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儿童NTRK重排间叶源性肿瘤临床病理学观察

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中华病理学杂志 2020年第7期49卷 675-680页

作者：殷敏智马靖何巧沈萍陈洁枫金晓婷张忠德 Chik Hong Kuick Chen huiyi eileen hui qi ng Sze Jet Aw Kenneth Tou En Chang 上海交通大学医学院附属上海儿童医学中心病理科 200127 Department of Pathology and Laboratory Medicine KK Women′s and Children′s HospitalSingapore 229899Singapore

目的:探讨儿童NTRK重排间叶源性肿瘤临床和病理学特征,以提高对该类疾病的认识。方法:收集上海交通大学医学院附属上海儿童医学中心及新加坡KK Women′s and Children′s Hospital从2017年1月至2019年9月5例手术切除标本,采用EnVision... 详细信息

目的:探讨儿童NTRK重排间叶源性肿瘤临床和病理学特征,以提高对该类疾病的认识。方法:收集上海交通大学医学院附属上海儿童医学中心及新加坡KK Women′s and Children′s Hospital从2017年1月至2019年9月5例手术切除标本,采用EnVision法检测免疫组织化学表型,荧光原位杂交(FISH)检测相关基因并对NTRK基因重排进行克隆性分析。结果:该组5例患儿,3例男性,2例女性。年龄从3个月到13岁,部位包括软组织(膝、胸腔、腹壁)和肾,肿瘤大小为4.5~12.5 cm。组织学检查主要呈梭形细胞肿瘤,浸润性生长,可伴有炎性细胞。免疫表型上,肿瘤细胞阳性表达Pan-TRK,分子检测均存在NTRK基因重排,包括DCTN1-NTRK1的发现。除2例目前接受靶向药物治疗,其余均为无疾病进展病例,随访时间9~29个月。结论:NTRK重排间叶源性肿瘤,其肿瘤发生部位广泛,组织学图像多变。免疫组织化学Pan-TRK可以帮助诊断,NTRK基因检测确认其存在重排是诊断的金标准,对不能完整切除或有复发、转移病例建议靶向药物治疗。

关键词：儿童免疫组织化学分子靶向治疗间叶源性肿瘤

Atmospheric reductive catalytic fractionation of lignocellulose integrated with one-pot catalytic conversion of carbohydrate yielding valuable lignin monomers and platform chemicals from corn straw

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Green Energy & Environment 2025年第1期10卷 161-172页

作者： Meng-Ying Liu Zhe-hui Zhang Xue-qi Wang qian Sun Chen Zhang Yu Li Zhuohua Sun Katalin Barta Feng Peng Tong-qi Yuan State Key Laboratory of Efficient Production of Forest Resources Beijing Forestry UniversityBeijing100083China Beijing Key Laboratory of Lignocellulosic Chemistry Beijing Forestry UniversityBeijing100083China Department of Chemistry Organic and Bioorganic ChemistryUniversity of GrazHeinrichstrasse 28/II8010 GrazAustria

Developing a cost-effective and environmentally friendly process for the production of valuable chemicals from abundant herbal biomass receives great attentions in recent ***,taking advantage of the“lignin first”strategy,corn straw is converted to valuable chemicals including lignin monomers,furfural and 5-methoxymethylfurfural via a two steps *** key of this research lies in the development of a green and low-cost catalytic process utilizing magnetic Raney Ni catalyst and high boiling point ethylene *** utilization of neat ethylene glycol as the sole slovent under atmospheric conditions obviates the need for additional additives,thereby facilitating the entire process to be conducted in glass flasks and rendering it highly convenient for scaling *** the initial step,depolymerization of corn straw lignin resulted in a monomer yield of 18.1 wt%.Subsequently,in a dimethyl carbonate system,the carbohydrate component underwent complete conversion in a one-pot process,yielding furfural and 5-methoxymethylfurfural as the primary products with an impressive yield of 47.7%.

关键词： Atmospheric reductive catalytic fractionation Corn straw Ethylene glycol Raney Ni 5-Methoxymethylfurfural

High-temperature oxidation behavior and degradation mechanism of chromium-coated zirconium alloy cladding: a review

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Tungsten 2025年第1期7卷 50-70页

作者： Yi Li Bei-qi Wang Xin-Yin Zhang Shi-Jie Wang Cong-Yi Li hui-Long Yang Ran-Ran Su Tong Liu School of Mechanical Engineering Shanghai Jiao Tong University College and Graduate School of Arts and Sciences University of Virginia Global Institute of Future Technology Shanghai Jiao Tong University

Accident-tolerant fuels(ATF) have been extensively studied to reduce the production rate and total amount of heat and hydrogen generated from high-temperature steam oxidation during severe ***-coated zirconium alloy cladding has become one of the most promising candidates for ATF because of its excellent corrosion and oxidation *** paper provides a comprehensive overview of the research progress on oxidation behaviors and degradation mechanisms in chromium-coated zirconium alloy cladding under high-temperature *** techniques to strengthen the oxidation resistance are highlighted and ***,challenges and opportunities for various future directions are addressed.

关键词： Accident-tolerant fuel Chromium coating Degradation mechanism High-temperature oxidation behavior Zirconium alloy cladding

Rotating electroosmotic flow of an Eyring fluid

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Acta Mechanica Sinica 2017年第2期33卷 295-315页

作者： Cheng qi Chiu-On ng Department of Mechanical Engineering The University of Hong Kong Hong Kong China

A perturbation analysis is presented in this paper for the electroosmotic (EO) flow of an Eyring fluid through a wide rectangular microchannel that rotates about an axis perpendicular to its own. Mildly shear-thinning rheology is assumed such that at the leading order the problem reduces to that of Newtonian EO flow in a rotating channel, while the shear thinning effect shows up in a higher-order problem. Using the relaxation time as the small ordering parameter, analytical solutions are deduced for the leading- as well as first-order problems in terms of the dimensionless Debye and rotation parameters. The velocity profiles of the Ekman-electric double layer (EDL) layer, which is the boundary layer that arises when the Ekman layer and the EDL are comparably thin, are also deduced for an Eyring fluid. It is shown that the present perturbation model can yield results that are close to the exact solutions even when the ordering parameter is as large as order unity. By this order of the relaxation time parameter, the enhancing effect on the rotating EO flow due to shear-thinning Eyring rheology can be significant.

关键词： Electroosmotic flow Eyring fluid Rotating channel

Enhanced subacute ischemic stroke treatment via multistage drug delivery system design for combination therapy

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Science China Chemistry 2025年

作者： Xihan Xu Juan-Juan Li Jiamin Li hui-Yan Zhang Yilin qi Bing-Sen Shi Tianqi Li Shan-Shan Su Weitao Zhao Chang Chen Zhongying Gong huiyu Liu Ke-Rang Wang Dong-Sheng Guo Xue Xue State Key Laboratory of Medicinal Chemical Biology College of Pharmacy Nankai University College of Chemistry State Key Laboratory of Elemento-Organic Chemistry Key Laboratory of Functional Polymer Materials (Ministry of Education) Frontiers Science Center for New Organic Matter Collaborative Innovation Center of Chemical Science and EngineeringNankai University College of Chemistry and Materials Science State Key Laboratory of New Pharmaceutical Preparations and Excipients Key Laboratory of Medicinal Chemistry and Molecular Diagnosis (Ministry of Education) Key Laboratory of Chemical Biology of Hebei Province Hebei Research Center of the Basic Discipline of Synthetic Chemistry Hebei University Department of Neurology Tianjin First Central Hospital School of Medicine Nankai University Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic-Inorganic Composites Beijing Laboratory of Biomedical Materials Bionanomaterials & Translational Engineering Laboratory Beijing Key Laboratory of BioprocessBeijing University of Chemical Technology

The management of acute ischemic stroke remains challenging due to its abrupt onset and the narrow treatment window,resulting in high rates of disability and *** therapy for neuroprotection and neurorepair strategies provided new hopes for subacute stroke *** we designed a multistage nanodelivery system that matches the unique microenvironment of the subacute phase of stroke,which utilizes calixarene as a building block to effectively load the neuroprotective drug *** calixarene is designed with glycosidic linkages targeting the glucose transporter 1 (GLUT1)on the blood-brain barrier (BBB) and azo bonds that are responsive to hypoxic ***,the decomposed calixarene molecules themselves possess intrinsic bio-activation to modulate inflammatory responses,achieving a multistage therapeutic approach that transitions from targeting to release and finally to *** approach combines anti-inflammation and neuroprotection,providing a multi-level treatment *** system was validated in a rat model of permanent middle cerebral artery occlusion (pMCAO),demonstrating that intravenous administration of the nanodelivery system repairs brain damage and improves motor function 24 h post-pMCAO *** work offers a precise and integrative strategy for stroke patients missing the acute therapy window to improve functional recovery and enhance the effect of comprehensive treatment.

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沥青路面裂缝高聚物注浆效果试验评价研究

山西建筑 2025年第2期51卷 129-132页

作者：祁敏曾辉江苏路通装配科技有限公司江苏宜兴214200 江苏众智交通创新产业研究院有限公司江苏南京211899

非开挖式注浆技术采用高聚物双组分材料注浆,能有效填充沥青路面裂缝处半刚性基层和底基层层间脱空,排出结构层水分,密封裂缝,达到补强路面结构层效果。为了评价注浆技术应用效果,通过施工过程注浆孔检测、注浆前后探地雷达图谱测试、... 详细信息

非开挖式注浆技术采用高聚物双组分材料注浆,能有效填充沥青路面裂缝处半刚性基层和底基层层间脱空,排出结构层水分,密封裂缝,达到补强路面结构层效果。为了评价注浆技术应用效果,通过施工过程注浆孔检测、注浆前后探地雷达图谱测试、弯沉测试以及取芯等方式来评判,结果显示注浆后裂缝处弯沉能降低20%,两侧弯沉差明显减小,三维探地雷达检测显示裂缝注浆后灰度图内部未出现异常信号,无振幅加强现象,证明裂缝处浆液被填充。

关键词：非开挖注浆高聚物半刚性基层三维探地雷达横向裂缝

Structure and Properties of β-Polypropylene Reinforced by Polypropylene Fiber and Polyamide Fiber

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Chinese Journal of Polymer Science 2014年第4期32卷 509-518页

作者： qi Liu hui-hui Li 闫寿科 State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology

Matrix/fiber composites of,β-form isotactic polypropylene （iPP） matrix and α-iPP or PA6 fibers were prepared by laminating technique under different preparation temperatures. The mechanical properties and interracial morphologies of these composites were studied by tensile test, optical microscopy and scanning electron microscopy, respectively. The experimental results show that the tensile yield load and tensile modulus of β-iPP/PA6 matrix/fiber systems increased significantly at the expense of elongation at break. These mechanical properties show essentially no dependence on the sample preparation temperature. On the other hand, the mechanical properties of iPP matrix/fiber single polymer composites depend strongly on the sample preparation temperature. At low sample preparation temperature, e.g., 172 ℃, the solid cr-iPP fiber induces tr-iPP crystallization, leading to the formation of a-iPP transcrystalline layer around the fiber. This results in a remarkable increment of the tensile yield load and tensile modulus. The elongation at break is also much better than that of the iPP/PA6 matrix/fiber system. It reflects a better interracial adhesion of the single polymer composite compared with the iPP/PA6 composite. At higher sample preparation temperature, e.g., 174 ℃ or 176 ℃, the partial surface melting of the oriented fiber allows interdiffusion of iPP molecular chains in the molten fiber and matrix melt. The penetration of matrix chains into the molten iPP fiber results in some iPP molecular chains being included partially in the recrystallized fiber and the induced β-transcrystalline layers. This kind of configuration leads to an improvement of interfacial adhesion between the fiber and matrix, which causes a simultaneous increase of the tensile yield load, tensile modulus and elongation at break of β-iPP.

关键词： Polypropylene Composite Mechanical property Interfacial morphology.

An online electricity cost budgeting algorithm for maximizing green energy usage across data centers

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Frontiers of Computer Science 2017年第4期11卷 661-674页

作者： hui DOU Yong qi School of Electronic and Information Engineering Xi'an Jiaotong University Xi'an 710049 China

With the sky-rocketing development of Internet services, the power usage in data centers has been signifi- cantly increasing. This ever increasing energy consumption leads to negative environmental impact such as global warming. To reduce their carbon footprints, large Internet service operators begin to utilize green energy. Since green energy is currently more expensive than the traditional brown one, it is important for the operators to maximize the green en- ergy usage subject to their desired long-term （e.g., a month） cost budget constraint. In this paper, we propose an online algorithm GreenBudget based on the Lyapunov optimization framework. We prove that our algorithm is able to achieve a delicate tradeoff between the green energy usage and the en- forcement of the cost budget constraint, and a control parameter V is the knob to arbitrarily tune such a tradeoff. We evaluate GreenBudget utilizing real-life traces of user requests, cooling efficiency, electricity price and green energy avail- ability. Experimental results demonstrate that under the same cost budget constraint, GreenBudget can increase the green energy usage by 11.55% compared with the state-of-the-art work, without incurring any performance violation of user requests.

关键词： electricity cost budgeting green energy coolingefficiency data center Lyapunov optimization

Unsteady rotating flows of a viscoelastic fluid with the fractional Maxwell model between coaxial cylinders

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Acta Mechanica Sinica 2006年第4期22卷 301-305页

作者： Haitao qi hui Jin Department of Applied Mathematics and Statistics Institute of Applied Mathematics Shandong University at Weihai Weihai 264209 Shandong China School of Mathematics and Systematical Science Shandong University Jinan 250100 Shandong China

The fractional calculus is used in the constitutive relationship model of viscoelastic fluid. A generalized Maxwell model with fractional calculus is considered. Based on the flow conditions described, two flow cases are solved and the exact solutions are obtained by using the Weber transform and the Laplace transform for fractional calculus.

关键词： Viscoelastic fluid Unsteady flow Fractional Maxwell model Exact solution