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胶囊内镜与常规上消化道内镜检查诊断食管静脉曲张准确性的比较:一项前瞻性、3中心先导性研究

世界核心医学期刊文摘（胃肠病学分册） 2006年第5期2卷 27-28页

作者： eisen g.m. Eliakim R. Zaman A. 纪泛扑 Oregon Health and Science University 3181 SWSam Jackson Park Rd. Portland OR 97239-3980 United States Dr.

Background and study aims: Variceal bleeding is a major complication of cirrhosis, and is associated with a 20% mortality at 6 weeks. Current international guidelines recommend that patients with cirrhosis are screened by conventional upper endoscopy (esophagogastroduodenoscopy, EgD) in order to detect esophageal varices. The recently developed PillCam ESO esophageal capsule endoscope has been shown to be an accurate diagnostic tool in the investigation of patients with gastroesophageal reflux and Barrett’ s esophagus. We compared the PillCam ESO capsule endoscope with EgD for the detection of esophagogastric varices and portal hypertensive gastropathy in patients with cirrhosis. Patients and methods: A pilot trial was conducted at three sites. Patients with cirrhosis who were undergoing clinically indicated EgD for screening or surveillance for esophageal varices underwent a PillCam ESO study followed by an EgD within 48 hours. Capsule videos were assessed by an investigator who was blinded to the patient’ s medical history and EgD findings. Results: A total of 23 of the 32 enrolled patients were found to have esophageal varices at both EgD and PillCam ESO endoscopy. In one patient PillCam ESO detected small varices that were not seen at EgD. The overall concordance between PillCam ESO and EgD was 96.9 % for the diagnosis of esophageal varices and 90.6% for the diagnosis of portal hypertensive gastropathy. There were no adverse events related to PillCam ESO endoscopy. Conclusions: In a high-prevalence population, PillCam ESO may represent an accurate noninvasive alternative to EgD for the detection of esophageal varices and portal hypertensive gastropathy. A large-scale trial is underway to validate and expand these findings.

关键词：胶囊内镜检查上消化道内镜检查食管静脉曲张检查诊断准确食管胃底静脉曲张门脉高压性胃病肝硬化患者先导性 Barrett食管

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胶囊内镜检查结果的一项综合分析

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世界核心医学期刊文摘（胃肠病学分册） 2006年第2期2卷 21-22页

作者： Lewis B.S. eisen g.m. Friedman S. 孟欣颖 1067 Fifth Avenue New York NY 10128 United States Dr.

Background and study aim: Capsule endoscopy is a new tool in the evaluation of the small intestine. To speed evaluation and acceptance of this technology, the manufacturer (given Imaging Ltd, Yoqneam, Israel) funded several trials. The data from these trials were collected at a central repository using a standardized reporting tool. Presentation of this data to the US Food and Drug Administration (FDA) in July 2003 led to the removal of the adjunctive term with regard to indication for capsule endoscopy, recognizing that the method is of independent importance for evaluating the small bowel. The aim of the present study was to combine the data from several capsule trials to help determine the yield and miss rate of capsule endoscopy for different diseases, compared with alternative diagnostic modalities. methods: Capsule studies were identified from a master database of funded studies. Studies were included in the pooled analysis if they reported a prospective comparison with another modality for evaluation of the small intestine. Results: 32 studies with a total of 691 patients were found in the master database, of which 24 studies, representing 530 patients, met inclusion criteria and were entered into the pooled analysis. Prior to study entry, patients had undergone a mean of 6.77 diagnostic procedures, without findings. Of these 24 studies, 14 (involving 310 patients) were categorized as “ bleeding" studies, and 10 studies (220 patients) as “ nonbleeding small bowel disorders" studies. The comparison procedure was push enteroscopy in 300 patients (in 45 for nonbleeding disorders), small- bowel series in 140 patients (in 125 for non- bleeding disorders), and colonoscopy with ileoscopy in 90 patients (50 for nonbleeding disorders). Overall analysis per patient showed new findings from capsule endoscopy in 50% of patients; 17% had new findings from the comparison method; in 22% there were similar findings; and in 11% there were no findings. A total of 1349 instance

关键词：胶囊内镜检查小肠病变综合分析出血性病变结肠镜中央存储器附加条款疾病诊断主数据库试验

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叙述性回顾:直肠肿瘤患者一级亲属的直肠结肠癌筛查

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世界核心医学期刊文摘（胃肠病学分册） 2005年第12期1卷 1-1页

作者： eisen g.m. Weinberg D.S. 马卉 Fox Chase Cancer Center 333 Cottman Avenue Philadelphia PA 19111 United States Dr.

many patients and providers are aware that colorectal cancer (CRC) “ runs in families." A patient with 1 first- degree relative with CRC has approximately twice the personal risk for CRC as a similar person without this family history. Colorectal cancer is the third most common type of cancer in the United States. When providers neglect to collect information on family history, they may fail to appropriately tailor recommendations for screening for CRC for many patients. This review considers the existing data and summarizes an evidence- based approach to the common clinical problem of how and when to implement screening for CRC in a patient with a family history of colonic neoplasia. The authors discuss the varying risks for CRC given the patient’ s age, health habits, and personal and family histories. In the context of a clinical case that focuses on the effect of a single affected first- degree relative, the authors weigh the risks and benefits of various screening alternatives and briefly address chemoprevention, genetic testing, and future directions in screening for CRC.

关键词：直肠结肠癌直肠肿瘤一级亲属筛查方法结肠直肠癌叙述性患病风险肿瘤家族史聚集性循证医学方法

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Impact of Zika virus non-structural protein mutations on hippocampal damage

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Neural Regeneration Research 2025年第8期20卷 2307-2308页

作者： Larissa m.g.Cassiano Roney S.Coimbra Neurogenômica/Imunopatologia Instituto RenéRachouFiocruzBelo HorizonteBrazil Departamento de Bioquímica e Imunologia Instituto de Ciências BiológicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil

The Zika virus(ZIKV),a member of the Flaviviridae family,attracted worldwide attention for its connection to severe neurological effects,notably microcephaly in newborns,first reported during the 2015 epidemic in ***,its impact goes beyond fetal and neonatal abnormalities,also affecting the central nervous system(CNS)in both children and adults,leading to enduring cognitive and behavioral impairments.

关键词： damage fetal neonatal

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Preparation of Ionic Liquid-based Vilsmier Reagent from Novel multi-purpose Dimethyl Formamide-like Ionic Liquid and Its Application

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Chinese Journal of Chemistry 2012年第7期30卷 1647-1657页

作者： Hullio,Ahmed Ali mastoi,g.m. Dr.m.A Kazi Institute of Chemistry University of Sindh Jamshoro-76080Pakistan

In continuation of research to explore the applied potential of DmF-like ionic liquid, the ionic liquid version of N,N-dimethyliminiumchloride （Vilsmier reagent） has been synthesized from DmF-like ionic liquid and tested effectively for its capacity to achieve more useful organic transformations. The results show that DmF-like ionic liquid is world＇s first task specific ionic liquid which has catalyzed numerous diverse type of reaction and is multipurpose in its application. Thus a new term for this DmF-like ionic liquid has been coined that is DmF-like ＂multipurpose＂ ionic liquid.

关键词： novel concept multipurpose DmF-like ionic liquid ionic liquid-based vilsmier reagent vilsmier reagent-catalysed reactions TCT/DmF complex

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Ocellar lamprophyre dyke bearing.m.neralization,Wadi Nugrus,Eastern Desert,Egypt:geology,mineralogy and geochemical implications

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Chinese Journal Of geochemistry 2010年第4期29卷 383-392页

作者： Ibrahim m.E. Saleh g.m. Dawood N.A. Aly g.m. Nuclear materials Authority P.O.Box 530El-MaadiCairoEgypt

The ocellar lamprophyre dyke(ENE-WSW) is recorded at Wadi Nugrus,Eastern Desert,*** cuts porphyritic biotite granites and varies in thickness from 0.5 to 1.5 m and up to 3 km in *** lamprophyre dyke has been altered,and it is characterized by porphyritic and panidiomorphic textures with plagioclase,olivine,and augite constituting the porphyritic phase in a fine groundmass of the same ***,titanite,apatite,fluorite,graphite,calcite,allanite,autunite and Fe-Ti oxides are accessory ***,chlorite and epidote are secondary *** and hematitization are *** to sub-rounded porphyritic and zoned ocelli with radiate or brush-like shapes are generally common and represent physical traps for *** ocellar features are interpreted to represent the late stage of magmatic segregation or magmatic crystallization involving two immiscible magmatic *** studies of altered lamprophyre samples,based on X-ray diffraction(XRD) and environmental scanning electron microscopy(ESEm),indicate the presence of secondary uranium minerals(autunite and uranophane),associated with gold,silver,nickel,atacamite,molybdenum,pyrite and *** presence of kaolinite indicates a high temperature *** mixing of volatile fluids with meteoric water and fluid-wall rock interaction result in changes of pH and oxygen activity and deposition of base metals in reducing environs(graphite and pyrite).Precipitation of hematite probably decreased the pH of the solution and rose acidic *** sudden change in pH and temperature of the fluids would lead to destabilization of base metal complexes favoring their *** magma source of the Nugrus lamprophyre is determined to be between calc-alkaline and alkaline and it has HKCAB and shoshonitic nature and may be derived from decomposition melting of such a metasomatised lithospheric *** is a major fractional phase to account for a rapid

关键词：煌斑岩脉矿物学地球化学沙漠埃及地质学黑云母花岗岩矿化

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X-ray absorption study of tribofilms from ZDDP and overbased salicylate detergents

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Chinese Chemical Letters 2009年第1期20卷 119-122页

作者： Yong Wan m. Kasrai g.m. Bancroft School of mechanical Engineering Qingdao Technological University Qingdao 266033 China Department of Chemistry University of Western Ontario London Ontario N6A 5B7 Canada

The interaction of overbased salicylate detergents with zinc dialkyldithiophosphates （ZDDP） and its effect on the formation of tribofilms under boundary lubrication have been studied by means of X-ray absorption near-edge structure spectroscopy. The results show that addition of metallic detergents to neat ZDDP results in the change of surface chemistry of the tribofilm formed from neat ZDDP. Calcium from detergents is digested in the tribofilm. For the high overbased detergents, the deposit of overbasing agent CaCO3 in the tribofilm is also observed along with the formation of calcium phosphate in tribofilms.

关键词： ZDDP Salicylate detergent Surface chemistry XANES analysis

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Effect of Y Addition on microstructure and mechanical Properties of Friction Stir Welded ZK60 Alloy

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Journal of materials Science & Technology 2009年第3期25卷 351-355页

作者： g.m. Xie Z.Y. ma L. geng School of materials Science and Engineering Harbin Institute of Technology Harbin 150001 China Shenyang National Laboratory for materials Science Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China

6 mm thick ZK60 and ZK60-Y alloy plates were successfully friction stir welded （FSW） at a tool rotation rate of 1200 r/min and a traverse speed of 100 mm/min. FSW resulted in the dissolution of mgZn2 particles in the ZK60 and the breakup and dispersion of W-phase （mg3Zn3Y2） particles in the ZK60-Y alloy, thereby leading; to a decrease in the hardness of the nugget zone （NZ） for the ZK60 alloy and an increase in the hardness of the NZ for the ZK60-Y alloy, respectively. While two FSW joints exhibited similar joint efficiency （87%-89% of ultimate tensile strengths of the parent materials）, the yield strength of the FSW ZK60-Y joint was substantially higher than that of the FSW ZK60 joint. The fracture occurred in the NZ and the heat affected zone for the ZK60 and ZK60-Y joints, respectively, which were consistent with the lowest hardness distribution of the welded joints.

关键词： Friction stir welding magnesium microstructure mechanical properties

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Effect of Rotation Rate on microstructures and mechanical Properties of FSW mg-Zn-Y-Zr Alloy Joints

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Journal of materials Science & Technology 2011年第12期27卷 1157-1164页

作者： g.m. Xie Z.Y. ma Z.A. Luo P. Xue g.D. Wang The State Key Laboratory of Rolling and Automation Northeastern University Shenyang 110819 China Shenyang National Laboratory for materials Science Institute of Metal Research Chinese Academy of SciencesShenyang 110016 China

Friction stir welding （FSW） of mg-Zn-Y-Zr plates with 6 mm in thickness was successfully carried out under a wide range of rotation rates of 600-1200 r/rain with a constant traverse speed of 100 mm/min. After FSW, the coarse grains in the parent material （Pm） were changed into fine equiaxed recrystallized grains at the＇nugget zone （NZ）. Furthermore, the coarse mg-Zn-Y particles （W-phase） were broken up and dispersed homogenously into the mg.m.trix. With increasing rotation rates, the size of the W-phase particles at the NZ significantly decreased, but the recrystallized grain size tended to increase. The hardness values of the NZs for all the FSW joints were higher than those of the Pm, and the lowest hardness values were detected in the heat affected zone （HAZ）. The fracture occurred in the thermo-mechanical affected zone （TmAZ） on the advancing side for all the FSW joints in the tensile test, due to the incompatibility of the plastic deformation between the NZ and TmAZ caused by remarkably different orientation of grains and W-phase particles. The strength of FEW ioint reaches 90% of that of its Pm

关键词： Friction stir welding magnesium alloys microstructure mechanical property

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Numerical modeling of friction stir welding using the tools with polygonal pins

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Defence Technology（防务技术） 2015年第3期11卷 229-236页

作者： m. mEHTA g.m. REDDY A.V. RAO A. DE Production Engineering Department BVM Engineering College Defense metallurgical Research Laboratory mechanical Engineering Department

Friction stir welding using the tools with polygonal pins is often found to improve the mechanical strength of weld joint in comparison to the tools with circular pins. However, the impacts of pin profile on the peak temperature, tool torque and traverse force, and the resultant mechanical stresses experienced by the tool have been rarely reported in a systematic manner. An estimation of the rate of heat generation for the tools with polygonal pins is challenging due to their non-axisymmetric cross-section about the tool axis. A novel methodology is presented to analytically estimate the rate of heat generation for the tools with polygonal pins. A three-dimensional heat transfer analysis of friction stir welding is carried out using finite element method. The computed temperature field from the heat transfer model is used to estimate the torque, traverse force and the mechanical stresses experienced by regular triangular, square, pentagon and hexagon pins following the principles of solid mechanics. The computed results show that the peak temperature experienced by the tool pin increases with the number of pin sides. However, the resultant maximum shear stress experienced by the pin reduces from the triangular to hexagonal pins.

关键词：搅拌摩擦焊接多边形管脚数值模拟摩擦搅拌焊接机械强度峰值温度机械应力

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