treatment.

关键词： Ectopic coronary arteries Coronary artery anomalies Coronary fistulae Coronary artery variants Myocardial bridging Coronary artery anatomy Sudden cardiac death

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Statin escape phenomenon: Fact or fiction?

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World Journal of Experimental Medicine 2017年第1期7卷 25-30页

作者： Fotios Barkas Moses Elisaf eleftherios Klouras Theodora Dimitriou Nikolaos Tentolouris Evangelos Liberopoulos Department of Internal Medicine School of MedicineUniversity of Ioannina First Department of Propaedeutic and Internal Medicine Medical SchoolNational and Kapodistrian University of AthensLaiko General Hospital

AIM To evaluate the presence of the so called "statin escape" phenomenon among hyperlipidemic subjects attending a lipid clinic. METHODS This was a retrospective analysis of 1240 hyperlipidemic individuals followed-up for ≥ 3 years. We excluded those individuals meeting one of the following criteria: Use of statin therapy at baseline visit, discontinuation of statin treatment at most recent visit, change in statin treatment during follow-up and poor compliance to treatment. Statin escape phenomenon was defined as an increase in lowdensity lipoprotein cholesterol(LDL-C) levels at the most recent visit by > 10% compared with the value at 6 mo following initiation of statin treatment. RESULTS Of 181 eligible subjects, 31% exhibited the statin escape phenomenon. No major differences regarding baseline characteristics were found between statin escapers and non-statin escapers. Both escapes and non-escapes had similar baseline LDL-C levels [174(152-189) and 177(152-205) mg/d L, respectively]. In comparison with nonescapers, statin escapers demonstrated lower LDL-C levels at 6 mo after treatment initiation [88(78-97) mg/d L vs 109(91-129) mg/d L, P < 0.05], but higher levels at the most recent visit [103(96-118) mg/d L vs 94(79-114) mg/d L, P < 0.05]. CONCLUSION These data confirm the existence of an escape phenomenon among statin-treated individuals. The clinical significance of this phenomenon remains uncertain.

关键词： Statin Escape Cholesterol

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