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The Influence of Gonadectomy on Anxiolytic and Antidepressant Effects of Melatonin in Male and Female Wistar Rats: A Possible Implication of Sex Hormones

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Neuroscience & Medicine 2012年第2期3卷 162-173页

作者： el mrabet fatima zahra Lagbouri Ibtissam Mesfioui Abdelhalim el Hessni Aboubakr Ouichou Ali Laboratory of Genetics Neuroendocrinology and Biotechnology Unit of Nervous and Endocrine Physiology Department of Biology Faculty of Sciences University Ibn Tofail Kenitra Morocco

The main objective of this study was to analyze the effects of sex, ovariectomy (Ovx) and orchidectomy (Orx) on antidepressant and anxiolytic effect of melatonin in forced swimming test, open field test and elevated plus maze test. Initially, 4 mg/kg of melatonin was daily administered, at 4:00 pm, to intact male and female rats during 8 weeks. Our results have shown that the effect of chronic injection of Mel is sex dependent in the three behaviors tests. Females rats have responded better than males in behavior test study after administration of melatonin, this difference between the sexes may be related to the action of sex hormones (androgens and estrogens) on behavior in males as well as in females. Secondly, to determine the possible interaction between Melatonin and steroid hormones, Ovx/sham female received Mel at dose of 4mg/kg alone or NaCl (0.9%) alone, and Orx/sham male received Mel at dose of 4 mg/kg alone or NaCl (0.9%) alone daily and during 8 weeks of treatment at 4:00 pm. All animals were tested in the open-field test, elevated plus maze test for anxiety behavior study, and forced swimming test for depression behavior study. Results revealed that Mel exerts an anxiolytic and antidepressant effects in the orchidectomized males and in intact females, confirming that the suppression of androgens by orchidectomy improved anxiolytic and antidepressant effects of melatonin in males. However in females, the suppression of estrogen by ovariectomy masked the antidepressant and anxiolytic effects of melatonin. Our results confirmed that the antidepressant and anxiolytic effects of melatonin are linked to sex hormones.

关键词： Melatonin Sex Dependent Anxiety Depression Behavior Tests Ovariectomy Orchidectomy Sex Hormones

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Pinealectomy and Exogenous Melatonin Regulate Anxiety-Like and Depressive-Like Behaviors in Male and Female Wistar Rats

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Neuroscience & Medicine 2012年第4期3卷 394-403页

作者： el mrabet fatima zahra Ouaaki Siham Mesfioui Abdelhalim el Hessni Aboubakr Ouichou Ali Laboratory of Genetics Neuroendocrinology and Biotechnology Unit of Nervous and Endocrine Physiology Department of Biology Faculty of Sciences University Ibn Tofail Kenitra Morocco

The main objective of this work was to 1) study the influence of endogenous melatonin (Mel) abolishment via pinealectomy and 2) explore exogenous Mel effect on anxiety-like and depressive-like behavior in male and female rats. Rats were shamoperated (Sh) or pinealectomized (Px) and following subgroups were selected 1) Px/NaCl (0.9%) and Sh/NaCl (0.9%) : rats injected subcutaneously, once daily for 8 weeks, with saline solution NaCl (0.9%) as vehicle;2) Px/Mel (4 mg/Kg) and Sh/Mel (4 mg/Kg): Rats similarly injected with 4 mg/Kg of Mel. All animals were housed under a photoperiod of (LD:16/8). After different treatments animals were tested in the open-field test (OFT), elevated plus maze test (EPM) to determine anxiety-like behavior, and forced swimming test (FST) to evaluate depressive-like level. Our results revealed that level of anxiety-like and depressive-like behavior are significantly higher in Px/NaCl (0.9%) when compared to Sh/NaCl (0.9%) group, suggesting that pinelectomy induced an anxiogenic and depressant effects. The Px effects would be due to the absence of endogenous Mel synthesis and release. Additionally, we clearly demonstrated that the level of anxiety-like and depressive-like behavior are higher in Px/Mel (4 mg/Kg) and Sh/Mel when compared respectively to Px/NaCl (4 mg/Kg) and Sh/NaCl groups suggesting an anxiolytic and antidepressant effects of exogenous Mel. Behavioral responses were sex dependent since the difference between females and males, especially, after melatonin administration, were statistically significant. These experiments provide evidence that pinealectomy and Mel regulated emotionally behavior in male and female rats.

关键词： Pinealectomy Melatonin Sex Dependent Anxiety Depression Behavioral Tests

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The Influence of Gonadectomy on Anxiolytic and Antidepressant Effects of Melatonin in Male and Female Wistar Rats: A Possible Implication of Sex Hormones

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Neuroscience ＆ Medicine 2012年第2期

作者： el mrabet fatima zahra Lagbouri Ibtissam Mesfioui Abdelhalim el Hessni Aboubakr Ouichou Ali

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Development and assessment of algorithms for DEM-LES simulations of fluidized bed

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Particuology 2023年第12期83卷 241-257页

作者： fatima Ez-zahra el Hamra Radouan Boukharfane UM6P College of Computing Mohammed Ⅵ Polytechnic University(UM6P)BenguerirMorocco

The use of high-fidelity Discrete element Method(DEM)coupled with Computational Fluid Dynamics(CFD)for particle-scale simulations demands extensive simulation times and restricts application to small particulate ***-CFD simulations require good performance and satisfactory scalability on high-performance computing platforms.A reliable parallel computing strategy must be developed to calculate the collision forces,since collisions can occur between particles that are not on the same processor,or even across processors whose domains are *** present paper describes a parallelization technique and a numerical verification study based on a number of tests that allow for the assessment of the numerical performance of DEM used in conjunction with Large-Eddy Simulation(LES)to model dense flows in fluidized *** fluid phase is computed through solving the volume-averaged four-way coupling Navier-Stokes equations,in which the Smagorinsky sub-grid scale tensor model is ***,the performance of Sub-Grid Scale(SGS)turbulence models applied to Fluidized Bed Reactor(FBR)configurations has been assessed and *** developed numerical solver represents an interesting combination of techniques that work well for the present purpose of studying particle formation in fluidized beds.

关键词： DEM-LES Fluidized bed Computational efficiency Numerical accuracy

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Adaptive Backstepping Control Design for Semi-Active Suspension of Half-Vehicle With Magnetorheological Damper

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IEEE/CAA Journal of Automatica Sinica 2021年第3期8卷 582-596页

作者： Khalid el Majdoub Fouad Giri fatima-zahra Chaoui Department of electrical Engineering University Hassan IIFaculty of Science and TechnologyMohammedia 20030Morocco Department of electrical Engineering University de Caen NormandieCaen 14032France Department of electrical Engineering University Mohamed VRabat 10000Morocco

This paper investigates the problem of controlling half-vehicle semi-active suspension system involving a magnetorheological(MR)*** features a hysteretic behavior that is presently captured through the nonlinear Bouc-Wen *** control objective is to regulate well the heave and the pitch motions of the chassis despite the road *** difficulty of the control problem lies in the nonlinearity of the system model,the uncertainty of some of its parameters,and the inaccessibility to measurements of the hysteresis internal state *** Lyapunov control design tools,we design two observers to get online estimates of the hysteresis internal states and a stabilizing adaptive state-feedback *** whole adaptive controller is formally shown to meet the desired control *** theoretical result is confirmed by several simulations demonstrating the supremacy of the latter compared to the skyhook control and passive suspension.

关键词： Adaptive control backstepping control Bouc-Wen model half vehicle model magnetorheological(MR)damper semiactive suspension skyhook control state observation

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Generation of Different Classes of Multipartite Entanglement Using Cavity-QED

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Communications in Theoretical Physics 2018年第2期69卷 131-136页

作者： Mustapha Ziane Rachid el Guerbouz fatima-zahra Siyouri Morad el Baz Equipe Sciences de la Matière et du Rayonnement Département de Physique Faculté des sciences Université Mohammed V Av.Ibn Battouta

Using a system of cavity quantum electrodynamics （QED） we present two schemes for multipartite entan- glement generation. In the first scheme, a three-level atom is interacting with three cavities successively. In the second one, two three-level atoms are interacted with a coherent optical cavity. These protocols allow us to generate the six c/asses of tripartite entanglement （GHZ, W, A-B-C, AB-C, C-AB, and B-AC class states） by controling the interaction time between atoms and cavities. Moreover, they allow us to generate entanglement between the cavity fields degrees of freedom （from the first scheme）, and a mixed entanglement between the cavity field degrees of freedom and the atomic degrees of freedom.

关键词： entanglement coherent states cavity QE-D GHZ states W states

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Apatite Fission-Track Datings on Hercynian Granites from Rehamna and Jebilet Massifs(Western Meseta,Morocco):Paleogeographic Implications and Interpretation of AFT Age Discrepancies

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地学前缘 2009年第S1期16卷 217-218页

作者： Omar Saddiqi fatima zahra el Haimer Hassan Ⅱ University CasablancaMoroccoFaculty of Sciences Laboratoire Géosciences Faculté des SciencesUniversite Hassan Ⅱ An Chock

This work is based on apatite fission-track analysis of samples(mostly granites)from the basement of the Cretaceous-Tertiary Phosphate and Ganntour Plateaus, exposed in the Jebilet and Rehamna massifs (Western Meseta,... 详细信息

关键词： thermochronology fission track apatite exhumation Rehamna Jebilet Western Meseta Morocco

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Mechanical and Thermal Properties of Polypropylene Reinforced with Almond Shells Particles： Impact of Chemical Treatments

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Journal of Bionic Engineering 2015年第3期12卷 483-494页

作者： fatima zahra el Mechtali Hamid Essabir Souad Nekhlaoui Mohammed Ouadi Bensalah Mohammad Jawaid Rachid Bouhfid AbouEIkacem Qaiss Laboratory of Mechanic and Materials (LMM) Mohammed V-Rabat University Faculty of Science Rabat Morocco Moroccan Foundation for Advanced Science Innovation and Research (MAScIR) Institute of Nanomaterials and Nanotechnology (NANOTECH) Laboratory of Polymer Processing Rabat Morocco Laboratory of Mechanics in Processes Energy and Environment National School of Applied Sciences Ibn Zohr University Agadir Morocco Department of Biocomposite Technology Institute of Tropical Forestry and Forest Products (INTROP) Universiti Putra Malaysia 43400 UPM Serdang Selangor Malaysia

Polypropylene （PP） matrix composites reinforced with chemically treated Almond Shell （AS） particles with and without compatibilizer （PP-g-MA） was prepared by a twin-screw extrusion at loading of 20 wt.% AS particles. Two types of chemical treatments （alkali treatment with sodium hydroxide and etherification with dodecane bromide） of the particles were carried out to improve the interface adhesion between particles and PP matrix. Results show that chemical modifications of AS particles affect the mechanical and viscoelastic properties of AS/PP composites. The composites reinforced with alkali treated particles and the compatibilized matrix lead to a notable increase in the Young＇s modulus （14%） compared to the composites with untreated AS particles. The ductility of composite was also evaluated by the yield strain, and results show a notable increase （31%） compared to that of composites with untreated particles. The thermal stability increased with the use of etherification （385 ℃）, with gains in the temperature up to 23 ℃ compared to neat PP （362 ℃）. The achieved results show that the AS/PP composites can be used in several applications. A thermoplastic matrix compsite mixed with treated AS particles appears to be a good alternative to obtain environmentally friendly products.

关键词： PP AS chemical treatment composite extrusion injection

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Conversion of L-Tryptophan into Melatonin Is the Possible Action Pathway Involved in the Effect of L-Tryptophan on Antidepressant-Related Behavior in Female Rats: Analysis of the Influence of Treatment Duration

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Journal of Behavioral and Brain Science 2013年第4期3卷 362-372页

作者： Sihame Ouakki fatima zahra el mrabet Aboubaker el Hessni Abdelhalem Mesfioui Paul Pévet Ali Ouichou Institute for Cellular and Integrative Neurosciences Strasbourg University Strasbourg France Laboratory of Genetics Neuroendocrinology and Biotechnology Unit of Nervous and Endocrine Physiology Faculty of Sciences Université Ibn Tofail Kenitra Morocco

The aim of this study was to determine the effect of pharmacological doses of melatonin (Mel) and L-tryptophan (L-TRP) on depression-like behavior in female rats submitted to the forced swimming test (FST) after 2, 4, 6 or 8 weeks of treatment. This will allow exploring the different mechanisms of L-TRP actions particularly that due to its conversion into Mel. For this purpose, four groups of 24 rats each were constituted;(Group 1: Control): received saline solution NaCl (0.9%), (Group 2: Mel4): received 4 mg/Kg of Mel, (Group 3: L-TRP4): received 4 mg/Kg of L-TRP and (Group 4: L-TRP20): received 20 mg/Kg of L-TRP. Animals of each group were distributed on 4 subgroups of 6 rats submitted to different time treatments. The duration of immobility (TIM) and struggling period (TST) of rats in FST were measured after 2, 4, 6 and 8 weeks of drug treatment and the effects of Mel and L-TRP were compared. Chronical administration of different doses of Mel or L-TRP failed to induce any anti-depressant activity in rats subjected to FST after 2 weeks of treatment. However, after 4 weeks, daily administration of Mel at 4 mg/Kg significantly reduced the immobility period and enhanced struggling time. After 6 weeks, Mel at 4 mg/Kg and L-TRP at 20 mg/Kg were both effective in reducing immobility and increasing struggling movement, their effects being statistically comparable. All treatments were able to significantly reduce immobility time and increase struggling duration after 8 weeks, but L-TRP at 4 mg/Kg was less potent than Mel and L-TRP at 20 g/Kg. The antidepressant-like activity of L-TRP was dose and time dependent, and that of Mel was time dependent. In conclusion, the study showed that at pharmacological doses, Mel and L-TRP have anti-depressant action, and such effect is dependent on time treatment;Mel?is more effective than L-TRP. In conclusion, L-TRP, through Mel, 5-HT or by itself could modulate aminergic neurotransmission in the different brain areas to ensure its beha

关键词： Melatonin L-Tryptophan Depression Forced Swimming Immobility Struggling Female Rats

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Recognition of the hydrogeological potential using electrical sounding in the Khemisset-Tiflet region, Morocco

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Journal of Groundwater Science and Engineering 2020年第2期8卷 172-179页

作者： fatima zahra FAQIHI Anasse BENSLIMANE Abderrahim LAHRACH Mohamed CHIBOUT Mohamed el MOKHTAR Laboratory Géodynamics and Natural Ressources Faculty of Sciences Dhar El MahrazUniversity Sidi Mohamed Ben AbdellahPB 1796 Fez-Atlas30003Morocco Laboratory of Georessourcesand Environment Faculty of Sciences and TechniqueUniversity Sidi Mohamed Ben AbdellahFES PB 2202-Route d’ImouzzerFES-Morocco Laboratory of Geosciences of Natural Resources Faculty of SciencesUniversity Ibn TofailPB 133Kenitra Morocco

The low recharge of reservoirs and the increasing demand for water limit the potential of mobilized resources, especially in arid to semi-arid areas like Morocco. Integrated management is essential to safeguard this resource. In respect with this perspective, this work provides the analysis of hydrogeological potential of Khemisset-Tiflet region, which falls within the action area of the Sebou Hydraulic Basin Agency. The basis of our studies was as follows:(1) The interpretation of the existing geoelectric data;(2) application of geophysical methods for non-destructive reconnaissance and their integration into a Geographic Information System(GIS). The analysis demonstrates that: The map of the isohypses and the geoelectric cross-section of the substratum of the superficial roof aquifer show clearly a plunge associated with development of the Paleozoic roof in the South and the direction of flow of the surface water is from south to north, from the upper zone to the north of the el Kansera dam. These conclusions constitute very useful contribution for any resource management projects in this area.

关键词： Geophysics Geoelectic Aquifer Hydrogeology GIS Khémisset-Tiflet

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