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Prevalence of occult hepatitis B virus infection in haemodialysis patients from central Greece

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World Journal of Gastroenterology 2010年第2期16卷 225-231页

作者： Paraskevi Mina Sarah P Georgiadou Christos Rizos George N Dalekos eirini I rigopoulou Department of Medicine and Research Laboratory of Internal Medicine Medical School University of Thessaly41110 LarissaThessalyGreece Research Group of Investigational Medicine Institute of Biomedical Research and TechnologyCentre for Research and Technology-Thessaly(CE.RE.TE.TH)41222 LarissaThessalyGreece RE.TE.TH)41222 LarissaThessalyGreece Research Group of Investigational Medicine Institute of Biomedical Research and TechnologyCentre for Research and Technology-Thessaly(CE.RE.TE.TH)41222 LarissaThessalyGreece

AIM:To assess the hepatitis B virus(HBV)-DNA and the prevalence of occult HBV infection in end-stage renal failure(ESRF)patients from Central Greece. METHODS:Sera from 366 ESRF patients attending five out of six dialysis units from Central Greece were investigated for HBV-DNA by real-time polymerase chain *** serum samples with repeatedly detectable HBV-DNA were considered *** antibodies to hepatitis C virus(anti-HCV)were tested by a third generation enzyme linked immunosorbent assay(ELISA),while IgG antibodies to hepatitis E virus (anti-HEV)were tested by two commercially available ***:HBV-DNA was detected in 15/366 patient (4.1%)and HBsAg in 20/366(5.5%).The prevalenc of occult HBV infection was 0.9%(3/346 HBsAg negative patients).Occult HBV was not associate with a specific marker of HBV infection or anti-HCV o anti-HEV *** was no significant differenc in HBV-DNA titres,demographic and biochemica features,between patients with occult HBV infectio and those with HBsAg-positive chronic HBV infection. CONCLUSION:In central Greece,4%of ESRF patient had detectable HBV-DNA,though in this setting,th prevalence of occult HBV seems to be very low(0.9%).

关键词： Hepatitis B virus-DNA Occult hepatitis B virus infection Haemodialysis Hepatitis B Real-time polymerase chain reaction

Role for mycobacterial infection in pathogenesis of primary biliary cirrhosis?

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World Journal of Gastroenterology 2012年第35期18卷 4855-4865页

作者： Daniel Smyk eirini I rigopoulou Yoh Zen Robin Daniel Abeles Charalambos Billinis Albert Pares Dimitrios P Bogdanos Institute of Liver Studies and Liver Unit King's College London School of Medicine at King's College Hospital and Kings College Hospital NHS Trust Foundation TrustLondon SE5 9RSUnited Kingdom Institute of Biomedical Research and Technology(BIOMED) CERETETHLarissa 41222Greece Dimitrios P Bogdanos Department of MedicineUniversity Hospital of LarissaUniversity of Thessaly Medical SchoolBiopolisLarissa 41110Greece Faculty of Veterinary Medicine University of Thessaly Liver Unit Digestive Diseases InstituteHospital ClínicIDIBAPSCIBEREHDUniversity of BarcelonaBarcelona 08036Spain

Primary biliary cirrhosis （PBC） is a progressive cho- lestatic liver disease characterized by the immune- mediated destruction of biliary epithelial cells in small intrahepatic bile ducts. The disease is characterized by circulating antimitochondrial antibodies （AMAs） as well as disease-specific antinuclear antibodies, cholestatic liver function tests, and characteristic histological fea- tures, including granulomas. A variety of organisms are involved in granuloma formation, of which mycobacte- ria are the most commonly associated. This has led to the hypothesis that mnycobacteria may be involved in the pathogenesis of PBC, along with other infectious agents. Additionally, AMAs are found in a subgroup of patients with rnycobacterial infections, such as lep- rosy and pulmonary tuberculosis. Antibodies against species-specific mycobacterial proteins have been re- ported in patients with PBC, but it is not clear whether these antibodies are specific for the disease. In addi- tion, data in support of the involvement of the role of molecular mimicry between rnycobacterial and human mitochondrial antigens as triggers of cross-reactive im- mune responses leading to the loss of immunological tolerance, and the induction of pathological features have been published. Thus, antibodies against myco- bacterial heat shock protein appear to cross-recognize AMA-specific autoantigens, but it is not clear whether these autoantibodies are mycobacterium-species-spe- cific, and whether they are pathogenic or incidental. The view that mycobacteria are infectious triggers of PBC is intriguing, but the data provided so far are not conclusive.

关键词： Antimitochondrial antibodies Autoantibody Autoimmunity Cholestasis Heat shock Infection Liverdisease Liver failure Mycobacterium Tuberculosis

Diagnostic and clinical significance of antigen-specific pancreatic antibodies in inflammatory bowel diseases: A meta-analysis

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World Journal of Gastroenterology 2020年第2期26卷 246-265页

作者： Konstantinos Gkiouras Maria G Grammatikopoulou Xenophon Theodoridis eirini Pagkalidou Evangelia Chatzikyriakou Anna G Apostolidou eirini I rigopoulou Lazaros I Sakkas Dimitrios Petrou Bogdanos Department of Rheumatology and Clinical Immunology Faculty of MedicineSchool of Health SciencesUniversity of ThessalyBiopolisLarissa GR41110Greece Faculty of Medicine School of Health SciencesAristotle University of ThessalonikiUniversity CampusThessaloniki GR54124Greece Department of Nutritional Sciences and Dietetics School of Health SciencesInternational Hellenic UniversitySindos CampusThessaloniki GR57400Greece Laboratory of Hygiene Social and Preventive Medicine and Medical StatisticsFaculty of MedicineSchool of Health SciencesAristotle University of ThessalonikiUniversity CampusThessaloniki GR54124Greece Laboratory of Clinical Neurophysiology AHEPA University HospitalFaculty of MedicineAristotle University of ThessalonikiUniversity CampusThessaloniki GR54124Greece Department of Medicine and Research Laboratory of Internal Medicine University Hospital of LarissaBiopolisLarissa GR41110Greece Division of Transplantation Immunology and Mucosal BiologyMRC Centre for TransplantationKing's College London Medical SchoolLondon GR41110United Kingdom

BACKGROUND Non-invasive criteria are needed for Crohn’s disease(CD)diagnosis,with several biomarkers being *** of individual diagnostic test accuracy studies assessing the diagnostic value of pancreatic autoantibodies-to-glycoprotein-2(anti-GP2)tests for the diagnosis of CD appear *** To systematically review and meta-analyze evidence on the diagnostic accuracy of anti-GP2 tests in patients with suspected/confirmed *** An electronic search was conducted on PubMed,Cochrane-CENTRAL and grey literature(CRD42019125947).The structured research question in PICPTR format was“Population”including patients with symptoms akin to CD,the“Index test”being anti-GP2 testing,the“Comparator”involved standard CD diagnosis,the“Purpose of test”being diagnostic,“Target disorder”was CD,and the“Reference standard”included standard clinical,radiological,endoscopical,and histological CD diagnostic *** was assessed with the Quality Assessment of Diagnostic Accuracy Studies-2 tool and hierarchical models were employed to synthesize the *** Out of 722 studies retrieved,15 were *** studies had industry-related conflicts-of-interest,and most included healthy donors as controls(spectrum bias).For the combination of IgA and/or IgG anti-GP2 test,the summary sensitivity was 20%(95%confidence interval:10%-29%)at a median specificity of 97%.If the test was applied in 10000 suspected patients,9669 would be true negatives and in 26,the diagnosis would be *** this hypothetical cohort,the anti-GP2 would fail to produce a diagnosis for 81.3%of the positive *** summary points of sensitivity and high specificity were estimated for the IgG or IgA anti-GP2 *** results were observed when the analyses were restricted using specific cut-offs,or when ulcerative colitis patients were used as *** Anti-GP2 tests demonstrate low sensitivity and high *** results indicate that caution is required

关键词： Inflammatory bowel disease Gastrointestinal disease Evidence-based diagnosis Sensitivity Specificity Ulcerative colitis Conflicts of interest Metaregression Industry bias

Efficient management of secondary haemophagocytic lymphohistiocytosis with intravenous steroids and γ-immunoglobulin infusions

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World Journal of Clinical Cases 2019年第21期7卷 3394-3406页

作者： Sarah Georgiadou Nikolaos K Gatselis Aggelos Stefos Kalliopi Zachou Konstantinos Makaritsis eirini I rigopoulou George N Dalekos Department of Medicine and Research Laboratory of Internal Medicine University Hospital of LarissaLarissa 41110Greece Institute of Internal Medicine and Hepatology University Hospital of LarissaLarissa 41447Greece

BACKGROUND Secondary haemophagocytic lymphohistiocytosis(sHLH)is a rare lifethreatening condition mainly associated with underlying infections,malignancies,and autoimmune or immune-mediated *** To analyse all sHLH cases that were diagnosed and managed under real-world circumstances in our department focusing on the treatment schedule and the *** Prospectively collected data from all adult patients fulfilling the criteria of sHLH who diagnosed and managed from January 1,2010 to June 1,2018,in our department of the tertiary care university hospital of Larissa,Greece,were analysed retrospectively(n=80;52%male;median age:55 years).The electronic records and/or written charts of the patients were reviewed for the demographic characteristics,clinical manifestations,underlying causes of sHLH,laboratory parameters,treatment schedule and 30-d-mortality *** of patients had received after consent intravenousγ-immunoglobulin(IVIG)for 5 d(total dose 2 g/kg)in combination with intravenous steroid pulses followed by gradual tapering of *** Seventy-five patients(94%)reported fever>38.5°C,47(59%)had liver or spleen enlargement and 76(95%)had ferritin>500 ng/mL including 20(25%)having considerably high levels(>10000 ng/mL).Anaemia and thrombocytopenia occurred in 72%and leucopoenia in 47%of *** infections were diagnosed in 59 patients(74%)as follows:leishmaniasis alone in 15/80(18.9%),leishmaniasis concurrently with Coxiella Burnetti or non-Hodgkin lymphoma in 2/80(2.5%),bacterial infections in 14/80(17.5%)including one case with concurrent non-Hodgkin lymphoma,viral infections in 13/80(16.3%),fungal infections in 2/80(2.5%),infections by mycobacteria in 1/80(1.3%)and unidentified pathogens in 12/80(15%).Seventy-two patients(90%)had received combination treatment with IVIG and intravenous ***,sHLH resolved in 76%of patients,15%died within the first month but 82.5%of patients were still alive 6 mo after ***

关键词： Haemophagocytic syndrome Haemophagocytic lymphohistiocytosis γ-immunoglobulin Leishmaniasis Ferritin

Helicobacter pylori and autoimmune disease:Cause or bystander

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World Journal of Gastroenterology 2014年第3期20卷 613-629页

作者： Daniel S Smyk Andreas L Koutsoumpas Maria G Myt-ilinaiou eirini I rigopoulou Lazaros I Sakkas Dimitrios P Bogdanos Institute of Liver Studies Division of Transplantation Immunology and Mucosal BiologyKing's College HospitalSchool of MedicineKing's College London Department of Medicine Faculty of MedicineSchool of Health SciencesUniversity of Thessaly Department of Rheumatology Faculty of MedicineSchool of Health SciencesUniversity of Thessaly Cellular Immunotherapy and Molecular Immunodiagnostics Biomedical SectionCEntre for REsearch and TEchnology Hellas (CE.R.T.H.)/Institute for REsearch and Technology-THessaly (I.RE.TE.TH)

Helicobacter pylori (H. pylori) is the main cause of chronic gastritis and a major risk factor for gastric cancer. This pathogen has also been considered a potential trigger of gastric autoimmunity, and in particular of autoimmune gastritis. However, a considerable number of reports have attempted to link H. pylori infection with the development of extra-gastrointestinal autoimmune disorders, affecting organs not immediately relevant to the stomach. This review discusses the current evidence in support or against the role of H. pylori as a potential trigger of autoimmune rheumatic and skin diseases, as well as organ specific autoimmune diseases. We discuss epidemiological, serological, immunological and experimental evidence associating this pathogen with autoimmune diseases. Although over one hundred autoimmune diseases have been investigated in relation to H. pylori, we discuss a select number of papers with a larger literature base, and include Sjögrens syndrome, rheumatoid arthritis, systemic lupus erythematosus, vasculitides, autoimmune skin conditions, idiopathic thrombocytopenic purpura, autoimmune thyroid disease, multiple sclerosis, neuromyelitis optica and autoimmune liver diseases. Specific mention is given to those studies reporting an association of anti-H. pylori antibodies with the presence of autoimmune disease-specific clinical parameters, as well as those failing to find such associations. We also provide helpful hints for future research.

关键词： Autoimmunity Helicobacter pylori Infection Gastritis Mimicry Rheumatology

Reversion of severe hepatopulmonary syndrome in a non cirrhotic patient after corticosteroid treatment for granulomatous hepatitis:A case report and review of the literature

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World Journal of Gastroenterology 2006年第2期12卷 336-339页

作者： Nikolaos Tzovaras Aggelos Stefos Sarah P Georgiadou Nikolaos Gatselis Georgia Papadamou eirini rigopoulou Maria Ioannou Ioannis Skoularigis Georgios N Dalekos Department of Medicine Academic Liver UnitMedical SchoolUniversity of Thessaly41222 LarissaGreece Department of Pathology Medical SchoolUniversity of Thessaly41222 LarissaGreece Division of Cardiology Medical SchoolUniversity of Thessaly41222 LarissaGreece

Hepatopulmonary syndrome （HPS） is defined as a clinical triad including liver disease, abnormal pulmonary gas exchange and evidence of intrapulmonary vascular dilatations. We report a 61-year-old male presented with fatigue, long-lasting fever, loss of weight, signs of portal hypertension, hepatosplenomegaly, cholestasis and progressive dyspnoea over the last year. Clinical, laboratory and histological findings confirmed the diagnosis of granulomatous hepatitis. HPS due to hepatic granulomainduced portal hypertension was proved to be the cause of severe hypoxemia of the patient as confirmed by contrast-enhanced echocardiography. Reversion of HPS after corticosteroid therapy was confirmed by a new contrastenhanced echocardiography along with the normalization of cholestatic enzymes and improvement of the patient＇ s conditions. This is the first case of complete reversion of HPS in a non-cirrhotic patient with hepatic granuloma, indicating that intrapulmonary shunt in liver diseases is a functional phenomenon and HPS can be developed even in miscellaneous liver involvement as in this case.

关键词： Hepatopulmonary syndrome Granulomatous hepatitis Liver cirrhosis Orthodeoxia Platypnoea

Primary biliary cirrhosis in HBV and HCV patients:Clinical characteristics and outcome

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World Journal of Hepatology 2013年第10期5卷 577-583页

作者： eirini I rigopoulou Kalliopi Zachou Nikolaos K Gatselis Georgia Papadamou George K Koukoulis George N Dalekos Department of Medicine and Research Laboratory of Internal Medicine Medical School University of Thessaly Department of Pathology Medical SchoolUniversity of Thessaly

AIM: To present the characteristics, management and outcome of patients with hepatitis B virus(HBV) or hepatitis C virus(HCV) infections concurrent with primary biliary cirrhosis(PBC).METHODS: Since January 2001 to September 2009,we retrospectively evaluated the medical records of all HBV(n = 1493) and HCV patients(n = 526) who are followed in our center for the presence of concurrent PBC. Seventeen patients identified with concurrent viral hepatitis and PBC(8 HCV and PBC; follow-up: 61 ± 37 mo and 9 HBV and PBC; follow-up: 57 ± 38 mo). PBC diagnosis was established if the patients met at least two of the following criteria: positivity for antimitochondrial antibody, elevated cholestatic enzymes and histological lesions of ***: HCV or HBV diagnosis preceded that of PBC in most patients by many years. PBC diagnosis was based on the presence of antimitochondrial antibody and elevated cholestatic enzymes in all 17 patients,while one third(5/17; 29.4%) experienced severe pruritus many years before diagnosis. Patients with PBC and HBV were significantly younger at diagnosis of PBC compared to patients with PBC and HCV(56.1 ± 11.2vs 68.5 ± 10.3, respectively, P < 0.05). At initial clinical and histological assessment the majority of patients were cirrhotics(10/17; 58.8%) with the group of PBC and HCV carrying the highest frequency(87.5% vs33.3% in PBC and HBV; P < 0.05). The patients with HBV and concomitant PBC seem to have better outcome compared to those with HCV and PBC since none of the 6 non-cirrhotics with HBV and PBC developed cirrhosis during ***: PBC diagnosis in HBV or HCV patients is very difficult and usually delayed. Therefore, in any case, cholestasis should alert physicians to further search for PBC.

关键词： Antimitochindrial antibodies Autoimmune liver disease Hepatitis B virus Hepatitis C virus Primary biliary cirrhosis.

Resuspension of spherical particles due to surface vibration

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Particuology 2021年第1期19卷 126-135页

作者： Sofia eirini Chatoutsidou Mihalis Lazaridis School of Environmental Engineering Technical University of Crete73100 ChaniaGreece

In this study,particle resuspension due to surface vibration was investigated.A spherical particle was assumed to rest on top of a thin plate,and an external vibrating force was applied normal on the plate at t=0 and at distance R from the *** external driving force created a displacement field in both time and space domains,where deformations in the body of the plate were considered small elastic oscillations that are perpendicular to the propagation of the *** oscillations were introduced via the theory of elasticity and the creation of waves on thin plates,i.e.,bending *** motion in the vertical direction was initiated through plate displacement,provided that inertia due to particle mass is *** particular,the particle was assumed to oscillate with a force(of oscillation)estimated via Newton’s second law of motion,comprising of two components:the acceleration due to the plate displacement and the particle ***,a simple force balance method was used to determine the conditions for ***,resuspension occurs when the oscillation force exceeds the couple of the adhesive and gravitational *** results suggest that the plate displacement depends on the characteristics of the applied force,material properties,and plate *** addition,it was found that the oscillation force is substantially lower than the applied force and that it depends on plate displacement and particle ***,the particle size significantly influencedthe outcome of ***,resuspension is favorable for large particles,strong applied forces,and high forcing frequencies.

关键词： Particle resuspension Vibration Bending waves

The impact of combined oral contraceptives on ocular tissues:a review of ocular effects

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International Journal of Ophthalmology(English edition) 2017年第10期10卷 1604-1610页

作者： Marilita M.Moschos eirini Nitoda Department of Ophthalmology Medical SchoolNational & Kapodistrian University of Athens

The aim of this manuscript is to review the action and adverse effects of combined oral contraceptives（COCs）on ocular *** percentage of unwanted pregnancies and the subsequent abortions make contraception crucial *** 100 million women around the world use common contraceptive methods,including intrauterine devices,combined estrogen and progestin oral contraceptives,as well as progestin only preparations（oral contraceptives,implants or injections）.COCs are widely used for contraception,but they are also indicated in menorrhagia,endometriosis,acne and hirsutism,fibroid uterus and premenstrual ***,they have been associated with high rates of cardiovascular events,venous thromboembolic disease,ischemic strokes and breast *** incidence of COCs-related ocular complications is estimated to be 1 in 230 000,including dry eye symptoms,corneal edema,lens opacities and retinal neuro-ophthalmologic or vascular *** may infer that the serious ocular complications of COCs can be prevented by eliminating the estrogen dosage and choosing third-generation *** any case,doctors should take into consideration the systemic and ocular history of the patients before selecting any method of contraception.

关键词： adverse effects ocular complications oral contraceptives