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Association Study of Two Polymorphisms in Vitamin D Pathway with Multiple Sclerosis in the Moroccan Population

World Journal of Neuroscience 2017年第4期7卷 363-375页

作者： Asmae Skalli el hachmia ait ben haddou Rachid Tazi-Ahnini Ghislain Armel Mpandzou Houyam Tibar Naima Bouslam Ali benomar Khadija Hajjout Mohamed Yahyaoui elmostafa el Fahime Ahmed Bouhouche Research Team in Neurology and Neurogenetics Medical School and Pharmacy Mohammed V University Rabat Morocco Department of Neurology and Neurogenetics Specialties Hospital Rabat Morocco Laboratory of Biotechnology Medical School and Pharmacy Mohammed V University Rabat Morocco National Blood Transfusion Center Rabat Morocco Assistance Units for Scientific and Technical Research Rabat Morocco

Background: Hypovitaminosis D is reported through the literature to be involved in autoimmune diseases such as multiple sclerosis (MS). In the last decade, numerous studies have investigated the association of single nucleotide polymorphisms (SNPs) with MS, including rs2248359 (CYP24A1) and rs703842 (CYP27B1) that are involved in vitamin D metabolic pathway. However, results were conflicting, probably due to ethnic differences between the studied populations. In this context, the present study aimed to analyze the association between these two SNPs and MS within the Moroccan population. Methods: rs2248359 and rs703842 were genotyped in 113 patients and 146 healthy controls. To assess their association with the disease risk, we compared the genotypic and allelic frequencies between the study groups. We also explored their possible influence on certain clinical features (age at onset, type, disability status and severity score) and with vitamin D3 serum level (DSL) by comparing mean values of these variables between the different genotypes. Results: No statistically significant differences in the distribution of both SNPs were found between patients and controls. A trend has emerged concerning the minor G allele of rs703842 which appears to have a protective effect on developing MS, but this result remained slightly below significance. Also, the two polymorphisms had no impact on the clinical features tested and the DSL. Conclusion: There is no convincing evidence that rs2248359 and rs703842 are associated with MS risk, its clinical features or vitamin D level in Moroccans. Further larger investigations are needed to confirm these findings.

关键词： Multiple Sclerosis Risk rs2248359 rs703842 Clinical Features Serum 25(OH)D3 Level

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Enhancing sustainability in phosphate ore processing:Performance of frying oil as alternative flotation collector for carbonate removal

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International Journal of Mining Science and Technology 2024年第4期34卷 557-571页

作者： Asmae el-bahi Yassine Taha Yassine ait-Khouia Abdellatif elghali Mostafa benzaazoua Geology&Sustainable Mining Institute(GSMI) Mohammed VI Polytechnic UniversityBen Guerir 43150Morocco

Recycling waste frying oils for the synthesis of flotation reagents presents a promising avenue for sustainable waste ***,it offers a cost-effective solution for crafting a specialized collector designed to efficiently remove carbonates and enhance phosphate enrichment in froth flotation *** study focuses on the synthesis of an anionic collector using the saponification reaction of a frying oil sample,subsequently applied to the flotation of calcite and *** elucidate the adsorption mechanisms of the frying oil collector(FrOC)and sodium oleate,a reference collector,on fluorapatite,calcite,dolomite,and quartz surfaces,comprehensive experiments were conducted,including zeta potential measurements and Fourier transform infrared *** revealed diverse adsorption affinities of the molecules towards these *** assess the practical performance of the collector,flotation tests were conducted using a natural phosphate ore mixture,employing a BoxBehnken experimental ***,under optimized conditions(pH 9,1000 g/t of FrOC,3.5 min of conditioning,and 6 min of flotation),FrOC exhibited excellent performance,with calcite and dolomite recoveries exceeding 80%,while apatite recovery in the concentrate fraction remained below 10%.This work exemplifies both circular economy practices and the distinctive approach to sustainable mineral processing.

关键词： Frying oils recycling Phosphate beneficiation Flotation separation Green surfactants Sustainability

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Numerical Study of Temperature and electric Field Effects on the Total Optical Absorption Coefficient in the Presence of Optical Inter-Conduction-Subband Transitions in InGaN/GaN Single Parabolic Quantum Wells

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Fluid Dynamics & Materials Processing 2022年第5期18卷 1253-1261页

作者： Redouane En-nadir haddou el-ghazi Anouar Jorio Izeddine Zorkani Hassan Abboudi Fath Allah Jabouti LPS Sidi Mohamed Ben Abdullah UniversityFez30000Morocco ENSAM Hassan-II UniversityCasablanca20470Morocco

In this paper,we theoretically investigate the total optical coefficient(TOAC)considering 1S-2P and 2S-2P conduction subband transitions in a single parabolic quantum well(SPQW)with an on-center hydrogen-like *** the framework of the effective-mass approximation,the Schrödinger equation is solved numerically to obtain the eigenvalues and their corresponding eigenvectors using the finite difference *** calculations are performed for finite confinement potential height,taking into account the dielectric and effective mass mismatches between GaN and InGaN materials under the considered electric field and temperature *** temperature dependence of the effective mass,dielectric constant and band gap energy are obtained *** the one hand,the results show that a significant shift is produced with the variation of both the temperature and the intensity of the electric *** the other hand,the absorption spectrum is shifted to lower energies with increasing both electric field strength and ***,its amplitude is enhanced with an increase in the intensity of the electric field,and show a slight drop with increasing temperature for the two optical transitions *** results show that such parameters can be used to adjust the optical properties of single parabolic Quantum Well for solar cell applications.

关键词： TOAC optical transitions SPQW electric field intensity temperature hydrogenic-impurity

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Capparis spinosa L waste activated carbon as an efficient adsorbent for crystal violet toxic dye removal: Modeling, optimization by experimental design, and ecological analysis

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Chinese Journal of Chemical Engineering 2024年第7期71卷 283-302页

作者： Mohammed benjelloun Youssef Miyah Salma Ssouni Soulaiman Iaich Mohamed el-habacha Salek Lagdali Khadija Saka el Mustafa Iboustaten Abdelaziz ait Addi Sanae Lairini Rabia Bouslamti Laboratory of Materials ProcessesCatalysisand EnvironmentHigher School of TechnologySidi Mohamed Ben Abdellah UniversityFez 30070Morocco Ministry of Health and Social Protection Higher Institute of Nursing Professions and Health TechniquesFez/Meknes 30070Morocco Laboratory of Biochemistry Faculty of MedicinePharmacy and DentistrySidi Mohamed Ben Abdellah UniversityFez 30070Morocco Laboratory of Applied Chemistry and Environment Faculty of SciencesIbnou Zohr UniversityAgadir 80322Morocco Research Team of Energy and Sustainable Development Higher School of TechnologyIbnou Zohr UniversityGuelmim 81000Morocco Organic Chemistry and Physical Chemistry Laboratory Faculty of SciencesIbnou Zohr UniversityAgadir 80322Morocco

Textile dyes are dramatic sources of pollution and non-aesthetic disturbance of aquatic life and therefore represent a potential risk of bioaccumulation that can affect living *** is imperative to reduce or eliminate these dyes from liquid effluents with innovative biomaterials and ***,this research aims to highlight the performance of Capparis spinosa L waste-activated carbon(CSLW-AC)adsorbent to remove crystal violet(CV)from an aqueous *** mechanism of CV adsorption on CSLW-AC was evaluated based on the coupling of experimental data and different characterization *** efficiency of the CSLW-AC material reflected by the equilibrium adsorption capacity of CV could reach more than 195.671 mg·g^(–1) when 0.5 g·L^(–1) of CSLW-AC(Particle size≤250μm)is introduced into the CV of initial concentration of 100 mg·L^(–1) at pH 6 and temperature 65℃ and in the presence of potassium ions after 60 min of contact time according to the one parameter at a time *** adsorption behavior of CV on CSLW-AC was found to be consistent with the pseudo-second-order kinetic model and Frumkin's linear isothermal *** thermodynamic aspects indicate that the process is physical,spontaneous,and *** optimization of the process by the Box Behnken design of experiments resulted in an adsorption capacity approaching 183.544 mg·g^(–1)([CV]=100 mg·L^(–1) and[CSLW-AC]=0.5 g·L^(–1) at 35 min).The results of the Lactuca sativa seeds germination in treated CV(70%),adsorbent solvent and thermal regeneration(more than 5 cycles),and process cost analysis(1.0484 USD·L^(–1))tests are encouraging and promising for future exploitations of the CSLW-AC material in different industrial fields.

关键词： Box Behnken Capparis spinosa L waste-activated carbon Cost analysis Isotherm Kinetic Regeneration

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Diversity of Entomopathogenic Fungi in Argane Forest Soil and Their Potential to Manage Mediterranean Fruit Fly （Ceratitis capitata）

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Journal of Pharmacy and Pharmacology 2017年第10期5卷 746-754页

作者： A. Hallouti A. Zahidi R. Bouharroud A. el Mousadik A. ait ben Aoumar H. Boubaker Laboratoire de Biotechnologies Microbiennes et Protection des Vegetaux Universitd Ibn Zohr Agadir 80000 Maroc Laboratoire de Biotechnologies et Valorisation des Ressources Naturelles Universite Ibn Zohr Agadir 8000 Maroc Unite de Production Integree des Cultures INRA Agadir 8000 Maroc

The present study forms a part of biological control against the medfly （Ceratitis capitata） and seeks to isolate and determine the diversity of the medfly-associated entomopathogenic fungi in soil samples collected from Argane （Argania spinosa） forest, in different localities of Souss-Massa region. Search and isolation of the indigenous populations of Ceratitis capitata entomopathogenic fungi was carried out by using larvae of this pest as baits. After trapping, isolation and identification of fungal isolates, a pathogenicity test was used to select fungal strains that have significant virulence potential against the Mediterranean fruit fly. The degree of virulence was estimated by the ability of the fungus to induce the disease and/or the death in the insect and also by calculating the lethal time 50 （LT50）. The obtained results were clearly demonstrated the sensitivity of medfly to tested fungal strains and particularly to strains of Fusarium sp., Aspergillus niger and Scopulariopsis sp. that have shown high mortality rates （more than 84%） and to Trichoderma harzianum, Scedosporium sp., Epicoeeum sp. and Ulocladium sp. with more than 70% mortality for the two tested concentrations. Furthermore these strains showed short LT50 （less than 83 hours）. All these results confirm the presence of entomopathogenic fungi of Ceratitis capitata in Argane soil, and prove the potential of entomopathogenic fungi for biocontrol of the Mediterranean fruit fly under laboratory conditions.

关键词： Biological control Ceratitis capitata entomopathogenic fungi Argania spinosa.

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Effect of Cellulose Microfibers from Sugar Beet Pulp By-product on the Reinforcement of HDPE Composites Prepared by Twin‐screw Extrusion and Injection Molding

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Journal of Bionic Engineering 2023年第1期20卷 349-365页

作者： Abdelghani Boussetta Anass ait benhamou Francisco J.Barba Nabil Grimi Mario J.Simirgiotis Amine Moubarik Laboratory of Chemical Processes and Applied Materials Poly Disciplinary FacultySultan Moulay Slimane UniversityBP 592Beni-MellalMorocco Materials Science Energy and Nanoengineering(MSN)DepartmentMohammed VI Polytechnic UniversityLot 660-Hay Moulay Rachid43150Ben GuerirMorocco Materials Science and Process Optimization Laboratory Faculty of Science SemlaliaCadi Ayyad University40000MarrakechMorocco Nutrition and Food Science Area Preventive Medicine and Public HealthFood ScienceToxicology and Forensic Medicine DepartmentFaculty of PharmacyUniversitat de ValènciaAvda.Vicent Andrés Estelléss/n46100BurjassotValènciaSpain Sorbonne Université Universitéde Technologie de CompiègneLaboratoire Transformations Intégrées de La Matière Renouvelable(UTC/ESCOMEA 4297 TIMR)Centre de recherches RoyallieuCS 6031960203Compiègne CedexFrance Campus Isla Teja Institute of PharmacyFaculty of SciencesUniversidad Austral de Chile5090000ValdiviaChile

The aims of this work turn towards the valorization of the underutilized Raw Sugar Beet Pulp by-product to produce white Cellulose Microfibers(CMFs),and its potential effect as a reinforcement for the development of High-Density Polyethylene(HDPE)*** CMFs were first obtained by subjecting raw SBP to alkali and bleaching *** characterization techniques were performed to confirm the successful removal of the amorphous compounds from the surface of individual fibers,including SEM,XRD,TGA,and FT-IR *** CMF loadings(5–10 wt%)were incorporated as bio-fillers into HDPE polymer to evaluate their reinforcing ability in comparison to raw and alkali-treated SBP using twin-screw extrusion followed by injection ***–(Ethylene–Butene)–Styrene Three-Block Co-Polymer Grafted with Maleic Anhydride was used as a compatibilizer to improve the interfacial adhesion between fibers and the ***,mechanical,and rheological properties of the produced composite samples were *** was found that the Young’s modulus were gradually increased with increasing of fibers loadings,with a maximum increase of 30%and 26%observed for composite containing 10 wt%of CMFs and raw SBP,respectively,over neat ***,the use of coupling agent enhances the ductile behavior of the *** was also found that all fiber improves the hardness and toughness behavior of all reinforced composites as well as the complex modulus particularly at 10 wt%.The thermal stability slightly increases with the addition of *** study demonstrates a new route for the valorization of SBP *** fibers can be considered as a valuable bio-fillers candidate for the development of composite materials with enhanced properties.

关键词： Sugar beet pulp By-product-Cellulose HDPE Coupling agent Composite Mechanical and rheological properties

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A Rare Cause of Stomach Gangrene: Necrotizing Gastritis

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Open Journal of Gastroenterology 2015年第2期5卷 7-10页

作者： Hicham el Bouhaddouti Tarik Souiki Khalid Mazine Abdelmalek Ousadden Khalid Mazaz Khalid ait Taleb Department of Visceral Surgery University Hospital Hassan II-Fes Faculty of Medicine and Pharmacy of Fez Sidi Mohamed Ben Abdellah University Fez Morocco

Necrosis of the stomach is rare. It occurs when there is vascular anomalies, gastric volvulus or her-niation and in infectious gastritis. We report a case in which infectious gastritis leads to a necrotiz-ing gastriti... 详细信息

关键词： Gastric Necrosis Necrotizing Gastritis Surgery

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应用蒙特卡罗方法计算能量低于3MeV的光子剂量

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中国医学物理学杂志 1998年第2期15卷 97-101页

作者： Ali benDAOUD A.FAHLI A.ait haddouUnity of work:A.ait haddou (National Center of Energy Science and Nuclear Technology) in Rabat MoroccoA.FAHLI: Hassan Ⅱ University of Science,Faculty ben M′Sik Casablanca Morocco Ali benDAOUD:Hassan Ⅱ Unive 阿里.班达乌德清华大学留学生

目的：用电脑计算在每个物体中每点处点源释放出的原始光子和平均能量损失，以获得光子线在水模体中的剂量分布情况。材料：钴６０机器，长方体的水模体（ＰＨＡＮＴＯＭ），圆柱状钴６０源，直径为２．５厘米，高为２．６厘米。野的范... 详细信息

目的：用电脑计算在每个物体中每点处点源释放出的原始光子和平均能量损失，以获得光子线在水模体中的剂量分布情况。材料：钴６０机器，长方体的水模体（ＰＨＡＮＴＯＭ），圆柱状钴６０源，直径为２．５厘米，高为２．６厘米。野的范围可从６ｃｍ２取到３０ｃｍ２。方法：蒙特卡罗方法。结果：有两种形式：①研究剂量随深度的变化；②相对剂量（Ｒｅｌａｔｉｖｅｄｏｓｅ）。与Ｐｒｏｗｅｓｓ３０００Ｖｅｒｓ３．０４治疗计划的相应结果比较，此程序所得曲线与Ｐｒｏｗｅｓｓ中曲线基本吻合。结论：本程序应用蒙特卡罗方法模拟能量低于３ＭｅＶ的光子输运具有重要的价值。

关键词：放射疗法钴60源剂量计算蒙特卡罗方法水模体

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Hemobilia Due to an Iatrogenic Arteriobiliary Fistula Complicating Laparoscopic Cholecystectomy: A Case Report

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Open Journal of Gastroenterology 2014年第6期4卷 275-278页

作者： Hicham el Bouhaddouti Khalid Mazine Abdesslam Bouassria Ouadii Mouaqit elbachir benjelloun Abdelmalek Ousadden Khalid ait Taleb Department of Visceral Surgery Faculty of Medicine and Pharmacy of Fez University Hospital Hassan II—Fes Sidi Mohamed Ben Abdellah University Fez Morocco

Hemobilia is the result of a pathological communication between bile duct and intra or extrahepatic vessel. 40% to 60% of the haemobilia cases are Iatrogenic, and the other causes are either vascular malformations or hepatic blunt trauma. We describe the case history of a patient in which laparoscopic cholecystectomy was complicated 3 months later by massive hemobilia. The cause of haemorrhage was a fistula between the principal bil duct and the right hepatic artery. This complication was successfully managed by surgery and angiographic embolization with full recovery of the patient.

关键词： Hemobilia Gastrointestinal Bleeding Arteriography

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A Rare Cause of Gastrointestinal Bleeding: Cholecystoenteric Fistula

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Case Reports in Clinical Medicine 2014年第9期3卷 521-523页

作者： Iliass Charif Hossam benhammane Dafr-Allah benajah Said ait Laalim Khalid Mazaz Adil Ibrahimi Mounia el Yousfi Department of Gastroenterology Hassan II University Hospital Faculty of Medicine and Pharmacy of Fez Sidi Mohammed Ben Abdellah University Fez Morocco Department of Surgery Hassan II University Hospital Faculty of Medicine and Pharmacy of Fez Sidi Mohammed Ben Abdellah University Fez Morocco

A 60-year-old woman presented to the emergency department of our university hospital for several episodes of upper gastro-intestinal bleeding (hematemesis and melena). The endoscopic examination (Figure 1) showed a large ulcer at the front of the bulb, with a calculation within it and a visible vessel on the banks of the ulcer treated by putting two clips. Computer tomography (CT), demonstrated a sclerotic, atrophic and multi gallstone gallbladder, with a calculation protruding in the duodenum. The patient underwent surgery which consisted on partial cholecystectomy with duodenal suture and closing of cystic duct.

关键词： Gastrointestinal Bleeding Cholecystoenteric Fistula

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