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Contribution of the Neuroanatomy of the Cingulate Gyrus to the Neuroscientific Approach to Depression

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Open Journal of Psychiatry 2022年第1期12卷 37-48页

作者： Racky Wade-Kane el hadji makhtar ba Momar Camara Mamadou Habib Thiam Department of Psychiatry and Medical Psychology Moussa Diop Psychiatric Clinic Fann National University Hospital Center Dakar Senegal

Introduction: Numerous studies show the involvement of the cingulate gyrus in affective disorders, particularly in depression. With a preventive and curative aim, the authors raise questions leading to therapeutic applications such as focal brain stimulation. The cingulate gyrus is the primary target of these brain stimulation therapies for the treatment of depression. The objective of this work is to establish anatomoclinical correlations and to deduce the therapeutic implications. Methodology: Our work is a review of the literature. The inventory of the cingulate gyrus and depression was based on the development of a critical synthesis of bibliographic knowledge. Results: We found a bipartite Brodmann subdivision which evolved into a subdivision into four regions of the cingulate gyrus. Descriptions of the cingulate gyrus boundaries are imprecise and divergent. The anterior end of the anterior cingulate cortex is a confirmed target of stimulation in the treatment of major and resistant depression, thus requiring the authors, a consensus in its delineation. Brodmann’s area 25 has been described as the main target of brain stimulation therapies. Dysfunction by local lesion or by alteration of the connectivity of Brodmann’s area has repercussions on these different structures to which it is interconnected. These disturbances when they are in the direction of collapse paint a picture similar to major depression. Conclusion: The anterior cingulate cortex is involved in depression. The functional system organization of affectivity will allow new brain stimulation techniques to act on the entire functional system or on one of its components.

关键词： Cingulate Gyrus Depression Anatomy Psychiatry

Perpetrators of Sexual Violence against Minors in Casamance (Senegal)

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Open Journal of Psychiatry 2023年第1期13卷 33-44页

作者： Adama Koundoul Ibra Diagne Bernadette F. Sambou Issa Wone el hadji makhtar ba Sokhna Seck Papa Lamine Faye Emile badiane Psychiatric Center Ziguinchor Senegal Health Emergency Operations Center Dakar Senegal Assane Seck University Ziguinchor Senegal Fann National University Hospital Center Cheikh Anta Diop University Dakar Senegal

Introduction: The causes of sexual delinquency against children are multifactorial and the motivations that drive the perpetrators of sexual assault are diverse. Nowadays, there is still no consensus on a single portrait of child sex offenders and studies that focus on sex offenders are still rare in Senegal and Africa. Objectives: To determine the profile of the perpetrators and to identify the circumstances of sexual violence against minors in Casamance. Materials and Methods: A retrospective descriptive and analytical study from April 1, 2014 to October 31, 2019 was conducted. The study population was made up of perpetrators of sexual violence against minors whose legal proceedings were dealt with at the Ziguinchor High Court. The data were entered into an Excel spreadsheet and then analyzed using Epi InfoTM 7 software. Results: A total of 106 cases of sexual violence against minors were collected for 113 aggressors and 106 victims. Rape accounted for 66.03% of sexual violence. Male aggressors were 98.23%. Female victims accounted for 95.28%. The average age of the attackers was 32.52 years (±13.68). Offenders over the age of 35 committed the most rape (p = 0.043). The average age of the victims was 12.62 years (±3.42). Victims aged ten and over (p = 0.015) and who had a low level of education (p = 0.016) were more exposed to rape. The assault took place during the day (65.71%) and at the home of the aggressor (62.26%). Victims knew their attackers (84.47%). Victims were assaulted more than once by the same assailant (40.57%). Those aged 10 years and over (p = 0.0037) and who knew their attackers (p = 0.014) were more at risk of being repeatedly sexually abused. Conclusion: In Senegal, sexual violence against minors is perpetrated by young adult men, single, with little or no education and exercising low-income professions. Rape is the type of aggression preferred by perpetrators, most of whom were known to their victims. The policy to fight sexual vio

关键词： Sexual Violence Minors Aggressor Casamance

Quantitative Study on Individual Representations in Senegalese Patients Living with HIV (PLHIV)

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Open Journal of Psychiatry 2022年第1期12卷 23-36页

作者： Racky Wade-Kane Momar Camara el hadji makhtar ba Idrissa ba Sokhna Seck Abou Sy Ibrahima Ndiaye Oumar Mamadou Samba Ndéye Dialé Ndiaye Ndongo Papa Lamine Faye Aida Sylla Mamadou Habib Thiam Department of Psychiatry and Medical Psychology National University Hospital Center of Fann Dakar Senegal Center for the Integrated Support of Addictions in Dakar (CEPIAD) National University Hospital Center of Fann Dakar Senegal

Context: HIV infection is an infectious, viral, chronic disease described as a public health problem. It has an impact on bio-psycho-social well-being. Thus, the objective of our study is to decrypt the representations of HIV infection in our patients. Methodology: 31 consecutively recruited HIV-infected patients participated in our study. The completed questionnaire included socio-demographic characteristics, association membership, psycho-social aspects of HIV infection, mode of transmission and adherence to antiretroviral treatment. Secondly, we proceeded to an assessment of the psychological state of the patient. Results: Almost 77% of HIV patients do not date peers in an association. At the time of the study, more than half of patients or 19/31 with HIV had a positive image of the disease. Before the diagnosis of the disease, more than 2/3 of patients with HIV, i.e. 25/31, have a negative image of the disease. The 31 PLHIV have been aware of their positive HIV status for an average of 11 years with extremes of 2 years and 21 years. Almost 21/31 of PLHIV have shared their positive serological status. The main barrier in patient communication was the risk of disclosure of HIV status. Most of the patients (45.2%) thought of death when they announced their positive HIV status, and 19.4% thought of their children. In 80.6% of cases, relationships with family, friends and neighbors were normal and remained unchanged for 74% of patients. The patients thought they had been infected through sexual intercourse in 84% of cases. Our study showed that 6 of the 31 PLHIV experienced stigma. Among these 6 patients, 3 had psychological repercussions and a voluntary interruption of treatment. Conclusion: The representations are dynamic. In Senegal, the eradication of discrimination among people living with HIV must imperatively involve a reconstruction of individual, collective and social representation

关键词： HIV Representations Stigma Senegal

Place of Bone Scintigraphy in the Assessment of Extension and Follow-Up of Breast Cancer in Senegal: Study of 165 Cases in the Nuclear Medicine Department of Idrissa Pouye General Hospital (Dakar)

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Open Journal of Medical Imaging 2024年第1期14卷 10-30页

作者： el hadji Amadou Lamine bathily Mamoudou Salif Djigo Djimby ba Gora Thiaw Ousseynou Diop Kalidou Gueye Olatounde Herbert Fachinan Boucar Ndong Omar Ndoye Mamadou Mbodj Nuclear Medicine Department Idrissa Pouye General Hospital (HOGIP) Dakar Senegal Biophysics Laboratory FMPO UCAD Dakar Senegal Nuclear Medicine Department Hospital Dalal Jamm Dakar Senegal Nursing and Obstetrics Training Institute Parakou University Parakou Benin

Introduction: Breast cancer is the most common cancer in women worldwide, accounting for an estimated 22% of all female cancers. It is the leading cause of cancer mortality in women, almost all of which is due to metastases, with 73% of metastases occurring in the bone. In oncology, metastable technetium 99-labelled methylene bisphosphonate bone scintigraphy (BS) remains the standard examination for detecting and assessing the extent of bone metastases. The aim of this study was to assess the role of BS in the evaluation and follow-up of breast cancer in Senegal. Methodology: This was a retrospective study of breast cancer patients who underwent bone scintigraphy with 99mTc-HMDP in the nuclear medicine department of Idrissa Pouye General Hospital (IPGHO), from July 2009 to June 2022. Results: We enrolled 165 patients, mean age 46.79 years (27 - 87 years). BS was performed in 94.37% of cases for post-therapeutic monitoring and in 5.63% for pre-therapeutic assessment. Results were contributory in 131 patients (92.25%), of whom 72 cases (50.70%) were normal and 59 cases (41.55%) positive or presenting bone metastases;and non-contributory or doubtful in 11 cases (7.75%). Secondary bone locations were multiple in 57 cases (96.61%) and single or solitary in 2 cases (3.39%). The scintigraphic appearance of bone metastases was hyper-fixative in 58 cases (98.31%) and mixed in 1 case (1.69%). Bone lesions were quantified using the Soloway’s grading classification. Conclusion: BS with 99mTc-labelled bisphosphonates remains the examination of choice for skeletal exploration, in the detection and extension of bone metastases in breast cancer. Performance has been enhanced by the development of SPECT coupled with CT (SPECT-CT).

关键词： Breast Cancer Bone Scintigraphy 99mTc-HMDP Bone Metastases

Late Diagnosis of Congenital Optic Disc Abnormalities

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Open Journal of Ophthalmology 2024年第3期14卷 229-235页

作者： Aïssatou Aw Soda Mbaye Jean Pierre Diagne Sy el hadji Malick Alassane ba Aly Mbara Ka Serigne Sohibou Gaye Ousmane Ndiaga Senghor Lamine Ndiaye Mouhamed Ndiaye el Hadj Abdellahi Seyid Papa Amadou Ndiaye Ophthalmology Department of Abass NDAO Hospital Cheikh Anta Diop University Dakar Senegal

Purpose: To show epidemiological and imaging aspects of congenital optic disc abnormalities diagnosed late. Method: It was a retrospective study, including all patients with congenital optic disc abnormalities diagnosed at a late age between January 2020 and October 2022 at the eye center of Abass Ndao Hospital. Complete ophthalmological examination was performed with eye imaging according to the cases. Results: 09 patients (10 eyes) were diagnosed with congenital optic disc abnormalities. The mean age was 29 years, with a sex ratio of 0.8. Three patients had consulted for unilateral decreased visual acuity since childhood, two for sudden vision loss and in four cases the diagnosis was fortuitous. Visual acuity was ranged from 1/200 to 20/20. Fundus examination showed myelinated retinal nerve fibers in four eyes, optic disc pit in three eyes including two complicated by maculopathy, two cases of morning glory syndrome and a case of pseudoduplication of the optic disc. Optical coherence tomography, ocular ultrasound B and OCT-Angiography were performed according to the cases. Conclusion: Congenital optic disc abnormalities are often diagnosed late. They are potentially amblyogenic and complications are not rare, worsening the visual prognosis. Their screening should be systematic by ophthalmological examination in newborns.

关键词： Myelinated Nerves Fibers Optic Disc Pit Morning Glory Syndrome Pseudoduplication Optic Disc

Results of the First 10 Cases of Coronary Bypass Surgery in Senegal

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World Journal of Cardiovascular Surgery 2024年第4期14卷 45-60页

作者： Papa Amath Diagne Jean Claude Ndiogou Dione Papa Ousmane ba Momar Sokhna Diop el hadji Boubacar ba Momar Dioum Marième Soda Mbaye Moussa Seck Diop Mory Camara Abdou Lahad Mbengue Abdou Aziz Thiaw Abdoul Khoudoss Diallo Moussa Mareme Samba Dialtabé Ibrahima Guéssé ba Anta Mbaye Sall Papa Salmaneba Amadou Gabriel Ciss Department of Cardiovascular and Thoracic Surgery FANN National University Hospital Dakar Senegal

This is a review of the first 10 coronary artery bypass surgeries performed by the local team. The mean age was 62 years old [45 - 74]. The patients were predominantly male, with a M/F ratio of 4:1. Cardiovascular risk factors were mainly myocardial infarction (MI) (60%), hypertension (50%), obesity (40%) and diabetes (30%), with at least two risk factors per patient. Angina was the main symptom (80%). The average time from presentation to surgery was 8 months. The mean Euroscore 2 was 2.92 ± 1.65 [1.33 - 6.60]. Coronary angiography revealed an average of 2 lesions per patient, with 3-vessel involvement in 70% of cases: the Interventricular artery (IVA) (100%), the right coronary artery (90%) and the circumflex artery (70%). On echocardiography, the mean Left ventricular ejection fraction (LVEF) was 59% [33% - 76%]. All patients underwent median sternotomy with bypass grafting. The average duration of the cardiopulmonary bypass was 150 min [46 - 275 min];that of aortic clamping, 120 min [43 - 232 min]. The grafts used were internal thoracic artery (ITA) in 100% of cases (80% on the left and 20% on the right), and the great saphenous vein (GSV) in 60% of cases (50% on the left and 10 on the right). Double bypass was performed in 60% of cases, single bypass in 30% and triple bypass in 10%. The bypasses were performed on the IVA (100%), the middle lateral of the circumflex (30%) and the bisector (20%). The average time to extubation was 11 hours and the length of stay in the intensive care unit was 7 days [03 - 17 days]. One patient had a reoperation on Day 0 post-op. The average hospital stay was 13 days [06 - 27 days]. Complications occurred in nine of the patients (90%), with a predominance of infectious and neurological complications. Overall operative mortality was 3%, all in intensive care.

关键词： Coronary Bypass Surgery Coronary Lesions Cardiac Surgery Senegal

Giant Cerebriform Nevus Cell Nevus of the Scalp: A Case Report

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Open Journal of Modern Neurosurgery 2024年第1期14卷 8-13页

作者： Mohamed el Hassimi Cissé N’daraw Ndoye Anne Aurore Sankale Pauline Diousse Abdoulaye Diop Alvine Nah Doe Sagar Diop Momar Codé ba Seydou Boubakar badiane Neurosurgery Department of CHU Mère-Enfant “Le Luxembourg” Bamako Mali Neurosurgery Department of CHNU de Fann Dakar Sénégal Plastic and Cosmetic Surgery Department of CHU Le Dantec Dakar Sénégal Dermatology Department of Thiès Regional Hospital Thiès Sénégal

Giant cerebriform nevus cell nevus of the scalp is an extremely rare form of congenital melanocytic nevus. Giant cerebriform nevus of the scalp has a major psychosocial impact because of its unsightly appearance with fetid maceration. We report the case of a 35-year-old woman who had a painless, malodorous swelling of the cerebriform scalp measuring 20 × 17 cm in diameter with a wide base of insertion at the occipital level adhering to the deep planes. The excision associated with a skin plasty was carried out. Histology concluded that there was a giant cerebriform naevo-cellular nevus of the scalp.

关键词： Giant Nevus Tumor of the Scalp Resection

Childhood asthma biomarkers including zinc: An exploratory crosssectional study

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World Journal of Clinical Pediatrics 2024年第1期13卷 31-40页

作者： Hoda Atef Abdelsattar Ibrahim Mona Mohsen Boles Salep Aziz Hanna Dina Mahmoud Khaled Mohamed Abdelhamid el-Khashab Pediatric Clinical Nutrition Unit Faculty of MedicineCairo UniversityCairo 12613Egypt Department of Pediatrics Faculty of MedicineCairo UniversityCairo 12613Egypt Department of Clinical Pathology Faculty of MedicineCairo UniversityCairo 12613Egypt

baCKGROUND Childhood bronchial asthma(ba)is a chronic inflammatory respiratory *** conditions,including zinc deficiency,can affect such allergic *** To outline the difference in serum zinc levels between asthmatic children and healthy *** A cross-sectional study was carried out at Children’s Hospital,Cairo University,investigating serum zinc levels in children with ba(n=40)and healthy children(n=21).Other markers included serum ferritin,iron,hemoglobin(Hb),and immunoglobulin E(IgE)*** t-tests and Mann-Whinny tests were used for *** Kruskal-Wallis test was applied to compare serum ferritin and IgE levels with regard to asthma ***'s rank correlation was performed to explore the relationship between serum ferritin levels and both iron and Hb levels in asthmatic *** Children with ba had higher levels of zinc,yet the difference was not significant(P=0.115).Serum ferritin and IgE levels were significantly higher in asthmatic children(P=0.006 and 0.001,respectively),yet their levels did not differ significantly by severity(P=0.623 and 0.126,respectively).There was a nonsignificant weak correlation between serum ferritin levels and both serum iron and Hb *** Serum zinc levels do not seem to differ between asthmatic children and healthy *** ferritin levels may be a marker of asthma *** IgE levels are not markers of asthma severity.

关键词： Children Asthma Zinc Ferritin

Petrology,geochemistry,and crystal size distribution of the basaltic andesite-dacite association at ***,Central Java,Indonesia:Insights to magma reservoir dynamics and petrogenesis

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Acta Geochimica 2024年第5期43卷 838-855页

作者： Indranova Suhendro Endra Yuliawan Revina Fitri Zen Zulfa Yogi Rahmawati Pandu Eka Priyana Sonna Diwijaya Muhammad Alsamtu Tita Sabila Pratama Suhartono Andre Jonathan Gammanda Adhny el Zamzamy Latief Department of Environmental Geography Faculty of GeographyUniversitas Gadjah MadaSekip Utara Jl.KaliurangBulaksumurYogyakarta 55281Indonesia Centre for Disaster Studies Universitas Gadjah MadaJl.Mahoni C-16BulaksumurYogyakarta 55281Indonesia

Ten rock samples consisting of one pyroclastic density current(PDC1)deposit,seven lava flows(LF1–7),and two summit lava domes(LD1,2)were studied to understand the petrogenesis and magma dynamics at *** stratigraphy is arranged as LF1,PDC1,LF2,LF3,LF4,LF5,LF6,LF7,LD1,and LD2;furthermore,these rocks were divided into two ***Ⅰ,observed in the oldest(LF1)sample,has poor MgO and high ba/Nb,Th/Yb and *** remaining samples(PDC1–LD2)represent typeⅡ,characterized by high MgO and low ba/Nb,Th/Yb and Sr *** suggest that type I is derived from AOC(altered oceanic crust)-rich melts that underwent significant crustal assimilation,while typeⅡoriginates from mantle-rich melts with less significant crustal *** early stage of typeⅡmagma(PDC1–LF3)was considered a closed system,evolving basaltic andesite into andesite(55.0–60.2 wt%SiO_(2))with a progressively increasing phenocryst(0.30–0.48φ_(PC))and decreasing crystal size distribution(CSD)slope(from-3.9 to-2.9).The evidence of fluctuating silica and phenocryst contents(between 55.9–59.7 wt%and 0.25–0.41φ_(PC),respectively),coupled with the kinked and steep(from-5.0 to-3.3)CSD curves imply the interchanging condition between open(i.e.,magma mixing)and closed magmatic systems during the middle stage(LF4–LF6).Finally,it underwent to closed system again during the final stage(LF7–LD2)because the magma reached dacitic composition(at most 68.9 wt%SiO_(2))with abundant phenocryst(0.38–0.45φ_(PC))and gentle CSD slope(from-4.1 to-1.2).

关键词： Sumbing Whole-rock geochemistry Petrogenesis Fractionation Magma mixing Crystal size distribution