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Neuroscience & Medicine 2013年第4期4卷 208-214页

作者： Anelya Kh. Alieva Maria I. Shadrina Elena V. Filatova Vera V. Ustinova ekaterina yu fedotova Alexey V. Karabanov Sergey N. Illarioshkin Petr A. Slominsky Institute of Molecular Genetics Russian Academy of Sciences Moscow Russia Research Centre of Neurology Russian Academy of Medical Sciences Moscow Russi Research Centre of Neurology Russian Academy of Medical Sciences Moscow Russia

Parkinson’s disease (PD) is one of the most common human neurodegenerative disorders caused by the loss of dopaminergic neurons in the brain. The α-synuclein (SNCA) gene is one of the most studied genes involved in the pathogenesis of PD. In our study, we conducted a genetic analysis of promoter and intron single-nucleotide polymorphisms (SNPs) in the SNCA gene. We also analyzed the association of genotypes of these SNPs with expression levels of SNCA mRNA. One of four SNPs in the SNCA gene, and the rs2736990 polymorphism, associates with the risk of the sporadic form of PD in Russian population. The risk of PD was increased almost twofold in carriers of allele C (odds ratios = 1.9, 95% confidence interval: 1.2-2.91, p = 0.003). However, no association was found between any of the genotypes of SNPs tested (rs2583988, rs2619363, rs2619364 and rs2736990) and alterations in SNCA levels. Our findings support the hypothesis that the rs2736990 polymorphism is associated with PD. SNPs rs2583988, rs2619363 and rs2619364 in the promoter region of the SNCA gene themselves do not significantly influence the expression of SNCA. Most likely, SNCA gene expression is a very complex process that is affected by different genetic and epigenetic factors.

关键词： Parkinson’s Disease Expression Analysis SNCA SNP

Cu/TiO_(2) Photocatalysts for CO_(2) Reduction: Structure and Evolution of the Cocatalyst Active Form

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Transactions of Tianjin University 2024年第2期30卷 140-151页

作者： Andrey A.Saraev Anna yu.Kurenkova Denis D.Mishchenko Alexandr L.Trigub Evgeniy yu.Gerasimov ekaterina A.Kozlova Boreskov Institute of Catalysis Lavrentieva Ave 5Novosibirsk 630090Russia Synchrotron Radiation Facility SKIF Boreskov Institute of CatalysisNikol’skiy Ave 1Kol’tsovo 630559Russia National Research Center “Kurchatov Institute”Kurchatova Sq 1Moscow 123182Russia

Extensive work on a Cu-modified TiO_(2) photocatalyst for CO_(2) reduction under visible light irradiation was conducted. The structure of the copper cocatalyst was established using UV-vis diff use refl ectance spectroscopy, high-resolution transmis- sion electron microscopy, X-ray absorption spectroscopy, and X-ray photoelectron spectroscopy. It was found that copper exists in different states (Cu 0 , Cu^(+) , and Cu^(2+) ), the content of which depends on the TiO_(2) calcination temperature and copper loading. The optimum composition of the cocatalyst has a photocatalyst based on TiO_(2) calcined at 700℃ and modified with 5 wt% copper, the activity of which is 22 μmol/(h·g cat ) (409 nm). Analysis of the photocatalysts after the photocatalytic reaction disclosed that the copper metal on the surface of the calcined TiO_(2) was gradually converted into Cu_(2) O during the photocatalytic reaction. Meanwhile, the metallic copper on the surface of the noncalcined TiO_(2) did not undergo any trans- formation during the reaction.

关键词： Photocatalysis Photocatalytic CO_(2)conversion Visible light Titanium dioxide Copper Copper oxides Methane formation Photocatalyst transformation

Investigation of electrophysical, photo- and gas-sensitive properties of ZnO–SnO_(2) sol–gel fflms

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Journal of Advanced Dielectrics 2024年第1期14卷 42-50页

作者： Irina A.Gulyaeva Alexandra P.Ivanisheva Maria G.Volkova Victoria yu.Storozhenko Soslan A.Khubezhov ekaterina M.Bayan Victor V.Petrov Research and Education Centre“Microsystem Technics and Multisensory Monitoring Systems”Southern Federal University Russia Department of Chemistry Southern Federal UniversityRussia Department of Physics North-Ossetian State University362025 VladikavkazRussia Department of Physics and Engineering ITMO University191002 PetersburgRussia

Thin nanocomposite fflms based on tin dioxide with a low content of zinc oxide(0.5–5 mol.%)were obtained by the sol–gel *** synthesized fflms are 300–600 nm thick and contains pore sizes of 19–29 *** resulting ZnO–SnO_(2) fflms were comprehensively studied by atomic force and Kelvin probe force microscopy,X-ray diffraction,scanning electron microscopy,and high-resolution X-ray photoelectron spectroscopy *** photoconductivity parameters on exposure to light with a wavelength of 470 nm were also *** study of the photosensitivity kinetics of ZnO–SnO_(2) fflms showed that the fflm with the Zn:Sn ratio equal to 0.5:99.5 has the minimum value of the charge carrier generation time *** of the activation energy of the conductivity,potential barrier,and surface potential of ZnO–SnO_(2) fflms showed that these parameters have maxima at ZnO concentrations of 0.5 mol.%and 1 mol.%.Films with 1 mol.%ZnO exhibit high response values when exposed to 5–50 ppm of nitrogen dioxide at operating temperatures of 200℃ and 250℃.

关键词： Sol–gel method,ZnO–SnO_(2) films gas-sensitive properties surface potential potential barrier conduction activation energy

Tailoring mesoporous-silica nanoparticles for robust immobilization of lipase and biocatalysis

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Nano Research 2017年第2期10卷 605-617页

作者： Mohammad Kalantari Meihua yu Yannan Yang ekaterina Strounina Zhengying Gu Xiaodan Huang Jun Zhang Hao Song Chengzhong yu Australian Institute for Bioengineering and Nanotechnology The University of Queensland Brisbane QLD 4072 Australia Center for Advanced Imaging The University of Queensland Brisbane QLD 4072 Australia

The rational design of nano-carriers is critical for modem enzyme immobilization for advanced biocatalysis. Herein, we report the synthesis of octadecylalkyl- modified mesoporous-silica nanoparticles （C18-MSNs） with a high C18 content （-19 wt.%） and tunable pore sizes （1.6--13 nm）. It is demonstrated that the increased hydrophobic content and a tailored pore size （slightly larger than the size of lipase） are responsible for the high performance of immobilized lipase. The optimized C18-MSNs exhibit a loading capacity of 711 mg/g and a specific activity 5.23 times higher than that of the free enzyme. Additionally, 93% of the initial activity is retained after reuse five times, which is better than the best performance reported to date. Our findings pave the way for the robust immobilization of lipase for biocatalytic applications.

关键词： silica hydrophobic lipase immobilization hyperactivation pore size

A simple method to model the reduced environment of lake bottom sapropel formation

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Chinese Journal of Oceanology and Limnology 2017年第4期35卷 956-966页

作者： Olga L.GASKOVA Vera D.STRAKHOVENKO Nadezhda I.ERMOLAEVA Eugene yu.ZARUBINA ekaterina A.OVDINA V.S.Sobolev Institute of Geology and Mineralogy Siberian Branch of the Russian Academy of Sciences Novosibirsk State University Institute for Water and Environmental Problems Siberian Branch of the Russian Academy of Sciences

The Kambala and Barchin brackish lakes （Baraba steppe, southern West Siberia） contain an organic-rich sapropel layer that was formed in oxygen-depleted waters. We measured the bulk sediment elemental composition, the water chemistry and determined the mineralogical composition and predominant biota species （Diatoms and Cyanobacteria in phytoplankton community respectively） in the lakes. The result indicates that the first lake has a siliceous type of sapropel and the second a carbonaceous one. A computer thermodynamic model was developed for chemical interaction in water-bottom sediment systems of the Kambala and Barchin Lakes. The surface sodium bicarbonate waters are supersaturated with respect to calcite, magnesite （or low Mg-calcite）, quartz and chlorite with minor strontianite, apatite and goethite （pH 8.9-9.3, Eh 0.3 V）. Nevertheless, it is shown that during sapropel deposition, deep silt waters should be anoxic （Eh〈0 V）. The virtual component CH20 has been used to create an anoxic environment suitable for pyrite formation due to the biotic community impact and abiotic reduction. Thermodynamic calculation has shown that silt water is not necessarily euxinic （anoxic and sulfidic）. Depending on Eh, sulfate sulfur can dominate in solution, causing the formation of gypsum together with pyrite. An attempt was made to find a reason for solution supersaturation with respect to Ca and Mg ions due to their complexation with humic acids.

关键词： brackish lakes sapropel sediments mineral composition silica calcite thermodynamic calculations

Evidence for polarization-induced phase transformations and degradation in CH_(3)NH_(3)PbI_(3)

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Nano Research 2023年第7期16卷 9435-9442页

作者： Aleksei yu.Grishko Maria A.Komkova ekaterina I.Marchenko Alexandra V.Chumakova Alexey B.Tarasov Eugene A.Goodilin Andrei A.Eliseev Department of Materials Science MSU-BIT UniversityShenzhen 517182China Department of Chemistry Lomonosov Moscow State UniversityMoscow 119991Russia Department of Materials Science Lomonosov Moscow State UniversityMoscow 119991Russia European Synchrotron Radiation Facility F-38042 GrenobleFrance

In solar cells,hybrid halide perovskites operate under constant bias,thus their stability towards electric field-induced degradation is of key *** we report on evidence of previously unidentified electric field-induced transitions and degradation path of CH_(3)NH_(3)PbI_(3)(MAPbI_(3))using elemental and phase *** films of MAPbI_(3) were deposited onto 1-2μm-pitch interdigitated electrodes and subjected to direct current(DC)-*** MAPbI_(3) layer polarized with<0.8 V/μm DC electric field undergoes pronounced ion redistribution to methylammonium-rich MAPbI_(3)-y(y<0.6)and iodine-rich MA1-xPbI3(x<0.3)***-induced loss of both methylammonium and iodine provokes degradation of MAPbI_(3).Using nanofocus grazing-incidence wide-angle X-ray scattering(GIWAXS),we unambiguously showed that the bias voltage induces the transformation ofβ-MAPbI_(3) to metastableδ-MAPbI_(3) polymorph via alignment of polar organic cation with the electric *** transformation is partially reversible upon field ***,once formed,δ-MAPbI_(3) disrupts the morphology of pristine film and undergoes decomposition toβ-MAPbI_(3)(β-MAPI)and PbI_(2).With the aforementioned compositional and phase changes,only MA-rich part serves as the charge separation layer,while the I-rich excitation is blocked with the PbI_(2) barrier serving as holes trapping *** observations reveal the intermediate steps in electric-field-driven degradation of halide perovskites and show the role of polar cations in the process,which is instructive for further material design with higher stability metrics.

关键词： halide perovskites stability degradation electric field ionic conductivity stoichiometry

Prins cyclisation of (-)-isopulegol with benzaldehyde over ZSM-5 based micro-mesoporous catalysts for production of pharmaceuticals

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Chinese Journal of Catalysis 2019年第11期40卷 1713-1720页

作者： ekaterina Kholkina Paivi Maki-Arvela Chloe Lozachmeuer Roman Barakov Nataliya Shcherban Dmitry yu. Murzin Johan Gadolin Process Chemistry Centre Faculty of Science and EngineeringAbo Akademi University Turku 20500 Finland L.V. Pisarzhevsky Institute of Physical Chemistry National Academy of Sciences of Ukraine 31 pr. Nauky Kiev 03028 Ukraine

Several ZSM-5 derived micro-mesoporous catalysts were investigated in Prins cyclisation of (-)-isopulegol with benzaldehyde acting as a reactant and a solvent for production of heterocyclic oxygen containing 2H-chromene derivatives including the tetrahydropyran structure and exhibiting biological activity. The investigated catalysts were characterized by nitrogen adsorption, ammonia temperature programmed desorption, adsorption-desorption of pyridine and 2,6-di-tert- butylpyridine with Fourier transform infrared spectroscopic control. For the Prins reaction performed at 70℃, the highest yield of the desired product, equal to 67% at complete conversion of (-)-isopulegol, was obtained over a micro-mesoporous catalyst containing an optimum amount of strong acid sites and mesopores, being 12 fold larger than the size of the desired product.

关键词： Micro-mesoporous material Prins cyclisation Tetrahydropyran

Substituted diamides of dipicolinic acid as extractants and ionophores for rare earth metals

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Journal of Rare Earths 2023年第8期41卷 1234-1241,I0005页

作者： Yingchao Ren Valery A.Polukeev ekaterina V.Kenf Liudmila I.Tkachenko Mikhail yu Alyapyshev Vasily A.Babain Andrey V.Nechaev Andrey V.Legin Dmitry O.Kirsanov Institute of Chemistry Saint-Petersburg UniversityPeterhofUniversitetsky Prospect 26198504Saint-PetersburgRussia JSVC Vekton Ul.2-oy Luch 9192019Saint-PetersburgRussia Khlopin Radium Institute 194021282nd Murinsky avRussia ThreeArc Mining LLC Pr.Narodnogo Opolchenia 10198216Saint-PetersburgRussia Rusredmet Vosstanovleniya str.15bl.3198320St.PeterburgKrasnoe seloRussia

The variety of newly synthesized diamides of dipicolinic acid(DPA)bearing methyl-and oxymethyl substituents in various positions of phenyl ring was investigated as potential ligands for liquid-liquid extraction of rare earth metal ions and as membrane active compounds in plasticized polymeric membranes of potentiometric *** is found that scandium is extracted with 2,6-pyridinedicarboxylic acid diamides similarly to heavy lanthanides,while yttrium is extracted together with light group *** shows high selectivity for the separation of cadmium/zinc,lead/nickel or copper/nickel *** four out of six studied ligands demonstrate significant potentiometric sensitivity towards scandium,yttrium and lanthanides in 10^(-7)-10^(-3)mol/L concentration range in nitric acid *** trends in sensitivity values vary depending on a ligand structure and the highest values are observed for Sc^(3+)and heavy *** to the evaluated selectivity Sm^(3+)is the most preferred ion,while La^(3+)is the most *** differences in sensor behavior in rare earth metal solutions assume that such devices can be applied in sensor arrays for potentiometric analysis of lanthanide mixtures.

关键词： Dipicolini cacid diamides Scandium Yttrium Lanthanides Extraction Potentiometric sensors

Lake-margin ecosystems of saline lakes of the Borzya group(Zabaikalsky Krai, Russia) during the initial filling phase

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Chinese Journal of Oceanology and Limnology 2014年第4期32卷 871-878页

作者： Evgenia P.GORLACHEVA Gazhit Ts.TSYBEKMITOVA Alexey V.AFONIN Natalya A.TASHLIKOVA ekaterina yu.AFONINA Alexey P.KUKLIN Natalia V.SALTANOVA Institute of Natural Resources Ecology and Cryology Siberian Branch of Russian Academy of Sciences16 a Nedorezov St Chita 672014Russia

This article presents the results of hydrochemical and hydrobiological studies of shallow saline lakes of the Borzya group(Zabaikalsky Krai, Russia) at the initial filling phase. The lake-margin ecosystems of the studied lakes are characterized by varying degrees of salinity from polyhaline to brine water. Cyclical variations of meteorological conditions and high salinity determined that the compositions of the aquatic organisms are specific, mostly between stenohaline and euryhaline species, the quantities are low, and the community structures are simple.

关键词： saline lakes hydrochemistry weeds zooplankton zoobenthos

Antiviral adsorption activity of porous silicon nanoparticles against different pathogenic human viruses

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Bioactive Materials 2022年第1期7卷 39-46页

作者： Liubov A.Osminkina Svetlana N.Agafilushkina ekaterina A.Kropotkina Nikolay yu Saushkin Ivan V.Bozhev Sergei S.Abramchuk Jeanne V.Samsonova Alexandra S.Gambaryan Lomonosov Moscow State University Physics DepartmentLeninskie Gory 1119991MoscowRussian Federation Institute for Biological Instrumentation of Russian Academy of Sciences 142290PushchinoMoscow RegionRussian Federation Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products Russian Academy of Sciences108819MoscowRussian Federation Lomonosov Moscow State University Faculty of ChemistryLeninskie Gory 1119991MoscowRussian Federation Quantum Technology Center Lomonosov Moscow State UniversityPhysics DepartmentLeninskie Gory 1119991MoscowRussian Federation A.N.Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences Vavilova 28119991MoscowRussian Federation

New viral infections,due to their rapid spread,lack of effective antiviral drugs and vaccines,kill millions of people every *** global pandemic SARS-CoV-2 in 2019-2021 has shown that new strains of viruses can widespread very quickly,causing disease and death,with significant socio-economic ***,the search for new methods of combating different pathogenic viruses is an urgent task,and strategies based on nanoparticles are of significant *** work demonstrates the antiviral adsorption(virucidal)efficacy of nanoparticles of porous silicon(PSi NPs)against various enveloped and non-enveloped pathogenic human viruses,such as Influenza A virus,Poliovirus,Human immunodeficiency virus,West Nile virus,and Hepatitis *** NPs sized 60 nm with the average pore diameter of 2 nm and specific surface area of 200 m^(2)/g were obtained by ball-milling of electrochemically-etched microporous silicon *** interaction with PSi NPs,a strong suppression of the infectious activity of the virus-contaminated fluid was observed,which was manifested in a decrease in the infectious titer of all studied types of viruses by approximately 104 times,and corresponded to an inactivation of 99.99%viruses in *** sorption capacity of PSi NPs is possible due to their microporous structure and huge specific surface area,which ensures efficient capture of virions,as confirmed by ELISA analysis,dynamic light scattering measurements and transmission electron microscopy *** results obtained indicate the great potential of using PSi NPs as universal viral sorbents and disinfectants for the detection and treatment of viral diseases.

关键词： Pathogenic human viruses Porous silicon nanoparticles Virus Antiviral activity Virucide