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Diagnostic and clinical significance of antigen-specific pancreatic antibodies in inflammatory bowel diseases: A meta-analysis

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World Journal of Gastroenterology 2020年第2期26卷 246-265页

作者： Konstantinos Gkiouras Maria G Grammatikopoulou Xenophon Theodoridis eirini pagkalidou Evangelia Chatzikyriakou Anna G Apostolidou eirini I Rigopoulou Lazaros I Sakkas Dimitrios Petrou Bogdanos Department of Rheumatology and Clinical Immunology Faculty of MedicineSchool of Health SciencesUniversity of ThessalyBiopolisLarissa GR41110Greece Faculty of Medicine School of Health SciencesAristotle University of ThessalonikiUniversity CampusThessaloniki GR54124Greece Department of Nutritional Sciences and Dietetics School of Health SciencesInternational Hellenic UniversitySindos CampusThessaloniki GR57400Greece Laboratory of Hygiene Social and Preventive Medicine and Medical StatisticsFaculty of MedicineSchool of Health SciencesAristotle University of ThessalonikiUniversity CampusThessaloniki GR54124Greece Laboratory of Clinical Neurophysiology AHEPA University HospitalFaculty of MedicineAristotle University of ThessalonikiUniversity CampusThessaloniki GR54124Greece Department of Medicine and Research Laboratory of Internal Medicine University Hospital of LarissaBiopolisLarissa GR41110Greece Division of Transplantation Immunology and Mucosal BiologyMRC Centre for TransplantationKing's College London Medical SchoolLondon GR41110United Kingdom

BACKGROUND Non-invasive criteria are needed for Crohn’s disease(CD)diagnosis,with several biomarkers being *** of individual diagnostic test accuracy studies assessing the diagnostic value of pancreatic autoantibodies-to-glycoprotein-2(anti-GP2)tests for the diagnosis of CD appear *** To systematically review and meta-analyze evidence on the diagnostic accuracy of anti-GP2 tests in patients with suspected/confirmed *** An electronic search was conducted on PubMed,Cochrane-CENTRAL and grey literature(CRD42019125947).The structured research question in PICPTR format was“Population”including patients with symptoms akin to CD,the“Index test”being anti-GP2 testing,the“Comparator”involved standard CD diagnosis,the“Purpose of test”being diagnostic,“Target disorder”was CD,and the“Reference standard”included standard clinical,radiological,endoscopical,and histological CD diagnostic *** was assessed with the Quality Assessment of Diagnostic Accuracy Studies-2 tool and hierarchical models were employed to synthesize the *** Out of 722 studies retrieved,15 were *** studies had industry-related conflicts-of-interest,and most included healthy donors as controls(spectrum bias).For the combination of IgA and/or IgG anti-GP2 test,the summary sensitivity was 20%(95%confidence interval:10%-29%)at a median specificity of 97%.If the test was applied in 10000 suspected patients,9669 would be true negatives and in 26,the diagnosis would be *** this hypothetical cohort,the anti-GP2 would fail to produce a diagnosis for 81.3%of the positive *** summary points of sensitivity and high specificity were estimated for the IgG or IgA anti-GP2 *** results were observed when the analyses were restricted using specific cut-offs,or when ulcerative colitis patients were used as *** Anti-GP2 tests demonstrate low sensitivity and high *** results indicate that caution is required

关键词： Inflammatory bowel disease Gastrointestinal disease Evidence-based diagnosis Sensitivity Specificity Ulcerative colitis Conflicts of interest Metaregression Industry bias

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Simple hematological predictors of AF recurrence in patients undergoing atrial fibrillation ablation

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Journal of Geriatric Cardiology 2019年第9期16卷 671-675页

作者： George Bazoukis Konstantinos P Letsas Konstantinos Vlachos Athanasios Saplaouras Dimitrios Asvestas Konstantinos Tyrovolas Aikaterini Rokiza eirini pagkalidou Gary Tse Stavros Stavrakis Antonios Sideris Michael Efremidis Department of Cardiology Electrophysiology Laboratory Evangelismos General Hospital of Athens Athens Greece Department of Hygiene and Epidemiology School of Medicine Aristotle University of Thessaloniki Thessaloniki Greece Department of Medicine and Therapeutics Faculty of Medicine Chinese University of Hong Kong Hong Kong China Li Ka Shing Institute of Health Sciences Faculty of Medicine Chinese University of Hong Kong Hong Kong SAR China Department of Medicine Cardiovascular Section Heart Rhythm Institute University of Oklahoma Health Sciences Center Oklahoma City Oklahoma USA

Backgound Red cell distribution width(RDW) and neutrophil-to-lymphocyte ratio(NLR) are simple hematologic indices that have been used to predict adverse outcomes in different clinical settings. The aim of our study is to determine whether RDW and NLR can predict atrial fibrillation(AF) recurrence in patients undergoing AF ablation. Methods Consecutive patients, without known hematological disorders, who underwent AF catheter ablation between January 2014 and April 2017 were enrolled into this study. Blood samples were taken one day before and five hours after the ablation procedure. Results A total of 346 patients(224 males(65%), mean age: 59 ± 11 years old) were included. After a mean follow up of 26.2 ± 12.1 months, 80(23.1%) patients experienced late AF recurrence(defined as any recurrence after the blanking period of three months), while 97(28%) patients experienced early AF recurrence during the blanking period. Univariate analysis showed that early arrhythmia recurrence, type of AF and NLR after the procedure were significantly associated with late AF recurrence, while early arrhythmia recurrence and NLR remained significant in multivariate analysis. RDW was not associated with late AF recurrence. None of the parameters above predicted early arrhythmia recurrence. Conclusions Simple and inexpensive hematological indices such as NLR should be evaluated for their ability to predict AF recurrence in patients undergoing catheter ablation in larger prospective studies.

关键词： Atrial fibrillation Neutrophils Radiofrequency ablation

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