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Prognostic Impact of Surgical Margin Width in Hepatectomy for Colorectal Liver Metastasis

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Journal of Clinical and Translational Hepatology 2023年第3期11卷 705-717页

作者： Katsunori Sakamoto Toru Beppu Kohei ogawa Kei Tamura Masahiko Honjo Naotake Funamizu Yasutsugu Takada Department of Hepato-Biliary-Pancreatic and Breast Surgery Ehime University Graduate School of MedicineToon EhimeJapan Department of Surgery Yamaga City Medical CenterKumamotoJapan

As for resection for colorectal liver metastasis (CRLM), secur-ing an adequate surgical margin is important for achieving a better prognosis. However, it is often difficult to achieve ade-quate margins for the resection of CRLM. So the current sur-vival impact of sub-centi/millimeter surgical margins in he-patectomy for CRLM should be evaluated. In the current era of multidisciplinary treatment options, this review focused on the prognostic impact of a sub-centi/millimeter surgical margin width in hepatectomy for CRLM. We systematically reviewed retrospective studies that clearly described the sur-gical margin width for hepatectomy for CRLM. We selected studies conducted since 2000 that involved patients diag-nosed as having CRLM. We focused on studies that investi-gated not only surgical margins, but also microscopic surgical curability such as R0 (microscopically complete resection) or R1 (microscopically incomplete resection), which clearly de-scribe their definitions. Based on our literature review, 1, 2, or 5 mm was considered the minimum surgical margin width for hepatectomy for CRLM. Although a surgical margin width of 1 mm is acceptable for hepatectomy for CRLM, submil-limeter margins, which are defined as R1 in many reports, are only acceptable for limited patients such as those who have undergone preoperative chemotherapy. Zero-mm mar-gins are also acceptable in limited patients such as those who show a good response to preoperative chemotherapy. New chemotherapy agents have been reported to reduce the prognostic impact of a narrow surgical margin width. The incidence of margin recurrence, which is a major concern regarding R1 resection of CRLM, is about 20-30% according to the majority of earlier reports. As evaluations of the actual prognostic impact of the surgical margin remain difficult, fur-ther study is warranted.

关键词： Surgical margin Colorectal liver metastasis Chemotherapy.

Risk factors for proximal migration of biliary tube stents

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World Journal of Gastroenterology 2014年第5期20卷 1318-1324页

作者： Yoshiaki Kawaguchi Masami ogawa Yohei Kawashima Hajime Mizukami Atsuko Maruno Hiroyuki Ito Tetsuya Mine Department of Gastroenterology Tokai University School of Medicine

AIM: To analyze the risk factors for biliary stent migration in patients with benign and malignant strictures.

关键词： Migration Endoscopic biliary stent Risk factor Endoscopic retrograde cholangiopancreatography Retrieval

Neural Network Inversion for Multilayer Quaternion Neural Networks

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Computer Technology and Application 2016年第2期7卷 73-82页

作者： Takehiko ogawa Department of Electronics and Computer Systems Faculty of Engineering Takushoku University Tokyo 193-0985 Japan

Recently, solutions to inverse problems have been required in various engineering fields. The neural network inversion method has been studied as one of the neural network-based solutions. On the other hand, the extension of the neural network to a higher-dimensional domain, e.g., complex-value or quaternion, has been proposed, and a number of higher-dimensional neural network models have been proposed. Using the quatemion, we have the advantage of expressing 3D （three-dimensional） object attitudes easily. In the quaternion domain, we can define inverse problems where the cause and the result are expressed by the quaternion. In this paper, we extend the neural network inversion method to the quatemion domain. Further, we provide the results of the computer experiments to demonstrate the process and effectiveness of our method.

关键词： Inverse problems neural network inversion quatemion inverse mapping inverse kinematics.

Coal Mine Dust: Health Reviews and Key Studies

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Electrical, mechanical and damage self-sensing properties of basalt fiber reinforced polymer composites modified by electrophoretic deposition

丛书名： Environmental Health - Physical, Chemical and Biological Factors

2013年

作者： Patrick Fitzhugh eileen Margach

ISBN: (数字)9781624170980

ISBN: (纸本)9781624170973

Coal mine dust is one of the most serious occupational hazards in the coal mining industry, and overexposure can cause coal workers' pneumoconiosis (CWP) and a number of other lung diseases, collectively referred to a black lung disease. CWP has been the underlying or contributing cause of death for more than 75,000 coal miners since 1968. This book provides an overview of key studies, background history and health reviews on occupational exposure to respirable coal mine dust.

关键词： Coal mining Dust prevention & control Pneumoconiosis prevention & control

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Progress in Natural Science:Materials International 2023年第5期33卷 593-600页

作者： Haoming Sun Dong Xiang Jie Zhang Wei Tan eileen Harkin-Jones Junjie Wang Menghan Wang Bin Wang Chunxia Zhao Hui Li Zhenyu Li Yuntao Li Yuanpeng Wu School of New Energy and Materials Southwest Petroleum University The Center of Functional Materials for Working Fluids of Oil and Gas Field Sichuan Engineering Technology Research Center of Basalt Fiber Composites Development and Application Southwest Petroleum University Collaborative Scientific Innovation Platform of Universities in Sichuan for Basalt Fiber Southwest Petroleum University School of Mechanical Engineering Southwest Petroleum University School of Engineering and Materials Science Queen Mary University of London School of Engineering Ulster University Department of Civil Engineering Tsinghua University College of Materials Science and Engineering Chongqing University

In this work, basalt fiber reinforced polymer(BFRP) with enhanced electrical, mechanical properties and in-situ damage self-sensing capability was prepared using carboxylic carbon nanotubes(COOH-CNTs) modified BF fabrics via electrophoretic deposition(EPD) at different voltages. The BFRP with BF fabrics modified at a deposition voltage of 20 V(EPD20-BFRP) showed the lowest electrical resistivity. Compared with unmodified BFRP, the tensile and flexual moduli of EPD20-BFRP increased by 37.5 % and 14.9 %, respectively. Single-layer EPD20-BFRP exhibited a high gauge factor(GF) of 44.3 during tensile damage self-sensing. The acoustic emission(AE) signals during tensile and flexual damage process agreed well with the relative resistance changes(RRC),which confirmed different damage stages within loading process, such as elastic deformation, damage evolution,crack coalescence, and complete fracture. In addition, the multi-layer BFRP containing a single-layer EPD20-BFRP on the upper or lower surface of laminate exhibited distinct electrical signal responses subjected to the flexural loading.

关键词： Carbon nanotubes and nanofibers Natural fibers Polymer-matrix composites (PMCs) Non-destructive testing

A Virtual Router Cluster System Based on the Separation of the Control Plane and the Data Plane

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信息通信技术 2012年第2期6卷 48-53页

作者： Kentaro ogawa NTT NETWORK SERVICE SYSTEM LABORATORIES NTT CORPORATION Tokyo 100-0004

This paper proposes a virtual router cluster system based on the separation of the control plane and the data plane from multiple perspectives,such as architecture,key technologies,scenarios and *** some extent,the virtual cluster simplifies network topology and management,achieves automatic *** and saves the IP *** is a kind of low-cost expansion method of aggregation equipment port density.

关键词：摘要编辑部编辑工作读者

Real-world Effectiveness and Tolerability of Interferonfree Direct-acting Antiviral for 15,849 Patients with Chronic Hepatitis C:A Multinational Cohort Study

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Journal of Clinical and Translational Hepatology 2024年第7期12卷 646-658页

作者： Fanpu Ji Sally Tran Eiichi ogawa Chung-Feng Huang Takanori Suzuki Yu Jun Wong Hidenori Toyoda Dae Won Jun Liu Li Haruki Uojima Akito Nozaki Makoto Chuma Cheng-Hao Tseng Yao-Chun Hsu Masatoshi Ishigami Takashi Honda Masanori Atsukawa Hiroaki Haga Masaru Enomoto Huy Trinh Carmen Monica Preda Phillip Vutien Charles Landis Dong Hyun Lee Tsunamasa Watanabe Hirokazu Takahashi Hiroshi Abe Akira Asai Yuichiro Eguchi Jie Li Xiaozhong Wang Jia Li Junping Liu Jing Liang Carla Pui-Mei Lam Rui Huang Qing Ye Hongying Pan Jiajie Zhang Dachuan Cai Qi Wang Daniel Q.Huang Grace Wong Vincent Wai-Sun Wong Junyi Li Son Do Norihiro Furusyo Makoto Nakamuta Hideyuki Nomura Eiji Kajiwara eileen L.Yoon Sang Bong Ahn Koichi Azuma Kazufumi Dohmen Jihyun An Do Seon Song Hyun Chin Cho Akira Kawano Toshimasa Koyanagi Aritsune Ooho Takeaki Satoh Kazuhiro Takahashi Ming-Lun Yeh Pei-Chien Tsai Satoshi Yasuda Yunyu Zhao Yishan Liu Tomomi Okubo Norio Itokawa Mi Jung Jun Toru Ishikawa Koichi Takaguchi Tomonori Senoh Mingyuan Zhang Changqing Zhao Raluca Ioana Alecu Wei Xuan Tay Pooja Devan Joanne Kimiko Liu Ritsuzo Kozuka Elena Vargas-Accarino Ai-Thien Do Mayumi Maeda Wan-Long Chuang Jee-Fu Huang Chia-Yen Dai Ramsey Cheung Maria Buti Junqi Niu Wen Xie Hong Ren Seng Gee Lim Chao Wu Man-Fung Yuen Jia Shang Qiang Zhu Yoshiyuki Ueno Yasuhito Tanaka Jun Hayashi Ming-Lung Yu Mindie H.Nguyen Department of Infectious Diseases The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxiChina Division of Gastroenterology and Hepatology Department of MedicineStanford University Medical CenterPalo AltoCAUSA Department of General Internal Medicine Kyushu University HospitalFukuokaJapan Hepatobiliary Division Department of Internal MedicineKaohsiung Medical University HospitalKaohsiung Hepatitis Research Center College of Medicine and Center for Liquid Biopsy and Cohort ResearchKaohsiung Medical UniversityKaohsiung Department of Gastroenterology and Metabolism Nagoya City University Graduate School of Medical SciencesNagoyaJapan Gastroenterology&Hepatology Changi General HospitalSinghealthSingapore Singhealth Duke-NUS Medicine Academic Clinical Program Singapore Department of Gastroenterology Ogaki Municipal HospitalOgakiJapan Department of Internal Medicine Hanyang UniversityCollege of MedicineSeoulKorea Hanyang Institute of Bioscience and Biotechnology Hanyang UniversitySeoulKorea Department of Hepatology The Third People's Hospital of Kunming CityKunmingYunnanChina Department of Gastroenterology Internal MedicineKitasato University School of MedicineSagamiharaJapan Gastroenterological Center Yokohama City University Medical CenterYokohamaJapan Division of Gastroenterology and Hepatology Department of Internal MedicineE-Da Cancer HospitalKaohsiung Department of Gastroenterology and Hepatology Nagoya University Graduate School of MedicineNagoyaJapan Division of Gastroenterology and Hepatology Nippon Medical SchoolTokyoJapan Department of Gastroenterology Yamagata University Faculty of MedicineYamagataJapan Department of Transfusion Medicine and Department of Hepatology Osaka Metropolitan University Graduate School of MedicineOsakaJapan San Jose Gastroenterology San JoseCAUSA Gastroenterology&Hepatology Department Clinic Fundeni InstituteBucharestRomania Division of Gastroenterology and Hepatology University of WashingtonSeattleWAUSA Department of

Background and Aims:As practice patterns and hepatitis C virus(HCV)genotypes(GT)vary geographically,a global real-world study from both East and West covering all GTs can help inform practice policy toward the 2030 HCV elimination *** study aimed to assess the effectiveness and tolerability of DAA treatment in routine clinical practice in a multinational cohort for patients infected with all HCV GTs,focusing on GT3 and ***:We analyzed the sustained virological response(SVR12)of 15,849 chronic hepatitis C patients from 39 Real-World Evidence from the Asia Liver Consortium for HCV clinical sites in Asia Pacific,North America,and Europe between 07/01/2014–07/01/***:The mean age was 62±13 years,with 49.6%*** demographic breakdown was 91.1%Asian(52.9%Japanese,25.7%Chinese/Taiwan residents,5.4%Korean,3.3%Malaysian,and 2.9%Vietnamese),6.4%White,1.3%Hispanic/Latino,and 1%Black/***,34.8%had cirrhosis,8.6%had hepatocellular carcinoma(HCC),and 24.9%were treatment-experienced(20.7%with interferon,4.3%with direct-acting antivirals).The largest group was GT1(10,246[64.6%]),followed by GT2(3,686[23.2%]),GT3(1,151[7.2%]),GT6(457[2.8%]),GT4(47[0.3%]),GT5(1[0.006%]),and untyped GTs(261[1.6%]).The overall SVR12 was 96.9%,with rates over 95%for GT1/2/3/6 but 91.5%for ***12 for GT3 was 95.1%overall,98.2%for GT3a,and 94.0%for ***12 was 98.3%overall for GT6,lower for patients with cirrhosis and treatment-experienced(TE)(93.8%)but≥97.5%for tretment-naive patients regardless of cirrhosis *** multivariable analysis,advanced age,prior treatment failure,cirrhosis,active HCC,and GT3/4 were independent predictors of lower SVR12,while being Asian was a significant predictor of achieving ***:In this diverse multinational realworld cohort of patients with various GTs,the overall cure rate was 96.9%,despite large numbers of patients with cirrhosis,HCC,TE,and GT3/***12 for GT3/6 with cirrhosis and TE was lower but st

关键词： Hepatitis C virus Liver cirrhosis Hepatocellular carcinoma Genotype DAA REAL-C

Five Years of Rice Cultivation in Paddy Fields for Treated Water from Humus Bioreactor-Type Rural Wastewater Treatment Plants

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Journal of Environmental Science and Engineering(B) 2021年第5期10卷 179-190页

作者： Hitoshi ogawa Research Institute University of TamagawaTokyo 194-0041Japan

The treated sewage has a color as well as odor and is difficult to *** methods to reduce color with odor are costly and more difficult to *** the color and odor were reduced by pellet-type bioreactor sewage treatment using humus,rice was cultivated for 3 ***,3 years is sufficient to investigate the stability of treatment facilities,but when biological treatment is applied,5 to 10 years of investigation is *** addition,in rice cultivation,a similar 5 to 10 years survey is required to investigate the accumulation of low-concentration *** report is a five-year report and is the result of paddy rice cultivation in a stable wastewater treatment *** cultivated rice fully satisfied the edible standards and was able to obtain safe rice,and the effect of reducing fertilizer applied was obtained by using nitrogen and phosphorus from the treated *** addition,the yield was able to be within the range of the standard yield of 500 kg to 550 kg/1,000 m^(2).

关键词： Water reuse odor reduce color reduce bio-reactor rice production

新型科研机构创新保护机制的扎根研究——以中山大学深圳研究院为例

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科技管理研究 2017年第24期37卷 10-18页

作者：张漪 Yang eileen Jianxun 北京市君泽君(深圳)律师事务所广东深圳518026 中山大学深圳研究院广东深圳518057

区别于传统科研机构,新型科研机构集科研开发与产业化于一体,在协同创新系统中通过技术创新与服务创新形成竞争优势,从而获取经济利润。目前新型科研机构整体处于发展的初级阶段,面临着体制制约和生存发展挑战。基于对现有创新保护理论... 详细信息

区别于传统科研机构,新型科研机构集科研开发与产业化于一体,在协同创新系统中通过技术创新与服务创新形成竞争优势,从而获取经济利润。目前新型科研机构整体处于发展的初级阶段,面临着体制制约和生存发展挑战。基于对现有创新保护理论的研究评述,尝试从创新独占视角入手,通过个案扎根分析,探索新型科研机构的创新保护方式、构成维度及其对创新绩效的影响。

关键词：新型科研机构创新独占性创新保护扎根理论