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Cell adhesion in renal tubular epithelial cells:Biochemistry,biophysics or both

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BIOCELL 2022年第4期46卷 937-940页

作者： CLAIRE ELIZABETH HILLS eleftherios SIAMANTOURAS PAUL EDWARD SQUIRES Diabetes Metabolism&Inflammation GroupSchool of Life SciencesJoseph Banks LaboratoriesUniversity of LincolnLincolnLN67DLUK

Changes in cell-cell and cell-substrate adhesion markers are increasingly used to characterize disease onset and ***,these relationships depend on both the biochemical and molecular association between cells and between cells and their extracellular matrix,as well as the biophysical and mechanical properties orchestrated by cytoskeletal,membrane and matrix *** fully appreciate the role of cell adhesion when determining normal physiology and the impact of disease on cellular function,it is important to consider both biochemical and biophysical attributes of the system being *** this short viewpoint we reflect on our experiences assessing cell-cell and/or cell-matrix interactions in renal tubular epithelial cells.

关键词： Cell-adhesion Cadherin Cytoskeleton AFM Kidney Epithelium

Billroth II anastomosis combined with brown anastomosis reduce reflux gastritis in gastric cancer patients

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World Journal of Methodology 2024年第1期14卷 71-79页

作者： Grigorios Christodoulidis Marina Nektaria Kouliou Konstantinos eleftherios Koumarelas Konstantinos Argyriou Garyfallia Apostolia Karali Konstantinos Tepetes Department of General Surgery University Hospital of LarissaLarissa 41110Greece Department of Gastroenterology University Hospital of LarissaLarissa 41334Greece

BACKGROUND The surgeon performing a distal gastrectomy,has an arsenal of reconstruction techniques at his disposal,Billroth II among *** anastomosis performed during a Billroth II procedure has shown evidence of superiority over typical Billroth II,in terms of survival,with no impact on postoperative morbidity and *** To compare Billroth II vs Billroth II and Braun following distal gastrectomy,regarding their postoperative *** Patients who underwent distal gastrectomy during 2002-2021,were separated into two groups,depending on the surgical technique used(Billroth II:74 patients and Billroth II and Braun:28 patients).The daily output of the nasogastric tube(NGT),the postoperative day that NGT was removed and the day the patient started per os feeding were *** complications were at the same time *** were then statistically *** There was difference in the mean NGT removal day and the mean start feeding *** total postoperative NGT output was lower in Braun group(399.17 mL vs 1102.78 mL)and it was statistically significant(P<0.0001).Mean daily postoperative NGT output was also statistically significantly lower in Braun *** to the postoperative follow up 40 patient experienced bile reflux and alkaline gastritis from the Billroth II group,while 9 patients who underwent Christodoulidis G et *** II and Braun compared with Billroth II WJM https://*** 2 March 20,2024 Volume 14 Issue 1 Billroth II and Braun anastomosis were presented with the same conditions(P<0.05).CONCLUSION There was evidence of superiority of Billroth II and Braun vs typical Billroth II in terms of bile reflux,alkaline gastritis and NGT output.

关键词： Billroth II Billroth II and Braun Reconstruction techniques Gastrectomy Distal gastrectomy

Robotic-assisted microsurgery in andrology: a systematic review

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Asian Journal of Andrology 2023年第4期25卷 454-461页

作者： Konstantinos Douroumis eleftherios Spartalis Konstantinos Stravodimos Panagiotis K Levis Gerasimos Tsourouflis Dimitrios Dimitroulis Nikolaos I Nikiteas Hellenic Minimally Invasive and Robotic Surgery(MIRS)Study Group National and Kapodistrian University of AthensMedical SchoolAgiou Thoma 15bGoudiAthens 11527Greece First Department of Urology National and Kapodistrian University of AthensMedical SchoolAgiou Thoma 17GoudiAthens 11527Greece Second Department of Propaedeutic Surgery National and Kapodistrian University of AthensMedical SchoolAgiou Thoma 17GoudiAthens 11527Greece

Robot-assisted surgery is the gold standard of treatment in many fields of urology. In this systematic review, we aim to reportits usage in andrology and to evaluate any advantages. A systematic search of the PubMed and Cochrane Library databases wasconducted to identify articles referring to robotic-assisted microsurgery in andrology. The search strategy was in line with thePreferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and the Cochrane Handbook. Thearticles were then reviewed by two authors. A qualitative analysis of the articles that met the inclusion criteria was ***-one articles that met the inclusion criteria were reviewed. The first results for robot-assisted vasovasostomy (RAVV) areencouraging as excellent patency rates, short operative times, and learning curves were achieved. Interestingly, patency rates weregreater in some case series for RAVV than for microsurgical vasovasostomy, with a statistically significant difference. In addition,robot has been shown to be of great use in bypassing fibrotic changes in cases of iatrogenic vasal injuries, difficulties encounteredwith traditional microsurgery. In addition, the feasibility of robot-assisted microsurgery has been proven for varicocelectomy andmicrosurgical denervation of the spermatic cord, with acceptable improvement in sperm parameters and pain, respectively. Thecurrent evidence suggests that there are potential advantages of the use of robots in andrology. However, for robotic surgery tobecome incorporated into the daily use of the andrologists, large, multicenter randomized trials are needed. As robotics systemsare becoming standard in urology practice, it is reasonable for one to believe that they will also find their place in andrology.

关键词： andrology male infertility robotic surgical procedures varicocele vasovasostomy

A systematic review of reading tests

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International Journal of Ophthalmology(English edition) 2023年第1期16卷 121-127页

作者： Panagiota Ntonti Christina Mitsi eleftherios Chatzimichael Eirini-Kanella Panagiotopoulou Minas Bakirtzis Aristeidis Konstantinidis Georgios Labiris Ophthalmology Department University Hospital of AlexandroupolisDragana 68100AlexandroupolisGreece

Adequate near and intermediate visual capacity is important in performing everyday tasks,especially after the introduction of smartphones and computers in our professional and recreational *** objective of this study was to review all available reading tests both conventional and digital and explore their integrated characteristics.A systematic review of the recent literature regarding reading charts was performed based on the PubM ed,Google Scholar,and Springer databases between February and March *** from 11 descriptive and 24 comparative studies were included in the present systematic *** settings are still dominated by conventional printed reading charts;however,the most prevalent of them(i.e.,Jaeger type charts)are not *** reading capacity assessment is done only by those that comply with the International Council of Ophthalmology(ICO)*** reading tests are gaining popularity both in clinical and research settings and are differentiated in standard computer-based applications that require installation either in a computer or a tablet(e.g.,Advanced VISION Test and web-based ones e.g.,Democritus Digital Acuity Reading Test requires no installation).It is evident that validated digital tests will prevail in future clinical or research settings and it is upon ophthalmologists to select the one most compatible with their examination routine.

关键词： digital reading chart paper reading chart presbyopia low vision chart reading acuity

Comparison of cosmetic outcomes between remote-access and conventional thyroidectomy:A review of the current literature

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2023年第1期9卷 1-8页

作者： Anna Kasouli eleftherios Spartalis Alexios Giannakodimos Gerasimos Tsourouflis Dimitrios Dimitroulis Nikolaos I.Nikiteas Hellenic Minimally Invasive and Robotic Surgery(MIRS)Study Group Medical School AthensNational and Kapodistrian University of AthensAthensGreece 2nd Department of Propaedeutic Surgery Medical SchoolNational and Kapodistrian University of AthensAthensGreece

Objective:The pursuit of an esthetically pleasing scar following open thyroid surgery has led to the development of endoscopic thyroidectomy through remote incisions placed in several locations outside the *** objective of this study is to review the recent literature and compare the incision site appearance and patient satisfaction with the cosmetic outcome after extracervical and conventional ***:The English literature published since 2010 was searched through the PubMed/Medline database for studies comparing the cosmetic outcomes between remote-access endoscopic and conventional thyroidectomy using a form of scar assessment ***:A total of 9 relevant papers fulfilled the eligibility criteria including 1486 *** them,595 patients underwent endoscopic thyroidectomy through several remote-access approaches and 891 patients were assigned to the conventional *** one randomized-controlled trial was identified,whereas among the rest,four were prospective and four were retrospective nonrandomized *** the extracervical modifications performed in the endoscopic groups,the axillary approach was performed in three studies and the breast approach in four studies,while the retroauricular facelift technique and the transoral vestibular method were applied in one study,***:Evaluation of the wound appearance and patient satisfaction with the cosmetic outcome at various time points during the follow-up highlighted the superiority of the extracervical approaches over the conventional *** these findings,remote-access techniques could possibly be the ideal surgical method for patients with high esthetic requirements,providing an excellent appearance of the thoroughly exposed neck.

关键词： esthetic cosmesis cosmetic cosmetic results incision scar thyroidectomy

Growth performance,welfare traits and meat characteristics of broilers fed diets partly replaced with whole Tenebrio molitor larvae

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Animal Nutrition 2023年第2期13卷 90-100页

作者： Stylianos Vasilopoulos Ilias Giannenas Soumela Savvidou eleftherios Bonos Christos I.Rumbos Elias Papadopoulos Paschalis Fortomaris Christos G.Athanassiou Laboratory of Nutrition Faculty of Veterinary MedicineAristotle University of Thessaloniki54124 ThessalonikiGreece Institute of Animal Science Hellenic Agricultural Organisation-DEMETERParalimni Giannitsa58100Greece Laboratory of Animal Science Nutrition and BiotechnologyDepartment of AgricultureSchool of AgricultureUniversity of IoanninaKostakioi Artas47100ArtaGreece Laboratory of Entomology and Agricultural Zoology Department of AgricultureCrop Production and Rural EnvironmentUniversity of ThessalyPhytokou str.38446N.IoniaVolosGreece Laboratory of Parasitology and Parasitic Diseases Faculty of Veterinary MedicineAristotle University of Thessaloniki54124ThessalonikiGreece Laboratory of Animal Husbandry Faculty of Veterinary MedicineAristotle University of Thessaloniki54124ThessalonikiGreece

The role of insects in animal nutrition has been reconsidered during recent years,paving the way for an increasing market for edible *** protein and amino acid balance make them a promising source of protein for replacing high value *** mealworm,Tenebrio molitor L.(TM;Coleoptera:Tenebrionidae)larvae,have shown positive effects on broiler performance in several research studies and have a strong potential as a sustainable alternative protein source for monogastric *** study aimed to assess the effect of replacing various ratios of basal diets with *** larvae on broiler performance as well as on several meat and welfare *** the study,120 one-day-old male chicks(Ross 308)were randomly allocated in 3 treatments and 4 replications(10 birds per pen).Birds of the control group(basal diet)were fed with typical commercial maize and soymeal-based rations in mash *** other 2 groups were treated with the same diet,after replacing 5%and 10%with dried TM larvae,*** d 35(end of trial),meat samples were collected and *** weight,feed intake,body weight gain and feed conversion ratio during the periods of 1 to 10 d(starter period),11 to 24 d(grower period),25 to 35 d(finisher period)and 1 to 35 d(total period)were ***-dermatitis,diarrhoea,feather score and litter conditions were also assessed during the *** results indicated that TM larvae inclusion in the broilers'diet positively affected body weight gain values,as well as the carcass yield,the meat composition and various welfare ***,the dietary treatments with TM larvae favourably affected meat composition and colour parameters,whereas there were also some positive effects on lipid and protein *** fatty acids were decreased by the dietary supplementation whereas the polyunsaturated fatty acids to SFA ratio *** general,the study showed that whole TM larvae addition can provide a promising alternat

关键词： Tenebrio molitor larvae Broiler Performance Welfare Meat trait

Provision of Ramp-rate Limitation as Ancillary Service from Distribution to Transmission System:Definitions and Methodologies for Control and Sizing of Central Battery Energy Storage System

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Journal of Modern Power Systems and Clean Energy 2023年第5期11卷 1507-1518页

作者： Spyros I.Gkavanoudis Kyriaki-Nefeli D.Malamaki eleftherios O.Kontis Aditya Shekhar Umer Mushtaq Sagar Bandi Venu Charis S.Demoulias Department of Electrical&Computer Engineering Aristotle University of ThessalonikiThessalonikiGreece Electrical Engineering Mathematics&Computer Science DepartmentDelft University of TechnologyDelftNetherlands FENECON Gmbh DeggendorfGermany

The variability of the output power of distributed renewable energy sources(DRESs)that originate from the fastchanging climatic conditions can negatively affect the grid ***,grid operators have incorporated ramp-rate limitations(RRLs)for the injected DRES power in the grid *** the DRES penetration levels increase,the mitigation of high-power ramps is no longer considered as a system support function but rather an ancillary service(AS).Energy storage systems(ESSs)coordinated by RR control algorithms are often applied to mitigate these power ***,no unified definition of active power ramps,which is essential to treat the RRL as AS,currently *** paper assesses the various definitions for ramp-rate RR and proposes RRL method control for a central battery ESS(BESS)in distribution systems(DSs).The ultimate objective is to restrain high-power ramps at the distribution transformer level so that RRL can be traded as AS to the upstream transmission system(TS).The proposed control is based on the direct control of theΔP/Δt,which means that the control parameters are directly correlated with the RR requirements included in the grid *** addition,a novel method for restoring the state of charge(So C)within a specific range following a high ramp-up/down event is ***,a parametric method for estimating the sizing of central BESSs(BESS sizing for short)is *** BESS sizing is determined by considering the RR requirements,the DRES units,and the load mix of the examined *** BESS sizing is directly related to the constant RR achieved using the proposed ***,the proposed methodologies are validated through simulations in MATLAB/Simulink and laboratory tests in a commercially available BESS.

关键词： Battery energy storage system distributed renewable energy resource sizing distribution system transmission system ramp-rate limitation state of charge

Effectiveness of high intensity interval training on cardiorespiratory fitness and endothelial function in type 2 diabetes:A systematic review

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World Journal of Cardiology 2023年第4期15卷 184-199页

作者： Christos Kourek eleftherios Karatzanos Vasiliki Raidou Ourania Papazachou Anastassios Philippou Serafim Nanas Stavros Dimopoulos Clinical Ergospirometry Exercise and Rehabilitation Laboratory1st Critical Care Medicine DepartmentEvangelismos HospitalAthens 10676Greece Department of Cardiology 417 Army Share Fund Hospital of AthensAthens 11521Greece Clinical Ergospirometry Exercise and Rehabilitation LaboratoryNational and Kapodistrian University of AthensAthens 10676Greece Department of Cardiology "Helena Venizelou"HospitalAthens 10676Greece Department of Physiology School of MedicineNational and Kapodistrian University of AthensAthens 11527Greece Cardiac Surgery Intensive Care Unit Onassis Cardiac Surgery CenterAthens 17674Greece

BACKGROUND Type 2 diabetes mellitus(T2DM)is a chronic metabolic syndrome characterized by insulin resistance and hyperglycemia that may lead to endothelial dysfunction,reduced functional capacity and exercise *** aerobic exercise has been promoted as the most beneficial non-pharmacological treatment of cardiovascular *** intensity interval training(HIIT)seems to be superior than moderate-intensity continuous training(MICT)in cardiovascular diseases by improving brachial artery flow-mediated dilation(FMD)and cardiorespiratory fitness to a greater ***,the beneficial effects of HIIT in patients with T2DM still remain under investigation and number of studies is *** To evaluate the effectiveness of high intensity interval training on cardiorespiratory fitness and endothelial function in patients with *** We performed a search on PubMed,PEDro and CINAHL databases,selecting papers published between December 2012 and December 2022 and identified published randomized controlled trials(RCTs)in the English language that included community or outpatient exercise training programs in patients with *** were assessed for methodological rigor and risk of bias via the Physiotherapy Evidence Database(PEDro).The primary outcome was peak VO_(2 ) and the secondary outcome was endothelial function assessed either by FMD or other indices of *** Twelve studies were included in our systematic *** 12 RCTs resulted in 661 participants in *** was performed in 310 patients(46.8%),MICT to 271 and the rest 80 belonged to the control *** VO_(2 ) increased in 10 out of 12 studies after *** studies compared HIIT with other exercise regimens(MICT or strength endurance)and 4 of them demonstrated additional beneficial effects of HIIT over MICT or other exercise ***,4 studies explored the effects of HIIT on endothelial function and FMD in T2DM *** 2 of them,HIIT further impro

关键词： Type 2 diabetes mellitus Exercise High intensity interval training Cardiorespiratory fitness Peak VO_(2) Endothelial function

Inherited arrhythmias and gene therapy: Are there any ethical considerations to take into account?

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World Journal of Cardiology 2023年第12期15卷 623-626页

作者： Michael Spartalis eleftherios Spartalis Gerasimos Siasos 3rd Department of Cardiology National and Kapodistrian University of AthensAthens 11527Greece Laboratory of Experimental Surgery and Surgical Research Medical SchoolNational and Kapodistrian University of AthensAthens 11527Greece

Interventional electrophysiology represents a relatively recent subspecialty within the field of *** the past half-century,there has been significant advan-cement in the development and implementation of innovative ablation treatments and ***,the treatment of arrhythmias continues to be *** arrhythmias,such as ventricular tachycardia and atrial fibrillation,pose significant challenges in terms of therapeutic efficacy,whether through interventional procedures or the administration of antiarrhythmic ***-logists are engaged in ongoing research to explore innovative methodologies,such as genome editing,with the purpose of effectively managing arrhythmias and meeting the growing needs of patients afflicted with rhythm *** field of genome editing has significant promise and has the potential to serve as a highly effective personalized therapy for rhythm disorders in ***,several ethical issues must be considered.

关键词： Arrhythmia Sudden cardiac death Genome editing Long QT Channelo-pathies Mutation