检索结果-南通市图书馆

Mesenchymal stromal cell delivery as a potential therapeutic strategy against COVID-19:Promising evidence from in vitro results

引用

World Journal of Biological Chemistry 2022年第2期13卷 47-65页

作者： Panagiotis Mallis Theofanis Chatzistamatiou Zetta Dimou eirini-faidra sarri Eleni Georgiou Maria Salagianni Vasiliki Triantafyllia Evangelos Andreakos Catherine Stavropoulos-Giokas Efstathios Michalopoulos Hellenic Cord Blood Bank Biomedical Research Foundation Academy of AthensAthens 11527Greece Laboratory of Immunobiology Center for ClinicalExperimental Surgery and Translational ResearchBiomedical Research Foundation Academy of AthensAthens 11527Greece

BACKGROUND Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is responsible for the coronavirus disease 2019(COVID-19)pandemic,which was initiated in December ***-19 is characterized by a low mortality rate(<6%);however,this percentage is higher in elderly people and patients with underlying ***-19 is characterized by mild to severe ***,several therapeutic strategies are evaluated,such as the use of anti-viral drugs,prophylactic treatment,monoclonal antibodies,and *** cellular therapies are also investigated,thus representing an additional therapeutic tool for *** stromal cells(MSCs),which are known for their immunoregulatory properties,may halt the induced cytokine release syndrome mediated by SARS-CoV-2,and can be considered as a potential stem cell *** To evaluate the immunoregulatory properties of MSCs,upon stimulation with COVID-19 patient *** MSCs derived from the human Wharton’s Jelly(WJ)tissue and bone marrow(BM)were isolated,cryopreserved,expanded,and defined according to the criteria outlined by the International Society for Cellular ***,WJ and BM-MSCs were stimulated with a culture medium containing 15%COVID-19 patient serum,1%penicillin-streptomycin,and 1%L-glutamine for 48 *** quantification of interleukin(IL)-1 receptor a(Ra),IL-6,IL-10,IL-13,transforming growth factor(TGF)-β1,vascular endothelial growth factor(VEGF)-a,fibroblast growth factor(FGF),platelet-derived growth factor(PDGF),and indoleamine-2,3-dioxygenase(IDO)was performed using commercial ELISA *** expression of HLA-G1,G5,and G7 was evaluated in unstimulated and stimulated WJ and ***,the interactions between MSCs and patients’macrophages were established using co-culture *** Thawed WJ and BM-MSCs exhibited a spindle-shaped morphology,successfully differentiated to“osteocytes”,“adipocytes”,and“chondrocytes”,and in flow cytometric analysis were characte

关键词： SARS-CoV-2 COVID-19 MSCs Stem cell therapy Cytokine storm Immunomodulation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：