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Targeting hormone-resistant breast cancer cells with docetaxel:a look inside the resistance

Cancer Drug Resistance 2023年第1期6卷 103-115页

作者： Alexander m.Scherbakov Anna A.Basharina Danila V.Sorokin ekaterina I.mikhaevich Iman E.mizaeva Alexandra L.mikhaylova Tatiana A.Bogush mikhail A.Krasil’nikov Department of Experimental Tumor Biology Blokhin N.N.National Medical Research Center of OncologyMoscow 115522Russian Federation Group of molecular Tumor markers Blokhin N.N.National Medical Research Center of OncologyMoscow 115522Russian Federation

Aim:The study aims to analyze the effect of long-term incubation of ERα-positive mCF7 breast cancer cells with 4-hydroxytamoxifen(HT)on their sensitivity to tubulin polymerization inhibitor ***:The analysis of cell viability was performed by the mTT *** expression of signaling proteins was analyzed by immunoblotting and flow ***αactivity was evaluated by gene reporter *** establish hormone-resistant subline mCF7,breast cancer cells were treated with 4-hydroxytamoxifen for 12 ***:The developed mCF7/HT subline has lost sensitivity to 4-hydroxytamoxifen,and the resistance index was *** Akt activity(2.2-fold)and decreased ERαexpression(1.5-fold)were revealed in mCF7/HT *** activity of the estrogen receptorαwas reduced(1.5-fold)in mCF7/*** of class Ⅲβ-tubulin expression(TUBB3),a marker associated with metastasis,revealed the following trends:higher expression of TUBB3 was detected in triple-negative breast cancer mDA-mB-231 cells compared to hormone-responsive mCF7 cells(Pmone-resistant mCF7/HT cells(mCF7/HTmCF7mDA-mB-231,approximately 1:2:4).High TUBB3 expression strongly correlated with docetaxel resistance:IC_(50)value of docetaxel for mDA-mB-231 cells was greater than that for mCF7 cells,whereas resistant mCF7/HT cells were the most sensitive to the *** accumulation of cleaved PARP(a 1.6-fold increase)and Bcl-2 downregulation(1.8-fold)were more pronounced in docetaxel-treated resistant cells(Pm docetaxel treatment,while this marker was unchanged in parental mCF7 breast cancer ***:Further development of taxane-based chemotherapy for hormone-resistant cancer looks highly promising,especially for cancers with low TUBB3 expression.

关键词： Cancer docetaxel 4-hydroxytamoxifen classⅢβ-tubulin resistance breast cancer estrogen receptors alpha

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meso-substituted cationic 3-and 4-N-Pyridylporphyrins and their Zn(II)derivatives for antibacterial photodynamic therapy

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Journal of Innovative Optical Health Sciences 2022年第1期15卷 1-16页

作者： Aram G.Gyulkhandanyan marina H.Paronyan Anna G.Gyulkhandanyan Karapet R.Ghazaryan marina V.Parkhats Boris m.Dzhagarov maria V.Korchenova ekaterina N.Lazareva Elena S.Tuchina Grigor V.Gyulkhandanyan Valery V.Tuchin H.Buniatyan Institute of Biochemistry National Academy of Sciences of Armenia 5/1 Paruir Sevak Street Yerevan 0014Armenia INSERm U1204 Universite d'Evry vald'Essonne-Universite Paris-Saclay 1 Ruedu Pere JarlanBatiment Maupertuis91025Evry-CourcouronnesFrance B.I.Stepanov Institute of Physics National Academy of Sciences of Belarus 68-2 Nezavisimosti AvenueMinsk 220072Belarus Science medical Center Saratov State University 83 Astrakhanskaya StreetSaratov 410012Russia Laboratory of Laser molecular Imaging and machine Learning(LmImL)National Research Tomsk State University 36 Lenin Avenue Tomsk 634050Russia Laboratory of Laser Diagnostics of Technical and Living Systems Institute of Precision mechanics and Control Russian Academy of Sciences Saratov 410028Russia

Photodynamic inactivation of microorganisms known as antibacterial photodynamic therapy(APDT)is one of the most promising and innovative approaches for the destruction of pathogenic *** the photosensitizers(PSs),compounds based on cationic porphyrins/metalloporphyrins are most successfully used to inactivate *** of meso-substituted cationic pyridylporphyrins and metalloporphyrins with various peripheral groups in the third and fourth positions of the pyrrole ring have been synthesized in *** aim of this work was to determine and test the most e®ective cationic porphyrins and metalloporphyrins with high photoactivity against Gram negative and Gram positive *** was shown that the synthesized cationic pyridylporphyrins/metalloporphyrins exhibit a high degree of phototoxicity towards both types of bacteria,including the methicillinresistant *** *** complexes of porphyrins are more phototoxic than metal-free porphyrin *** e®ectiveness of these Zn–metalloporphyrins on bacteria is consistent with the level of singlet oxygen *** was found that the high antibacterial activity of the studied cationic porphyrins/metalloporphyrins depends on four factors:the presence in the porphyrin macrocycle of a positive charge(+4),a central metal atom(Zn2þÞand hydrophobic peripheral functional groups as well as high values of quantum yields of singlet *** results indicate that meso-substituted cationic pyridylporphyrins/metalloporphyrins cannd wider application in photoinactivation of bacteria than anionic or neutral PSs usually used in APDT.

关键词： Antibacterial photodynamic therapy cationic porphyrins/metalloporphyrins phototoxicity Zn-metalloporphyrins singlet oxygen quantum yield Gram negative and Gram positive bacteria S.aureus mRSA E.coli Salmonella typhimurium.

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Postglacial incision-infill cycles at the Borisoglebsk Upland: Correlations between interfluve headwaters and fluvial network

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International Soil and Water Conservation Research 2019年第2期7卷 184-195页

作者： Yuliya V.Shishkina ekaterina V.Garankina Vladimir R.Belyaev Ilya G.Shorkunov Pavel V.Andreev Aleksey I.Bondar Viktoria I.Potapova Tatiana A.Verlova Faculty of Geography Department of Geomorphology and Palaeogeography and Laboratory for Soil Erosion and Fluvial ProcessesLomonosov Moscow State UniversityLeninskie Gory1Moscow 119991Russia Institute of Geography Department of Soil Geography and EvolutionRussian Academy of SciencesStaromonetnyj Lane29Moscow 119017Russia Institute of Earth Sciences of Saint-Petersburg State University St.PetersburgUniversitetskaya nab.7-9 199034Russia

The article discusses postglacial landscape transformation in the Northern Hemisphere middle Pleistocene glaciation area located in the center of the Russian *** attempted to verify the regional paleogeographic model by reconstructing the Late Pleistocene incision-infill cycles at the Eastern Borisoglebsk Upland based on a comparison of inactive interfluves headwaters and actual fluvial network *** study was also aimed to determine the past extent of fluvial *** research of the actual and buried topography,Ethology and pedogenic properties of surface deposits was carrid out with remote sensing data interpretation,DGPS survey,and detailed description of geological cores *** study was followed by analysis of grain size,chemical and organic contents,microstructure,and numerical *** the available results,we propose a scenario of the fluvial network transformation at the Eastem Borisoglebsk Upland over the last 150 *** least four fluvial incision stages were determined while network extent has significantly changed through the Late *** can be generally associated with the regional base level decrease-Late moscow,Late Valdai and Late Holocene and accompanying isolation of the Nero Lake terraces of 130 m,100-105 m and 95-98 *** stages were separated by landscape stability or aggradation periods those were asynchronous at the middle and upper parts of the fluvial *** main agent of initial valley infill appears to be local lacustrine sedimentation altered by alluvial and colluvial deposition towards the second half of *** landscape conditions variability emphasize the importance of comprehensive local correlations for regional retrospective models.

关键词： Interfluve headwaters Fluvial Incision-Infill Cycle Pleistocene

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Reconstructions of model equations of time-delay system from short experimental time series

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International Journal of modeling, Simulation, and Scientific Computing 2020年第2期11卷 91-99页

作者： Anatoly S.Karavaev Yurii m.Ishbulatov ekaterina I.Borovkova Danil D.Kulminskiy Vladimir S.Khorev Anton R.Kiselev Vladimir I.Ponomarenko Vladimir I.Gridnev mikhail D.Prokhorov Boris P.Bezruchko Department of Dynamic modeling and Biomedical Engineering Saratov State University 83 Astrakhanskaya Street Saratov410012Russia Laboratory of Nonlinear Dynamics modeling Saratov Branch of the Institute of Radio Engineering and Electronics of Russian Academy of Sciences 38 Zelyonaya Street Saratov410019Russia Department of New Cardiological Informational Technologies Institute of Cardiological Research Saratov State medical University 112 Bolshaya Kazachaya StreetSaratov410012Russia

This study aims to investigate the scope of methods for the reconstruction of time-delay *** consider an approach to the reconstruction of time-delay systems based on the synchronous response of the driven system with the structure similar to the structure of the studied *** approach is used for the recovery of the parameters of timedelay systems from short and noisy time *** show the operational performance and capabilities of this approach,the parameters were reconstructed for a radiophysical chaotic generator with quadratic nonlinearity and for the model of a system for the baroreflectory regulation of the mean arterial pressure.

关键词： Time-delay systems reconstruction chaos radiophysical experiment

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Novel materials for solid oxide fuel cells cathodes and oxygen separation membranes:Fundamentals of oxygen transport and performance

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Carbon Resources Conversion 2020年第1期3卷 112-121页

作者： Vladislav A.Sadykov ekaterina m.Sadovskaya Nikita F.Eremeev Elena Yu.Pikalova Nina m.Bogdanovich Elena A.Filonova Tamara A.Krieger Yulia E.Fedorova Alexey V.Krasnov Pavel I.Skriabin Anton I.Lukashevich Robert Steinberger-Wilckens Izaak C.Vinke Federal Research Center Boreskov Institute of Catalysis SB RAS 630090 NovosibirskRussia Novosibirsk State University 630090 NovosibirskRussia Institute of High Temperature Electrochemistry UB RAS 620137 YekaterinburgRussia Ural Federal University 620002 YekaterinburgRussia University of Birmingham EdgbastonBirmingham B152TTUK Forschungszentrum Jülich GmbH 52425 JülichGermany

In the field of modern hydrogen energy,obtaining pure hydrogen and syngas and then being able to use them for green energy production are significant *** solid oxide fuel cells(SOFC)and catalytic membranes for oxygen separation as well as materials for these devices is one of the most likely ways to solve these *** this work,the authors’recent studies in this field are reviewed;the fundamentals of developing materials for SOFC cathodes and oxygen separation membranes’permselective layers based on research of their oxygen mobility and surface reactivity are ***-Popper phases Ln_(2-x)Ca_(x)NiO_(4+δ)(LnCNO)and perovskite-fluorite nanocomposites PrNi_(0.5)Co_(0.5)O_(3-δ)-Ce_(0.9)Y_(0.1)O_(2-δ)(PNC-YDC)were studied by isotope exchange of oxygen with C_(18)O_(2)and^(18)O_(2)in flow and closed *** LnCNO a high oxygen mobility was shown(D*~10^(-7)cm^(2)/s at 700℃),being provided by the cooperative mechanism of oxygen migration involving both regular and highly-mobile interstitial *** PNC-YDC dominated a wide fast diffusion channel via fluorite phase and interphases due to features of the redistribution of cations resulting in superior oxygen mobility(D*~10^(-8)cm^(2)/s at 700℃).After optimization of composition and nanodomain structure of these materials,as cathodes of SOFC they provided a high power density,while for asymmetric supported oxygen separation membranes-a high oxygen permeability.

关键词： Solid oxide fuel cells Oxygen separation membranes Oxygen mobility Perovskites Nanocomposites Ruddlesden-Popper phases

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Prospects for the use of olfactory mucosa cells in bioprinting for the treatment of spinal cord injuries

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World Journal of Clinical Cases 2023年第2期11卷 322-331页

作者： Olga Vladislavovna Stepanova Grigorii Andreevich Fursa Svetlana Sergeevna Andretsova Valentina Sergeevna Shishkina Anastasia Denisovna Voronova Andrey Viktorovich Chadin ekaterina Konstantinovna Karsuntseva Igor Vladimirovich Reshetov Vladimir Pavlovich Chekhonin Department of Basic and Applied Neurobiology V.P.Serbsky National Medical Research Center for Psychiatry and NarcologyMoscow 119034Russia Department of Neurohumoral and Immunological Research National Medical Research Center of CardiologyMoscow 121552Russia Department of Biology Moscow State UniversityMoscow 119991Russia Department of Plastic Surgery I.M.Sechenov First Moscow State Medical UniversityMoscow 119435Russia Department of medical Nanobiotechnologу N.I.Pirogov Russian National Research Medical UniversityMoscow 117997Russia

The review focuses on the most important areas of cell therapy for spinal cord *** mucosa cells are promising for *** these cells is safe for *** use of olfactory mucosa cells is effective in restoring motor function due to the remyelination and regeneration of axons after spinal cord *** cells express neurotrophic factors that play an important role in the functional recovery of nerve tissue after spinal cord *** addition,it is possible to increase the content of neurotrophic factors,at the site of injury,exogenously by the direct injection of neurotrophic factors or their delivery using gene *** advantages of olfactory mucosa cells,in combination with neurotrophic factors,open up wide possibilities for their application in threedimensional and four-dimensional bioprinting technology treating spinal cord injuries.

关键词： Olfactory mucosa cells Neurotrophic factors Cell therapy Injury of spinal cord Three-dimensional bioprinting Four-dimensional bioprinting

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Antiviral adsorption activity of porous silicon nanoparticles against different pathogenic human viruses

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Bioactive materials 2022年第1期7卷 39-46页

作者： Liubov A.Osminkina Svetlana N.Agafilushkina ekaterina A.Kropotkina Nikolay Yu Saushkin Ivan V.Bozhev Sergei S.Abramchuk Jeanne V.Samsonova Alexandra S.Gambaryan Lomonosov moscow State University Physics DepartmentLeninskie Gory 1119991MoscowRussian Federation Institute for Biological Instrumentation of Russian Academy of Sciences 142290PushchinoMoscow RegionRussian Federation Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products Russian Academy of Sciences108819MoscowRussian Federation Lomonosov moscow State University Faculty of ChemistryLeninskie Gory 1119991MoscowRussian Federation Quantum Technology Center Lomonosov Moscow State UniversityPhysics DepartmentLeninskie Gory 1119991MoscowRussian Federation A.N.Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences Vavilova 28119991MoscowRussian Federation

New viral infections,due to their rapid spread,lack of effective antiviral drugs and vaccines,kill millions of people every *** global pandemic SARS-CoV-2 in 2019-2021 has shown that new strains of viruses can widespread very quickly,causing disease and death,with significant socio-economic ***,the search for new methods of combating different pathogenic viruses is an urgent task,and strategies based on nanoparticles are of significant *** work demonstrates the antiviral adsorption(virucidal)efficacy of nanoparticles of porous silicon(PSi NPs)against various enveloped and non-enveloped pathogenic human viruses,such as Influenza A virus,Poliovirus,Human immunodeficiency virus,West Nile virus,and Hepatitis *** NPs sized 60 nm with the average pore diameter of 2 nm and specific surface area of 200 m^(2)/g were obtained by ball-milling of electrochemically-etched microporous silicon *** interaction with PSi NPs,a strong suppression of the infectious activity of the virus-contaminated fluid was observed,which was manifested in a decrease in the infectious titer of all studied types of viruses by approximately 104 times,and corresponded to an inactivation of 99.99%viruses in *** sorption capacity of PSi NPs is possible due to their microporous structure and huge specific surface area,which ensures efficient capture of virions,as confirmed by ELISA analysis,dynamic light scattering measurements and transmission electron microscopy *** results obtained indicate the great potential of using PSi NPs as universal viral sorbents and disinfectants for the detection and treatment of viral diseases.

关键词： Pathogenic human viruses Porous silicon nanoparticles Virus Antiviral activity Virucide

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Treg/Th17 cell balance and phytohaemagglutinin activation of T lymphocytes in peripheral blood of systemic sclerosis patients

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World Journal of Experimental medicine 2017年第3期7卷 84-96页

作者： ekaterina Krasimirova Tsvetelina Velikova ekaterina Ivanova-Todorova Kalina Tumangelova-Yuzeir Desislava Kalinova Vladimira Boyadzhieva Nikolay Stoilov Tsvetelina Yoneva Rasho Rashkov Dobroslav Kyurkchiev Laboratory of Clinical Immunology University Hospital "St. Ivan Rilski"Department of Clinical Laboratory and Clinical ImmunologyMedical University of Sofia Clinic of Rheumatology University Hospital "St. Ivan Rilski"Department of Internal MedicineMedical University of Sofia

AIm To investigate T-cell activation, the percentage of peripheral T regulatory cells(Tregs), Th17 cells and the circulating cytokine profile in systemic sclerosis(SSc).mETHODS We enrolled a total of 24 SSc patients and 16 healthy controls in the study and divided the patients as having diffuse cutaneous SSc(dc SSc, n = 13) or limited cutaneous SSc(lc SSc, n = 11). We performed a further subdivision of the patients regarding the stage of the disease-early, intermediate or late. Peripheral venous blood samples were collected from all subjects. We performed flow cytometric analysis of the activationcapacity of T-lymphocytes upon stimulation with PHA-m and of the percentage of peripheral Tregs and Th17 cells in both patients and healthy controls. We used ELISA to quantitate serum levels of human interleukin(IL)-6, IL-10, tissue growth factor-β1(TGF-β1), and IL-17 *** We identified a decreased percentage of CD3+CD69+ cells in PHA-stimulated samples from SSc patients in comparison with healthy controls(13.35% ± 2.90% vs 37.03% ± 2.33%, P mphocytes were represented in decreased percentage in patients when compared to controls(6.30% ± 0.68% vs 9.36% ± 1.08%, P = 0.016). Regarding the forms of the disease, dc SSc patients demonstrated lower frequency of CD4+CD25+ T cells against healthy subjects(5.95% ± 0.89% vs 9.36% ± 1.08%, P = 0.025). With regard to Th17 cells, our patients demonstrated increased percentage in comparison with controls(18.13% ± 1.55% vs 13.73% ± 1.21%, P = 0.031). We detected up-regulated Th17 cells within the lc SSc subset against controls(20.46% ± 2.41% vs 13.73% ± 1.21%, P = 0.025), nevertheless no difference was found between dc SSc and lc SSc patients. Flow cytometric analysis revealed an increased percentage of CD4+CD25-Foxp3+ in dc SSc patients c

关键词： Systemic sclerosis T-cell activation Th17 Tregs CD4+CD25-Foxp3+cells Interleukin-17 Tissue growth factor-β Interleukin-10 Interleukin-6

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NEW SPICULE-BEARING ORGANISm OF SPONGE GRADE FROm THE EDIACARAN (VENDIAN) OF THE WHITE SEA, RUSSIA

NEW SPICULE-BEARING ORGANISM OF SPONGE GRADE FROM THE EDIACA...

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第二届国际古生物学大会

作者： ekaterina A.SEREZHNIKOVA Andrey Yu.IVANTSOV Paleontological Institute Russian Academy of Sciences 123 Profsoyuznaya Moscow117997 Russia

The fossil locality on the Solza River is one of the rich in the region;the fossil concentration reaches here a few tens of specimens per the square meter. The fossiliferous deposits belong to UstPinega Formation of the upper Ediacaran (Vendian. In addition to the new fossils and rare cyclic forms the same bedding planes contain some characteristic Ediacara species: Dickinsonia costata, Kimberella quadrata, Tribrachidium heraldicum Armilifera parva, Cyanorus singularis, Vendia rachiata, Solza margarita .Kimberella- fusiform trace fossils that are the most abundant fossils cover all the surface of the bed. New organisms are preserved as negative imprints on the slightly pyritized sole of fine-grained cross-bedded sandstone layer. That sandy layer was probably formed as a result of single rapid sedimentation event over a large area of the Ediacaran (Vendian sea floor with

关键词： Vend-Ediacaran biota Sponges

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Structure and properties of micro-arc calcium phosphate coatings on pure titanium and Ti-40Nb alloy

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Transactions of Nonferrous metals Society of China 2017年第1期27卷 125-133页

作者： Yurii SHARKEEV ekaterina KOmAROVA maria SEDELNIKOVA Ze-ming SUN Qi-fang ZHU Jing ZHANG Tatiana TOLKACHEVA Pavel UVARKIN Institute of Strength Physics and materials Science of Siberian Branch of Russian Academy of Sciences 2/4 Academicheskii pr.Tomsk 634055Russia 北京有色金属研究总院北京100088

The microstructure, physical and mechanical, and chemical properties of micro-arc calcium phosphate （CAP） coatings deposited under different process voltages in the range of 150-400 V on the commercially pure titanium （Ti） and Ti-40%Nb （Ti-40Nb）（mass fraction） alloy were investigated by the SEm, TEm, XRD and EDX methods. The coating thickness, roughness, and sizes of structural elements were measured and showed similar linear character depending on the process voltage for the coatings on both substrates. SEm results showed the porous morphology with spherical shape structural elements and rough surface relief of the coatings. XRD and TEm studies exhibited the amorphous structure of the CaP coating. With increasing the process voltage to 300-400 V, the crystalline phases, such as CaHPO4 and β-Ca2P207, were formed onto the coatings. The annealing leads to the formation of complex poly-phase structure with crystalline phases： CaTi4（PO4）6, β-Ca2P2O7, TiP2O7, TiNb（PO4）3, TiO2, NbO2, and Nb2O5. The applied voltage and process duration in the ranges of 200-250 V and 5-10 min, respectively, revealed the coating formed on Ti and Ti-40Nb with optimal properties： thickness of 40-70μm, porosity of 20%-25%, roughness （Ra） of 2.5-5.0 μm, adhesion strength of 15-30 mPa, and Ca/P mole ratio of 0.5-0.7.

关键词： calcium phosphate coating micro-arc oxidation Ti-40%Nb alloy commercially pure titanium microstructure

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