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Acquired sensorineural hearing loss,oxidative stress,and microRNAs

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Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru c.Guo Division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of Medicine–The University of British columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Science core collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P Gc-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon c.Smith Jessica L.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(cNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

c2-cofiniteness of cyclic-Orbifold Vertex Operator Superalgebras

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Algebra colloquium 2017年第2期24卷 315-322页

作者： chunrui ai School of Mathematics and Statistics Zhengzhou University Zhengzhou 450001 China

In this paper, it is proved that for any c2-cofinite, simple, cFT-type vertex operator superalgebra V and a finite solvable group G consisting of automorphisms of V, the fixed point subalgebra Vc is a c2-cofinite vert... 详细信息

关键词： vertex operator superalgebra c2-cofiniteness solvable group

Remarks on the Single-Photon Spectra from cERN-WA80

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chinese Physics Letters 1996年第9期13卷 656-659页

作者： ai Xiao-bai Institute of Nuclear Research Chinese Academy of SciencesShanghai 201800

In this letter the author points out that in recent WA80 data an apparent slope parameter of Texp≈180 MeV/c must not mean the fireball becoming equilibrated in whole at some temperatures throughout the stages of the *** author also demonstrates that Texp is merely a mean value of the temperatures of various high-energy photon sources,and predicts that for higher colliding energies(>200 A GeV)the shape of the measured single-photon spectra would exhibit some concave curvature,which may be used as a probe for diagnosing quark-gluon plasma.

关键词： evolution curvature letter

Epidemiology and outcome of crohn's disease in a teaching hospital in Riyadh

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World Journal of Gastroenterology 2004年第9期10卷 1341-1344页

作者： Abdullah S.ai-Ghamdi Ibrahim A.ai-Mofleh Rashed S.aiRashed Saleh M.ai-Amri Abdulrahman M.Aljebreen Reda EI-Badawi Arthur c.Isnani Gastroenterology Division Department of Medicine (38)King Khalid University HospitalRiyadhKingdom of Saudi Arabia King Khalid University Hospital College of Medicine and Research Center (74)PO Box 2925RiyadhKingdom of Saudi Arabia

aiM: To know the epidemiology and outcome of crohn's disease at King Khalid University Hospital, Riyadh, Saudi Arabia and to compare the results from other world ***: A retrospective analysis of patients seen for 20 years (between 1983 and 2002). Individual case records were reviewed with regard to history, clinical, findings from colonoscopy, biopsies, small bowel enema, computerized tomography scan, treatment and ***: Seventy-seven patients with crohn's disease were revisited, 13% presented the disease in the first 10 years and 87% over the last 10 years. Thirty-three patients (42.9%) were males and 44 (57.1%) were females. Age ranged from 11-70 years (mean of 25.3+11.3 years). Ninety-two (92%) were Saudi. The mean duration of symptoms was 26+34.7 mo. The mean annual incidence of the disease over the first 10 years was 0.32:100 000 and 1.66:100 000 over the last 10 years with a total mean annual incidence of 0.94:100 000 over the last 20 years. The chief clinical features included abdominal pain, diarrhea, weight loss,anorexia, rectal bleeding and palpable mass. colonoscopic findings were abnormal in 58 patients (76%) showing mostly ulcerations and inflammation of the colon. Eighty nine percent of patients showed nonspecific inflammation with chronic inflammatory cells and half of these patients revealed the presence of granulomas and granulations on bowel biopsies. Similarly, 69 (89%) of small bowel enema results revealed ulcerations (49%), narrowing of the bowel lumen (42%), mucosal thickening (35%) and cobblestone appearance (35%). cT scan showed abnormality in 68 (88%) of patients with features of thickened loops (66%) and lymphadenopathy (37%). Seventy-eight percent of patients had small and large bowel disease, 16% had small bowel involvement and only 6% had colitis alone. Of the total 55 (71%) patients treated with steroids at some point in their disease history, a satisfactory response to therapy was seen in 28 patients (51%) w

关键词： Hospitals, Teaching Adolescent Adult Aged child comparative Study crohn Disease Female Humans Male Middle Aged Retrospective Studies Saudi Arabia Treatment Outcome

Bridging PcR and partially overlapping primers for novel allergen gene cloning and expression insert decoration

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World Journal of Gastroenterology 2004年第14期10卷 2103-2108页

作者： ai-LinTao Shao-HengHe AllergyandInflammationResearchInstitute MedicalCollegeShantouUniversityShantou515031GuangdongProvinceChina

aiM: To obtain the entire gene open reading frame (ORF) and to construct the expression vectors for recombinant allergen ***: Gene fragments corresponding to the gene specific region and the cDNA ends of pollen allergens of short ragweed (Rg, Ambrosia artemisiifolia L.) were obtained by pan-degenerate primer-based PcR and rapid amplification of the cDNA ends (RAcE), and the products were mixed to serve as the bridging PcR (BPcR) template. The full-length gene was then obtained. Partially overlapping primer-based PcR (POP-PcR) method was developed to overcome the other problem, i.e., the non-specific amplification of the ORF with routine long primers for expression insert *** blot was conducted to confirm pollen sources of the gene. The full-length coding region was evaluated for its gene function by homologue search in Genl3ank database and Western blotting of the recombinant protein Arab a 8(D106) expressed in Escherichia coli pET-44 ***: The full-length cDNA sequence of Arab a 8(D106) was obtained by using the above procedure and deduced to encode a 131 amino acid polypeptide. Multiple sequence alignment exhibited the gene D106 sharing a homology ashigh as 54-89% and 79-89% to profilin from pollen and food sources, vespectively. The expression vector of the allergen gene D106 was successfully constructed by employing the combined method of BPcR and POP-PcR. Recombinant allergen rAmb a 8(D106) was then successfully *** allergenicity was hallmarked by immunoblotting with the allergic serum samples and its RNA source was confirmed by Northern ***: The combined procedure of POP-PcR and BPcR is a powerful method for full-length allergen gene retrieval and expression insert decoration, which would be useful for recombinant allergen production and subsequent diagnosis and immunotherapy of pollen and food allergy.

关键词：桥变PcR 部分重叠引物变态反应原基因插入无性繁殖基因表达

A phase-field study on the oxidation behavior of Ni considering heat conduction

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Acta Mechanica Sinica 2016年第5期32卷 881-890页

作者： chao Wang Shigang ai Daining Fang State Key Laboratory for Turbulence and complex Systems Peking UniversityBeijing 100871China Institute of Engineering Mechanics Beijing Jiaotong UniversityBeijing 100044China Beijing Institute of Technology Beijing 100081China

Phase-field modeling approach has been used to study the oxidation behavior of pure Ni when considering heat conduction. In this calculation, the dependence of the coefficient of the cahn–Hilliard equation Lc on the temperature T was considered. To this end, high-temperature oxidation experiments and phase-field modeling for pure Ni were performed in air under atmospheric pressure at 600,700, and 800？c. The oxidation rate was measured by thermogravimetry and Lc at these temperatures was determined via interactive algorithm. With the Lc-T relationship constructed, oxidation behavior of Ni when considering heat conduction was investigated. The influence of temperature boundaries on the oxidation degree, oxide film thickness, and specific weight gain were discussed. The phase-field modeling approach proposed in this study will give some highlights of the oxidation resistance analysis and cooling measures design of thermal protection materials.

关键词： High-temperature oxidation Phase-field approach Heat conduction Thermogravimetry analysis Nickel

Evolution of the corrosion Product Film and Its Effect on the Erosion–corrosion Behavior of Two commercial 90cu–10Ni Tubes in Seawater

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Acta Metallurgica Sinica(English Letters) 2018年第11期31卷 1148-1170页

作者： Okpo O. Ekerenam ai-Li Ma Yu-Gui Zheng Si-Yu He Peter c. Okafor cAS Key Laboratory of Nuclear Materials and Safety Assessment Institute of Metal Research Chinese Academyof Sciences Shenyang 110016 China University of chinese Academy of Sciences (UcAS) Beijing 100049 China Department of Pure and Applied chemistry University of Calabar PMB 1115 Calabar CRS Nigeria

The composition and structural evolution of the corrosion product film of two commercial 90cu-10Ni tubes, namely TubeA and Tube B, after being immersed in natural seawater for 1, 3, and 6 months were characterized by scanning electronmicroscopy, energy-dispersive X-ray spectroscopy, X-ray diffraction, and X-ray photoelectron spectroscopy, and its effecton the erosion--corrosion behavior of the tubes was determined through a rotating cylinder electrode system using variouselectrochemical techniques. For the freshly polished samples used as contrast samples, the flow velocity mainly enhancedthe cathodic reaction at low flow velocities while both the anodic and the cathodic reactions were remarkably accelerated athigher flow velocities. The corrosion product films formed on the two commercial 90cu-10Ni tubes after being immersedin seawater for up to 6 months are of a complex three-layer or multilayer structure. The structural evolution of the films isout of sync for the two tubes. A continuous residual substrate layer depleted of Ni was observed in the inner layer of thefilms on Tube B after 30, 90, and 180 days＇ immersion, while it was observed in the film on Tube A only after 180 days＇immersion. The nature of the inner layer plays a crucial role in the erosion-corrosion resistance of the 90cu-10Ni tubes athigher flow velocity. The film with a compact and continuous inner layer of cu20 doped with Ni2＋ and Ni3＋ which bondsfirmly with the substrate could survive and even get repaired with the increased flow velocity. The film on Tube Bpossessing a hollow and discontinuous inner layer composed of the residual substrate was degraded rapidly with increasingrotation speed in spite of its quite good resistance at the stagnant or lower speed conditions.

关键词： copper-nickel alloy Seawater immersion Erosion-corrosion corrosion product film Flow velocity

Modelling the biological performance of a side-stream membrane bioreactor using ASM1

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Journal of Environmental Sciences 2004年第6期16卷 1020-1023页

作者： TIANKe-jun LIUXin-ai JIANGTao M.D.Kennedy J.c.Schippers P.A.Vanrolleghem MinistryofWaterResourcesofPRc Beijing100053China UNEScO-IHEInstituteforWaterEducation POBox30152601DADelftTheNetherlands BIOMATH GhentUniversityCoupureLinks653B-9000GentBelgium

Membrane bioreactors(MBRs) are attracting global interest but the mathematical modeling of the biological performance of MBRs remains very limited. This study focuses on the modelling of a side-stream MBR system using Activated Sludge Model No.1(ASM1), and comparing the results with the modelling of traditional activated sludge processes. ASM1 parameters relevant for the long-term biological behaviour in MBR systems were calibrated(i.e. Y H=0.72gcOD/gcOD, Y A=0.25gcOD/gN, b H=0.25 d -1, b A=0.080 d -1 and f P=0.06), and generally agreed with the parameters in traditional activated sludge processes, with the exception that a higher autotrophic biomass decay rate was observed in the MBR. A sensitivity analysis for steady state operation and DO dynamics suggested that the biological performance of the MBR system(the sludge concentration, effluent quality and the DO dynamics) are very sensitive to the parameters(i.e. Y H, Y A, b H, b A, μ maxH and μ maxA), and influent wastewater components(X I, S S, X S, S NH).

关键词： membrane bioreactor modelling parameter estimation