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Criginal

疯狂英语（初中天地） 2020年第10期 21-23页

作者： sia Furler 不详

Original是澳洲女歌手希雅·富勒为电影《多力特的奇幻冒险》献唱的一首原声歌曲,单曲于2020年1月10日发行。Know More:希雅·富勒,1975年出生于澳大利亚南澳大利亚州阿德莱德,澳大利亚流行女歌手、词曲作者。20世纪90年代,以爵士乐队"C... 详细信息

Original是澳洲女歌手希雅·富勒为电影《多力特的奇幻冒险》献唱的一首原声歌曲,单曲于2020年1月10日发行。Know More:希雅·富勒,1975年出生于澳大利亚南澳大利亚州阿德莱德,澳大利亚流行女歌手、词曲作者。20世纪90年代,以爵士乐队"Crisp"主唱的身份出道。1997年,乐队解散,希雅于同年发行首张个人专辑OnlySee。2000年,与唱片公司Dance pool签约,并发行单曲Taken for Granted。2002年,获得澳大利亚表演权协会音乐奖"最具突破词曲作者"奖。

关键词：单曲女歌手爵士乐队南澳大利亚州富勒词曲作者澳大利亚阿德莱德

Reliability Based Multi-Objective Thermodynamic Cycle Optimisation of Turbofan Engines Using Luus-Jaakola Algorithm

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Energy Engineering 2021年第4期118卷 1057-1068页

作者： Vin Cent Tai Yong Chai Tan Nor Faiza Abd Rahman Yaw Yoong sia Chan Chin Wang Lip Huat Saw Centre for Modelling and Simulation Faculty of EngineeringBuilt Environment and Information TechnologySEGi UniversityPetaling JayaSelangor47810Malaysia Mechanical Engineering Department Faculty of EngineeringBuilt Environment and Information TechnologySEGi UniversityPetaling JayaSelangor47810Malaysia Lee Kong Chian Faculty of Engineering and Science Universiti Tunku Abdul RahmanKajangSelangor43200Malaysia

Aircraft engine design is a complicated process,as it involves huge number of *** design process begins with parametric cycle *** is crucial to determine the optimum values of the cycle parameters that would give a robust design in the early phase of engine development,to shorten the design cycle for cost saving and man-hour *** obtain a robust solution,optimisation program is often being executed more than once,especially in Reliability Based Design Optimisations(RBDO)with Monte-Carlo Simulation(MCS)scheme for complex systems which require thousands to millions of optimisation loops to be *** paper presents a fast heuristic technique to optimise the thermodynamic cycle of two-spool separated flow turbofan engines based on energy and probability of failure criteria based on Luus-Jaakola algorithm(LJ).A computer program called Turbo Jet Engine Optimiser v2.0(TJEO-2.0)has been developed to perform the optimisation *** program is made up of inner and outer loops,where LJ is used in the outer loop to determine the design variables while parametric cycle analysis of the engine is done in the inner loop to determine the engine ***-Hypercube-Sampling(LHS)technique is used to sample the design and model variations for uncertainty *** results show that optimisation without reliability criteria may lead to high probability of failure of more than 11%on *** thrust obtained with uncertainty quantification was about 25%higher than the one without uncertainty quantification,at the expense of less than 3%of fuel *** proposed algorithm can solve the turbofan RBDO problem within 3 min.

关键词： Multi-objective design optimisation reliability based design optimisation turbofan engines luus-jaakola algorithm

Maternal reproductive health: Expression patterns of antioxidant enzyme selenoproteins of post-implantation embryos conceived by ethanol-treated murine mothers supplemented with α-tocopherol

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Asian pacific Journal of Reproduction 2017年第1期6卷 21-25页

作者： Gliceria B Ramos Noel F Alfonso Glenn G Oyong Aleli Jillian L sia Biology Department De La Salle UniversityTaft AvenueManilaPhilippines1004 University Science Foundation-University Research Coordination Office (USF-URCO)De La Salle UniversityManilaPhilippines Molecular Biology Unit CENSERDe La Salle UniversityTaft AvenueManilaPhilippines Department of Biology College of Arts and SciencesUniversity of the Philippines-Manila

Objective:To investigate if the protective effect ofα-tocopherol against the impact of ethanol on brain morphogenesis involved the activity of the selenoproteins phospholipid hydroperoxide glutathione peroxidase (pHGpx;Gpx4) and selenoprotein p (Selpp) that have roles against oxidative ***:Forty female mice were randomly assigned into natural control (CON), positive control (ETOH), low-, medium-, and high-α-tocopherol-supplemented-ethanol groups (LTOC, MTOC, HTOC, respectively). CON received drinking water without ethanol while ETOH, LTOC, MTOC and HTOC groups received 20% ethanol in drinking water. The supplemented groups were given respective dosages ofα-tocopherol, 0.410, 0.819, and 1.640 mg/g body weight, at day 14 before mating onwards to the day 9 of gestation. At 10.5 ED of gestation (1100 h), the pregnant females were sacrificed by cervical dislocation and the embryos were harvested. Total RNA were extracted, cDNA synthesis and qRT- pCR analyses were carried ***: The level of expression of pHGpx in the positive control was significantly lower than that of the natural control. Among the threeα-tocopherol-supplemented groups, only the medium dose- group was significantly higher than the positive control. The level of expression of Selpp in the positive control was significantly lower than those of the natural control, the low- and medium- dose -tocopherol supplemented groups. in the high dose-α-tocopherol supplemented group, the level of expression was not significantly different from the positive control but significantly lower than the natural ***: The activity of the selenoproteins pHGpx and Selpp are involved in the internetwork of antioxidative enzymes with vitamin E when given up to a medium dose only and is one of the possible pathways of shielding embryonic development against the impact of ethanol on brain morphogenesis. This study strengthens the impact of dietaryα-tocopherol and Selenium supplement during the criti

关键词： α-tocopherol Dysmorphogenesis Ethanol pHGpx postimplantation embryos Selenoproteins Selpp

Genetic and Agronomic parameter Estimates of Growth, Yield and Related Traits of Maize (Zea mays L.) under Different Rates of Nitrogen Fertilization

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Cilostazol for secondary stroke prevention:systematic review and meta-analysis

American Journal of plant Sciences（美国植物学期刊） 2024年第4期 274页

作者： prince Emmanuel Norman Lansana Kamara Aloysius Beah Kelvin Sahr Gborie Francess sia Saquee Sheku Alfred Kanu Fayia Augustine Kassoh Yvonne Sylvia Gloria Ethel Norman Abdul Salaam Kargbo

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Stroke & Vascular Neurology 2021年第3期6卷 410-423,I0035-I0053页

作者： Choon Han Tan Andrew GR Wu Ching-Hui sia Aloysius ST Leow Bernard pL Chan Vijay Kumar Sharma Leonard LL Yeo Benjamin YQ Tan Department of Medicine Lee Kong Chian School of MedicineNanyang Technological UniversitySingapore Department of Medicine Yong Loo Lin School of MedicineNational University of SingaporeSingapore Department of Cardiology National University Heart CentreSingapore Division of Neurology Department of MedicineNational University Health SystemSingapore

Background Stroke is one of the leading causes of death ***,an antiplatelet and phosphodiesterase 3 inhibitor,has not been clearly established for ischaemic stroke *** aim to determine the efficacy and safety of cilostazol for secondary stroke *** MEDLiNE,EMBASE,Cochrane Library,Web of Science and *** were searched from inception to 25 September 2020,for randomised trials comparing the efficacy and safety of cilostazol monotherapy or dual therapy with another antiplatelet regimen or placebo,in patients with ischaemic *** 2 of the Cochrane risk-of-bias tool for randomised trials(RoB 2)was used to assess study *** meta-analysis was reported in line with the preferred Reporting items for Systematic Reviews and Meta-Analyses(pRiSMA)*** Eighteen randomised trials comprising 11429 participants were included in this *** trials possessed low risk of bias and were of low *** significantly reduced the rate of ischaemic stroke recurrence(risk ratio,RR=0.69,95%Ci 0.58 to 0.81),any stroke recurrence(RR=0.64,95%Ci 0.54 to 0.74)and major adverse cardiovascular events(RR=0.67,95%Ci 0.56 to 0.81).Cilostazol did not significantly decrease mortality(RR=0.90,95%Ci 0.64 to 1.25)or increase the rate of good functional outcome(Modified Rankin Scale score of 0–1;RR=1.07,95%Ci 0.95 to 1.19).Cilostazol demonstrated favourable safety profile,significantly reducing the risk of intracranial haemorrhage(RR=0.46,95%Ci 0.31 to 0.68)and major haemorrhagic events(RR=0.49,95%Ci 0.34 to 0.70).Conclusions Cilostazol demonstrated superior efficacy and safety profiles compared with traditional antiplatelet regimens such as aspirin and clopidogrel for secondary stroke prevention but does not appear to affect functional *** randomised trials can be conducted outside East Asia,or compare cilostazol with a wider range of antiplatelet agents.

关键词： prevention Cilostazol regimen

psychosocial Factors Associated with Transfer Anxiety among Open Heart Surgery patients Transferred from the intensive Care Unit to the General Ward

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Health 2020年第12期12卷 1583-1597页

作者： Jaya Rijal Wipa Sae-sia Luppana Kitrungrote Department of Adult and Elderly Nursing Faculty of Nursing Prince of Songkla University Hat Yai Thailand

introduction: patient’s transfer from the intensive care unit (iCU) to the general ward indicates their improving health status. However, the transfer produces anxiety when patients enter an unfamiliar environment with different care protocols and circumstances. Objectives: This study aimed to examine the level of iCU transfer anxiety among open heart surgery patients and determine the psychosocial factors associated with iCU transfer anxiety among open heart surgery patients. Methods: Data were collected in a cardiac center in Kathmandu City, Nepal among 95 open heart surgery patients within 24 hours of their transfer from an iCU to a general ward. The study used four self-reported questionnaires, namely the modified Mishel Uncertainty in illness Scale for Adults, modified Brief COpE inventory, Nurses’ Support Questionnaire, and State Anxiety inventory. Results: Fifty-two patients (54.7%) had a high level of transfer anxiety. Spearman’s rank correlation showed that uncertainty in illness, coping, and nurses’ support were significantly related to transfer anxiety (p Conclusion: The results of this study suggest nurses to address uncertainty in illness of the patients, improve their coping abilities, and provide need-based nursing support to them during the transitional phase. Besides, clinicians and governmental agencies should contribute to implication of transitional guidelines, which can reduce transfer anxiety and promote health and recovery of the patients.

关键词： Transfer Anxiety Uncertainty Coping intensive Care Unit Open Heart Surgery

氯化十六烷基吡啶（CpC）对不同生命阶段斑马鱼（Danio rerio）的影响

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氯化十六烷基吡啶（CPC）对不同生命阶段斑马鱼（Danio rerio）的...

作者： Michaela sia Tengbe 江苏大学

学位级别：硕士

氯化十六烷基吡啶(CpC,CHCiN),一种阳离子季铵盐表面活性剂,被广泛用作药物和个人护理产品(ppCps)的抗菌成分,特别是在牙膏和漱口水等口腔产品中。此外,CpC还被用作公共卫生领域(如游泳池)的消毒剂,食品加工中的微生物抑制剂,以及石油... 详细信息

氯化十六烷基吡啶(CpC,CHCiN),一种阳离子季铵盐表面活性剂,被广泛用作药物和个人护理产品(ppCps)的抗菌成分,特别是在牙膏和漱口水等口腔产品中。此外,CpC还被用作公共卫生领域(如游泳池)的消毒剂,食品加工中的微生物抑制剂,以及石油工业中的离子液体成分。由于其广泛的用途,大量的CpC可以进入污水处理厂或直接排放到自然环境中。因此,CpC引起水体污染引起的潜力生态风险引起了广泛的关注。然而,人们对于CpC对鱼类毒性效应及其不利影响仍知之甚少、亟待开展相关研究。综上,本研究以CpC对斑马鱼的神经行为毒性为切入点,通过分析不同CpC暴露浓度下斑马鱼在行为、生理、生化和分子等层面的响应来探讨了该污染物对不同发育阶段斑马鱼的毒性效应及相关作用机制。研究的主要内容和结果如下:(1)CpC对斑马鱼早期生命阶段的影响:本实验考察了CpC暴露(0,4,40,400和1200μg/L)对斑马鱼早期生命阶段的生存、发育、行为和氧化应激的响应。结果表明,浓度为400和1200μg/L的CpC暴露表现出显著的致死效应,其120 h-EC值为175.9μg/L。此外,亚致死浓度CpC暴露可显著降低了胚胎(48 hpf)和幼虫(72 hpf)的心率。在120 hpf时,CpC暴露对幼鱼的运动的运动活性呈现出双重影响(400μg/L时下降,在4和40μg/L时增加),并且在400μg/L时显著提高其体内活性氧自由基、超氧化物歧化酶和谷胱甘肽水平。相关分析表明CpC诱导的氧化应激可能在介导其对斑马鱼仔鱼的心脏毒性和行为毒性中起重要作用。(2)CpC对斑马鱼稚鱼和成鱼的行为和脑神经递质的影响:本实验将斑马鱼稚鱼和成鱼暴露于CpC(0、10和40μg/L)四天。随后,调查了斑马鱼行为特征和脑组织中几种神经递质的响应。行为学分析表明,CpC暴露可显著降低了斑马鱼在的运动活动和社会互动,而稚鱼对CpC暴露较成鱼更加敏感。通过比较对照组中稚鱼和成鱼发现其脑神经递质浓度随着年龄的增长而增加。然而,CpC暴露倾向于增加稚鱼的脑神经递质浓度,但会降低其在成鱼脑组织中的浓度。相关分析表明,脑组织中单胺神经递质及其代谢活性在调控斑马鱼对CpC暴露的行为响应中起重要作用。我们的研究结果表明,即使在环境相关的浓度下,CpC暴露也足以导致斑马鱼稚鱼和成鱼的异常行为并干扰其大脑神经递质,因此需要进一步评估其对水生生态系统的潜在风险。(3)CpC对成年斑马鱼毒性的潜在机制:本实验通过对脑组织的比较转录组分析,研究CpC(40μg/L,4天)对成年斑马鱼影响的分子机制。通过比较CpC暴露和对照,共鉴定了96个差异表达基因(DEG)。在这些基因中,25个基因被上调,而71个基因被CpC暴露下调。基因本体(GO)分析表明,DEGs主要富集于细胞过程、代谢过程、生物调控、生物过程调控、对刺激的反应以及多细胞生物过程的生物和负调控。京都基因和基因组百科全书分析(KEGG)显示,DEG显着富集到昼夜节律、内质网中的蛋白质加工、昼夜节律飞行以及抗原加工和呈递的途径中。基于KEGG通路关系网络,CpC可能通过破坏与昼夜节律、蛋白质过程和免疫系统相关的通路所涉及的通路,对斑马鱼产生不利影响。此外,CpC还可能通过破坏胰岛素抵抗而表现出内分泌干扰作用。

关键词：氯化十六烷基吡啶斑马鱼生命阶段行为响应氧化压力神经递质分子机制

Agreement of angle closure assessments between gonioscopy, anterior segment optical coherence tomography and spectral domain optical coherence tomography

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international Journal of Ophthalmology(English edition) 2015年第2期8卷 342-346页

作者： Elton Lik Tong Tay Vernon Khet Yau Yong Boon Ang Lim Stelson sia Elizabeth poh Ying Wong Leonard Wei Leon Yip Department of Ophthalmology Tan Tock Seng Hospital Republic of Singapore Air Force Aeromedical Centre Cardinal Santos Medical Center

AiM: To determine angle closure agreements between gonioscopy and anterior segment optical coherence tomography(AS-OCT), as well as gonioscopy and spectral domain OCT(SD-OCT). A secondary objective was to quantify inter-observer agreements of AS-OCT and SD-OCT ***: Seventeen consecutive subjects(33 eyes)were recruited from the study hospital’s Glaucoma *** was performed by a glaucomatologist masked to OCT results. OCT images were read independently by 2 other glaucomatologists masked to gonioscopy findings as well as each other’s analyses of OCT ***: Totally 84.8% and 45.5% of scleral spurs were visualized in AS-OCT and SD-OCT images respectively(p ioscopy was fair at k =0.31(95% confidence interval, Ci: 0.03-0.59) and k =0.35(95%Ci: 0.07-0.63) for reader 1 and 2 respectively. The agreement for angle closure between SD-OCT and gonioscopy was fair at k =0.21(95% Ci: 0.07-0.49) and slight at k =0.17(95% Ci: 0.08-0.42) for reader 1 and 2 respectively. The inter-reader agreement for angle closure in AS-OCT images was moderate at 0.51(95% Ci: 0.13-0.88). The inter-reader agreement for angle closure in SD-OCT images was slight at 0.18(95% Ci: 0.08-0.45).CONCLUSiON: Significant proportion of scleral spurs were not visualised with SD-OCT imaging resulting in weaker inter-reader agreements. identifying other angle landmarks in SD-OCT images will allow more consistent angle closure assessments. Gonioscopy and OCT imaging do not always agree in angle closure assessments but have their own advantages, and should be used together and not exclusively.

关键词： anterior segment imaging spectral domain imaging angle closure assessment

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新西兰中医针灸发展及特点研究

新西兰中医针灸发展及特点研究

作者： AVRiL sia SiEN LYNN 厦门大学

学位级别：硕士

通过对新西兰针灸历史发展轨迹,教育、临床和政策现状分析,初步总结新西兰针灸的现状特点,并为新西兰的针灸教育和临床提供借鉴性经验。同样也希望能够推动针灸在新西兰的合法化,进一步促使针灸在新西兰的发展。通过对新西兰针灸师临床... 详细信息

通过对新西兰针灸历史发展轨迹,教育、临床和政策现状分析,初步总结新西兰针灸的现状特点,并为新西兰的针灸教育和临床提供借鉴性经验。同样也希望能够推动针灸在新西兰的合法化,进一步促使针灸在新西兰的发展。通过对新西兰针灸师临床治疗病种和所用针法情况进行调查问卷,共发放二十二份。研究结果:十九世纪中后期针灸传入新西兰,直到二十世纪末期才慢慢发展起来。1990年由于意外伤害赔偿局(ACC)认可了针灸师作为治疗者,从此针灸在新西兰开始飞速发展。由于ACC职能的特殊性,所接收的患者大多数的均为意外损伤,其中软组织损伤者占95%以上。与此同时,当时新西兰的中医师执医范围的局限性,限制了其在临上的应用,促使中医师努力提升针灸技术。在中医教育方面,新西兰共有两所私立中医学院,仅提供本科课程;而在公立高校内只有研究生的硕士课程可供选择。新西兰的中医院校注重中医经典的学习,全英文授课。至今新西兰的中医还未立法,只有ACC的治疗由协会自我监管,其他包括中药、自费针灸等都是无人监管。

关键词：新西兰针灸发展