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Laparoscopic, Endoscopic and Robotic Surgery 2018年第2期1卷 33-36页

作者： m.johnson O.A.Khan E.R.mcGlone A.A.Roman J.S.Qureshi A.Kayal Anaesthetic Registrar St Helier HospitalWrythe LaneSM51AAUK St Georges NHS Trust LondonSW17 OQTUK

Complete and reliable neuromuscular reversal is important to successful anaesthetic recovery in the morbidly obese patient undergoing laparoscopic *** goal was to determine whether sugammadex,a selective reversal agent is associated with better respiratory recovery than neostigmine following the reversal of anaesthesia-associated neuromuscular blockade by rocuronium in the morbidly *** Expiratory Flow Rate a surrogate marker for respiratory function,was the primary outcome measured and secondary outcome measures included post-operative nausea and vomiting,pain and head *** found that patients reversed with sugammadex had a significantly higher post-operative PEFR as compared to those reversed with neostigmine and glycopyrrolate group.

关键词： Sugammadex Laparoscopic surgery Neuromuscular blockade morbidly obese

Neurogenesis dynamics in the olfactory bulb:deciphering circuitry organization, function, and adaptive plasticity

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Neural Regeneration Research 2025年第6期20卷 1565-1581页

作者： moawiah m.Naffaa Department of Psychology and Neuroscience Duke UniversityDurhamNCUSA Department of Cell Biology Duke University School of MedicineDurhamNCUSA

Adult neurogenesis persists after birth in the subventricular zone, with new neurons migrating to the granule cell layer and glomerular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfactory bulb supports both structural and functional plasticity, aiding in circuit remodeling triggered by memory and learning processes. However, the presence of these neurons, coupled with the cellular diversity within the olfactory bulb, presents an ongoing challenge in understanding its network organization and function. moreover,the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory information processing. This adaptive process responds to changes in epithelial composition and contributes to the formation of olfactory memories by modulating cellular connectivity within the olfactory bulb and interacting intricately with higher-order brain regions. The role of adult neurogenesis in olfactory bulb functions remains a topic of debate. Nevertheless, the functionality of the olfactory bulb is intricately linked to the organization of granule cells around mitral and tufted cells. This organizational pattern significantly impacts output, network behavior, and synaptic plasticity, which are crucial for olfactory perception and memory. Additionally, this organization is further shaped by axon terminals originating from cortical and subcortical regions. Despite the crucial role of olfactory bulb in brain functions and behaviors related to olfaction, these complex and highly interconnected processes have not been comprehensively studied as a whole. Therefore, this manuscript aims to discuss our current understanding and explore how neural plasticity and olfactory neurogenesis contribute to enhancing the adaptability of the olfactory system. These mechanisms are thought to support olfactory learning and memory, potentially through increased

关键词： network adaptability neurogenesis neuronal communication olfactory bulb olfactory learning olfactory memory synaptic plasticity

Alkaline igneous rocks,a potential source of rare metals and radioactive minerals:Case study at Amreit area,south Eastern Desert,Egypt

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Acta Geochimica 2025年第1期44卷 189-214页

作者： Baaha m.Emad Nuclear materials Authority El MaadiP.O.Box:530CairoEgypt

Alkaline igneous rocks represent one of the most economically important resources of radioactive minerals and rare *** field observations and petrographic studies are integrated with whole-rock geochemical analyses and Gamma ray spectroscopy data of alkaline rocks associated with the Amreit *** fieldwork was achieved by the collection of more than forty samples from alkaline granites and alkaline *** youngest rocks cropping out in the study area are the cogenetic alkaline rocks,ranging from alkaline granite to alkaline *** alkaline rocks are composed essentially of K-feldspar,alkali amphiboles(arfvedsonite),and sodic pyroxene,with accessories such as zircon,apatite,and *** characterization of the highly radioactive zones in both alkaline granite and alkaline syenite displays enrichment in monazite,thorite,zircon,ferro-columbite,xenotime,and allanite *** analyses indicate that the Amreit rocks are alkaline with peralkaline affinity and have high concentrations of total alkalis(K_(2)O+Na_(2)O),large ion lithophile elements(LILEs;Ba and Rb),high field strength elements(HFSEs;Y,Zr and Nb),rare earth elements(REEs)and significantly depleted in K,Sr,P,Ti,and Eu,typically of post-collision A-type ***,the Amreit alkaline igneous rocks are classified as within plate granites and display A2 subtype *** fractionation of K-feldspars played a distinctive role during the magmatic evolution of these alkaline *** geochemical characteristics indicate that the studied alkaline igneous rocks which were originated by fractional crystallization of alkaline magmas were responsible for the enrichment of the REE and rare metals in the residual *** high radioactivity is essentially related to accessory minerals,such as zircon,allanite,and *** alkaline granite is the most U-and Thrich rock,where radioactivity level reaches up to 14.7 ppm(181.55 Bq/kg)e U,40.6 ppm(164.84 Bq/kg)e

关键词： Amreit area Alkaline rocks Radioactivity Geochemistry Post-collision A-type granite Egypt

mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología molecular Severo Ochoa(CBm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

SBL-JP-0004:A promising dual inhibitor of JAK2 and PI3KCD against gastric cancer

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Oncology Research 2025年第1期33卷 235-243页

作者： HASSAN m.OTIFI Department of Pathology College of MedicineKing Khalid UniversityAbha62521Saudi Arabia

Background:Gastric cancer(GC)remains a global health burden and is often characterized by heterogeneous molecular profiles and resistance to conventional *** phosphoinositide 3-kinase and PI3K and Janus kinase(JAK)signal transducer and activator of transcription(JAK-STAT)pathways play pivotal roles in GC progression,making them attractive targets for therapeutic ***:This study applied a computational and molecular dynamics simulation approach to identify and characterize SBL-JP-0004 as a potential dual inhibitor of JAK2 and PI3KCD *** and SNU-5 GC cells were used for in vitro ***:SBL-JP-0004 exhibited a robust binding affinity for JAK2 and PI3KCD kinases,as evidenced by molecular docking scores and molecular dynamics *** interactions and Gibbs binding free energy estimates confirmed stable and favorable interactions with target ***-JP-0004 displayed an half-maximal inhibitory concentration(IC_(50))value of 118.9 nm against JAK2 kinase and 200.9 nm against PI3KCD ***-JP-0004 exhibited potent inhibition of cell proliferation in KATOIII and SNU-5 cells,with half-maximal growth inhibitory concentration(GI50)values of 250.8 and 516.3 nm,respectively.A significant elevation in the early phase apoptosis(28.53%in KATOIII cells and 26.85%in SNU-5 cells)and late phase apoptosis(17.37%in KATOIII cells and 10.05%in SNU-5 cells)were observed with SBL-JP-0004 treatment compared to 2.1%and 2.83%in their respective ***:The results highlight SBL-JP-0004 as a promising dual inhibitor targeting JAK2 and PI3KCD kinases for treating GC and warrant further preclinical and clinical investigations to validate its utility in clinical settings.

关键词： Gastric cancer(GC) Dual inhibition JAK2 PI3KCD SBL-JP-0004 molecular docking molecular dynamics simulation

Assessment of the heartwood contribution to carbon accumulation in Pinus sylvestris L. trees under different forest site conditions

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FOREST ECOSYSTEmS 2025年第1期12卷 159-175页

作者： Galibina, Natalia A. Nikerova, Kseniya m. moshnikov, Sergey A. Kryshen, Alexander m. Russian Acad Sci Forest Res Inst Karelian Res Ctr 11 Pushkinskaya St Petrozavodsk 185910 Karelia Russia

Background: The heartwood (HW) proportion in the trunk of mature trees is an important characteristic not only for wood quality but also for assessing the role of forests in carbon sequestration. We have for the first time studied the proportion of HW in the trunk and the distribution of carbon and extractives in sapwood (SW) and HW of 70-80 year old Pinus sylvestris L. trees under different growing conditions in the pine forests of North-West Russia. method: We have examined the influence of conditions and tree position in stand (dominant, intermediate and suppressed trees) in the ecological series: blueberry pine forest (Blu) - lingonberry pine forest (Lin) - lichen pine forest (Lic). We have analyzed the influence of climate conditions in the biogeographical series of Lin: the middle taiga subzone - the northern taiga subzone - the transition area of the northern taiga subzone and tundra. Results: We found that the carbon concentration in HW was 1.6%-3.4% higher than in SW, and the difference depended on growing conditions. Carbon concentration in HW increased with a decrease in stand productivity (Blu-Lin-Lic). In medium-productive stands, the carbon concentration in SW was higher in intermediate and supressed trees compared to dominant trees. In the series from south to north, carbon concentration in HW increased by up to 2%, while in SW, it rose by 2.7%-3.8%. Conclusions: Our results once again emphasized the need for an empirical assessment of the accurate carbon content in aboveground wood biomass, including various forest growing conditions, to better understand the role of boreal forests in carbon storage.

关键词： Scots pine Blueberry pine forest Lingonberry pine forest Lichen pine forest Tree social class Climate Carbon content Extractives Cellulose Lignin

Robust-optimal control of electromagnetic levitation system with matched and unmatched uncertainties:experimental validation

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Control Theory and Technology 2025年第1期23卷 28-48页

作者： Amit Pandey Dipak m.Adhyaru Department of Electronics and Instrumentation Engineering Institute of TechnologyNirma UniversityAhmedabadGujarat382481India

The electromagnetic levitation system(EmLS)serves as the most important part of any magnetic levitation ***,its characteristics are defined by its highly nonlinear dynamics and ***,the uncertainties in the dynamics of an electromagnetic levitation system make the controller design more ***,it is necessary to design a robust control law that will ensure the system’s stability in the presence of these *** this framework,the dynamics of an electromagnetic levitation system are addressed in terms of matched and unmatched *** robust control problem is translated into the optimal control problem,where the uncertainties of the electromagnetic levitation system are directly reflected in the cost *** optimal control method is used to solve the robust control *** solution to the optimal control problem for the electromagnetic levitation system is indeed a solution to the robust control problem of the electromagnetic levitation system under matched and unmatched *** simulation and experimental results demonstrate the performance of the designed control *** performance indices such as integral absolute error(IAE),integral square error(ISE),integral time absolute error(ITAE),and integral time square error(ITSE)are compared for both uncertainties to showcase the robustness of the designed control scheme.

关键词： Nonlinear system Robust control Optimal control HJB equation Lyapunov stability Electromagnetic levitation system

Structural,dielectric and magnetic properties of terbium doped strontium spinel ferrite（SrFe2O4） synthesized by sol-gel method

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Journal of Rare Earths 2025年第2期43卷 337-344页

作者： Rifat Shaheen Hafeez Ullah m.m.moharam Ahmad m.Saeedi Ebraheem Abdu musad Saleh muhammad Ijaz Adel A.El-Zahhar Gamil A.A.m.Al-Hazmi Sana Ullah Asif Hafiz muhammad Tahir Institute of Physics Gomal University Department of Chemistry College of Arts and SciencesPrince Sattam Bin Abdulaziz University Chemical and Electrochemical Processing Department Central Metallurgical Research and Development Institute (CMRDI) Department of Physics Faculty of Applied ScienceUmm AL-Qura University Department of Chemistry College of ScienceKing Khalid University School of materials and Energy Yunnan University Department of Physics Govt. Graduate College Taunsa

In this research work,sol-gel technique was employed to prepare the strontium based spinel ferrite nanoparticles（SrFe2O4） with different ratios of terbium（Tb）.Different characterization techniques were used to investigate the structural,morphological,dielectric and magnetic properties of the prepared samples.X-ray diffraction（XRD） result suggests that face-centered cube spinel nanocrystalline structure is *** size of the SrFe2O4decreases with rising of Tb *** morphology,shape and size of the SrFe2O4were examined by scanning electron microscopy（SEm） analysis and results reveal inhomogeneous distributions of the nanostructures with high *** electrical resistivity of the SrFe2O4increases with rising of Tb ratio,which is confirmed from the cyclic *** is observed that dielectric constant of all the samples decreases with the increasing frequency *** is determined that the dielectric constants of the spinel ferrites are frequency dependent and decrease with increasing the frequency of applied electric *** magnetic behavior of SrFe2O4with different ratios of Tb was studied and it is found that the saturation magnetization values of samples decrease with increase in the substitution of Tb3+at octahedral sites for Fe3+.This decrease in the values of msis also attributed to spin at surface of nanoparticles.

关键词： Dielectric properties magnetic properties Rare earths Sol-gel Spinel ferrites Structural properties

Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holmström Henri J.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

microsoft Powerpoint 4 for Windows使用教程

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