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Influence of Carcinogenic Factors in the Maxillofacial Region

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哈尔滨医科大学学报 2015年第5期49卷 470-472,F0003页

作者： vladimir N.Nikolenko ekaterina v.Kochurova Department of Human Anatomy I.M.Sechenov First Moscow State Medical University Department of Normal and Topographical Anatomy of the Faculty of Basic Medicine M.V.Lomonosov Moscow State University Harbin Medical University Department of Prosthetic Dentistry I.M.Sechenov First Moscow State Medical University

Objective To study the influence of carcinogenic factors on tissues and organs of the maxillofacial region(MFR)by measuring the expression of biomarkers in the oral *** We recruited 421 patients who were divided into 2 groups:356 patients with a tumour of the MFR and 65 healthy people without somatic pathology in medical *** The effects of carcinogenic factors on the expression of biomarkers in the oral fluid in patients with a tumour of the MFR revealed a significant increase in the levels of biomarkers of tobacco use-MMP-8,TIMP-1,TIMP-2,and CA 72-4,CEA and CA 125;frequent use or abuse of alcohol-MMP-8,TIMP-1,TIMP-2,AFP and NSE;use of narcotics-TIMP-1 and TIMP-2;presence of occupational hazards in the medical history-MMP-8,MMP-9,TIMP-1 and TIMP-2;with a diagnostic sensitivity(DS)of over 60%.Also our analysis showed that the use of tobacco was significantly affecting the expression of TIMP-1and CA 125;frequent use or abuse of alcohol-CA 19-9,AFP and CEA;use of drugs had an impact on ***,the occupational hazards in the medical history did not show a statistically significant *** Factors of carcinogenesis affect the expression of biomarkers in the oral *** expression of the biomarkers of the MFR should be compared with that in the control group of patients with no carcinogenic factors.

关键词： maxillofacial region factors of cancerogenesis tobacco alcohol drugs occupational hazard oncology

Atrial fibrillation among Russian men and women aged 55 years and older:prevalence,mortality,and associations with biomarkers in a population-based study

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Journal of Geriatric Cardiology 2020年第2期17卷 74-84页

作者： Maria A.Shkolnikova Dmitri A.Jdanov Rukizhat A.Ildarova Natalia v.Shcherbakova ekaterina B.Polyakova Evgeny N.Mikhaylov Svetlana A.Shalnova vladimir M.Shkolnikov veltischev Research and Clinical Institute for Pediatrics of the Pirogov Russian National Research Medical University MoscowRussian Federation Laboratory of Demographic Data Max Planck Institute for Demographic ResearchRostockGermany International Laboratory for Population and Health Research University Higher School of EconomicsMoscowRussian Federation Arrhythmia Department and Neuromodulation Laboratory Almazov National Medical Research CentreSaint-PetersburgRussian Federation National Research Center for Preventive Medicine MoscowRussian Federation

Objective To examine the prevalence of atrial fibrillation(AF),its impacts on cardiovascular disease(CvD)and all-cause mortality,and the associations between AF and inflammatory and serum biomarkers in a population-based sample of *** The study is a secondary analysis of data from the Stress,Aging and Health in Russia(SAHR)survey that includes information on 1800 individuals with an average age of 68.5 years at baseline,and on their subsequent mortality during 7.4 years on *** is detected by 12-lead electrocardiogram(ECG)and 24-hour Holter *** statistical analysis includes proportional hazard and logistic regression *** Of the 1732 participants with relevant Holter data,AF was detected in 100(74 by ECG and Holter,26 by Holter only).The prevalence of AF was 5.8%for men and 7.4%for *** fully adjusted model showed strongly elevated hazard of CvD and all-cause mortality in men and women with long non-self-limiting AF(LAF).LAF was found to be negatively associated with elevated total and lowdensity lipoprotein cholesterol and to be positively associated with elevated markers of inflammation in *** The study assessed for the first time the prevalence and the risks of death related to AF among older *** was shown to be a strong and independent predictor of CvD and all-cause *** is unlikely to contribute to the large excess male mortality in *** finding that one-quarter of AF cases were detected only by Holter monitoring demonstrates the usefulness of diagnostics with prolonged ECG registration.

关键词： Aging Atrial fibrillation Gender differences Holter monitoring Mortality Prevalence

Tunable interlayer excitons and switchable interlayer trions via dynamic near-field cavity

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Light(Science & Applications) 2023年第3期12卷 425-434页

作者： Yeonjeong Koo Hyeongwoo Lee Tatiana Ivanova Ali Kefayati vasili Perebeinos ekaterina Khestanova vasily Kravtsov Kyoung-Duck Park Department of Physics Pohang University of Science and Technology(POSTECH)Pohang37673Republic of Korea School of Physics and Engineering ITMO UniversitySaint Petersburg197101Russia Department of Electrical Engineering University at BuffaloNew YorkNY14260USA

Emerging photo-induced excitonic processes in transition metal dichalcogenide(TMD)heterobilayers,e.g.,interplay of intra-and inter-layer excitons and conversion of excitons to trions,allow new opportunities for ultrathin hybrid photonic ***,with the associated large degree of spatial heterogeneity,understanding and controlling their complex competing interactions in TMD heterobilayers at the nanoscale remains a ***,we present an all-round dynamic control of interlayer-excitons and-trions in a WSe_(2)/Mo_(0.5 )W_(0.5) Se_(2) heterobilayer using multifunctional tip-enhanced photoluminescence(TEPL)spectroscopy withversion between interlayer-trions and-excitons,through the combinational tip-induced engineering of GPa-scale pressure and plasmonic hot electron injection,with simultaneous spectroscopic TEPL *** unique nano-opto-electro-mechanical control approach provides new strategies for developing versatile nano-excitonic/trionic devices using TMD heterobilayers.

关键词： interlayer dynamic tunable

variation Trend and Characteristics of Anthropogenic CO Column Content in the Atmosphere over Beijing and Moscow

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Atmospheric and Oceanic Science Letters 2014年第3期7卷 243-247页

作者： WANG Pu-Cai Georgy S.GOLITSYN WANG Geng-Chen Evgeny I.GRECHKO vadim S.RAKITIN ekaterina v.FOKEEvA Anatoly v.DZHOLA Institute of Atmospheric Physics Chinese Academy of Sciences А.М.Оbukhov Institute of Atmospheric Physics Russian Academy of Sciences

The anthropogenic CO column content in the atmosphere is derived from measurements with infrared grating spectrometers in Beijing,China,and Moscow,Russia,during 1992–*** specific variation characteristics and long-term variation trends of the CO column content in the atmosphere in these regions are *** evident variation trend of anthropogenic CO in the atmosphere for the Beijing region is not observed during 1992–2012,while for the Moscow region,it decreases yearly by about 1.4% for the same *** CO concentrations appear quite frequently in Beijing,but much less frequently in Moscow,except during the natural fire events in summer *** back trajectory analysis,the high CO concentration observed in Beijing can be attributed to the intensive CO emission sources in its surrounding areas.

关键词： anthropogenic CO column contentinfrared grating spectrometerair pollution

Multispectral sensing of biological liquids with hollow-core microstructured optical fibres

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Light(Science & Applications) 2020年第1期9卷 346-357页

作者： Timur Ermatov Roman E.Noskov Andrey AMachnev Ivan Gnusov vsevolod Atkin ekaterina N.Lazareva Sergei v.German Sergey S.Kosolobov Timofei S.Zatsepin Olga v.Sergeeva Julia S.Skibina Pavel Ginzburg valery v.Tuchin Pavlos G.Lagoudakis Dmitry A.Gorin Skolkovo Institute of Science and Technology 3 Nobelya str.Moscow 121205Russia Department of Electrical Engineering Tel Aviv UniversityRamat AvivTel Aviv 69978Israel Light-Matter Interaction Centre Tel Aviv UniversityRamat AvivTel Aviv 69978Israel Saratov State University 83 Astrakhanskaya str.Saratov 410012Russia Tomsk State University 36 Lenin’s av.Tomsk 634050Russia M.v.Lomonosov Moscow State University Leninskie Gory1-3Moscow 119992Russia SPE LLC Nanostructured Glass Technology 10150 Let OktjabrjaSaratov 410033Russia Center for Photonics and 2D Materials Moscow Institute of Physics and TechnologyDolgoprudny 141700Russia Institute of Precision Mechanics and Control of the Russian Academy of Sciences 24 Rabochaya str.Saratov 410028Russia

The state of the art in optical biosensing is focused on reaching high sensitivity at a single wavelength by using any type of optical *** common strategy,however,disregards the promising possibility of simultaneous measurements of a bioanalyte’s refractive index over a broadband spectral ***,we address this issue by introducing the approach of in-fibre multispectral optical sensing(IMOS).The operating principle relies on detecting changes in the transmission of a hollow-core microstructured optical fibre when a bioanalyte is streamed through it via liquid *** offers a unique opportunity to measure the refractive index at 42 wavelengths,with a sensitivity up to ~3000 nm per refractive index unit(RIU)and a figure of merit reaching 99 RIU^(−1) in the visible and near-infra-red spectral *** apply this technique to determine the concentration and refractive index dispersion for bovine serum albumin and show that the accuracy meets clinical needs.

关键词： refractive spectral microstructure

Gut dysbiosis is associated with poorer long-term prognosis in cirrhosis

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World Journal of Hepatology 2021年第5期13卷 557-570页

作者： Roman Maslennikov vladimir Ivashkin Irina Efremova Aliya Alieva ekaterina Kashuh ekaterina Tsvetaeva Elena Poluektova Elena Shirokova Konstantin Ivashkin Department of Internal Medicine Gastroenterology and HepatologySechenov UniversityMoscow 119435Russia The Interregional Public Organization“Scientific Community for the Promotion of the Clinical Study of the Human Microbiome” Moscow 119435Russia

BACKGROUND Gut dysbiosis is common in *** To study the influence of gut dysbiosis on prognosis in *** The case-control study included 48 in-patients with cirrhosis and 21 healthy *** microbiome was assessed using 16S ribosomal ribonucleic acid gene *** used modified dysbiosis ratio(MDR):[Bacilli(%)+Proteobacteria(%)]/[Clostridia(%)+Bacteroidetes(%)].Patients with MDR more the median made up the group with severe dysbiosis,others did the group with nonsevere *** follow-up period was 4 *** The mortality rate of patients with severe dysbiosis was significantly higher than that of patients with non-severe dysbiosis(54.2%vs 12.5%;P=0.001).The presence of severe dysbiosis was independent risk factors for death[hazard ratio=8.6×(1.9-38.0);P=0.005].The abundance of Enterobacteriaceae(P=0.002),Proteobacteria(P=0.002),and Lactobacillaceae(P=0.025)was increased and the abundance of Firmicutes(P=0.025)and Clostridia(P=0.045)was decreased in the deceased patients compared with the *** deceased patients had a higher MDR value than the survivors[0.131×(0.069-0.234)vs 0.034×(0.009-0.096);P=0.004].If we applied an MDR value of 0.14 as the cutoff point,then it predicted patient death within the next year with a sensitivity of 71.4%and a specificity of 82.9%[area under the curve=0.767×(0.559-0.974)].MDR was higher in patients with cirrhosis than in health controls[0.064×(0.017-0.131)vs 0.005×(0.002-0.007);Pvs 0.033×(0.012-0.074);P=0.031].MDR correlated negatively with prothrombin(r=-0.295;P=0.042),cholinesterase(r=-0.466;P=0.014)and serum albumin(r=-0.449;P=0.001)level and positively with Child–Turcotte–Pugh scale value(r=0.360;P=0.012).CONCLUSION Gut dysbiosis is associated with a poorer long-term prognosis in cirrhosis.

关键词： Cirrhosis Dysbiosis Gut ROC-analysis Microbiota Microbiome Gut-liver axis

Influence of beam current on microstructure of electron beam melted Ti-6Al-4v alloy

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Progress in Natural Science:Materials International 2019年第4期29卷 440-446页

作者： Roman Laptev Natalia Pushilina Egor Kashkarov Maxim Syrtanov ekaterina Stepanova Andrey Koptyug Andrey Lider National Research Tomsk Polytechnic University Mid Sweden University

The defect microstructure of the samples manufactured from Ti-6A1-4v powder was studied using electron beam melting(EBM) in the beam current range of 17-13 *** hybrid digital complex combined positron lifetime spectroscopy and coincidence Doppler broadening spectroscopy was used to characterize the defect structure of the *** microstructure and defects were also analyzed by transmission electron *** has been established that the main type of the defects in the EBM manufactured samples is *** to the conducted measurements and calculations,the dislocation density in the EBM manufactured samples exceeds by two orders the similar value for the cast Ti-6Al-4 *** of Ti-Ti-Al nanoscale clusters has been found in the EBM manufactured samples.

关键词： Titanium alloy Additive technology Electron beam melting Positron spectroscopy Defects Transmission electron microscopy

Chemical and biological features of the saline Lake Krasnovishnevoye(Baraba,Russia)in comparison with Lake Malinovoe(Kulunda,Russia):a reconnaissance study

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Journal of Oceanology and Limnology 2018年第6期36卷 1993-2001页

作者： Anastasia KOMOvA Anna MELNIKOvA Zorigto NAMSARAEv Roman ROMANOv vera STRAKHOvENKO ekaterina OvDINA Nadezhda ERMOLAEvA National Research Centre“Kurchatov Institute” Moscow 123182Russia Central Siberian Botanical Garden of the Siberian Branch of the Russian Academy of Sciences Novosibirsk 630090Russia v.S.Sobolev Institute of Geology and Mineralogy of the Russian Academy of Sciences Novosibirsk 630090Russia Institute for Water and Environmental Problems Siberian Branch of the Russian Academy of SciencesBarnaul 656038Russia

The Baraba and Kulunda steppes are located in southwestern Siberia in an area with an arid continental climate. This paper presents results of the first study of the hypersaline Lake Krasnovishnevoye(Baraba steppe, TDS(total dissolved solids)=297 g/L, pH 7.88). The major chemical, mineralogical and biological features of the lake were studied and compared to those of Lake Malinovoe, a typical saline neutral lake of Kulunda steppe(TDS=396 g/L, pH 7.63). The phytoplankton composition and the culturable diversity of anoxygenic phototrophic bacteria from Lake Krasnovishnevoye correspond to the ones in the Kulunda lakes. Nevertheless, the peculiarities of water composition and regime of Lake Krasnovishnevoye reduce the biodiversity to prokaryotes and unicellular algae.

关键词： saline and soda lakes hydrochemistry hydrobiology phytoplankton zooplankton anoxygenic phototrophic bacteria

PD-1^(+)and TIM-3^(+)T cells widely express commonγ-chain cytokine receptors in multiple myeloma patients,and IL-2,IL-7,IL-15 stimulation up-regulates PD-1 and TIM-3 on T cells

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Oncology Research 2024年第10期32卷 1575-1587页

作者： EGOR v.BATOROv ALISA D.INESHINA TATIANA A.ARISTOvA vERA v.DENISOvA SvETLANA A.SIZIKOvA DARIA S.BATOROvA GALINA Y.USHAKOvA ekaterina Y.SHEvELA ELENA R.CHERNYKH Laboratory of Cellular Immunotherapy Research Institute of Fundamental and Clinical ImmunologyNovosibirsk630099Russia v.Zelman Institute of Medicine and Psychology Novosibirsk National Research State UniversityNovosibirsk630090Russia Department of Hematology and Bone Marrow Transplantation Research Institute of Fundamental and Clinical ImmunologyNovosibirsk630099Russia

Background:Immune checkpoint ligand-receptor interactions appear to be associated with multiple myeloma(MM)***,previous studies showed the possibility of PD-1 and TIM-3 expression on T cells upon stimulation with commonγ-chain family cytokines in vitro and during homeostatic *** aim of the present work was to study the impact of homeostatic proliferation on the expansion of certain T cell subsets upregulating PD-1 and TIM-3 checkpoint ***:The expression of CD25,CD122,CD127 commonγ-chain cytokine receptors,phosphorylated signal transducer and activator of transcription-5(pSTAT5)and eomesodermin(EOMES)was comparatively assessed with flow cytometry in PD-1-and TIM-3-negative and positive T cells before the conditioning and during the first post-transplant month in peripheral blood samples of MM ***:Substantial proportions of PD-1-and TIM-3-positive T lymphocytes expressed commonγ-chain cytokine receptors and *** of cytokine receptor expressing cells were significantly higher within TIM-3+T cells compared to PD-1+TIM-3−*** proportions of both PD-1-/TIM-3-negative and positive CD8+T cells express EOMES,while only moderate frequencies of CD4+PD-1+/TIM-3+T cells up-regulate this transcription ***,the surface presence of CD25 and intranuclear expression of EOMES in CD4+T cells were mutually exclusive regardless of PD-1 and TIM-3 *** stimulation with commonγ-chain cytokines up-regulates PD-1 and TIM-3 during the proliferation of initially PD-1/TIM-3-negative T cells but fails to expand initially PD-1+and TIM-3+T cell subsets in ***:Both PD-1 and TIM-3 expressing T cells appear to be able to respond to homeostatic cytokine *** in commonγ-chain cytokine receptor expression between PD-1+and TIM-3+T cells may reflect functional dissimilarity of these cell *** blockade appears to alleviate lymphopenia-induced prolif

关键词： Autologous hematopoietic stem cell transplantation(AHSCT) CD25 CD122 Eomesodermin(EOMES) Homeostatic proliferation