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Acute kidney injury in leptospirosis:overview and perspectives

Asian Pacific Journal of Tropical Medicine 2018年第10期11卷 549-554页

作者： Geraldo Bezerra da Silva Junior Nattachai Srisawat Gabriela Studart Galdino ênio Sima Macedo joséReginaldo Pinto Geysa Maria Nogueira Farias Renan Lima Alencar Roberto da Justa Pires Neto el.ino jos.guardao barros.el.zabeth de frances.o daher Medical Sciences and Public Health and Graduate Programs School of Medicine Health Sciences Center University of Fortaleza Excellence Center for Critical Care Nephrology Division of Nephrology Department of Medicine Chulalongkorn University Collaborating CRISMA faculty member Department of Critical Care Medicine Univeristy of Pittsburgh School of Medicine Medical Sciences and Public Health Graduate Programs Department of Internal Medicine School of Medicine Federal University of Ceara department of Internal Medicine School of Medicine Federal University of Rio Grande do Sul

Leptospirosis is a bacterial disease disseminated through the centuries in the whole world which causes symptoms that go from self-limited diseases to hemorrhagic manifestations and organ failure, including acute kidney injury(AKI), composing the severe disease known as the Weil's syndrome. Mortality rates varies according to the clinical presentation and usually increases when kidney injury is present, and is even higher in the setting of pulmonary hemorrhage. There are recent advances in the search for novel biomarkers of renal involvement and early detection of AKI in leptospirosis, as well as in its pathophysiology. We review in this article the clinical aspects of leptospirosis-associated AKI and the perspectives for future research.

关键词： Leptospirosis Acute kidney injury Perspectives Bacterial infections

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