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Operational Degradation Mechanism of Perovskite Solar Cells

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Operational Degradation Mechanism of Perovskite Solar Cells

第六届新型太阳能电池材料科学与技术学术研讨会

作者： Chuanjiang Qin Toshinori Matsushima Chihaya adachi OPERA Kyushu Universityand Japan Science and Technology AgencyERATOAdachi Molecular Exciton Engineering Project

Organic-inorganic hybrid halide perovskites have became an interesting class of materials that have excellent photovoltaic and electric properties for application to solar cells and light-emitting diodes. However, the device stability of perovskite solar cells(PSCs) is still a bottleneck towards final commercialization, and the actual degradation mechanisms are not fully understood. In our group, we investigate the degradation mechanisms of CHNHPbI-based PSCs using a thermally stimulated current technique, which is a versatile technique used to analyze carrier traps in inorganic and organic materials. We observed that a large density of hole traps is formed in PSCs degraded by continuous solar illumination and that the formation of hole traps is strongly related to the stability. One source of the traps is metallic lead resulting from photodegradation of CHNHPbI under continous light irradiation. We greatly extended the lifetime of PSCs under standard laboratory weathering testing(ISOS-L-1 Laboratory) with a light intensity of 100 mW cm without using a UV filter from 150 hours to 4000 hours by suppressing the formation of Frenkel defect-metallic lead using benzoquinone additive, which is among longest device lifetime reported at that moment. Futhermore, we revealed influrence of phase transition on the device stability, and developed efficient and thermally stable PSCs under standard thermal cycling test(ISOS-T-1 Thermal Cycling).

关键词： Operational stability degradation mechanism perovskite solar cells carrier traps

Elasto-Viscoplastic Model with Strain Softening

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Elasto-Viscoplastic Model with Strain Softening

第10届亚洲地区土壤力学与基础工程会议

作者： adachi,T. Oka,F. Kyoto University KyotoJapan Professor Gifu University GifuJapan Professor

＜正＞In this papcr,an clasto-viscoplastic constitutivc model with strain softening is proposed for geologic materials.A comparison of the analytical and the experimental results indicates that the model is not only able to describe all the aspects of time dependency,such as strain rate dependency,creep and stress relaxation,but also the strain softening behavior of geologic materials.

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Effect of estradiol-17β on pituitary-thyroidal axis of Japanese eel (Anguilla japonica)

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Acta Oceanologica Sinica 2001年第4期20卷 585-596页

作者：曲宪成 Fisheries College Shanghai Fisheries University 334 Jungong Road Shanghai 200090 China Department of Environmental Biology Faculty of Environmental Studies Nagasaki University Nagasaki 852-8521 Japan Department of Biology Faculty of Fisheries Hokkaido University 3-1-1 Minato-cho Hakodate 041-0821 Japan

The effect of estradiol-17β (E2)treatment on the pituitary-thyroidal axis has been investi- gated in female Japanese eels in seawater. The eels were injected with 1 mg/kg body weight (BW) weekly for two to eight weeks; another group was treated with 5 mg/kg BW weekly for eight weeks and sacrificed three days after the last injection. In the pituitary, using RT-PCR systern, the thyroid stim- ulating hormone 3 subunit mRNA (TSHβ MRNA) level is slowly increased in the low-dose E2 treatment group. A significant increase in values occurred after eight weeks E2 injections. The histological structure of the thyroid follicles suggests a hypo-activity as shown by a reduced epithelial cell height in eels injected with E2 after six and eight times, and eventually reached a minimum level after eight weeks. Using ra- dioimmunoassay of thyroxine (T4),triiodothyronine (T3) in the serum, a slowly decrease of both hor- mones is demonstrated. On the other hand, the TSHβ mRNA level is significantly increased from initial in the high-dose E2 treatment group. The histological structure of the thyroid follicles suggests a hypo- activity, and a sharp decrease of the both hormones is also indicated. These data suggest that the expres- sion of TSHβ mRNA level is increased and thyroid hormone release is depressed by E2, the effects de- pend upon E2 inection period and dose. Furthermore, E2 could not directly influence the TSHβ mRNA expression and, TSH transcription might be controlled by a negative feedback of thyroid hormone.

关键词： Thyroid activity thyroxine (T4) triiodothyronine (T3) Japanese eel RT-PCR

Determining factors for carotid mean/max intima-media thickness and brachial flow-mediated dilation in healthy young women

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World Journal of Cardiovascular Diseases 2012年第2期2卷 43-49页

作者： Shiro Hoshida Takashi Miki Takafumi Nakagawa Yukinori Shinoda Takayoshi adachi Division of Cardiovascular Medicine Yao Municipal Hospital Yao Japan

Background: Many factors can contribute to atherosclerotic-type vascular changes in older individuals or men. Thus, confining the investigation to young women with no clinical evidence of the condition could enhance understanding of the early stages of cardiovascular disease. The aim of this study was to determine whether carotid mean/max intima-media thickness (IMT) and brachial flow-mediated dilation (FMD) values, which are well-known event-related indices, are associated with laboratory data and the other vascular indices of atherosclerosis in healthy young women. Methods: Carotid mean/max IMT and brachial FMD were measured in young women with no clinical evidence of atherosclerosis (n = 110;mean age, 39 years) who were instructed not to eat, drink or smoke after 9 PM the evening before testing. All participants also underwent laboratory assessment, including simultaneous measurements of arterial stiffness such as augmentation index (AI), cardioankle vascular index (CAVI) and brachial-ankle pulse wave velocity (baPWV). Results: Mean IMT was signifi-cantly and positively associated with age (p = 0.002), CAVI (p = 0.044), low-density lipoprotein-cholesterol (LDL-C, p = 0.047) and high-sensitive C-reactive protein (hs-CRP, p = 0.002) values but was not related to FMD, AI, baPWV or triglycerides (TG) in the multivariate regression analysis. Similarly, max IMT was positively associated with age (p p = 0.003) and hs-CRP (p = 0.005) values but was not related to FMD, AI, CAVI, baPWV, TG or blood pressure level in the multivariate regression analysis. The association between LDL-C and max IMT was much stronger than that between LDL-C and mean IMT. Brachial FMD was positively associated only with heart rate in the multivariate regression analysis. Conclusions: These results suggest that mean IMT more closely represents the sclerotic aspect of vascular change, whereas max IMT represents the atherotic aspect in healthy young women. Although the relationship between the auto

关键词： Intima-Media Thickness Flow-Mediated Dilation Young Women

Is there any correlation between Iiver graft regeneration and recipient's pretransplant skeletal muscle mass?-a study in extended Ieft Iobe graft Iiving-donor Iiver transplantation

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Hepatobiliary Surgery and Nutrition 2020年第2期9卷 183-194页

作者： Riccardo Pravisani Akihiko Soyama Shinichiro Ono Umberto Baccarani Miriam Isola Mitsuhisa Takatsuki Masaaki Hidaka Tomohiko adachi Takanobu Hara Takashi Hamada Florian Pecquenard Andrea Risaliti Susumu Eguchi Department of Surgery Nagasaki University Graduate School of Biomedical SciencesNagasakiJapan Liver-Kidney Transplant Unit Department of MedicineUniversity of UdineUdineItaly Division of Medical Statistic Department of MedicineUniversity of UdineUdineItaly

Background:The end-stage liver disease causes a metabolic dysfunction whose most prominent clinical feature is the loss of skeletal muscle mass(SMM).In living-donor liver transplantation(LDLT),liver graft regeneration(GR)represents a crucial process to normalize the portal hypertension and to meet the metabolic demand of the *** data are available on the correlation between pre-LDLT low SMM and ***:Retrospective study on a cohort of 106 LDLT patients receiving an extended left liver lobe *** skeletal muscle index(SMI)at L3 level was used for muscle mass measurement,and the recommended cut-off values of the Japanese Society of Hepatology guidelines were used as criteria for defining low *** was evaluated as rate of volume increase at 1 month post-LT[graft regeneration rate(GRR)].Results:The median GRR at 1 month post-LT was 91%(IQR,65-128%)and a significant correlation with graft volume-to-recipient standard liver volume ratio(GV/SLV)(rho-0.467,P<0.001),graft-to-recipient weight ratio(GRWR)(rho-0.414,P<0.001),donor age(rho-0.306,P=0.001),1 month post-LT cholinesterase serum levels(rho 0.397,P=0.002)and pre-LT low muscularity[absent *** GRR 97.5%(73.1-130%)vs.83.5%(45.2-110.9%),P=0.041]was *** in male recipients,but not in women,it was shown a direct correlation with pre-LT SMI(rho 0.352,P=0.020)and inverse correlation with 1 month post-LT SMI variation(rho-0.301,P=0.049).A low GRR was identified as an independent prognostic factor for recipient overall survival(HR 6.045,P<0.001).Conclusions:Additionally to the hemodynamic factors of portal circulation and the quality of the graft,the metabolic status of the recipients has a significant role in the GR process.A pre-LT low SMM is associated with impaired GRR and this negative impact is more evident in male recipients.

关键词： Liver regeneration living-donor liver transplantation(LDLT) skeletal muscle mass index sarcopenia malnutrition

Proposal of criteria to select candidates with colorectal liver metastases for hepatic resection:Comparison of our scoring system to the positive number of risk factors

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World Journal of Gastroenterology 2006年第39期12卷 6305-6309页

作者： Ikuo Nagashima Tadahiro Takada Miki adachi Hirokazu Nagawa Tetsuichiro Muto Kota Okinaga Department of Surgery Teikyo University School of Medicine Tokyo Japan Department of Surgical Oncology University of Tokyo Graduate School of Medicine Tokyo Japan

AIM: To select accurately good candidates of hepatic resection for colorectal liver metastasis. METHODS: Thirteen clinicopathological features, which were recognized only before or during surgery, were selected retrospectively in 81 consecutive patients in one hospital (GroupⅠ). These features were entered into a multivariate analysis to determine independent and significant variables affecting long-term prognosis after hepatectomy. Using selected variables, we created a scoring formula to classify patients with colorectal liver metastases to select good candidates for hepatic resection. The usefulness of the new scoring system was examined in a series of 92 patients from another hospital (Group Ⅱ), comparing the number of selected variables. RESULTS: Among 81 patients of GroupⅠ, multivariate analysis, i.e. Cox regression analysis, showed that multiple tumors, the largest tumor greater than 5 cm in diameter, and resectable extrahepatic metastases were significant and independent prognostic factors for poor survival after hepatectomy (P < 0.05). In addition, these three factors: serosa invasion, local lymph node metastases of primary cancers, and post- operative disease free interval less than 1 year including synchronous hepatic metastasis, were not significant, however, they were selected by a stepwise method of Cox regression analysis (0.05 < P < 0.20). Using these six variables, we created a new scoring formula to classify patients with colorectal liver metastases. Finally, our new scoring system not only classified patients in GroupⅠvery well, but also that in Group Ⅱ, according to long-term outcomes after hepatic resection. The positive number of these six variables also classified them ***: Both, our new scoring system and the positive number of significant prognostic factors are useful to classify patients with colorectal liver metastases in the preoperative selection of good candidates for hepatic resection.

关键词：结肠癌直肠癌肝移植病理机制

New anti-proliferative agent,MK615,from Japanese apricot “Prunus mume” induces striking autophagy in colon cancer cells in vitro

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World Journal of Gastroenterology 2007年第48期13卷 6512-6517页

作者： Shozo Mori Tokihiko Sawada Toshie Okada Tatsushi Ohsawa Masakazu adachi Kubota Keiichi Second Department of Surgery Dokkyo University School of Medicine Japan Apricot Co. Ltd

AIM: To investigate the anti-neoplastic effects of MK615, an extract from the Japanese apricot (Prunus mume), against colon cancer cells. METHODS: Three colon cancer cell lines, SW480, COLO, and WiDr, were cultured with MK615. Growth inhibition was evaluated by cell proliferation assay and killing activity was determined by lactate dehydrogenase assay. Induction of apoptosis was evaluated by annexin Ⅴ flow cytometry. Morphological changes were studied by light and electron microscopy, and immunofluorescence staining with Atg8. RESULTS: MK615 inhibited growth and lysed SW480, COLO and WiDr cells in a dose-dependent manner. Annexin Ⅴ flow cytometry showed that MK615 induced apoptosis after 6 h incubation, at which point the occurrence of apoptotic cells was 68.0%, 65.7% and 64.7% for SW480, COLO, and WiDr cells, respectively. Light and electron microscopy, and immunofluorescence staining with Atg8 revealed that MK615 induced massive cytoplasmic vacuoles (autophagosomes) in all three cell lines. CONCLUSION: MK615 has an anti-neoplastic effect against colon cancer cells. The effect may be exerted by induction of apoptosis and autophagy.

关键词：结肠癌李子细胞调亡 MK615

Overexpression of the receptor tyrosine kinase EphA4 in human gastric cancers

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World Journal of Gastroenterology 2008年第37期14卷 5650-5656页

作者： Mariko Oki Hiroyuki Yamamoto Hiroaki Taniguchi Yasushi adachi Kohzoh Imai Yasuhisa Shinomura First Department of Internal Medicine Sapporo Medical University School of MedicineSapporo 060-8543 Japan Sapporo Medical University Sapporo 060-8556 Japan

AIM: To clarify the expression and role of Ephrin receptor A4 (EphA4) in gastric cancer in relation to clinicopathological characteristics and the expression of fibroblast growth factor receptor 1 (FGFR1) and ephrin ligands. METHODS: Eleven gastric carcinoma cell lines, 24 paired surgical fresh specimens of gastric adenocarcinoma and adjacent nontumor tissue, 74 conventional formalin-fixed, paraffin-embedded tumor specimens, and 55 specimens spotted on tissue microarray (TMA) were analyzed. Reverse transcription-PCR (RT-PCR), real-time RT-PCR, immunohistochemistry, and cell growth assays were performed. RESULTS: Overexpression of EphA4 mRNA expres-sion was observed in 8 (73%) of 11 gastric cancer cell lines and 10 (42%) of 24 gastric cancer tissues. Over-expression of EphA4, analyzed by immunohistochemistry, was observed in 62 (48%) of 129 gastric cancer tissues. EphA4 overexpression, at the protein level, was significantly associated with depth of invasion and recurrence. EphA4 overexpression was also correlated with FGFR1 overexpression. Patients with EphA4-positive cancer had significantly shorter overall survival periods than did those with EphA4-negative cancer (P = 0.0008). The mRNAs for ephrin ligands were coexpressed in various combinations in gastric cancer cell lines and cancer tissues. Downregulation of EphA4 expression by siRNA in EphA4-overexpressing gastric cancer cell lines resulted in a significant decrease in cell growth. CONCLUSION: Our results suggest that overexpres-sion of EphA4 plays a role in gastric cancer.

关键词：胃癌纤维原细胞生长因子受体1 酪氨酸激酶预后

SOME ASPECTS OF DICHLOROSILANE BASED CVD-WSix FOR POLYCIDE APPLICATIONS

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SOME ASPECTS OF DICHLOROSILANE BASED CVD-WSix FOR POLYCIDE A...

The Third International Conference on Solid State and Integrated Circuit Technology

作者： John E.J.Schmitz John adachi Process Development Engineering Thin Films Division Genus Inc. 515 Ellis Street Mountain View CA 94043 USA Process Development Engineering Thin Films Division Genus Inc. 515 Ellis Street Mountain View CA 94043 USA

＜正＞ Several issues which exist in poly-cide gate electrode applications will be reviewed in this presentation. Among those are film adhesion, step coverage, and gate oxide thickness control. It will be pointed out that WSix based on SiH6/WF6 chemistry exhibits certain shortcomings such as limited step coverage when applied in circuits with design rules smaller than 0.5um,such as 16MbDRAM and beyond. Fortunately, WSix based on SiH2Cl2/WF6 chemistry appears very promising for application in gate electrodes in ULSI devices.

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