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Real-time fluorescence image-guided gastrointestinal oncologic surgery:Towards a new era

World Journal of Gastrointestinal Oncology 2021年第9期13卷 1029-1042页

作者： elías martínez-lópez Aleix martínez-Pérez Sergio Navarro-martínez Juan Carlos Sebastián-Tomás Nicola de'Angelis Eduardo García-Granero Department of Surgery University of ValenciaValencia 46010Spain Department of General and Digestive Surgery Hospital Universitario Doctor PesetValencia 46017Spain Faculty of Health Sciences Valencian International UniversityValencia 46002Spain Minimally Invasive and Robotic Digestive Surgery Unit Miulli HospitalAcquaviva delle Fonti 70021Italy Department of General and Digestive Surgery Hospital Universitario y Politécnico La FeValencia 46026Spain

Technological improvements are crucial in the evolution of ***-time fluorescence-guided surgery(FGS)has spread worldwide,mainly because of its usefulness during the intraoperative decision-making *** success of any gastrointestinal oncologic resection is based on the anatomical identification of the primary tumor and its regional lymph *** allows also to evaluate the blood perfusion at the gastrointestinal stumps after colorectal or esophageal ***,a reduction on the anastomotic leak rates has been postulated as one of the foreseeable benefits provided by the use of FGS in these *** the use of fluorescence in lymph node detection was initially described in breast cancer surgery,the technique is currently applied in gastric or splenic flexure cancers,as they both present complex and variable lymphatic *** allows also to perform intraoperative lymphograms or sentinel lymph node *** applications of FGS are being developed to assist in the detection of peritoneal metastases or in the evaluation of the tumor resection *** present review aims to provide a general overview of the current status of real-time FGS in gastrointestinal oncologic *** put a special focus on the different applications of FGS,discussing the main findings and limitations found in the contemporary literature and also the promising near future applications.

关键词： Surgery Colorectal cancer Esophageal cancer Fluorescence Image-guided surgery Anastomotic leak lymph node

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Robotic transanal total mesorectal excision:Is the future now?

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World Journal of Gastrointestinal Surgery 2021年第8期13卷 834-847页

作者： Juan Carlos Sebastián-Tomás Aleix martínez-Pérez elías martínez-lópez Nicola de'Angelis Marcos Gómez Ruiz Eduardo García-Granero Department of Surgery Universidad de ValenciaValencia 46010Spain Department of General and Digestive Surgery Hospital Universitario Doctor PesetValencia 46017Spain Faculty of Health Sciences Valencian International UniversityValencia 46002Spain Minimally Invasive and Robotic Digestive Surgery Unit Miulli HospitalAcquaviva delle Fonti 70021Italy Department of General and Digestive Surgery Hospital Universitario Marqués de ValdecillaSantander 39008Spain Grupo de Investigación en Innovación Quirúrgica Instituto de Investigación Biomédica Valdecilla(IDIVAL)Santander 39008Spain Department of General and Digestive Surgery Hospital Universitarioy Politécnico la FeValencia 46026Spain

Total mesorectal excision(TME)is the standard surgical treatment for the curative radical resection of rectal *** invasive TME has been gaining ground favored by the continuous technological *** procedures,such as transanal TME(TaTME),have been introduced to overcome some technical limitations,especially in low rectal tumors,obese patients,and/or narrow *** earliest TaTME reports showed promising results when compared with the conventional laparoscopic ***,recent publications raised concerns regarding the high rates of anastomotic leaks or local recurrences observed in national *** TaTME(R-TaTME)has been proposed as a novel technique incorporating the potential benefits of a perineal dissection together with precise control of the distal margins,and also offers all those advantages provided by the robotic technology in terms of improved precision and *** short-term results have been reported for R-TaTME,but further studies are needed to assess the real role of the new technique in the long-term oncological or functional *** present review aims to provide a general overview of R-TaTME by analyzing the body of the available literature,with a special focus on the potential benefits,harms,and future perspectives for this novel approach.

关键词： Rectal cancer Minimally-invasive surgery Robotics Total mesorectal excision Transanal approach Natural orifice surgery

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link between caries,periodontitis,and pregnancy:The role of personalized oral hygiene

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World Journal of Clinical Cases 2025年第6期13卷 51-57页

作者： Melissa martínez Nieto martha leticia De león Rodríguez Francisco Javier Alcaraz Baturoni Alma Alicia Soto Chávez Sarah Monserrat lomelímartínez Periodontics Program Department of Integrated Dentistry ClinicsCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340Mexico Department of Medical and life Sciences Centro Universitario de la CiénegaUniversidad de GuadalajaraOcotlán 47810JaliscoMexico Master of Public Health Department of Well-being and SustainableCentro Universitario del NorteUniversidad de GuadalajaraColotlán 46200Mexico

Optimal health during pregnancy is crucial for ensuring the well-being of the mother and the developing *** article is focused on the impact of oral health and the role of personalized oral hygiene management in addressing prevalent dental issues among pregnant women,with particular emphasis on periodontal disease and dental *** the high prevalence of these dental problems and their association with obstetric complications such as pre-term birth and low birth weight,many pregnant women do not receive adequate dental *** gap in care is often due to misconceptions about the safety of dental treat-ments during pregnancy and lack of awareness on the part of healthcare *** of the impacts of oral health and personalization of oral hygiene strategies such as tailored education and support,have proven effective in improving oral health in this *** reductions in the incidence of caries and periodontal disease may be achieved by adapting care to the specific needs of each patient,thereby enhancing maternal and fetal health *** of personalized oral hygiene management into maternal health pro-grams and enhancement of ongoing education for pregnant women and healthcare professionals are essential steps in the reduction of pregnancy-related risks and improvement of maternal and neonatal *** Tip:In this article,we reviewed a recent study on the effects of personalized oral hygiene management on the oral health of pregnant women,as discussed in the article by Men et *** study demonstrated that personalized oral hygiene interventions significantly improved oral health outcomes during pregnancy by reducing the prevalence of dental caries and periodontal *** emphasized the importance of individualized oral care programs that integrate education and tailored support,and we highlighted their significance in enhancing maternal and fetal *** approach underscores the need for

关键词： Pregnancy Periodontal disease Periodontitis Dental caries Oral hygiene

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Would behavioral thermoregulation enable pregnant viviparous tropical lizards to cope with a warmer world?

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Integrative Zoology 2017年第5期12卷 379-395页

作者： Saúl lÓpez-AlCAIDE Miguel NAKAMURA Eric N.SMITH Enrique martÍnez-MEYER Departament of Zoology Institute of BiologyNational Autonomous University of MexicoMexico CityMexico Center for Research in Mathematics GuanajuatoMexico Amphibian and Reptile Diversity Research Center and Department of Biology University of Texas at ArlingtonArlingtonTexasUSA

Sceloporus lizards depend on external heat to achieve their preferred temperature(Tsel)for performing physiological *** both in the field and laboratory indicates that pregnant females of this Genus select body temperatures(Tb)lower than 34℃ as higher temperatures may be lethal to ***,thermoregulation is crucial for successful embryo *** the increase in global air temperature,it is expected that the first compensatory response of species that inhabit tropical climates will be behavioral *** tested whether viviparous Sceloporus formosus group lizards in the wild exhibited differences in thermoregulatory behavior to achieve the known Tsel for developing embryos regardless of local thermal *** quantified field active body temperature,thermoregulatory behavior mechanisms(time of sighting,microhabitat used and basking time)and available microhabitat thermal conditions(*** temperature)for 10 lizard species during gestation,distributed along an altitudinal *** applied both conventional and phylogenic analyses to explore whether Tb or behavioral thermoregulation could be regulated in response to different thermal *** species showed no significant differences in field Tb during gestation regardless of local thermal *** contrast,they exhibited significant differences in their behavioral thermoregulation associated with local environmental *** on these observations,the differences in thermoregulatory behavior identified are interpreted as compensatory adjustments to local thermal *** conclude that these species may deal with higher temperatures predicted for the tropics by modulating their thermoregulatory behavior.

关键词： altitudinal gradient behavior global warming Sceloporus formosus thermal stress

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Effect of initial microstructure on austenite formation kinetics in high-strength experimental microalloyed steels

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International Journal of Minerals,Metallurgy and Materials 2015年第12期22卷 1304-1312页

作者： Edgar lópez-martínez Octavio Vázquez-Gómez Héctor Javier Vergara-Hernández Bernardo Campillo Faculty of Chemistry Metallurgical Engineering Department Autonomous National University of Mexico National Council for Science and Technology Metallurgy Science Postgraduate Programme Morelia Institute of Technology Institute of Physical Sciences Autonomous National University of Mexico

Austenite formation kinetics in two high-strength experimental microalloyed steels with different initial microstructures comprising bainite-martensite and ferrite-martensite/austenite microconstituents was studied during continuous heating by dilatometric analysis. Austenite formation occurred in two steps：（1） carbide dissolution and precipitation and （2） transformation of residual ferrite to austenite. Dilatometric analysis was used to determine the critical temperatures of austenite formation and continuous heating transformation diagrams for heating rates ranging from 0.03°C.s^-1 to 0.67°C.s^-1. The austenite volume fraction was fitted using the Johnson-Mehl-Avrami-Kolmogorov equation to determine the kinetic parameters k and n as functions of the heating rate. Both n and k parameters increased with increasing heat- ing rate, which suggests an increase in the nucleation and growth rates of austenite. The activation energy of austenite formation was determined by the Kissinger method. Two activation energies were associated with each of the two austenite formation steps. In the first step, the austenite growth rate was controlled by carbon diffusion from carbide dissolution and precipitation; in the second step, it was controlled by the dissolution of residual ferrite to austenite.

关键词： non-isothermal kinetics microalloyed steel austenite heating dilatometry

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Amyloid-beta pathology-induced nanoscale synaptic disruption:the case of the GABA_B-GIRK assembly

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Neural Regeneration Research 2025年第5期20卷 1409-1410页

作者： Rafael lujan Alejandro martín-Belmonte Sergi Ferré Francisco Ciruela Synaptic Structure laboratory Instituto de Biomedicina de la UCLM(IB-UCLM)Departamento de Ciencias MédicasInstituto de Investigación en Salud de Castilla-La Mancha(IDISCAM)Facultad de MedicinaUniversidad Castilla-La ManchaCampus BiosanitarioC/AlmansaAlbaceteSpain Integrative Neurobiology Section National Institute on Drug AbuseIntramural Research ProgramNational Institutes of HealthBaltimoreMDUSA Pharmacology Unit Department of Pathology and Experimental TherapeuticsSchool of Medicine and Health SciencesInstitute of NeurosciencesUniversity of BarcelonaNeuropharmacology&Pain GroupNeuroscience ProgramBellvitge Institute for Biomedical ResearchL’Hospitalet de LlobregatSpain

Alzheimer's disease (AD) is characterized by an imbalance between excitatory and inhibitory brain networks,leading to aberrant homeostatic synaptic *** has progressively been recognized as syna ptopathy and syna ptic dysfunction has been identified as a key component of its pathogenesis (Schirinzi et al.,2020).Syna ptic dysfunction is believed to precede synapse loss,a primary biological correlate of cognitive decline in AD,inevita bly associated with neuronal death.

关键词： Alzheimer pathology

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Influence of agriculture and aquaculture activities on the response of autotrophic picoplankton in laguna Macapule, Gulf of California (Mexico)

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Ecological Processes 2017年第1期6卷 41-51页

作者： Aída martínez-lópez Cristian Hakspiel-Segura Diana Cecilia Escobedo-Urías Bárbara González-Acosta Centro Interdisciplinario de Ciencias Marinas-IPN(CICIMAR) Av.IPN s/nCol.Playa Palo de Santa RitaLa PazB.C.S.23096Mexico Centro de Interdisciplinario de Investigación para el Desarrollo Integral Regional (CIIDIR–Unidad Sinaloa)Bulevar Juan de Dios Bátiz Paredes 250Col.San JoachinGuasaveSinaloa 81101Mexico

Introduction:The lagoon is a component of coastal zones,whose populations of autotrophic picoplankton(APP)remain largely *** lagoons display high-nutrient productivity and additionally may also be subjected to anthropogenic *** study selected laguna Macapule,located on the eastern shore in the mid-region of the Gulf of California,due to the fact that a drainage network servicing the surrounding agricultural region(>230,000 hectares under cultivation)directs irrigation runoff,shrimp farm effluents,and urban wastewater containing large quantities of nutrients to be discharged into this *** propose to identify the APP’s response to various types of environmental and anthropogenic influence in this highly impacted coastal ***:Two sites(separated by 2.7 km)were monitored from December 2007 to December ***,located at the entrance to laguna Macapule(oceanic influence)and the other a discharge canal(eutrophic conditions)inside the lagoon at el Tortugó***:APP was the numerically dominant phytoplankton fraction(15×106 to 620×106 cells l−1)with coccoidal cyanobacteria as the dominant fraction throughout the *** levels were reached in spring-early autumn and they were the second largest contributor to *** of APP cells corresponds to the lagoon’s eutrophic *** numbers and a higher average of APP were recorded at the el Tortugón channel during the warm season(months with SST higher than 24°C).The general positive relationship of the APP’s annual cycle at both sites as well as a negative relationship with heterotrophic nanoflagellates(HNF)abundance,supports the idea that natural forcing,in particular sea surface temperature(SST)is the predominant influences on APP’s seasonal ***:Distinguishable significant differences in APP abundances and nutrients were recognizable between the two *** interplay of these variables contributed to lower densities of APP in winter and high de

关键词： Aquaculture Autotrophic picoplankton Eutrophic conditions Heterotrophic ciliates Heterotrophic nanoflagellates Urea

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Physiopathology of ischemic stroke and its modulation using memantine:evidence from preclinical stroke

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Neural Regeneration Research 2021年第3期16卷 433-439页

作者： Hilda martínez-Coria Isabel Arrieta-Cruz María-Esther Cruz Héctor E.lópez-Valdés División de Investigación Facultad de MedicinaUniversidad Nacional Autónoma de México(UNAM)Ciudad de MéxicoMéxico laboratorio Experimental de Enfermedades Neurodegenerativas Facultad de MedicinaUNAM/Instituto Nacional de Neurología y NeurocirugíaCiudad de MéxicoMéxico Departamento de Investigación Básica Instituto Nacional de GeriatríaCiudad de MéxicoMéxico Unidad de Investigación en Biología de la Reproducción Laboratorio de NeuroendocrinologíaFacultad de Estudios Superiores ZaragozaUNAMCiudad de MéxicoMéxico Unidad Periférica de Neurociencia Facultad de MedicinaUNAM/Instituto Nacional de Neurología y NeurocirugíaCiudad de MéxicoMéxico

Ischemic stroke is the most common type of cerebrovascular disease and is caused by an interruption of blood flow in the *** this disease,two different damage areas are identifying:the lesion core,in which cells quickly die;and the penumbra(surrounding the lesion core),in which cells are functionally weakened but may recover and restore their *** currently approved treatments for ischemic stroke are the recombinant tissue plasminogen activator and endovascular thrombectomy,but they have a short therapeutic window(4.5 and 6 hours after stroke onset,respectively)and a low percentage of stroke patients actually receive these *** is an approved drug for the treatment of Alzheimer's *** is a noncompetitive,low affinity and use-dependent antagonist of N-methyl-D-aspartate glutamate *** has several advantages over developing a new drug to treat focal ischemic stroke,but the most important is that it has sufficient safe probes in preclinical models and humans,and if the preclinical studies provide more evidence about pharmacological actions in tissue protection and repair,this could help to increase the number of clinical *** present review summarizes the physiopathology of isquemic stroke and the pharmacological actions in neuroprotection and neuroplasticity of memantine in the post stroke stage of preclinical stroke models,to illustrate their potential to improve functional recovery in human patients.

关键词： focal ischemic stroke memantine neuroplasticity neuroprotection stroke therapy

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A simple and fast method to calculate the coil currents and the external poloidal flux and magnetic field for fixed boundary equilibria

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Plasma Science and Technology 2024年第11期26卷 65-70页

作者： Ricardo FARENGO Pablo l GARCÍA-martÍnez Hugo E FERRARI Centro Atómico Bariloche Comisión Nacional de Energía AtómicaBariloche 8400Argentina Instituto Balseiro Universidad Nacional de CuyoBariloche 8400Argentina CONICET CCT-Patagonia Norte Bariloche 8400Argentina

A simple and fast method to calculate the coil currents and the external poloidal flux and magnetic field consistent with a given internal magnetohydrodynamic(MHD) equilibrium and coil geometry is presented. The constrained optimization technique employed allows to fix the exact position of the X-points. The external poloidal flux and field are calculated using Green's functions expressed in terms of elliptic integrals that are calculated using a fast and accurate *** calculation can be limited to the region between the plasma and the device wall. An example for a double null configuration is presented.

关键词： MHD equilibrium Green's functions tokamak

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Resilience to the effects of social stress on vulnerability to developing drug addiction

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World Journal of Psychiatry 2022年第1期12卷 24-58页

作者： Claudia Calpe-lópez Maria A martínez-Caballero Maria P García-Pardo Maria A Aguilar Department of Psychobiology University of ValenciaValencia 46010Spain Faculty of Social and Human Sciences University of ZaragozaTeruel 44003Spain

We review the still scarce but growing literature on resilience to the effects of social stress on the rewarding properties of drugs of *** define the concept of resilience and how it is applied to the field of drug addiction *** also describe the internal and external protective factors associated with resilience,such as individual behavioral traits and social *** then explain the physiological response to stress and how it is modulated by resilience *** the subsequent section,we describe the animal models commonly used in the study of resilience to social stress,and we focus on the effects of chronic social defeat(SD),a kind of stress induced by repeated experience of defeat in an agonistic encounter,on different animal behaviors(depression-and anxiety-like behavior,cognitive impairment and addiction-like symptoms).We then summarize the current knowledge on the neurobiological substrates of resilience derived from studies of resilience to the effects of chronic SD stress on depressionand anxiety-related behaviors in ***,we focus on the limited studies carried out to explore resilience to the effects of SD stress on the rewarding properties of drugs of abuse,describing the current state of knowledge and suggesting future research directions.

关键词： Resilience Stress Depression Drug addiction Animal models Social defeat

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