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The prognostic role of high-sensitivity C-reactive protein in patients with acute myocardial infarction

Journal of Geriatric Cardiology 2020年第7期17卷 379-383页

作者： ekaterina a polyakova Evgeny N Mikhaylov Department of Faculty Therapy Pavlov First Saint-Petersburg State Medical UniversitySaint-PetersburgRussian Federation Metabolic Syndrome Laboratory Institute of EndocrinologyAlmazov National Medical Research CentreSaint-PetersburgRussian Federation Neuromodulation Lab and Arrhythmia Department Almazov National Medical Research CentreSaint PetersburgRussian Federation Department of Bioengineering Systems Saint-Petersburg Electrotechnical University“LETI”Saint PetersburgRussian Federation

1 Introduction Inflammation is one of the main mechanisms in the pathogenesis of atherosclerosis,and the interest to the evaluation of inflammatory biomarkers in coronary artery disease(CAD)has been increasing over the last decade.[1,2]Destabilization of chronic artery plaques,which leads to acute coronary syndromes,has been associated with inflammatory status.[1,3]。

关键词： Atrial fibrillation Coronary artery disease High sensitive C-reactive protein Myocardial infarction Prognosis

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Human bone graft cytocompatibility with mesenchymal stromal cells is comparable after thermal sterilization and washing followed byγ-irradiation:an in vitro study

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Regenerative Biomaterials 2018年第2期5卷 85-92页

作者： Dmitry Labutin Konstantin Vorobyov Svetlana Bozhkova ekaterina polyakova Tatyana Vodopyanova Division of Wound Infection Treatment and Prevention Vreden Russian Research Institute of Traumatology and OrthopedicsSt.PetersburgRussian Federation

Human bone allografts present a better alternative to autografts in terms of minimization of the harvesting procedure *** to the use in clinical applications,they require sterilization which aims to reduce *** often comes at the expense of their biological properties as carriers of *** this study,we evaluated the cytocompatibility of human bone allografts processed and sterilized by three different methods withmesenchymal stromal *** morphology,biological and biochemical properties of the extracted bone-conditionedmedium and viability of cells were *** found that chemical sterilization had a strong negative effect on cell viability,whereas thermal sterilization and washing with subsequentγ-irradiation both resulted in a bone graft compatible with the progenitor ***,washing of the bone prior to sterilization allowed solid removal of cell debris and other bone marrow *** together,our findings demonstrate the importance of a proper choice of the bone graft processing method for the production of the biomaterial suitable for tissue engineering.

关键词： bone grafts bone sterilization mesenchymal stromal cells biocompatibility testing

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Neurohumoral,cardiac and inflammatory markers in the evaluation of heart failure severity and progression

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Journal of Geriatric Cardiology 2021年第1期18卷 47-66页

作者： ekaterina a polyakova Evgeny N Mikhaylov Dmitry L Sonin Yuri V Cheburkin Mikhail M Galagudza Almazov National Medical Research Centre Saint-PetersburgRussia

Heart failure is common in adult population,accounting for substantial morbidity and mortality *** main risk factors for heart failure are coronary artery disease,hypertension,obesity,diabetes mellitus,chronic pulmonary diseases,family history of cardiovascular diseases,cardiotoxic *** main factor associated with poor outcome of these patients is constant progression of heart *** the current review we present evidence on the role of established and candidate neurohumoral biomarkers for heart failure progression management and diagnostics.A growing number of biomarkers have been proposed as potentially useful in heart failure patients,but not one of them still resembles the characteristics of the"ideal biomarker."A single marker will hardly perform well for screening,diagnostic,prognostic,and therapeutic management ***,the pathophysiological and clinical significance of biomarkers may depend on the presentation,stage,and severity of the *** authors cover main classification of heart failure phenotypes,based on the measurement of left ventricular ejection fraction,including heart failure with preserved ejection fraction,heart failure with reduced ejection fraction,and the recently proposed category heart failure with mid-range ejection *** could envisage specific sets of biomarker with different performances in heart failure progression with different left ventricular ejection fraction especially as concerns prediction of the future course of the disease and of left ventricular adverse/reverse *** article is intended to provide an overview of basic and additional mechanisms of heart failure progression will contribute to a more comprehensive knowledge of the disease pathogenesis.

关键词： cardiac and inflammatory markers in the evaluation of heart failure severity and progression Neurohumoral

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Atrial fibrillation among Russian men and women aged 55 years and older:prevalence,mortality,and associations with biomarkers in a population-based study

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Journal of Geriatric Cardiology 2020年第2期17卷 74-84页

作者： Maria A.Shkolnikova Dmitri A.Jdanov Rukizhat A.Ildarova Natalia V.Shcherbakova ekaterina B.polyakova Evgeny N.Mikhaylov Svetlana A.Shalnova Vladimir M.Shkolnikov Veltischev Research and Clinical Institute for Pediatrics of the Pirogov Russian National Research Medical University MoscowRussian Federation Laboratory of Demographic Data Max Planck Institute for Demographic ResearchRostockGermany International Laboratory for Population and Health Research University Higher School of EconomicsMoscowRussian Federation Arrhythmia Department and Neuromodulation Laboratory Almazov National Medical Research CentreSaint-PetersburgRussian Federation National Research Center for Preventive Medicine MoscowRussian Federation

Objective To examine the prevalence of atrial fibrillation(AF),its impacts on cardiovascular disease(CVD)and all-cause mortality,and the associations between AF and inflammatory and serum biomarkers in a population-based sample of *** The study is a secondary analysis of data from the Stress,Aging and Health in Russia(SAHR)survey that includes information on 1800 individuals with an average age of 68.5 years at baseline,and on their subsequent mortality during 7.4 years on *** is detected by 12-lead electrocardiogram(ECG)and 24-hour Holter *** statistical analysis includes proportional hazard and logistic regression *** Of the 1732 participants with relevant Holter data,AF was detected in 100(74 by ECG and Holter,26 by Holter only).The prevalence of AF was 5.8%for men and 7.4%for *** fully adjusted model showed strongly elevated hazard of CVD and all-cause mortality in men and women with long non-self-limiting AF(LAF).LAF was found to be negatively associated with elevated total and lowdensity lipoprotein cholesterol and to be positively associated with elevated markers of inflammation in *** The study assessed for the first time the prevalence and the risks of death related to AF among older *** was shown to be a strong and independent predictor of CVD and all-cause *** is unlikely to contribute to the large excess male mortality in *** finding that one-quarter of AF cases were detected only by Holter monitoring demonstrates the usefulness of diagnostics with prolonged ECG registration.

关键词： Aging Atrial fibrillation Gender differences Holter monitoring Mortality Prevalence

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