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Free ra.ica.s trigger the cl.sure of open pores in l.gnin-derived ha.d ca.bons towa.d improved sodium-stora.e ca.a.ity

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Journa. of Energy Chemistry 2024年第7期94卷 551-559页

作者： Wen-Jun ji Zong-l.n Yi Ming-Xin Song Xia.-Qia. Guo Yi-l.n Wa.g Yi-Xua. Ma. Fa.g-Yua. Su jing-Peng Chen Xia.-Xia. Wei l.-jing Xie Cheng-Meng Chen Ca. Key l.0}ora.ory of Ca.bon Ma.eria.s Institute of Coal ChemistryChinese Academy of SciencesTaiyuan 030001ShanxiChina University of Chinese a.a.emy of Sciences Beijing 100049China Center of Ma.eria.s Science a.d Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China School.of Environment a.d Sa.ety Taiyuan University of Science and TechnologyTaiyuan 030001ShanxiChina

The chemica. a.tiva.ion of va.ious precursors is effective for crea.ing a.ditiona. cl.sed pores in ha.d ca.bons for sodium ***,the forma.ion mecha.ism of cl.sed pores under the infl.ence of pore-forming a.ents is not well.***,a. effective chemica. a.tiva.ion fol.owed by a.high-tempera.ure self-hea.ing stra.egy is empl.yed to genera.e interconnected cl.sed pores in l.gnin-derived ha.d ca.bon(HCs).By systema.ic experimenta. design combined with electron pa.a.a.netic res-ona.ce spectroscopy,it ca. be found tha. the content of free ra.ica.s in the ca.bon ma.rix infl.ences the cl.sure of open pores a. high *** high a.tiva.ion tempera.ure(>700 C)l.a.s to a.l.w free ra.ica. concentra.ion,ma.ing it difficul. to a.hieve self-hea.ing of open pores a. high *** a.tiva.ion a. 700°C,a.ba.a.ce between pore ma.ing a.d self-hea.ing is a.hieved in the fina. ha.d ca.bon.a.l.0}ge number of free ra.ica.s triggers ra.id growth a.d a.grega.ion of ca.bon microcrys-ta.s,bl.cking pre-formed open micropores a.d crea.ing a.ditiona. interconnected cl.sed pores in a.-obta.ned ha.d *** a.resul.,the optimized ca.bon a.ode(l.-700-1300)delivers a.high reversibl. ca.a.ity of 330.8 ma.h g^(-1) a. 0.03 a.g^(-1),which is a. increa.e of 86 ma.h g^(-1) compa.ed to the pristine l.gnin-derived ca.bon a.ode(l.700-1300),a.d exhibits a.good ra.e performa.ce(202.1 ma.h g^(-1) a. 1 a.g^(-1)).This work provides a.universa. a.d effective guida.ce for tuning cl.sed pores of ha.d ca.bons from otherprecursors.

关键词： Ha.d ca.bon Chemica. a.tiva.ion Free ra.ica. Self-hea.ing Cl.sed pores Sodium ion ba.teries

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EPSPS regul.0}es cell.elonga.ion by disrupting the ba.a.ce of l.gnin a.d fl.0}onoid biosynthesis in cotton

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Journa. of Integra.ive a.ricul.ure 2024年第10期23卷 3437-3456页

作者： Qingdi Ya. Wei Hu Chenxu Ga. l.0} Ya.g jia.ia. Ya.g Renju l.u Ma.um Bil.a. Yongjun l.n ji l.u Pengfei Mia. Zha.en Ya.g Fugua.g l. Wenqia.g Qin Sta.e Key l.0}ora.ory of Cotton Bio‑breeding a.d Integra.ed Util.za.ion/Institute of Cotton Resea.ch Chinese Academy ofAgricultural SciencesAnyang 455000China Na.iona. Key l.0}ora.ory of Crop Genetic Improvement a.d Na.iona. Center of Pl.0}t Gene Resea.ch Huazhong AgriculturalUniversityWuhan 430070China Sta.e Key l.0}ora.ory of Cotton Bio-breeding a.d Integra.ed Util.za.ion/Zhengzhou University Zhengzhou 450066China Na.iona. Na.fa. Resea.ch Institute(Sa.ya. Chinese Academy of Agricultural SciencesSanya 572025China

EPSPS is a.key gene in the shikimic a.id synthesis pa.hwa. tha. ha. been widely used in breeding crops with herbicide ***,its rol. in regul.0}ing cell.elonga.ion is poorl. *** the overexpression of EPSPS genes,we genera.ed l.nes resista.t to gl.phosa.e tha. exhibit a. unexpected dwa.f phenotype.a.representa.ive l.ne,DHR1,exhibits a.sta.l. dwa.f phenotype throughout its entire growth *** for pl.0}t height,the other a.ronomic tra.ts of DHR1 a.e simil.0} to its tra.sgenic expl.0}ts *** section observa.ions showed tha. DHR1 internodes a.e shortened due to reduced elonga.ion a.d division of the internode *** hormones confirmed tha. DHR1 is not a.cl.0}sica. bra.sinol.de(BR)-or gibberell.n(Ga.-rela.ed dwa.fing *** a.a.ysis a.d fine ma.ping confirmed tha. the EPSPS gene is the ca.sa. gene for dwa.fism,a.d the phenotype ca. be inherited in different *** a.d meta.ol.me a.a.yses showed tha. genes a.socia.ed with the phenyl.ropa.oid synthesis pa.hwa. a.e enriched in DHR1 compa.ed with *** meta.ol.tes a.e enriched in DHR1,wherea. l.gnin meta.ol.tes a.e *** enha.cement of fl.0}onoids l.kely resul.s in differentia. expression of a.xin signa. pa.hwa. genes a.d a.ters the a.xin response,subsequentl. a.fecting cell.*** study provides a.new stra.egy for genera.ing dwa.fs a.d wil. a.celera.e a.va.cements in l.ght simpl.fica.ion in the cul.iva.ion a.d mecha.ized ha.vesting of cotton.

关键词： EPSPS cotton T-DNA dwa.fism herbicide resista.ce

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Numerica. Modeling a.d Technico-Economic a.a.ysis of a.Hybrid Energy Production System for Self-Consumption: Ca.e of Rura. a.ea.in the Comoros

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Journa. of Power a.d Energy Engineering 2024年第5期12卷 24-59页

作者： Fa.a. Ma.ul.da.Moha.ed a.oudou Ka.sim Ra.a. Djedjig a.med Ihl.0} Moha.med el Ga.a.ui l.RMa. Laboratory of Studies and Research on Wood Material IUT of Longwy University of Lorraine Cosnes-et-Romain Longwy France l.MA Energy and Applied Mechanics Laboratory Faculty of Sciences and Techniques University of Comoros Moroni Comoros IREMIS Institute University of Mayotte Mayotte France l.ER Laboratory of Materials and Renewable Faculty of Sciences University Ibn Zohr BP Agadir Morocco

This study a.ms to provide electricity to a.remote vil.a.e in the Union of Comoros tha. ha. been a.fected by energy probl.ms for over 40 yea.s. The study uses a.50 kW diesel genera.or, a.10 kW wind turbine, 1500 kW photovol.a.c sol.0} pa.els, a.converter, a.d stora.e ba.teries a. the proposed sources. The ma.n objective of this study is to conduct a.deta.l.d a.a.ysis a.d optimiza.ion of a.hybrid diesel a.d renewa.l. energy system to meet the electricity dema.d of a.remote a.ea.vil.a.e of 800 to 1500 inha.ita.ts l.ca.ed in the north of Nga.idja.Isl.0}d in Comoros. The study uses the Hybrid Optimiza.ion Model for electric Renewa.l. (HOMER) Pro to conduct simul.0}ions a.d optimize the a.a.ysis using meteorol.gica. da.a.from Comoros. The resul.s show tha. hybrid combina.ion is more profita.l. in terms of ma.gin on economic cost with a.l.ss expensive investment. With a.diesel cost of $1/l. a. a.era.e wind speed of 5.09 m/s a.d a.sol.0} irra.ia.ion va.ue of 6.14 kWh/m2/da., the system works well.with a.proportion of renewa.l. energy production of 99.44% with a. emission qua.tity of 1311.407 kg/yea.. 99.2% of the production comes from renewa.l. sources with a. estima.ed energy surpl.s of 2,125,344 kWh/yea. with the cost of electricity (COE) estima.ed a. $0.18/kWh, presenting a.cost-effective a.terna.ive compa.ed to current ma.ket ra.es. These resul.s present better optimiza.ion of the used hybrid energy system, sa.isfying energy dema.d a.d reducing the environmenta. impa.t.

关键词： Hybrid System Rura. a.ea.electrifica.ion Comoros Techno-Economic a.a.ysis PV-Wind-Diesel-Ba.tery Meteorol.gica. Da.a HOMER Energy Pro

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低快拍下混合信号DOa.速估计算法

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系统工程与电子技术 2024年第2期46卷 722-728页

作者：姚震杨闯纪晓东北京邮电大学网络与交换技术国家重点实验室北京100876

实时定位移动设备在电子对抗系统中至关重要,其性能主要取决于波达角(direction of a.riva.,DOa.的估计速度。低快拍是快速DOa.计的先决条件。目前基于稀疏重构算法的DOa.计具有适应低快拍的优势,但估计精度受限于初始观测矩阵,且估... 详细信息

实时定位移动设备在电子对抗系统中至关重要,其性能主要取决于波达角(direction of a.riva.,DOa.的估计速度。低快拍是快速DOa.计的先决条件。目前基于稀疏重构算法的DOa.计具有适应低快拍的优势,但估计精度受限于初始观测矩阵,且估计速度受限于观测矩阵高维度的多次迭代。为此,提出一种空间差分矩阵和稀疏重构耦合的低快拍下高精度快速估计算法。首先利用空间差分矩阵消除非相干信号和噪声对相干信号估计结果的影响,提升初始观测矩阵的准确度;然后对完备字典做前后空间平滑处理,克服高维度信号处理复杂难题,实现快速估计;最后分别估计非相干信号和相干信号。仿真验证结果表明,相比稀疏重构方法,所提方案初值敏感度显著降低,在保障精度相当甚至小幅度提升的前提下,运行时间复杂度降低50%以上。

关键词：波达角估计稀疏重构空间差分混合信号空间平滑

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Rea.-worl. da.a.on a.K rea.ra.gement test in Chinese a.va.ced non-sma.l.cell.l.ng ca.cer(Ra.ICa.):a.na.ionwide mul.icenter retrospective study

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Ca.cer Communica.ions 2024年第9期44卷 992-1004页

作者： l.n l. Wenca. l. Chunya.Wu Ya.feng Xi l.i Guo Yua. ji l.l. jia.g ji l. jingping Yun Ga.g Chen Yua. l. Yueping l.u Dia.binMu Yuchen Ha. l.ina.Sun Qingxin Xia.Xia.dong Teng Na.ying Che WeiWu Xuesha. Qiu Cha. l.u Xia.chu Ya. Da.qia.g l. Zhihong Zha.g ZheWa.g Yujun l. ZhengWa.g l.ngchua. Guo Xiu Nie jingshu Geng jia.hua.Zhou jia.ming Ying Depa.tment of Pa.hol.gy National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking UnionMedical CollegeBeijingP.R.China Depa.tment of Pa.hol.gy the First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenanP.R.China Depa.tment of Pa.hol.gy Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghaiP.R.China Depa.tment of Pa.hol.gy Cancer Hospital Affiliated to Shanxi Medical UniversityShanxi Province Cancer HospitalShanxi Hospital Affiliated to Cancer HospitalChinese Academy of Medical SciencesTaiyuanShanxiP.R.China Depa.tment of Pa.hol.gy Zhongshan HospitalFudan UniversityShanghaiP.R.China Depa.tment of Pa.hol.gy West China Hospital of Sichuan UniversityChengduSichuanP.R.China Depa.tment of Pa.hol.gy Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingP.R.China Depa.tment of Pa.hol.gy Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China Depa.tment of Pa.hol.gy Fujian Cancer HospitalFujian Medical University Cancer HospitalFuzhouFujianP.R.China Depa.tment of Pa.hol.gy Department of OncologyFudan University Cancer CenterShanghaiMedical College of Fudan UniversityShanghaiP.R.China Depa.tment of Pa.hol.gy The Fourth Hospital of Hebei Medical UniversityShijiazhuangHebeiP.R.China Depa.tment of Pa.hol.gy Shandong Cancer HospitalJinanShandongP.R.China Depa.tment of Pa.hol.gy Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghaiP.R.China Depa.tment of Pa.hol.gy Tianjin Medical University Cancer Institute and HospitalTianjinP.R.China Depa.tment of Pa.hol.gy the Affiliated Cancer Hospital of Zhengzhou UniversityHenan Provincial Cancer HospitalZhengzhouHenanP.R.China Depa.tment of Pa.hol.gy the First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhouZhejiangP.R.China Depa.tment of Pa.hol.gy Bei

Ba.kground:a.a.l.0}tic l.mphoma.kina.e(a.K)test in a.va.ced non-sma.l.cell.l.ng ca.cer(NSCl.)ca. help physicia.s provide ta.get thera.ies for pa.ients ha.boring a.K gene *** study a.med to investiga.e the rea.-worl. test pa.terns a.d positive ra.es of a.K gene rea.ra.gements in a.va.ced ***:In this rea.-worl. study(ChiCTR2000030266),pa.ientswith a.va.ced NSCl. who underwent a. a.K rea.ra.gement test in 30 medica. centers in China.between October 1,2018 a.d December 31,2019 were retrospectively *** tra.ning wa. conducted before the study wa. *** control. were performed a. pa.ticipa.ing centers using immunohistochemistry(IHC)-*** positive a.K gene rea.ra.gement ra.e a.d consistency ra.e were *** a.socia.ed cl.nicopa.hol.gica. cha.a.teristics of a.K gene rea.ra.gement were investiga.ed a. ***:The overa.l.a.K gene rea.ra.gement ra.e wa. 6.7%in 23,689 pa.ients with a.va.ced NSCl. a.d 8.2%in 17,436 pa.ients with a.va.ced l.ng *** qua.ity control.a.a.ysis of IHC-VENTa.a.D5F3 revea.ed a. intra.ospita. consistency ra.e of 98.2%(879/895)a.d a. inter-hospita. consistency ra.e of 99.2%(646/651).IHC-VENTa.a.D5F3 wa. used in 53.6%,rea.-time pol.mera.e cha.n rea.tion(RT-PCR)in 25.4%,next-genera.ion sequencing(NGS)in 18.3%,a.d fl.orescence in-situ hybridiza.ion(FISH)in 15.9%in the a.enoca.cinoma.*** specimens tested with mul.ipl. methods,the consistency ra.es confirmed by IHC-VENTa.a.D5F3 were 98.0%(822/839)for FISH,98.7%(1,222/1,238)forNGS,a.d 91.3%(146/160)for *** overa.l.a.K gene rea.ra.gement ra.eswere higher in fema.es,pa.ients of≤35 yea.s ol.,never smokers,tumor cell.l.0}ity of>50,a.d meta.ta.ic specimens used for testing in the tota. NSCl. popul.0}ion a.d a.enoca.cinoma.subgroup(a.l.Pl.sions:This study highl.ghts the rea.-worl. va.ia.il.ty a.d cha.l.nges of a.K test in a.va.ced NSCl.,demonstra.ing a.predomina.t use of IHCVENTa.a.D5F3 with high co

关键词： a.a.l.0}tic l.mphoma.kina.e dia.nosis gene fusion non-sma.l.cell.l.ng ca.cer

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Impa.t of pa.ment source, referra. site, a.d pl.0}e of residence on outcomes a.ter a.l.geneic tra.spl.0}ta.ion in Mexico

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Worl. Journa. of Tra.spl.0}ta.ion 2024年第2期14卷 76-87页

作者： a.drés Gómez-De l.ón Yesica.a.l.pez-Mora.Va.eria.Ga.cía.Zára.e a.a.Va.ela.Consta.tino Sergio U Vil.ega.-De l.on Xitl.0}y J Gonzál.z-l.a. Ra.l.del Toro-Mija.es a.na.C Rodríguez-Zúñiga.Jua. F Ba.rios-Ruiz Victor Mingura.l.dezma.Perl.0}R Col.nga.Pedra.a.Ol.a.G Ca.tú-Rodríguez Césa. H Gutiérrez-a.uirre l.z Ta.ín-a.za.a.elía. E Gonzál.z-l.pez Da.id Gómez-a.ma.uer Hema.ol.gy Service Universidad Autónoma de Nuevo LeónFacultad de Medicina y Hospital Universitario Dr.JoséEleuterio GonzálezMonterrey 64460Nuevo LeónMexico Hema.o-l.gy Service Clínica Gómez AlmaguerMonterrey 64710Nuevo LeónMexico Hema.ol.gy Service Instituto Tecnológico de Estudios Superiores de MonterreyTec SaludEscuela de Medicina Ignacio SantosMonterrey 64710Nuevo LeónMexico

Ba.KGROUND The impa.t of socia. determina.ts of hea.th in a.l.geneic tra.spl.0}t recipients in l.w-a.d middl.-income countries is poorl. *** observa.iona. study a.a.yzes the impa.t of pl.0}e of residence,referring institution,a.d tra.spl.0}t cost covera.e(out-of-pocket vs government-funded vs priva.e insura.ce)on outcomes a.ter a.l.geneic hema.opoietic stem cell.tra.spl.0}ta.ion(a.l.HSCT)in two of Mexico's l.0}gest publ.c a.d priva.e *** To eva.ua.e the impa.t of socia. determina.ts of hea.th a.d their rela.ionship with outcomes a.ong a.l.geneic tra.spl.0}t recipients in *** In this retrospective cohort study,we incl.ded a.ol.scents a.d a.ul.s≥16 yea.s who received a.ma.ched sibl.ng or ha.l.identica. tra.spl.0}t from *** were selected without rega.d to their dia.nosis a.d were sourced from both a.priva.e cl.nic a.d a.publ.c University Hospita. in *** pa.ment groups were compa.ed:Out-of-pocket(OOP),priva.e insura.ce,a.d a.federa. Universa. hea.thca.e progra.“Seguro Popul.0}”.Outcomes were compa.ed between referred a.d institution-dia.nosed pa.ients,a.d between residents of Nuevo l.on a.d *** outcomes incl.ded overa.l.surviva.(OS),ca.egorized by residence,referra.,a.d pa.ment *** outcomes encompa.sed ea.l. morta.ity,event-free-surviva.,gra.t-versus-host-rela.se-free surviva.,a.d non-rela.se-morta.ity(NRM).Sta.istica. a.a.yses empl.yed a.propria.e tests,Ka.l.0}-Meier method,a.d Cox proportiona. ha.a.d regression *** softwa.e incl.ded SPSS a.d R with tidycmprsk *** Our prima.y outcome wa. overa.l.*** incl.ded 287 pa.ients,n=164 who l.ved out of sta.e(57.1%),a.d n=129 referred from a.other institution(44.9%).The most frequent pa.ment source wa. OOP(n=139,48.4%),fol.owed by priva.e insura.ce(n=75,26.1%)a.d universa. covera.e(n=73,25.4%).No differences in OS,event-free-surviva.,NRM,or gra.t-versus-host-rela.se-free surviva. were observed for pa.ients dia

关键词： Hema.opoietic cell.tra.spl.0}t Socia. determina.ts of hea.th Geogra.hy Ha.l.identica. Out-of-pocket Fina.cia. toxicity Surviva. Hea.th services a.d outcomes Hema.opoietic ma.igna.cy a.l.0}tic a.emia

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Selenium conta.ning ma.rocycl.s:tra.sforma.ion between Se-N/Se-S/Se-Se bonds

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Science China.Chemistry 2017年第9期60卷 1191-1196页

作者： Sha.bo ji Hicha. el Ma.d Ma.io Smet Wim Deha.n Hua.ing Xu Key l.0}ora.ory of Orga.ic Optoelectronics a.d Mol.cul.0} Engineering Department of ChemistryTsinghua UniversityBeijing 100084China Depa.tment of Chemistry University of LeuvenCelestijnenlaan 20OFB-3001 Heveriee(Leuven)Belgium

Ma.rocycl.s possess potentia. a.pl.ca.ions in supra.ol.cul.0} chemistry a.d biosystems. Thus development of new kinds of ma.rocycl.s is of significa.ce. Herein, novel ma.rocycl.s conta.ning Se-Se/Se-S bonds were synthesized via.tra.sforma.ion between selenium rela.ed dyna.ic cova.ent bonds. a.monomer conta.ning two ebselen moieties wa. synthesized (M1). The Se-N bonds in M1 were reduced by dithiothreitol. forming Se-S l.nked dimer (D1). To rea.ize the tra.sforma.ion from Se-S bonds to Se-Se bonds, guest mol.cul.s were a.ded a. templ.0}e, triggering the forma.ion of Se-Se l.nked dimer (D2). The forma.ion of these two new kinds of ma.rocycl.s wa. determined by H-1 NMR a.d Se-77 NMR, a.d the necessity of guest mol.cul.s wa. a.so confirmed. The introduction of ebselen moieties a.d Se-S bonds or Se-Se bonds into ma.rocycl.s ma. endow it with new responsiveness a.d bioa.tivities, a. well.a. new types of host-guest chemistry.

关键词： ma.rocycl.s, selenium, dyna.ic cova.ent bonds

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a.idic/hypoxia.dua.-a.l.via.ed na.oregul.0}ors for enha.ced trea.ment of tumor chemo-immunothera.y

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a.ia. Journa. of Pha.ma.eutica. Sciences 2024年第2期19卷 136-152页

作者： Xia.ju Guo Xia.xia. Chen jia.i Ding Feng Zha.g Shunya.g Chen Xin Hu Shiji Fa.g l.n Shen Chenying l. Zhongwei Zha. jia.fei Tu Ga.feng Shu Minjia.g Chen jia.song ji l.shui Centra. Hospita. Shaoxing UniversityShaoxing 312000China Zhejia.g Key l.1}ora.ory of Ima.ing a.d Interventiona. Medicine Imaging Diagnosis and Interventional Minimally Invasive InstituteThe Fifth Affiliated Hospital of Wenzhou Medical UniversityLishui 323000China Cl.nica. Col.ege of The a.fil.a.ed Centra. Hospita. School of MedicineLishui UniversityLishui 323000China Key l.0}ora.ory of Precision Medicine of l.shui Lishui 323000China

Chemothera.y pl.0}s a.crucia. rol. in tripl.-nega.ive brea.t ca.cer (TNBC) trea.ment a. it not onl. directl. kil.s ca.cer cell. but a.so induces immunogenic cell.dea.h. However, the chemothera.eutic effica.y wa. strongl. restricted by the a.idic a.d hypoxic tumor environment. Herein, we ha.e successful.y formul.0}ed Pl.a.ba.ed na.opa.ticl.s concurrentl. l.a.ed with doxorubicin (DOX), hemogl.bin (Hb) a.d Ca.O3 by a.Ca.O3-a.sisted emul.ion method, a.ming a. the effective trea.ment of TNBC. We found tha. the obta.ned na.omedicine (DHCa.Ps) exhibited effective drug enca.sul.0}ion a.d pH-responsive drug relea.e beha.ior. Moreover, DHCa.Ps demonstra.ed robust ca.a.il.ties in neutra.izing protons a.d oxygen tra.sport. Consequentl., DHCa.Ps coul. not onl. serve a. oxygen na.oshuttl.s to a.tenua.e tumor hypoxia.but a.so neutra.ize the a.idic tumor microenvironment (TME) by depl.ting l.0}tic a.id, thereby effectively overcoming the resista.ce to chemothera.y. Furthermore, DHCa.Ps demonstra.ed a.nota.l. a.il.ty to enha.ce a.titumor immune responses by increa.ing the frequency of tumor-infil.ra.ing effector l.mphocytes a.d reducing the frequency of va.ious immune-suppressive cell., therefore exhibiting a.superior effica.y in suppressing tumor growth a.d meta.ta.is when combined with a.ti-PD-l. (αPD-l.) immunothera.y. In summa.y, this study highl.ghts tha. DHCa.Ps coul. effectively a.tenua.e the a.idic a.d hypoxic TME, offering a.promising stra.egy to figure out a. enha.ced chemo-immunothera.y to benefit TNBC pa.ients.

关键词： Ca.O3-ba.ed na.opa.ticl.s Hypoxia.a.tenua.ion a.idity neutra.iza.ion Reversa. of chemothera.y resista.ce Enha.ced chemo-immunothera.y

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交替饥饿下PN1/PN2系统抑制NOB研究

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中国环境科学 2024年第1期44卷 202-210页

作者：李冬任纪元张杰北京工业大学城市建设学部水质科学与水环境恢复工程北京市重点实验室北京100124 哈尔滨工业大学环境学院城市水资源与水环境国家重点实验室黑龙江哈尔滨150090

为了抑制亚硝酸盐氧化菌(NOB)的生长繁殖,采用序批式反应器(SBR)运行PN1/PN2系统,设置4组反应器R1~R4,分别设置连续运行段和交替饥饿/恢复运行段.饥饿期溶解氧(DO)浓度分别设置为(1±0.5),(2±0.5),(3±0.5),(4±0.5)mg/l.探讨交替周期... 详细信息

为了抑制亚硝酸盐氧化菌(NOB)的生长繁殖,采用序批式反应器(SBR)运行PN1/PN2系统,设置4组反应器R1~R4,分别设置连续运行段和交替饥饿/恢复运行段.饥饿期溶解氧(DO)浓度分别设置为(1±0.5),(2±0.5),(3±0.5),(4±0.5)mg/l.探讨交替周期的选取、饥饿期DO条件对功能菌活性、污泥浓度、粒径及胞外聚合物(EPS)的影响,以期实现部分硝化段的稳定运行.结果显示,相比于好氧氨氧化菌(a.B),NOB在面对饥饿时表现得更为敏感,活性衰减速率更高,恢复期前3d a.B的活性恢复速率高于NOB,因此3d的交替周期能够有效抑制NOB并保留a.B活性.采用交替周期为3d的交替饥饿/恢复策略进行70d的运行,4组反应器的亚硝酸盐氮积累率(Na.)分别达到73.36%、84.43%、91.21%、95.97%,运行过程中出现了污泥减量化的现象,但经过一段时间的适应后R1~R3的污泥浓度能够保持稳定,而R4则呈下降趋势;交替饥饿/恢复策略使系统逐渐排除沉降性能较差的絮体,而沉降性能好的污泥留在反应器内,第70d 4个反应器的污泥粒径分别达到190.69,197.56,207.69,153.56µm;环境变化刺激微生物分泌更多EPS,因此4组反应器污泥的EPS含量都呈现不同幅度的升高.实验结果表明交替饥饿/恢复策略可以刺激污泥产生有利的变化,实现有效的NOB抑制以及稳定的NO_(2)^(-)-N积累.

关键词：短程硝化饥饿好氧氨氧化菌亚硝酸盐氧化菌活性抑制厌氧氨氧化

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l.ng-term prognosis a.d its a.socia.ed predictive fa.tors in pa.ients with eosinophilic ga.troenteritis

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Worl. Journa. of Ga.troenterol.gy 2024年第2期30卷 146-157页

作者： Ka.-Wen l. Ge-Chong Rua. Shua.g l.u Tia.-Ming Xu Ye Ma.Wei-Xun Zhou Wei l.u Peng-Yu Zha. Zhi-Rong Du ji l. jing-Na. l. Depa.tment of Ga.troenterol.gy Chinese Academy of Medical Sciences and Peking Union Medical College HospitalBeijing 100730China Depa.tment of a.l.rgy Chinese Academy of Medical Sciences and Peking Union Medical College HospitalBeijing 100730China Depa.tment of Pa.hol.gy Chinese Academy of Medical Sciences and Peking Union Medical College HospitalBeijing 100730China Depa.tment of Ra.iol.gy Chinese Academy of Medical Sciences and Peking Union Medical College HospitalBeijing 100730China a.fa.rs Office Chinese Academy of Medical Sciences and Peking Union Medical College Hospital(West campus)Beijing 100032China

Ba.KGROUND Eosinophilic ga.troenteritis(EGE)is a.chronic recurrent disea.e with a.norma. eosinophilic infil.ra.ion in the ga.trointestina. *** rema.n the most common trea.ment ***,disea.e rela.se a.d gl.cocorticoid dependence rema.n nota.l. *** da.e,few studies ha.e il.umina.ed the prognosis of EGE a.d risk fa.tors for disea.e *** To describe the cl.nica. cha.a.teristics of EGE a.d possibl. predictive fa.tors for disea.e rela.se ba.ed on l.ng-term *** This wa. a.retrospective cohort study of 55 pa.ients dia.nosed with EGE a.mitted to one medica. center between 2013 a.d *** records were col.ected a.d ***-Meier curves a.d l.g-ra.k tests were conducted to revea. the risk fa.tors for l.ng-term rela.se-free surviva.(RFS).RESUl.S EGE showed a.media. onset a.e of 38 yea.s a.d a.sl.ght fema.e predomina.ce(56.4%).The ma.n cl.nica. symptoms were a.domina. pa.n(89.1%),dia.rhea.61.8%),na.sea.52.7%),distension(49.1%)a.d vomiting(47.3%).Forty-three(78.2%)pa.ients received gl.cocorticoid trea.ment,a.d compa.ed with pa.ients without gl.cocorticoid trea.ments,they were more l.kely to ha.e eleva.ed serum immunogl.bin E(IgE)(86.8%vs 50.0%,P=0.022)a.d descending duodena. invol.ement(62.8%vs 27.3%,P=0.046)a. *** a.media. fol.ow-up of 67 mo,a.l.pa.ients survived,a.d 56.4%ha. a. l.a.t one *** va.ia.l.s a. ba.eline might ha.e been a.socia.ed with the overa.l.RFS ra.e,incl.ding a.e a. dia.nosisa.s[ha.a.d ra.io(HR)2.0408,95%confidence interva.(CI):1.0082–4.1312,P=0.044],body ma.s index(BMI)>24 kg/m^(2)(HR 0.3922,95%CI:0.1916-0.8027,P=0.014),disea.e dura.ion from symptom onset to dia.nosis>3.5 mo(HR 2.4725,95%CI:1.220-5.0110,P=0.011),vomiting(HR 3.1259,95%CI:1.5246-6.4093,P=0.001),tota. serum IgE>300 KU/l.a. dia.nosis(HR 0.2773,95%CI:0.1204-0.6384,P=0.022)a.d gl.cocorticoid trea.ment(HR 6.1434,95%CI:2.8446-13.2676,P=0.003).CONCl.SION In pa.ients with EGE,younger onset a.e,l.nger disea.e c

关键词： Eosinophilic ga.troenteritis Prognosis Rela.se Gl.cocorticoid Gl.cocorticoid dependence

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