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Preservation of platelet function in patients with cirrhosis and thrombocytopenia undergoing esophageal variceal ligation

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Hepatobiliary & Pancreatic diseases International 2020年第6期19卷 555-560页

作者： Evandro de Oliveira Souza elbio antonio d’amico Tania Rubia Flores da Rocha Caroline Marcondes Ferreira Juliana Medeiros Batista Luiz Augusto Carneirod’Albuquerque Flair Jose Carrilho Alberto Queiroz Farias division of Gastroenterology and Hepatology University of Sao Paulo School of MedicineAv.Dr.Eneas Carvalho de Aguiar2559th flooroffice 9159Sao PauloSP 05403-000Brazil Hemostasis Laboratory Hematology ServiceUniversity of Sao Paulo School of MedicineAv.Dr.Eneas Carvalho de Aguiar2552nd floorSao PauloSP 05403-000Brazil

Background:Thrombocytopenia is a possible risk factor for bleeding after band ligation of esophageal ***,elevated von Willebrand factor(VWF)in cirrhosis improves platelet function and could decrease this *** objective was to assess platelet function in patients with cirrhosis undergoing esophageal variceal ligation(EVL).Methods:The assessment consisted of platelet count,antigen and activity of VWF and VWF-cleaving protease AdAMTS-13 activity,and a platelet adhesion and aggregation test simulating vascular flow in vivo(Impact-RR)prior to ***:Totally 111 patients were divided into three groups according to platelet count:(1)d(3)>100×109/L(n=26,23.4%).No statistically significant difference was found in the aggregate size of platelets[group 1:41.0(31.8–67.3)μm 2;group 2:47.0(33.8–71.3)μm 2;and group 3:47.0(34.0–66.0)μm 2;P=0.60]and no significant correlation was found between aggregate size and platelet count(Spearman r=0.07;P=0.47).Surface coverage was 4.1%(2.8%–6.7%),8.5%(4.0%–10.0%),and 9.0%(7.1%–12.0%)(Pd 3,respectively and correlated with platelet count(Spearman r=0.39;Pdifference between groups in VWF or ***-EVL bleeding occurred in six(5.4%)patients(n=2 in group 1,n=1 in group 2,and n=3 in group 3;P=0.32).Patients with bleeding had higher MELd scores[15.0(11.3–20.3)versus 12.0(10.0–15.0);P=0.025],but no difference was demonstrated for platelet function ***:Platelet function is preserved even in the presence of thrombocytopenia,including in the patients with post-EVL bleeding.

关键词： Cirrhosis Hemostasis Thrombocytopenia Platelet aggregation Endoscopy Hemorrage

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Branch retinal vein thrombosis and visual loss probably associated with pegylated interferon therapy of chronic hepatitis C

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World Journal of Gastroenterology 2006年第28期12卷 4602-4603页

作者： Luciana Lofego Gonalves Alberto Queiroz Farias Patrícia Lofego Gonalves elbio antonio d'amico Flair José Carrilho Santa Casa de Misericórdia de Vitória Espírito Santoand University of Sao Paulo School of MedicineBrazil University of Sao Paulo School of Medicine Brazil Federal University of Espírito Santo School of Medicine Brazil

Ophthalmological complications with interferon therapy are usually mild and reversible, not requiring the withdrawal of the treatment. We report a case of a patient who had visual loss probably associated with interferon therapy. Chronic hepatitis C virus infection （genotype la） was diagnosed in a 33-year old asymptomatic man. His past medical history was unremarkable and previous routine ophthalmologic check-up was normal. Pegylated interferon alpha and ribavirin were started. Three weeks later he reported painless reduction of vision. Ophthalmologic examination showed extensive intraretinal hemorrhages and cottonwool spots, associated with inferior branch retinal vein thrombosis. Antiviral therapy was immediately discontinued, but one year later he persists with severely decreased visual acuity. This case illustrates the possibility of unpredictable and severe complications during pegylated interferon therapy.

关键词： Hepatitis C Interferon Visual loss

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Therapeutic targeting of cellular prion protein: toward the development of dual mechanism anti-prion compounds

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Neural Regeneration Research 2025年第4期20卷 1009-1014页

作者： antonio Masone Chiara Zucchelli Enrico Caruso Giovanna Musco Roberto Chiesa Laboratory of Prion Neurobiology Department of NeuroscienceIstituto di Ricerche Farmacologiche Mario Negri IRCCSMilanItaly Biomolecular NMR Unit Division of Genetics and Cell BiologyIRCCS Ospedale San RaffaeleMilanItaly department of Biotechnology and Life Sciences University of InsubriaVareseItaly

PrPSc,a misfolded,aggregation-prone isoform of the cellular prion protein(PrPC),is the infectious prion agent responsible for fatal neurodegenerative diseases of humans and other *** adopt different pathogenic conformations(prion strains),which can be resistant to potential drugs,or acquire drug resistance,posing challenges for the development of effective *** PrPCis the obligate precursor of any prion strain and serves as the mediator of prion neurotoxicity,it represents an attractive therapeutic target fo r prion *** this minireview,we briefly outline the approaches to target PrPCand discuss our recent identification of Zn(Ⅱ)-Bn PyP,a PrPC-targeting porphyrin with an unprecedented bimodal mechanism of *** argue that in-depth understanding of the molecular mechanism by which Zn(Ⅱ)-Bn PyP targets PrPCmay lead toward the development of a new class of dual mechanism anti-prion compounds.

关键词： anti-prion drug anti-PrPC antibody antisense oligonucleotide neurodegeneration pharmacological chaperone porphyrin prion disease PrPC degrader PrPC shedding zinc finger repressor

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Neoadjuvant radiotherapy dose escalation for locally advanced rectal cancers in the new era of radiotherapy:A review of literature

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World Journal of Clinical Cases 2021年第30期9卷 9077-9089页

作者： durim delishaj Ilaria Costanza Fumagalli Stefano Ursino Agostino Cristaudo Francesco Colangelo antonio Stefanelli Alessandro Alghisi Giuseppe de Nobili Romerai d’amico Alessandra Cocchi antonio Ardizzoia Carlo Pietro Soatti department of Radiation Oncology Alessandro Manzoni HospitalLecco 23900Italy department of Radiation Oncology San Donato HospitalMilan 20097Italy department of Radiation Oncology Santa Chiara University HospitalPisa 56126Italy Royal Preston Hospital Lancashire Teaching Hospital-NHS TustPreston PR29HTUnited Kingdom department of Radiation Oncology Azienda Ospedaliero-Universitaria di FerraraFerrara 44124Italy department of Clinical Oncology Alessandro Manzoni HospitalLecco 23900Italy

BACKGROUNd The standard treatment of locally advanced rectal cancers(LARC)consists on neoadjuvant chemoradiotherapy followed by total mesorectal *** data in literature showed a benefit on tumor downstaging and pathological complete response(pCR)rate using radiotherapy dose escalation,however there is shortage of studies regarding dose escalation using the innovative techniques for LARC(T3-4 or N1-2).AIM To analyze the role of neoadjuvant radiotherapy dose escalation for LARC using innovative radiotherapy *** In december 2020,we conducted a comprehensive literature search of the following electronic databases:PubMed,Web of Science,Scopus and Cochrane *** limit period of research included articles published from January 2009 to december *** by title and abstract was carried out to identify only studies using radiation doses equivalent dose 2 Gy fraction(EQd2)≥54 Gy and Volumetric Modulated Arc Therapy(VMAT),intensity-modulated radiotherapy or image-guided radiotherapy(IGRT)*** authors’searches generated a total of 2287 results and,according to PRISMA Group(2009)screening process,21 publications fulfil selection criteria and were included for the *** The main radiotherapy technique used consisted in VMAT and IGRT *** mainly dose prescription was 55 Gy to high risk volume and 45 Gy as prophylactic volume in 25 fractions given with simultaneous integrated boosts technique(42.85%).The mean pCR was 28.2%with no correlation between dose prescribed and response rates(P value≥0.5).The R0 margins and sphincter preservation rates were 98.88%and 76.03%,*** a mean follow-up of 35 months local control was 92.29%.G3 or higher toxicity was 11.06%with no correlation between dose prescription and *** receiving EQd2 dose>58.9 Gy and BEd>70.7 Gy had higher surgical complications rates compared to other group(P value=0.047).CONCLUSION dose escalation neoadjuvant radiotherapy usi

关键词： Rectal cancer Radiotherapy Volumetric Modulated Arc Therapy Imageguided radiotherapy Intensity-modulated radiotherapy Neoadjuvant radiotherapy

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Summing Boolean Algebras

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Acta Mathematica Sinica,English Series 2004年第5期20卷 949-960页

作者： antonio AIZPURU antonio GUTI■RREZ-d■VILA departamento de Matemáticas Universidad de CádizApdo4011510-Puerto Real(Cádiz)Spain

In this paper we will study some families and subalgebras■of■(N)that let us character- ize the unconditional convergence of series through the weak convergence of subseries ∑_(i∈A)x_i,A∈(?). As a consequence,we obtain a new version of the Orlicz Pettis theorem,for Banach *** also study some relationships between algebraic properties of Boolean algebras and topological properties of the corresponding Stone spaces.

关键词： Unconditionally convergent series (weak)Summation Orlicz Pettis theorem Boolean Algebras

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Oxidative reforming of methane for hydrogen and synthesis gas production:Thermodynamic equilibrium analysis

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Journal of Natural Gas Chemistry 2012年第5期21卷 571-580页

作者： antonio C.d.Freitas Reginaldo Guirardello School of Chemical Engineering University of Campinas (UNICAMP)Av.Albert Einstein 50013083-852Campinas-SPBrazil

A thermodynamic analysis of methane oxidative reforming was carried out by Gibbs energy minimization （at constant pressure and temperature） and entropy maximization （at constant pressure and enthalpy） methods,to determine the equilibrium compositions and equilibrium temperatures,*** cases were treated as optimization problems （non-linear programming formulation）.The GAMS 23.1 software and the CONOPT2 solver were used in the resolution of the proposed *** hydrogen and syngas production were favored at high temperatures and low pressures,and thus the oxygen to methane molar ratio （O 2 /CH 4） was the dominant factor to control the composition of the product *** O 2 /CH 4 molar ratios higher than 0.5,the oxidative reforming of methane presented autothermal behavior in the case of either utilizing O 2 or air as oxidant agent,but oxidation reaction with air possessed the advantage of avoiding peak temperatures in the system,due to change in the heat capacity of the system caused by the addition of *** calculated results were compared with previously published experimental and simulated data with a good agreement between them.

关键词： thermodynamic analysis methane oxidative reforming Gibbs energy minimization entropy maximization hydrogen and syngas production

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data trustworthiness and user reputation as indicators of VGI quality

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Geo-Spatial Information Science 2018年第3期21卷 213-233页

作者： Paolo Fogliaroni Fausto d’antonio Eliseo Clementini department for Geodesy and Geoinformation Vienna University of TechnologyViennaAustria department of Industrial and Information Engineering and Economics University of L’AquilaL’AquilaItaly

Volunteered geographic information(VGI)has entered a phase where there are both a substantial amount of crowdsourced information available and a big interest in using it by *** the issue of deciding the quality of VGI without resorting to a comparison with authoritative data remains an open *** article first formulates the problem of quality assessment of VGI *** presents a model to measure trustworthiness of information and reputation of contributors by analyzing geometric,qualitative,and semantic aspects of edits over *** implementation of the model is running on a small data-set for a preliminary empirical *** results indicate that the computed trustworthiness provides a valid approximation of VGI quality.

关键词： Volunteered geographic information data quality trustworthiness reputation

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Source Parameters Evaluation of the 28^(th) december 1908 and 16^(th) January 1975 Earthquakes in the Messina Straits(Southern Italy)

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地学前缘 2009年第S1期16卷 213-213页

作者： Maria d'amico antonio Bottari Seismological Observatory-dIC Messina University

The Calabria-Peloritani Arc is one of the most seismically active regions of Southern *** most damaging event(Ⅰ0=ⅪMSK)occurred on december 28th,1908 in the Messina Straits *** event,which caused at least 85000 casua... 详细信息

关键词： macroseismic source parameters Southern Italy Messina Straits

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Target Capturing in an Ellipsoidal Region for a Swarm of double Integrator Agents

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IEEE/CAA Journal of Automatica Sinica 2022年第5期9卷 801-811页

作者： antonio Bono Luigi d'Alfonso Giuseppe Fedele Veysel Gazi IEEE department of Informatics ModelingElectronics and Systems EngineeringUniversity of CalabriaRende 87036Italy dept.Electrical and Electronics Eng. Faculty of EngineeringMarmara UniversityIstanbul 34722 department of Control and Automation Engineering Faculty of Electrical and Electronics EngineeringYildiz Technical UniversityEsenler 34220Turkey

In this paper we focus on the target capturing problem for a swarm of agents modelled as double integrators in any finite space *** agent knows the relative position of the target and has only an estimation of its velocity and *** that the estimation errors are bounded by some known values,it is possible to design a control law that ensures that agents enter a user-defined ellipsoidal ring around the moving *** know the relative position of the other members whose distance is smaller than a common detection ***,in the case of no uncertainty about target data and homogeneous agents,we show how the swarm can reach a static configuration around the moving *** simulations are reported to show the effectiveness of the proposed strategy.

关键词： Agents-based systems cooperative control swarms target-capturing

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Corneal collagen cross‑linking epithelium‑on ***‑off:a systematic review and meta‑analysis

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Eye and Vision 2021年第6期8卷 338-352页

作者： Francesco d’Oria antonio Palazón Jorge L.Alio Vissum Innovation c/Cabañal103016 AlicanteSpain division of Ophthalmology Universidad Miguel HernándezAlicanteSpain Section of Ophthalmology Department of Basic Medical ScienceNeuroscience and Sense OrgansUniversity of BariBariItaly department of Clinical Medicine Miguel Hernández UniversitySan Juan de AlicanteSpain

Background:The purpose of the study was to determine the advantages and disadvantages of epi-on corneal crosslinking(CXL)techniques compared with standard epi-off ***:We searched MEdLINE and EMBASE for randomized controlled trials(RCTs)and non-randomized studies of interventions(NRSIs)and we evaluated the selected papers according to the Cochrane risk of bias *** considered,as primary outcomes,average Kmax flattening,changes in uncorrected and corrected distance visual acuity(UdVA and CdVA);as secondary outcomes,we considered changes in pachymetry values and endothelial cell density(ECd).We also investigated adverse events related to the treatments and treatment ***-analysis was conducted with a fixed or random-effects model using weighted mean difference(Md)with 95%confidence interval(CI)as the effect ***:A total of 15 studies were included and among these 15 trials,9 were RCTs and 6 were NRSIs,but only 4 studies showed no high risk of bias and were included in this *** analysis revealed significant postoperative differences in CdVA(Md=0.07;95%CI 0.04 to 0.10;Pd no significative differences in UdVA,Kmax,central corneal thickness(CCT)and ECd(P>0.05).Epi-on CXL protocol was found to be significantly less prompt to have risks of delay in epithelial healing(P=0.035)and persistent stromal haze(P=0.026).Conclusion:Epi-on CXL is as effective as epi-off *** for a higher significant improvement in CdVA with current epi-on protocols,our meta-analysis demonstrates that epi-on and epi-off CXL have comparable effects on visual,topographic,pachymetric,and endothelial ***-on CXL has clinical advantages in terms of comfort and avoidance of complications as it reduces the risk of developing delay in epithelial healing and persistent stromal haze.

关键词： Corneal collagen cross-linking Keratoconus Transepithelial CXL Epithelium-off CXL Epithelium-on CXL Iontophoresis

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