检索结果-南通市图书馆

World Journal of Clinical Oncology 2023年第2期14卷 40-68页

作者： Evgeny N Imyanitov ekaterina S Kuligina Anna P Sokolenko Evgeny N Suspitsin Grigoriy A Yanus Aglaya G Iyevleva Alexandr O Ivantsov Svetlana N Aleksakhina Department of Tumor Growth Biology N.N.Petrov Institute of OncologySt.-Petersburg 197758Russia Department of Clinical Genetics St.-Petersburg Pediatric Medical UniversitySt.-Petersburg 194100Russia

Hereditary cancer syndromes(HCSs)are arguably the most frequent category of Mendelian genetic diseases,as at least 2%of presumably healthy subjects carry highly-penetrant tumor-predisposing pathogenic variants(Pvs).Hereditary breast-ovarian cancer and Lynch syndrome make the highest contribution to cancer morbidity;in addition,there are several dozen less frequent types of familial *** development of the majority albeit not all hereditary malignancies involves two-hit mechanism,*** somatic inactivation of the remaining copy of the affected *** studies on cancer families suggested nearly fatal penetrance for the majority of HCS genes;however,population-based investigations and especially large-scale next-generation sequencing data sets demonstrate that the presence of some highly-penetrant Pvs is often compatible with healthy *** cancer research initially focused mainly on cancer detection and *** studies identified multiple HCS-specific drug vulnerabilities,which translated into the development of highly efficient therapeutic options.

关键词： Hereditary cancer syndromes Germline pathogenic variants Cancer predisposition Cancer treatment Next-generation sequencing

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Recurrent oropharyngeal cancer: Analysis of surgical treatment outcomes

引用

World Journal of Otorhinolaryngology 2024年第3期11卷 25-32页

作者： Konstantin Ilkaev Shalva R Gvetadze ekaterina A Roshchina Ruben I Azizyan Ali M Mudunov Mikhail v Bolotin Xin Yang Denis Larinov Head and Neck Cancer Surgery and Oncology Department NN Blokhin National Medical Research Center of OncologyMoscow 115478MoskvaRussia Department of Out-Patient PA Hertzen Moscow Oncology Research Institute-branch of the National Medical Research Radiological CenterMoscow 125284MoskvaRussia Department of Surgical Oncology Russian Scientific Center of RoentgenoradiologyMoscow 117997MoskvaRussia Department of Emergency University of Mississippi Medical CentreJacksonMS 3921United States Department of Oncology Sechenov First Moscow State Medical UniversityMoscow 119048MoskvaRussia Head&Neck Oncology NN Blokhin National Medical Research Center of OncologyMoscow 115478MoskvaRussia Department of Oral and Maxillofacial-Head and Neck Oncology Hanghai Key Laboratory of Stomatology&Shanghai Research Institute of StomatologyNational Clinical Center for Oral DiseaseShanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China Radiation Oncology Department Advanced Care Oncology CenterDubai 214630DubaiUnited Arab Emirates

BACKGROUND The main goal of our research is to introduce transoral robotic surgery and laser resection(TLR)as a considerable way of treating patients with recurrent oropha-ryngeal *** To develop a foundation of minimally invasive transoral surgical technique for patients with oropharyngeal *** This study prospectively and retrospectively included patients with recurrent tumors from 2003 to *** were allocated into two groups:(1)Group I;underwent TLR;and(2)Group II(control);underwent open surgeries of varying *** was done with intraoperative blood loss,postoperative infection incidence,and quality of life using the scale for patients with head and neck tumors known as the Functional Assessment of Cancer Therapy-Head&Neck *** One-hundred and forty one patients were included(103 males and 38 females),in 82 cases(85.4%),a recurrent tumor developed earlier than a year after primary tumor therapy;forty-six were in group I and 69 in group II,age ranging from 18 years to 86 years(average:57.6 years).The first group showed a statistically significant less amount of blood loss and a decreased incidence of infectious complications(Pvival *** In properly elected patients,TLR is not just reasonable but tends to be a favorable alternative for recurrent oropharyngeal cancers compared to the outcomes of the open surgery group.

关键词： Oropharyngeal cancer Transoral laser resection Open surgery Recurrent tumor Oropharyngeal squamous cell carcinoma

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Achieving higher photoabsorption than groupⅢ-Ⅴsemiconductors in ultrafast thin silicon photodetectors with integrated photon-trapping surface structures

引用

Advanced Photonics Nexus 2023年第5期2卷 33-43页

作者： Wayesh Qarony Ahmed S.Mayet ekaterina Ponizovskaya Devine Soroush Ghandiparsi Cesar Bartolo-Perez Ahasan Ahamed Amita Rawat Hasina H.Mamtaz Toshishige Yamada Shih-Yuan Wang M.Saif Islama University of California DavisDepartment of Electrical and Computer EngineeringDavisCaliforniaUnited States W&WSens Devices Inc.Los AltosCaliforniaUnited States University of California Baskin School of EngineeringDepartment of Electrical and Computer EngineeringSanta CruzCaliforniaUnited States

The photosensitivity of silicon is inherently very low in the visible electromagnetic spectrum,and it drops rapidly beyond 800 nm in near-infrared *** have experimentally demonstrated a technique utilizing photon-trapping surface structures to show a prodigious improvement of photoabsorption in 1-μm-thin silicon,surpassing the inherent absorption efficiency of gallium arsenide for a broad *** photon-trapping structures allow the bending of normally incident light by almost 90 deg to transform into laterally propagating modes along the silicon ***,the propagation length of light increases,contributing to more than one order of magnitude improvement in absorption efficiency in *** high-absorption phenomenon is explained by finitedifference time-domain analysis,where we show an enhanced photon density of states while substantially reducing the optical group velocity of light compared to silicon without photon-trapping structures,leading to significantly enhanced light–matter *** simulations also predict an enhanced absorption efficiency of photodetectors designed using 30-and 100-nm silicon thin films that are compatible with CMOS *** a very thin absorption layer,such photon-trapping structures can enable high-efficiency and high-speed photodetectors needed in ultrafast computer networks,data communication,and imaging systems,with the potential to revolutionize on-chip logic and optoelectronic integration.

关键词： photoabsorption photon trapping group-velocity reduction photodetectors silicon photonics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：