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Multimodal nonlinear endomicroscopic imaging probe using a double-core double-clad fiber and focus-combining micro-optical concept

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Light(Science & Applications) 2021年第11期10卷 2173-2183页

作者： ekaterina pshenay-severin Hyeonsoo Bae Karl Reichwald Gregor Matz Jörg Bierlich Jens Kobelke Adrian Lorenz Anka Schwuchow Tobias Meyer-Zedler Michael Schmitt Bernhard Messerschmidt Juergen Popp GRINTECH GmbH Schillerstr.107745JenaGermany Leibniz Institute of Photonic Technology Member of Leibniz Health TechnologiesAlbert-Einstein-Str.907745JenaGermany Institute of Physical Chemistry and Abbe Center of Photonics Friedrich Schiller University JenaHelmholtzweg 407743JenaGermany

Multimodal non-linear microscopy combining coherent anti-Stokes Raman scattering,second harmonic generation,and two-photon excited fluorescence has proved to be a versatile and powerful tool enabling the label-free investigation of tissue structure,molecular composition,and correlation with function and disease *** a routine medical application,the implementation of this approach into an in vivo imaging endoscope is ***,this is a difficult task due to the requirements of a multicolour ultrashort laser delivery from a compact and robust laser source through a fiber with low losses and temporal synchronization,the efficient signal collection in epi-direction,the need for small-diameter but highly corrected endomicroobjectives of high numerical aperture and compact ***,we introduce an ultra-compact fiber-scanning endoscope platform for multimodal non-linear endomicroscopy in combination with a compact four-wave mixing based fiber *** heart of this fiber-scanning endoscope is an in-house custom-designed,single mode,double clad,double core pure silica fiber in combination with a 2.4 mm diameter NIR-dual-waveband corrected endomicroscopic objective of 0.55 numerical aperture and 180µm field of view for non-linear imaging,allowing a background free,low-loss,high peak power laser delivery,and an efficient signal collection in backward direction.A linear diffractive optical grating overlays pump and Stokes laser foci across the full field of view,such that diffraction-limited performance is demonstrated for tissue imaging at one frame per second with sub-micron spatial resolution and at a high transmission of 65%from the laser to the specimen using a distal resonant fiber scanner.

关键词： fiber double scanner

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Tailoring the properties of optical metamaterials

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中国光学与应用光学 2010年第1期3卷 1-10页

作者： Christian Helgert Thomas Pertsch Carsten Rockstuhl ekaterina pshenay-severin Christoph Menzel Ernst-Bernhard Kley Arkadi Chipouline Christoph Etrich Uwe Huebner Andreas Tuennermann Falk Lederer ZIK ＂ultra-optics＂ Institute of Applied Physics Friedrich Schiller University .lena Max- Wien-Platz 1 07743 Jena Germany Institute of Condensed Matter Theory and Solid State Optics Friedrich Schiller University Jena Max-Wien-Platz 1 07743 Jena Germany Institute of Photonic Technology Albert-Einstein-Str. 9 07745 .lena Germany Fraunhofer Institute of Applied Optics and Precision Engineering Albert-Einstein-Str. 707745 Jena Germany

In this contribution we review our latest achievements of combined experimental and theoretical studies to tailor the properties of optical metamaterials(MMs) at will. We give three examples of metamaterial designs that have been realized by means of electron-beam lithography and whose spectroscopic characteristics have been comprehensively investigated. In every case, our experiments are complemented by rigorous numerical simulations. Particular emphasis is put on the significance of such tailored effective properties of optical MMs.

关键词：光学材料材料性能物理性能光谱特征

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