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Neuroinflammation revisited through the microglial lens

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Neural Regeneration Research 2025年第7期20卷 1989-1990页

作者： Renato Socodato João B.Relvas Institute of Research and Innovation in Health(i3S)and Institute for Molecular and Cell Biology(IBMC) University of PortoPortoPortugal Department of Biomedicine Faculty of Medicine of the University of Porto(FMUP)PortoPortugal

Neuroimmunology is emerging as a pivotal field,shedding light on the intricate dialogues between the central nervous system(CNS)and the immune *** exploration is particularly significant in understanding microglia,the CNS’s innate immune cells,beyond the conventional conflation of“neuroinflammation”and“microglial activation.”This conflation has clouded the true complexity of these processes,potentially stalling scientific progress and the development of new *** challenge the long-standing perspectives that have oversimplified these interactions,advocating for a deeper exploration of the dynamic relationship between neuroinflammation and microglial *** dissecting specific molecular pathways,we aim to illuminate their elaborate roles in neuroinflammatory responses,especially in the context of Alzheimer’s disease(AD).Here,neuroinflammation is not merely a passive observer or a direct antagonist but a complex agent in the disease’s *** article calls for a significant paradigm shift towards an integrative,multi-omics approach to *** such a comprehensive framework is crucial for advancing our understanding of neuroinflammatory conditions and paving the way for targeted therapeutic strategies for brain diseases.

关键词： inflammation simplified activation

Contribution of mechanical forces to structural synaptic plasticity:insights from 3D cellular motility mechanisms

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Neural Regeneration Research 2025年第7期20卷 1995-1996页

作者： Rita o.Teodoro Mafalda Ribeiro Ramos Lara Carvalho iNoVA4Health NOVA Medical School|Faculdade de Ciências MédicasNMS|FCMUniversidade Nova de LisboaLisboaPortugal

Cells,tissues,and organs are constantly subjected to the action of mechanical forces from the extracellular environment-and the nervous system is no ***-intrinsic properties such as membrane lipid composition,abundance of mechanosensors,and cytoskeletal dynamics make cells more or less likely to sense these *** and extrinsic cues are integrated by cells and this combined information determines the rate and dynamics of membrane protrusion growth or retraction(Yamada and Sixt,2019).Cell protrusions are extensions of the plasma membrane that play crucial roles in diverse contexts such as cell migration and neuronal synapse *** the nervous system,neurons are highly dynamic cells that can change the size and number of their pre-and postsynaptic elements(called synaptic boutons and dendritic spines,respectively),in response to changes in the levels of synaptic activity through a process called *** plasticity is a hallmark of the nervous system and is present throughout our lives,being required for functions like memory formation or the learning of new motor skills(Minegishi et al.,2023;Pillai and Franze,2024).

关键词： plasticity structural mechanisms

Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

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Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher J.o’Connell Matthew J.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA james L.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

Coarse to Fine: The Role of Severe plastic Deformation in Advancing Titanium-Based Medical Implants - A Comprehensive Review

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 295-306页

作者： Dragana R Mihajlović Bojan I Međo Ivana Lj Cvijović-Alagić Veljko R Djokić Faculty of Technology and Metallurgy University of BelgradeKarnegijeva 411120 BelgradeSerbia Vinča Institute of Nuclear Sci-ences-National Institute of the Republic of Serbia University of Belgrade11001BeogradSerbia Innovation Centre of the Faculty of Technology and Metallurgy Karnegijeva 411120 BelgradeSerbia

This paper describes severe plastic deformation(SPD)procedures,which are utilized to form an ultrafine-grained structure in metallic *** the SPD process,a solid material sample is subjected to very high loads without a significant change in sample *** the present work,the high-pressure torsion(HPT)process,as one of the SPD techniques,which achieves a high degree of deformation and ensures refinement of the microstructure,will be discussed in more *** that grain size control is accepted as a method to obtain materials with desired characteristics,an overview of the properties of ultrafine-grained titanium-based biomaterials to be used in medicine is ***,particular attention is dedicated to the influences of HPT process parameters,primarily hydrostatic pressure,and number of revolutions during torsion,on the grain size and physical and mechanical characteristics(modulus of elasticity,microhardness,and tensile properties),corrosion resistance,and biocompatibility of the titanium-based biomaterials.A review of the literature indicates that titanium-based materials obtained by the SPD process show improved mechanical and physical properties without losing biocompatibility and corrosion resistance,which suggests that these methods of obtaining implants are something that should be further developed in the future.

关键词： high-pressure torsion process ultrafine-grained titanium-based materials electrochemical anodization physical properties mechanical properties

Dynamic stress concentration in an infinitely long cylindrical cavity due to a point spherical source embedded within a fluid-saturated poroelastic formation of infinite extent

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 139-156页

作者： H.HoSSEINI o.BALILASHAKI Department of Mechanical Engineering Faculty of EngineeringGolestan University

The effects of a harmonically exciting monopole source on an infinitely long cylindrical cavity embedded entirely within a fluid-saturated poroelastic formation of infinite extent are examined theoretically. It is assumed that the source is located outside the cavity at a specified distance from the borehole axis. The magnitudes of the hoop and radial stresses beside the pore pressures exerted on the interface and inside the porous medium surrounding the borehole are calculated and discussed. Biot's poroelastic modeling along with three types of boundary conditions for the cylindrical interface including the ideal fluid, empty borehole, and rigid inclusion with a hard boundary is employed for the analysis. Utilizing a proper translational addition theorem for expressing the incident spherical wave in terms of cylindrical wave expansions, the proposed boundary conditions at the interface are satisfied. Stresses are formulated by means of wave potential functions in a three-dimensional(3D) manner. The effects of the frequency and the radial distance between the source and borehole on the induced stresses are examined for the first cylindrical modes over frequency spectra. Two permeability conditions for the interface and three types of soils for the porous formation are considered throughout the analysis. To give an overall outline of the study, a numerical example is presented. The results clearly indicate that the distance is a key parameter and has considerable effects on the induced stress values. In addition, the interface permeability condition and soil characteristics play an important role in determining the dynamic response of the borehole. Finally,the obtained results are compared with the relevant analyses existing in the literature for some limit cases, and good agreement is achieved.

关键词： Stress concentration

High diversity of Graphidaceae (lichenized Ascomycota: ostropales) in Amazonian Perú

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Fungal Diversity 2013年第1期58卷 13-32页

作者： eimy riva. plata Robert Lücking Department of Biological Sciences University of Illinois-Chicago845 West Taylor Street(MC 066)ChicagoIL 60607USA Department of Botany The Field Museum1400 South Lake Shore DriveChicagoIL 60605-2496USA

A survey of crustose microlichens at Los Amigos Biological Station in Amazonian Peru revealed 116 species of Graphidaceae at this *** is the second highest number of Graphidaceae ever reported for a single site world-wide,after the Surumoni crane station in Venezuela,with 131 species,and followed by Fakahatchee Strand Park Preserve in Florida,with 111 *** on the number of Graphidaceae found at Los Amigos,we predict the total lichen species richness at this site to be approximately 700 *** the 116 species encountered at Los Amigos,59 were graphidoid species(former Graphidaceae ***.)and 67 thelotremoid species(former Thelotremataceae).The following 18 species are described as new:Ampliotrema sorediatum riva. plata&Lücking,***,Chapsa hypoconstictica riva. plata&Lücking,***,Chapsa scabiocarpa riva. plata&Lücking,***,Chapsa subsorediata riva. plata&Lücking,***,Diorygma nigricans riva. plata&Lücking,***,Fissurina flavomedullosa riva. plata&Lücking,***,Fissurina platythecioides riva. plata&Lücking,***,Graphis apertoinspersa riva. plata&Lücking,***,Graphis pitmanii riva. plata&Lücking,***,Leucodecton inspersum riva. plata&Lücking,***,ocellularia cicra riva. plata&Lücking,***,ocellularia fenestrata riva. plata&Lücking,***,ocellularia microsorediata riva. plata&Lücking,***,ocellularia natashae riva. plata&Lücking,***,ocellularia plicata riva. plata&Lücking,***,ocellularia protoinspersa riva. plata&Lücking,***,ocellularia pustulata riva. plata&Lücking,***,and Thelotrema amazonicum riva. plata&Lücking,***.

关键词： Lichens Thelotremoid Tropical Rainforest Corticolous Madre de Dios

A new classification for the family Graphidaceae(Ascomycota:Lecanoromycetes:ostropales)

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Fungal Diversity 2012年第1期52卷 107-121页

作者： eimy riva. plata Robert Lücking H.Thorsten Lumbsch Department of Biological Sciences University of Illinois-Chicago845 West Taylor Street(MC 066)ChicagoIL 60607USA Department of Botany The Field Museum1400 South Lake Shore DriveChicagoIL 60605-2496USA

A revised classification for the emended family Graphidaceae is proposed,based on recent phylogenetic studies,including the finding that three previously separated families(Asterothyriaceae,Gomphillaceae,Thelotremataceae)are nested within Graphidaceae and in part *** family comprises three major clades which are here delimited as subfamilies Fissurinoideae,Gomphilloideae,and *** latter is composed of three major clades which are formally delimited as tribes Graphideae,ocellularieae,and *** addition,three new genera are described to accommodate the ocellularia clandestina(Clandestinotrema)group,the ocellularia cruentata group(Cruentotrema)and Myriotrema pycnoporellum(Pycnotrema).

关键词： Asterothyriaceae Classification Gomphillaceae Thelotremataceae

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注蒸汽—溶剂工艺机理的理论分析

采油工艺情报 1992年第4期 15-20页

作者： riva.,oR 薛伟

A finite element analysis(FEA)approach to simulate the coefficient of friction of a brake system starting from material friction characterization

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Friction 2021年第1期9卷 191-200页

作者： Gabriele riva.Francesco VARRIALE Jens WAHLSTRÖM Brembo S.p.A. Stezzano(BG)Stezzano(BG)24040Italy KTH Royal Institute of Technology Stockholm 11428Sweden Department of Mechanical Engineering Lund UniversityLund 22100Sweden

The coefficient of friction(CoF)is one of the most important parameters to evaluate the performance of a brake *** design proper brake systems,it is important to know the CoF when estimating the brake force and resulting *** is challenging to simulate the CoF since friction in disc brakes is a complex phenomenon that depends on several parameters such as sliding velocity,contact pressure,materials,and temperatures,*** is a lack of studies found in the literature focusing on simulation of the CoF for a full brake system based on tribometer material *** aim of this work is therefore to investigate the possibility to use a finite element analysis(FEA)approach combined with a CoF pv-map to compute the global CoF of a disc brake *** local CoF is determined from a pv-map for each local sliding velocity and contact pressure determined by the *** the local CoF,the braking force of the entire brake system and the global CoF can be *** obtained by the simulation are compared with dyno bench test of the same brake system to investigate the validity of the simulation *** show that the simulation is perfectly in line with the experimental measurements in terms of in-stop CoF development,but slightly higher with a positive offset for every braking.

关键词： disc brakes friction coefficient simulation brake performance pin-on-disc